One-year access to more than 500 world journals available in the system
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Covid-19 Vaccine Trials and Incarcerated People — The Ethics of Inclusion
Camila Strassle, B.A., E. Jardas, B.S., Jorge Ochoa, B.A., Benjamin E. Berkman, J.D., Marion Danis, M.D., Annette Rid, M.D., and Holly A. Taylor, Ph.D.
doi : 10.1056/NEJMp2025955
N Engl J Med 2020; 383:1897-1899
Bridging the Gap at Warp Speed — Delivering Options for Preventing and Treating Covid-19
Moncef Slaoui, Ph.D., Shannon E. Greene, Ph.D., and Janet Woodcock, M.D.
doi : 10.1056/NEJMp2028535
N Engl J Med 2020; 383:1899-1901
When Actions Speak Louder Than Words — Racism and Sickle Cell Disease
Alexandra Power-Hays, M.D., and Patrick T. McGann, M.D.
doi : 10.1056/NEJMp2022125
N Engl J Med 2020; 383:1902-1903
Them and Me — The Care and Treatment of Black Boys in America
Kevin M. Simon, M.D.
doi : 10.1056/NEJMp2022606
N Engl J Med 2020; 383:1904-1905
A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis
doi : 10.1056/NEJMoa2014320
N Engl J Med 2020; 383:1907-1919
Antibiotic therapy has been proposed as an alternative to surgery for the treatment of appendicitis.
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Lisa A. Jackson, M.D., M.P.H., Evan J. Anderson, M.D., Nadine G. Rouphael, M.D., Paul C. Roberts, Ph.D., Mamodikoe Makhene, M.D., M.P.H., Rhea N. Coler, Ph.D., Michele P. McCullough, M.P.H., James D. Chappell, M.D., Ph.D., Mark R. Denison, M.D., Laura J. Stevens, M.S., Andrea J. Pruijssers, Ph.D., Adrian McDermott, Ph.D.,
doi : 10.1056/NEJMoa2022483
N Engl J Med 2020; 383:1920-1931
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally, prompting an international effort to accelerate development of a vaccine. The candidate vaccine mRNA-1273 encodes the stabilized prefusion SARS-CoV-2 spike protein.
Intussusception after Rotavirus Vaccine Introduction in India
Samarasimha N. Reddy, M.D., Nayana P. Nair, M.Sc., Jacqueline E. Tate, Ph.D., Varunkumar Thiyagarajan, M.Sc., Sidhartha Giri, M.D., Ph.D., Ira Praharaj, M.D., Ph.D., Venkata R. Mohan, M.D., Sudhir Babji, M.D., Mohan D. Gupte, M.D., Rashmi Arora, M.D., Sunita Bidari, D.N.B., Sowmiya Senthamizh, M.P.H.,
doi : 10.1056/NEJMoa2002276
N Engl J Med 2020; 383:1932-1940
A three-dose, oral rotavirus vaccine (Rotavac) was introduced in the universal immunization program in India in 2016. A prelicensure trial involving 6799 infants was not large enough to detect a small increased risk of intussusception. Postmarketing surveillance data would be useful in assessing whether the risk of intussusception would be similar to the risk seen with different rotavirus vaccines used in other countries.
Macrolide and Nonmacrolide Resistance with Mass Azithromycin Distribution
Thuy Doan, M.D., Ph.D., Lee Worden, Ph.D., Armin Hinterwirth, Ph.D., Ahmed M. Arzika, M.S., Ramatou Maliki, M.S., Amza Abdou, M.D., Lina Zhong, B.S., Cindi Chen, M.S., Catherine Cook, M.P.H., Elodie Lebas, R.N., Kieran S. O’Brien, Ph.D., M.P.H., Catherine E. Oldenburg, Sc.D., M.P.H.,
doi : 10.1056/NEJMoa2002606
N Engl J Med 2020; 383:1941-1950
Mass distribution of azithromycin to preschool children twice yearly for 2 years has been shown to reduce childhood mortality in sub-Saharan Africa but at the cost of amplifying macrolide resistance. The effects on the gut resistome, a reservoir of antimicrobial resistance genes in the body, of twice-yearly administration of azithromycin for a longer period are unclear.
Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration
Gabriel J. Escobar, M.D., Vincent X. Liu, M.D., Alejandro Schuler, Ph.D., Brian Lawson, Ph.D., John D. Greene, M.A., and Patricia Kipnis, Ph.D.
doi : 10.1056/NEJMsa2001090
N Engl J Med 2020; 383:1951-1960
Hospitalized adults whose condition deteriorates while they are in wards (outside the intensive care unit [ICU]) have considerable morbidity and mortality. Early identification of patients at risk for clinical deterioration has relied on manually calculated scores. Outcomes after an automated detection of impending clinical deterioration have not been widely reported.
Esophageal Motility Disorders and Gastroesophageal Reflux Disease
Ravinder Mittal, M.D., and Michael F. Vaezi, M.D., Ph.D.
doi : 10.1056/NEJMra2000328
N Engl J Med 2020; 383:1961-1972
Percutaneous Tracheostomy
Daniel A. Hashimoto, M.D., Andrea L. Axtell, M.D., and Hugh G. Auchincloss, M.D.
doi : 10.1056/NEJMvcm2014884
N Engl J Med 2020; 383:e112
Couvelaire Uterus
Pradip Dashraath, M.R.C.O.G., and Yee-Chee Wong, F.R.C.O.G.
doi : 10.1056/NEJMicm2010749
N Engl J Med 2020; 383:1973
Pseudomelanosis Duodeni
Dane Cook, B.Med., and Kate Napthali, M.B., B.S.
doi : 10.1056/NEJMicm2001352
N Engl J Med 2020; 383:e113
Case 35-2020: A 59-Year-Old Woman with Type 1 Diabetes Mellitus and Obtundation
David N. Caplan, M.D., Ph.D., Otto Rapalino, M.D., Amel Karaa, M.D., Rachel P. Rosovsky, M.D., and Sacha Uljon, M.D., Ph.D.
doi : 10.1056/NEJMcpc2002412
N Engl J Med 2020; 383:1974-1983
Antibiotics for Appendicitis — Proceed with Caution
Danny Jacobs, M.D., M.P.H.
doi : 10.1056/NEJMe2029126
N Engl J Med 2020; 383:1985-1986
The Covid-19 Vaccine-Development Multiverse
Penny M. Heaton, M.D.
doi : 10.1056/NEJMe2025111
N Engl J Med 2020; 383:1986-1988
Audio Interview: An Update from Operation Warp Speed
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Janet Woodcock, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2033111
N Engl J Med 2020; 383:e127
Givosiran for Acute Intermittent Porphyria
doi : 10.1056/NEJMc2026458
N Engl J Med 2020; 383:1989-1990
