New England Journal of Medicine




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Solving Population-wide Obesity — Progress and Future Prospects

Shiriki Kumanyika, Ph.D., M.P.H., and William H. Dietz, M.D., Ph.D.

doi : 10.1056/NEJMp2029646

N Engl J Med 2020; 383:2197-2200

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The Bottom of the Health Care Rationing Iceberg

Tim Lahey, M.D., M.M.Sc.

doi : 10.1056/NEJMp2021953

N Engl J Med 2020; 383:2200-2201

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“When Will We Have a Vaccine?” — Understanding Questions and Answers about Covid-19 Vaccination

Barry R. Bloom, Ph.D., Glen J. Nowak, Ph.D., and Walter Orenstein, M.D.

doi : 10.1056/NEJMp2025331

N Engl J Med 2020; 383:2202-2204

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From Portraits to Role Models — Why We Need Black Physicians in Academic Medicine

Adetomiwa V. Owoseni, B.S.

doi : 10.1056/NEJMp2027850

N Engl J Med 2020; 383:2204-2205

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Mapping Racial and Ethnic Inequities in Health and Opportunity

The Health Opportunity and Equity (HOPE) Initiative

doi : 10.1056/NEJMp2029139

N Engl J Med 2020; 383:e124

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No-Fault Compensation for Vaccine Injury — The Other Side of Equitable Access to Covid-19 Vaccines

Sam Halabi, J.D., Andrew Heinrich, J.D., and Saad B. Omer, M.B., B.S., Ph.D., M.P.H.

doi : 10.1056/NEJMp2030600

N Engl J Med 2020; 383:e125

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The Missing Piece — SARS-CoV-2 Testing and School Reopening

Yasmin Rafiei, B.Sc., and Michelle M. Mello, J.D., Ph.D.

doi : 10.1056/NEJMp2028209

N Engl J Med 2020; 383:e126

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Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer

Thierry André, M.D., Kai-Keen Shiu, F.R.C.P., Ph.D., Tae Won Kim, M.D., Ph.D., Benny Vittrup Jensen, M.D., Lars Henrik Jensen, M.D., Ph.D., Cornelis Punt, M.D., Ph.D., Denis Smith, M.D., Rocio Garcia-Carbonero, M.D., Ph.D., Manuel Benavides, M.D., Ph.D., Peter Gibbs, M.D., Christelle de la Fouchardiere, M.D., Fernando Rivera, M.D., Ph.D.,

doi : 10.1056/NEJMoa2017699

N Engl J Med 2020; 383:2207-2218

Programmed death 1 (PD-1) blockade has clinical benefit in microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) tumors after previous therapy. The efficacy of PD-1 blockade as compared with chemotherapy as first-line therapy for MSI-H–dMMR advanced or metastatic colorectal cancer is unknown.

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Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

George L. Bakris, M.D., Rajiv Agarwal, M.D., Stefan D. Anker, M.D., Ph.D., Bertram Pitt, M.D., Luis M. Ruilope, M.D., Peter Rossing, M.D., Peter Kolkhof, Ph.D., Christina Nowack, M.D., Patrick Schloemer, Ph.D., Amer Joseph, M.B., B.S., and Gerasimos Filippatos, M.D. for the FIDELIO-DKD Investigators*

doi : 10.1056/NEJMoa2025845

N Engl J Med 2020; 383:2219-2229

Finerenone, a nonsteroidal, selective mineralocorticoid receptor antagonist, reduced albuminuria in short-term trials involving patients with chronic kidney disease (CKD) and type 2 diabetes. However, its long-term effects on kidney and cardiovascular outcomes are unknown.

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“Super-Spreaders” and Person-to-Person Transmission of Andes Virus in Argentina

Valeria P. Mart?nez, Ph.D., Nicholas Di Paola, Sc.D., Daniel O. Alonso, B.Sc., Unai Pérez-Sautu, Ph.D., Carla M. Bellomo, Ph.D., Ayelén A. Iglesias, B.Sc., Rocio M. Coelho, B.Sc., Beatriz L?pez, B.Sc., Natalia Periolo, Ph.D., Peter A. Larson, Ph.D., Elyse R. Nagle, M.Sc., Joseph A. Chitty, B.Sc.,

doi : 10.1056/NEJMoa2009040

N Engl J Med 2020; 383:2230-2241

From November 2018 through February 2019, person-to-person transmission of Andes virus (ANDV) hantavirus pulmonary syndrome occurred in Chubut Province, Argentina, and resulted in 34 confirmed infections and 11 deaths. Understanding the genomic, epidemiologic, and clinical characteristics of person-to-person transmission of ANDV is crucial to designing effective interventions.

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Malaria Chemoprevention in the Postdischarge Management of Severe Anemia

Titus K. Kwambai, M.D., Ph.D., Aggrey Dhabangi, M.D., Ph.D., Richard Idro, M.D., Ph.D., Robert Opoka, M.D., Victoria Watson, B.Sc., Simon Kariuki, Ph.D., Nickline A. Kuya, Dip.Clin.Med., Eric D. Onyango, B.Sc., Kephas Otieno, M.P.H., Aaron M. Samuels, M.D., M.H.S., Meghna R. Desai, Ph.D., Michael Boele van Hensbroek, M.D., Ph.D.,

doi : 10.1056/NEJMoa2002820

N Engl J Med 2020; 383:2242-2254

Children who have been hospitalized with severe anemia in areas of Africa in which malaria is endemic have a high risk of readmission and death within 6 months after discharge. No prevention strategy specifically addresses this period.

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Cytokine Storm

David C. Fajgenbaum, M.D., and Carl H. June, M.D.

doi : 10.1056/NEJMra2026131

N Engl J Med 2020; 383:2255-2273

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Corneal Bee Sting

Teena M. Mendonca, M.S., and Gladys R. Rodrigues, M.B., B.S., D.N.B.

doi : 10.1056/NEJMicm2024132

N Engl J Med 2020; 383:2274

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Green Urine

Maja Boshkovska Spaseski, M.D., and Dejan Spaseski, M.D.

doi : 10.1056/NEJMicm2017137

N Engl J Med 2020; 383:e128

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Looking for the Outsider

Danica M. Vodopivec, M.D., Dylan D. Thomas, M.D., Nadine E. Palermo, D.O., Devin W. Steenkamp, M.B., Ch.B., and Stephanie L. Lee, M.D., Ph.D.

doi : 10.1056/NEJMcps2004935

N Engl J Med 2020; 383:2275-2281

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Pembrolizumab in MSI-H–dMMR Advanced Colorectal Cancer — A New Standard of Care

Axel Grothey, M.D.

doi : 10.1056/NEJMe2031294

N Engl J Med 2020; 383:2283-2285

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Finerenone — Halting Relative Hyperaldosteronism in Chronic Kidney Disease

Julie R. Ingelfinger, M.D., and Clifford J. Rosen, M.D.

doi : 10.1056/NEJMe2031382

N Engl J Med 2020; 383:2285-2286

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Audio Interview: Caring for Hospitalized Patients with Covid-19

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2034472

N Engl J Med 2020; 383:e140

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Prostate Cancer Progression and the Epigenome

Wadih Arap, M.D., Ph.D., Renata Pasqualini, Ph.D., and Joseph F. Costello, Ph.D.

doi : 10.1056/NEJMcibr2030475

N Engl J Med 2020; 383:2287-2290

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Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

doi : 10.1056/NEJMc2031364

N Engl J Med 2020; 383:2291-2293

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Sodium Phenylbutyrate–Taurursodiol for ALS

doi : 10.1056/NEJMc2030710

N Engl J Med 2020; 383:2293-2294

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Rapid Response to an Outbreak in Qingdao, China

doi : 10.1056/NEJMc2032361

N Engl J Med 2020; 383:e129

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