New England Journal of Medicine




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Essential but Undefined — Reimagining How Policymakers Identify Safety-Net Hospitals

Paula Chatterjee, M.D., M.P.H., Benjamin D. Sommers, M.D., Ph.D., and Karen E. Joynt Maddox, M.D., M.P.H.

doi : 10.1056/NEJMp2030228

N Engl J Med 2020; 383:2593-2595

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Medicaid and Child Health Equity

James M. Perrin, M.D., Genevieve M. Kenney, Ph.D., and Sara Rosenbaum, J.D.

doi : 10.1056/NEJMp2030646

N Engl J Med 2020; 383:2595-2598

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FDA Approval of Remdesivir — A Step in the Right Direction

Daniel Rubin, Ph.D., Kirk Chan-Tack, M.D., John Farley, M.D., M.P.H., and Adam Sherwat, M.D.

doi : 10.1056/NEJMp2032369

N Engl J Med 2020; 383:2598-2600

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Whiteout

Elizabeth J. Rourke, M.D.

doi : 10.1056/NEJMp2031266

N Engl J Med 2020; 383:2600-2601

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Reentry

Richard E. Leiter, M.D.

doi : 10.1056/NEJMp2027447

N Engl J Med 2020; 383:e141

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Supporting Clinicians during Covid-19 and Beyond — Learning from Past Failures and Envisioning New Strategies

Jo Shapiro, M.D., and Timothy B. McDonald, M.D., J.D.

doi : 10.1056/NEJMp2024834

N Engl J Med 2020; 383:e142

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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

Fernando P. Polack, M.D., Stephen J. Thomas, M.D., Nicholas Kitchin, M.D., Judith Absalon, M.D., Alejandra Gurtman, M.D., Stephen Lockhart, D.M., John L. Perez, M.D., Gonzalo Pérez Marc, M.D., Edson D. Moreira, M.D., Cristiano Zerbini, M.D., Ruth Bailey, B.Sc., Kena A. Swanson, Ph.D.,

doi : 10.1056/NEJMoa2034577

N Engl J Med 2020; 383:2603-2615

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (Covid-19) have afflicted tens of millions of people in a worldwide pandemic. Safe and effective vaccines are needed urgently.

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Trial of Dexamethasone for Chronic Subdural Hematoma

Peter J. Hutchinson, Ph.D., F.R.C.S. (SN), F.Med.Sci., Ellie Edlmann, Ph.D., M.R.C.S., Diederik Bulters, B.Sc., F.R.C.S. (SN), Ardalan Zolnourian, M.R.C.S., Patrick Holton, M.R.C.S., Nigel Suttner, F.R.C.S. (SN), Kevin Agyemang, M.R.C.S., Simon Thomson, F.R.C.S. (SN), Ian A. Anderson, F.R.C.S. (SN), Yahia Z. Al-Tamimi, M.D., F.R.C.S. (SN), Duncan Henderson, M.R.C.S., Peter C. Whitfield, Ph.D., F.R.C.S. (SN),

doi : 10.1056/NEJMoa2020473

N Engl J Med 2020; 383:2616-2627

Chronic subdural hematoma is a common neurologic disorder that is especially prevalent among older people. The effect of dexamethasone on outcomes in patients with chronic subdural hematoma has not been well studied.

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Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease

David B. Beck, M.D., Ph.D., Marcela A. Ferrada, M.D., Keith A. Sikora, M.D., Amanda K. Ombrello, M.D., Jason C. Collins, Ph.D., Wuhong Pei, Ph.D., Nicholas Balanda, B.Sc., Daron L. Ross, M.D., Daniela Ospina Cardona, B.Sc., Zhijie Wu, M.D., Ph.D., Bhavisha Patel, M.D., Kalpana Manthiram, M.D.,

doi : 10.1056/NEJMoa2026834

N Engl J Med 2020; 383:2628-2638

Adult-onset inflammatory syndromes often manifest with overlapping clinical features. Variants in ubiquitin-related genes, previously implicated in autoinflammatory disease, may define new disorders.

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Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants

Haresh Kirpalani, B.M., Edward F. Bell, M.D., Susan R. Hintz, M.D., Sylvia Tan, M.S., Barbara Schmidt, M.D., Aasma S. Chaudhary, B.S., R.R.T., Karen J. Johnson, R.N., B.S.N., Margaret M. Crawford, B.S., C.C.R.P., Jamie E. Newman, Ph.D., M.P.H., Betty R. Vohr, M.D., Waldemar A. Carlo, M.D., Carl T. D’Angio, M.D.,

doi : 10.1056/NEJMoa2020248

N Engl J Med 2020; 383:2639-2651

Limited data suggest that higher hemoglobin thresholds for red-cell transfusions may reduce the risk of cognitive delay among extremely-low-birth-weight infants with anemia.

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Pathophysiology of Inflammatory Bowel Diseases

John T. Chang, M.D.

doi : 10.1056/NEJMra2002697

N Engl J Med 2020; 383:2652-2664

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Echinococcal Cysts in the Leg

Naseem Akhtar, M.S., M.Ch., and Vijay Kumar, M.S., M.Ch.

doi : 10.1056/NEJMicm2022686

N Engl J Med 2020; 383:2665

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Acquired Hypertrichosis Lanuginosa

Tom Kovitwanichkanont, M.B., B.S., M.P.H., and Mark Darling, M.B., Ch.B.

doi : 10.1056/NEJMicm2018796

N Engl J Med 2020; 383:e144

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Case 41-2020: A 62-Year-Old Man with Memory Loss and Odd Behavior

Bruce H. Price, M.D., David L. Perez, M.D., M.M.Sc., Otto Rapalino, M.D., and Derek H. Oakley, M.D., Ph.D.

doi : 10.1056/NEJMcpc1916251

N Engl J Med 2020; 383:2666-2675

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SARS-CoV-2 Vaccination — An Ounce (Actually, Much Less) of Prevention

Eric J. Rubin, M.D., Ph.D., and Dan L. Longo, M.D.

doi : 10.1056/NEJMe2034717

N Engl J Med 2020; 383:2677-2678

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Beneath a Tough Mother (Dura Mater) — Chronic Subdural Hematoma

Allan H. Ropper, M.D.

doi : 10.1056/NEJMe2031257

N Engl J Med 2020; 383:2678-2680

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Hiding in Plain Sight — Somatic Mutation in Human Disease

Ephrat Levy-Lahad, M.D., and Mary-Claire King, Ph.D.

doi : 10.1056/NEJMe2030754

N Engl J Med 2020; 383:2680-2682

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Employees of the Massachusetts Medical Society in 2020

Eric J. Rubin, M.D., Ph.D.

doi : 10.1056/NEJMe2034826

N Engl J Med 2020; 383:2683

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Audio Interview: A Look at Covid-19 Prevention and Care in 2020

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2036225

N Engl J Med 2020; 383:e147

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The FDA and the Importance of Trust

Lindsey R. Baden, M.D., Caren G. Solomon, M.D., M.P.H., Michael F. Greene, M.D., Ralph B. D’Agostino, Ph.D., and David Harrington, Ph.D.

doi : 10.1056/NEJMe2030687

N Engl J Med 2020; 383:e148

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Emergence of a Highly Fit SARS-CoV-2 Variant

Ralph S. Baric, Ph.D.

doi : 10.1056/NEJMcibr2032888

N Engl J Med 2020; 383:2684-2686

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Causal Genetic Variants in Stillbirth

doi : 10.1056/NEJMc2032136

N Engl J Med 2020; 383:2687-2688

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Physician Work Hours and the Gender Pay Gap — Evidence from Primary Care

doi : 10.1056/NEJMc2032395

N Engl J Med 2020; 383:2688-2689

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Visualization of SARS-CoV-2 in the Lung

doi : 10.1056/NEJMc2030450

N Engl J Med 2020; 383:2689-2690

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March On — Diversity in the Face of Adversity

Shikha Jain, M.D., Vineet M. Arora, M.D., M.A.P.P., Kimberly D. Manning, M.D.,

doi : 10.1056/NEJMpv2026445

N Engl J Med 2020; 383:e145

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