New England Journal of Medicine




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Regulation of Over-the-Counter Hearing Aids — Deafening Silence from the FDA

Kevin H. Franck, Ph.D., M.B.A., and Vinay K. Rathi, M.D., M.B.A.

doi : 10.1056/NEJMp2027050

N Engl J Med 2020; 383:1997-2000

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Transgender Women on College Athletic Teams — The Case of Lindsay Hecox

Janet Dolgin, Ph.D., J.D.

doi : 10.1056/NEJMp2028697

N Engl J Med 2020; 383:2000-2002

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An Unexpected Education — Unclaimed Bodies in the Anatomy Lab

Mary Peeler, M.D., M.P.H.

doi : 10.1056/NEJMp2015975

N Engl J Med 2020; 383:2002-2004

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Screen Time

Elizabeth Rourke, M.D., and illustrated by Natalie Koscal, M.A.

doi : 10.1056/NEJMp2025321

N Engl J Med 2020; 383:2005

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Ruthless Health Law

R. Alta Charo, J.D.

doi : 10.1056/NEJMp2030358

N Engl J Med 2020; 383:e115

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Two Steps Back — Rescinding Transgender Health Protections in Risky Times

Sula Malina, B.A., Sarah Warbelow, J.D., and Asa E. Radix, M.D., Ph.D.

doi : 10.1056/NEJMp2024745

N Engl J Med 2020; 383:e116

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Golimumab and Beta-Cell Function in Youth with New-Onset Type 1 Diabetes

Teresa Quattrin, M.D., Michael J. Haller, M.D., Andrea K. Steck, M.D., Eric I. Felner, M.D., Yinglei Li, Ph.D., Yichuan Xia, Ph.D., Jocelyn H. Leu, Pharm.D., Ph.D., Ramineh Zoka, Pharm.D., Joseph A. Hedrick, Ph.D., Mark R. Rigby, M.D., Ph.D., and Frank Vercruysse, M.D. for the T1GER Study Investigators*

doi : 10.1056/NEJMoa2006136

N Engl J Med 2020; 383:2007-2017

Type 1 diabetes is an autoimmune disease characterized by progressive loss of pancreatic beta cells. Golimumab is a human monoclonal antibody specific for tumor necrosis factor ? that has already been approved for the treatment of several autoimmune conditions in adults and children. Whether golimumab could preserve beta-cell function in youth with newly diagnosed overt (stage 3) type 1 diabetes is unknown.

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First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer

Alice T. Shaw, M.D., Ph.D., Todd M. Bauer, M.D., Filippo de Marinis, M.D., Ph.D., Enriqueta Felip, M.D., Ph.D., Yasushi Goto, M.D., Ph.D., Geoffrey Liu, M.D., Julien Mazieres, M.D., Ph.D., Dong-Wan Kim, M.D., Ph.D., Tony Mok, M.D., Anna Polli, B.Sc., Holger Thurm, M.D., Anna M. Calella, Ph.D.,

doi : 10.1056/NEJMoa2027187

N Engl J Med 2020; 383:2018-2029

Lorlatinib, a third-generation inhibitor of anaplastic lymphoma kinase (ALK), has antitumor activity in previously treated patients with ALK-positive non–small-cell lung cancer (NSCLC). The efficacy of lorlatinib, as compared with that of crizotinib, as first-line treatment for advanced ALK-positive NSCLC is unclear.

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Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

The RECOVERY Collaborative Group

doi : 10.1056/NEJMoa2022926

N Engl J Med 2020; 383:2030-2040

Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from uncontrolled studies and small, randomized trials.

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Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19

Alexandre B. Cavalcanti, M.D., Ph.D., Fernando G. Zampieri, M.D., Ph.D., Regis G. Rosa, M.D., Ph.D., Luciano C.P. Azevedo, M.D., Ph.D., Viviane C. Veiga, M.D., Ph.D., Alvaro Avezum, M.D., Ph.D., Lucas P. Damiani, M.Sc., Aline Marcadenti, Ph.D., Let?cia Kawano-Dourado, M.D., Ph.D., Thiago Lisboa, M.D., Ph.D., Debora L. M. Junqueira, M.D., Pedro G.M. de Barros e Silva, M.D., Ph.D.,

doi : 10.1056/NEJMoa2019014

N Engl J Med 2020; 383:2041-2052

Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety and efficacy of these therapies is limited.

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Endometrial Cancer

Karen H. Lu, M.D., and Russell R. Broaddus, M.D., Ph.D.

doi : 10.1056/NEJMra1514010

N Engl J Med 2020; 383:2053-2064

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Wandering Spleen

Alexander Wester, M.D., and Ivan Co, M.D.

doi : 10.1056/NEJMicm2003627

N Engl J Med 2020; 383:2065

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Transition Zone in Hirschsprung’s Disease

Shouptik Basu, M.S.

doi : 10.1056/NEJMicm2007613

N Engl J Med 2020; 383:e118

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Case 36-2020: A 72-Year-Old Woman with Dark Urine and Weakness

Rajeev Malhotra, M.D., Mayooran Namasivayam, M.B., B.S., Ph.D., Brian B. Ghoshhajra, M.D., Jonathan J. Passeri, M.D., Peter A. Hoenig, M.D., and James R. Stone, M.D., Ph.D.

doi : 10.1056/NEJMcpc2027077

N Engl J Med 2020; 383:2066-2076

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Whither Type 1 Diabetes?

Domenico Accili, M.D.

doi : 10.1056/NEJMe2030472

N Engl J Med 2020; 383:2078-2079

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Audio Interview: Covid-19 in Europe and New Information on Vaccines

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Charlotte J. Haug, M.D., Ph.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2033666

N Engl J Med 2020; 383:e134

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Killing the Pathogen and Sparing the Placenta

Indira U. Mysorekar, Ph.D.

doi : 10.1056/NEJMcibr2028357

N Engl J Med 2020; 383:2080-2082

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Physician–Public Defender Collaboration — A New Medical–Legal Partnership

Rahul Vanjani, M.D., Sarah Martino, M.P.A., Sheridan F. Reiger, M.D., M.P.H., James Lawless, M.A., Chelsea Kelly, J.D., Vincent J. Mariano, M.D., and M. Catherine Trimbur, M.D.

doi : 10.1056/NEJMms2002585

N Engl J Med 2020; 383:2083-2086

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Azacitidine and Venetoclax in AML

doi : 10.1056/NEJMc2029153

N Engl J Med 2020; 383:2087-2089

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Rivaroxaban in Peripheral Artery Disease after Revascularization

doi : 10.1056/NEJMc2030413

N Engl J Med 2020; 383:2089-2091

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Facial Masking for Covid-19

doi : 10.1056/NEJMc2030886

N Engl J Med 2020; 383:2092-2094

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Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19

doi : 10.1056/NEJMx200021

N Engl J Med 2020; 383:e119

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