Journal of Investigative Dermatology




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Editorial Board

doi : 10.1016/S0022-202X(22)01827-9

Volume 142, Issue 10, October 2022, Page A5

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The JID: A Scientific Home for Innovative, Rigorously Conducted, Clinical, and Epidemiologic Research in Dermatology from Around the World

Joel M.Gelfand

doi : 10.1016/j.jid.2022.06.004

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Toward Cannabinoid Use for Refractory Cutaneous Dermatomyositis

MiriamWittmann1PetraStaubach1DennisMcGonagle23

doi : 10.1016/j.jid.2022.07.017

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Platelet Plugs Prevent Vascular Hemorrhage at Sites of Neutrophil Diapedesis

AlexVargas1Scott I.Simon12

doi : 10.1016/j.jid.2022.06.009

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Monkeypox: Considerations as a New Pandemic Looms

Matthew G.Brewer1Stephanie R.Monticelli23Brian M.Ward4

doi : 10.1016/j.jid.2022.08.030

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Wound-Induced Hair Neogenesis Model

YingchaoXue1Chae HoLim23Maksim V.Plikus4567MayumiIto23GeorgeCotsarelis8Luis A.Garza1910

doi : 10.1016/j.jid.2022.07.013

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miR-10a, miR-30c, and miR-451a Encapsulated in Small Extracellular Vesicles Are Prosenescence Factors in Human Dermal Fibroblasts

Jae KyungLee1Soo-JinOh1Jeong-AnGim2Ok SarahShin1

doi : 10.1016/j.jid.2022.03.032

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Aging-Conferred SIRT7 Decline Inhibits Rosacea-Like Skin Inflammation by Modulating Toll-Like Receptor 2‒NF-κB Signaling

GuoLi1XiaolongTang239ShupingZhang1ZhiliDeng1456BenWang1WeiShi1HongfuXie145BaohuaLiu237JiLi145689

doi : 10.1016/j.jid.2022.03.026

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Advanced Glycation End Products Promote Melanogenesis by Activating NLRP3 Inflammasome in Human Dermal Fibroblasts

JiaqiFang12MengtingOuyang12YingyingQu12MengyaoWang1XianyinHuang1JingjingLan1WeiLai1QingfangXu1

doi : 10.1016/j.jid.2022.03.025

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Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle

WeiShang1Alvin Yong QuanTan1Maurice A.M.van Steensel12XinhongLim1

doi : 10.1016/j.jid.2021.11.034

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Sox9 Is Required for Nail-Bed Differentiation and Digit-Tip Regeneration

MiguelLao1AliciaHurtado12AlejandroChacón de Castro1MiguelBurgos1RafaelJiménez13Francisco J.Barrionuevo13

doi : 10.1016/j.jid.2022.03.020

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Mitochondrial Activity Is Upregulated in Nonlesional Atopic Dermatitis and Amenable to Therapeutic Intervention

GeraldineLeman1PetraPavel1MartinHermann2DebraCrumrine3Peter M.Elias3DeborahMinzaghi1DominiqueGoudounèche4Natalia M.Roshardt Prieto1MariaCavinato5AndreaWanner1StefanBlunder1RobertGruber1PidderJansen-Dürr5SandrineDubrac1

doi : 10.1016/j.jid.2022.01.035

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OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis

Yan-ZhouHuang12Yu-XinZheng12YuanZhou12FanXu1Ying-ZheCui1Xue-YanChen1Zhao-YuanWang1Bing-XiYan1MinZheng1Xiao-YongMan1

doi : 10.1016/j.jid.2022.02.018

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Predictors of QOL in Patients with Alopecia Areata

MaryanneSenna1JustinKo2MarcGlashofer3ChloeWalker1SusanBall4EmilyEdson-Heredia4BaojinZhu4JerryShapiro5

doi : 10.1016/j.jid.2022.02.019

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Safety and Efficacy of Lenabasum, a Cannabinoid Receptor Type 2 Agonist, in Patients with Dermatomyositis with Refractory Skin Disease: A Randomized Clinical Trial

Victoria P.Werth12EmilyHejazi12Sandra M.Pena12JessicaHaber12MajidZeidi12NithinReddy12JoyceOkawa12RuiFeng3Muhammad M.Bashir12KirubelGebre12Arvin S.Jadoo12Josef Symon S.Concha12NancyDgetluck4ScottConstantine4BarbaraWhite4

doi : 10.1016/j.jid.2022.03.029

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T Helper 2 IL-4/IL-13 Dual Blockade with Dupilumab Is Linked to Some Emergent T Helper 17‒Type Diseases, Including Seronegative Arthritis and Enthesitis/Enthesopathy, but Not to Humoral Autoimmune Diseases

CharlieBridgewood1MiriamWittmann123TomMacleod1AbdullaWatad1456DarrenNewton7KanchanBhan8HowardAmital45GiovanniDamiani91011SamiGiryes11213Nicola LuigiBragazzi114DennisMcGonagle12

doi : 10.1016/j.jid.2022.03.013

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IL-33/Regulatory T-Cell Axis Suppresses Skin Fibrosis

Se YunCheon126Jong HoPark126Amir H.Ameri12Richard T.Lee3Rosalynn M.Nazarian4ShadmehrDemehri12

doi : 10.1016/j.jid.2022.03.009

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Transcription Factor EGR1 Regulates the Expression of the Clock Gene PER2 under IL-4 Stimulation in Human Keratinocytes

HyunjinYeo1Sung ShinAhn1EuitaekJung1YoonghoLim2Young HanLee1Soon YoungShin1

doi : 10.1016/j.jid.2022.03.021

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Biallelic Variants in Lanosterol Synthase (LSS) Cause Palmoplantar Keratoderma-Congenital Alopecia Syndrome Type 2

FangYang1234510XingyuanJiang12310YuhaoZhu6MingyangLee123ZhengrenXu6JianglinZhang45QianLi7Mao-yingLin8HuijunWang911ZhimiaoLin18911

doi : 10.1016/j.jid.2022.03.023

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Human-Induced Pluripotent Stem Cell‒Derived Keratinocytes, a Useful Model to Identify and Explore the Pathological Phenotype of Epidermolysis Bullosa Simplex

JulienCoutier16ManonBonnette236SabrinaMartineau23AurélieMercadier1SophieDomingues1ManoubiaSaidani1MargotJarrige1HélènePolveche1AnnabelleDarle1NathalieHolic23SmailHadj-Rabia45ChristineBodemer45GillesLemaitre23CécileMartinat2ChristineBaldeschi23

doi : 10.1016/j.jid.2022.04.009

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Vγ2+ γδ T Cells in the Presence of Anti-CD40L Control Surgical Inflammation and Promote Skin Allograft Survival

ShilpiGiri1Heikrujam ThoihenMeitei1AmritaMishra1GirdhariLal1

doi : 10.1016/j.jid.2022.03.016

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C5aR2 Deficiency Ameliorates Inflammation in Murine Epidermolysis Bullosa Acquisita by Regulating Fcγ Receptor Expression on Neutrophils

Daniel LeonardSeiler12MarieKleingarn1Katja HendrikaKähler1CarolineGruner1JovanSchanzenbacher1ElviraEhlers-Jeske1SamyrKenno1Christian DavidSadik34EnnoSchmidt345KatjaBieber345JörgKöhl16Ralf J.Ludwig345Christian MarcelKarsten1

doi : 10.1016/j.jid.2021.12.029

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Confocal Real-Time Analysis of Cutaneous Platelet Recruitment during Immune Complex‒Mediated Inflammation

Silke M.Currie17Rebekka I.Stegmeyer17KarinaMildner2LeonhardBreitsprecher3DagmarZeuschner2Olympia EkateriniPsathaki3KerstinSchäfer1MarkusWilkens1StefanVolkery4BernhardNieswandt56DietmarVestweber1

doi : 10.1016/j.jid.2022.03.011

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Associations between TERT Promoter Mutations and Survival in Superficial Spreading and Nodular Melanomas in a Large Prospective Patient Cohort

Gregory A.Chang127EricRobinson127Jennifer M.Wiggins127YilongZhang234Jyothirmayee S.Tadepalli12Christine N.Schafer12FarbodDarvishian25Russell S.Berman26RichardShapiro26YongzhaoShao23ImanOsman12DavidPolsky125

doi : 10.1016/j.jid.2022.03.031

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Ablation of Proton/Glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis

YeLiu17WennaChi127LeiTao12GuoqiangWang1R.N.V. KrishnaDeepak3LinlinSheng1TaiqiChen4YaqianFeng1XizhiCao1LiliCheng1XinbinZhao1XiaohuiLiu5HaitengDeng5HaoFan3PengJiang4LigongChen12

doi : 10.1016/j.jid.2022.04.008

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Staphylococcus epidermidis-Derived Protease Esp Mediates Proteolytic Activation of Pro‒IL-1β in Human Keratinocytes

FranziskaRademacher1JoachimBartels1RegineGläser1MenoRodewald1SabineSchubert2DanielDrücke3HolgerRohde4JürgenHarder1

doi : 10.1016/j.jid.2022.04.010

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Longitudinal Characterization of the Fungal Skin Microbiota in Healthy Subjects Over a Period of 1 Year

BettinaSchmid1AxelKünstner2AnkeFähnrich2HaukeBusch2MartinGlatz1Philipp P.Bosshard1

doi : 10.1016/j.jid.2022.03.014

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Skin Microbiome Variation with Cancer Progression in Human Cutaneous Squamous Cell Carcinoma

Anita Y.Voigt1AkintundeEmiola1Jethro S.Johnson12Elizabeth S.Fleming1HoanNguyen1WeiZhou1Kenneth Y.Tsai34ChristineFink5JuliaOh1

doi : 10.1016/j.jid.2022.03.017

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Merkel Cell Carcinoma Sensitivity to EZH2 Inhibition Is Mediated by SIX1 Derepression

Ashley K.Gartin12Thomas C.Frost12Camille H.Cushman12Brittaney A.Leeper34Prafulla C.Gokhale34James A.DeCaprio125

doi : 10.1016/j.jid.2022.03.008

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Circular RNA Signatures of Human Healing and Nonhealing Wounds

Maria A.Toma127ZhuangLiu1278QizhangWang123LetianZhang12DongqingLi124PehrSommar5Ning XuLandén1268

doi : 10.1016/j.jid.2022.03.024

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γδ T Cell‒Mediated Wound Healing Is Diminished by Allergic Skin Inflammation

JocelynWang124AbigailPajulas14YongyaoFu1DjamilatouAdom1WenwuZhang1Andrew S.Nelson12Dan F.Spandau13Mark H.Kaplan12

doi : 10.1016/j.jid.2022.03.012

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The Psoriasis Glycome: Differential Expression of Cholesterol Particle Glycans and IgA Glycans Linked to Disease Severity

EmanualMaverakis18WilliamLiakos18DayoungPark23ForumPatel1FarihaSiddiqui1Muchena J.Kailemia2L. ReneeRuhaak4Alina I.Marusina1GuillaumeLuxardi1Johann E.Gudjonsson5Stephanie T.Le1April W.Armstrong6WilsonLiao7Alexander A.Merleev1Carlito B.Lebrilla2

doi : 10.1016/j.jid.2022.03.030

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The Double-Stranded RNA Analog, Poly(I:C), Triggers Distinct Transcriptomic Shifts in Keratinocyte Subsets

KeikoSakamoto1KeisukeNagao1

doi : 10.1016/j.jid.2022.03.015

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Identification of Genetic Loci Associated with Facial Wrinkles in a Large Korean Population

Seo-GyeongLee1Joong-GonShin1YunkwanKim1SangseobLeem1Sun GyooPark1Hong-HeeWon23Nae GyuKang13

doi : 10.1016/j.jid.2022.03.027

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In Vivo Imaging of CD8+ T-Cell‒Mediated Keratinocyte Apoptosis in Graft-Versus-Host Disease‒Like Dermatitis in Involucrin Membrane-Bound Ovalbumin Mice

Hui MeiCheng12TetsuyaHonda13RyotaAsahina1ToshiyaMiyake1ZacharyChow14MichioTomura4Jun-ichiSakabe35YoshikiTokura3KenjiKabashima15

doi : 10.1016/j.jid.2022.03.010

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A Distinct Immature Low-Density Neutrophil Population Characterizes Acute Generalized Pustular Psoriasis

NingYu123HuiQin123YingyuanYu123YingLi12JiajingLu12YulingShi12

doi : 10.1016/j.jid.2022.04.011

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Utility of a circulating tumor DNA test for detecting clinically evident and occult Merkel cell carcinoma

TomokoAkaike1NaomiSo2Daniel S.Hippe3LindsayGunnell1Coley Doolittle-Amieva1KristinaLachance1EvanHall4ShailenderBhatia4AlecEschholz2RichaRathore5NicoleHook5KathrynBaker5AngelRodriguez5AndrewEcklund5AlexeyAleshin5PaulNghiem1Lisa C.Zaba2

doi : 10.1016/j.jid.2022.08.002

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Cancer-associated fibroblasts exert a pro-angiogenic activity in Merkel cell carcinoma

SilviaAlbertini12LiciaMartuscelli2CinziaBorgogna2SanamjeetVirdi3DanielaIndenbirken3RenzoBoldorini4MarisaGariglio2NicoleFischer1

doi : 10.1016/j.jid.2022.08.003

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Milademetan is a highly potent MDM2 inhibitor in TP53 wild-type (p53 WT) models of Merkel cell carcinoma (MCC)

VarshaAnanthapadmanabhan12Thomas C.Frost13Kara M.Soroko4AineKnott4BriannaMagliozzi4Prafulla C.Gokhale4VijayaTirunagaru5Robert C.Doebele5James A.DeCaprio123

doi : 10.1016/j.jid.2022.08.004

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Inhibition potentiates immunogenicity in Merkel cell carcinoma: a promising approach to overcome resistance to anti-PD-1 immunotherapy

RashmiBhakuni1Peter H.Goff2Jung HyunLee1ThomasPulliam1Shira Tabachnick-Cherny1Carina D.Morningstar1PaulNghiem1

doi : 10.1016/j.jid.2022.08.005

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Phase 2 Study of Intratumoral Vidutolimod With Intravenous Cemiplimab in Patients With Locally Advanced or Metastatic Merkel Cell Carcinoma (CMP-001- 009)

ShailenderBhatia1John R.Hyngstrom2AlexandraIkeguchi3Sajeve S.Thomas4Ann W.Silk5DmitriBobilev6LupingZhao6James E.Wooldridge6Arthur M.Krieg6DiwakarDavar7

doi : 10.1016/j.jid.2022.08.006

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ADAM Trial: A multicenter, randomized, double-blinded, placebo-controlled, phase 3 trial of adjuvant avelumab (anti-PD-L1 antibody) in Merkel cell carcinoma patients with lymph node metastases; NCT03271372

WenwenChen1∗ShailenderBhatia1Andrew S.Brohl2SunandanaChandra3SumiaDakhil1Leslie A.Fecher4LingGao5Ted A.Gooley6Glenn J.Hanna7ReinaHibbert1Ciara M.Kelly8Samantha M.Kiriluk1KarlLewis9StergiosMoschos10PaulNghiem11John A.Thompson1Scott S.Tykodi1

doi : 10.1016/j.jid.2022.08.007

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What is the risk of Merkel cell carcinoma recurrence beyond pathologically clear margins? An analysis of 926 cases

AlexFu1NehaSingh2KristinaLachance1DanielHippe3PaulNghiem1Song YounPark1

doi : 10.1016/j.jid.2022.08.008

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The paranuclear dot in Merkel cell carcinoma, how does it form and what does it do?

Natasha T.Hill1LorenCollado1TylerKellenberger1KunioNagashima2SerenaVilasi1Paul W.Harms3IsaacBrownell1

doi : 10.1016/j.jid.2022.08.009

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Development of a Merkel polyomavirus-specific T cell receptor analysis tool to guide cancer immunotherapy

SaumyaJani13Thomas H.Pulliam1KoshlanMayer-Blackwell4PhilipBradley5David M.Koelle23PaulNghiem13

doi : 10.1016/j.jid.2022.08.010

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Virally mediated mechanisms of HLA class I loss in Merkel cell carcinoma and implications for viral epitope presentation

Derin B.Keskin1Patrick C.Lee1SusanKlaeger2Phuong M.Le1KeeganKorthauer3JingweiCheng1VarshaAnanthapadmanabhan1Thomas C.Frost1J. BryanIorgulescu1Camilla K.Lemvigh4Christina B.Pedersen4SiranushSarkizova3ShuqiangLi1XiaoxiLiu5Laura M.Doherty5DonnaNeuberg1GuanglanZhang6Lars R.Olsen4…Catherine J.Wu1

doi : 10.1016/j.jid.2022.08.011

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Understanding the Interaction Between Merkel Cell Polyomavirus Small T Antigen and Delta-Catenin

JoselynLandazuri12KristineDye3Nick J.H.Salisbury1AnnRoman1Denise A.Galloway1

doi : 10.1016/j.jid.2022.08.012

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Understanding the Influence of Patient Demographics and Socioeconomic Status in Merkel Cell Carcinoma

KyleLauck1Quoc-BaoNguyen23RohitGupta4DawenSui5Hung Q.Doan23

doi : 10.1016/j.jid.2022.08.013

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Postoperative radiotherapy in stage I-III Merkel cell carcinoma

SonjaLevy1Stephanie A.Blankenstein2Dirk JanGrünhagen3MathildeJalving4OlgaHamming-Vrieze5Lukas B.Been6LisaTans7Alexander C.J.van Akkooi2Margot E.T.Tesselaar8

doi : 10.1016/j.jid.2022.08.014

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Understanding Socioeconomic and Racial Disparities in Merkel Cell Carcinoma

MackenzieMartin1NoreenMohsin1DanielleReed1IsaacBrownell1

doi : 10.1016/j.jid.2022.08.015

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From database to clinic: Using a multivariable recurrence risk calculator to guide Merkel cell carcinoma surveillance

AubrianaMcEvoy12KristinaLachance1DanielHippe3MaryRedman3TedGooley3Michael W.Kattan4PaulNghiem1

doi : 10.1016/j.jid.2022.08.016

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Early-Onset Merkel Cell Carcinoma is Associated with Germline Defects in DNA Repair Genes and a Rare Immunodeficiency

NoreenMoshin1∗DevinHunt2∗Austin J.Jabbour3PaulNghiem4Alexandra F.Freemam5Jenna R.E.Bergerson5MorganSimiluk2KristinaLachance4RimaKulikauskas4Bryce A.Seifert2RajarshiGhosh2Magdalena A.Walkiewicz2IsaacBrownell1

doi : 10.1016/j.jid.2022.08.017

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Persistent seropositivity of antibodies to Merkel cell polyomavirus oncoprotein (AMERK) in patients in remission from Merkel cell carcinoma

Daniel G.Noe1Julie G.Grossman2NataliaJaimes13GeorgeElgart13ClaraMilikowski14LynnFeun15JoseLutzky15Mecker G.Möller16

doi : 10.1016/j.jid.2022.08.018

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An intratumoral STING agonist-mediated clinical response in PD-L1-refractory MCC via an unexpected mechanism of action

Thomas H.Pulliam1RashmiBhakuni1SaumyaJani1KimberlySmythe2BrandonSeaton2LisaTachiki3RimaKulikauskas1PaulNghiem12ShailenderBhatia23

doi : 10.1016/j.jid.2022.08.019

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Racial Differences in Population Demographics, Tumor Characteristics, and Overall Survival in Merkel Cell Carcinoma Patients

AbbasRattaniMD1JeremyGaskinsPhD2GrantMcKenzieMD1Virginia KateScharf3KristyBromanMD4MariaPisuPhD5AshleyHolderMD4NealDunlapMD1MehranYusufMD6

doi : 10.1016/j.jid.2022.08.020

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Repurposing disulfiram for the treatment of Merkel cell carcinoma

Danielle J.Reed1Natasha T.Hill1TaraGelb1DanUrban2TylerKellenberger1AnnaLin1SerenaVilasi1MatthewHall2IsaacBrownell1

doi : 10.1016/j.jid.2022.08.021

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Real-world assessment of ipilimumab plus nivolumab in anti-PD-L1/PD-1- refractory Merkel Cell Carcinoma

Sophia Z.ShalhoutPhD1Kevin S.EmerickMD2Howard L.KaufmanMD3David M.MillerMD, PhD14

doi : 10.1016/j.jid.2022.08.022

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Defining myeloid cells in the tumor microenvironment of Merkel cell carcinoma and their role in resistance to immunotherapy

ShiraTabachnick-Cherny1ThomasPullliam1KimberlySmythe2PaulNghiem1

doi : 10.1016/j.jid.2022.08.023

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Impact of duration of immunotherapy on clinical outcomes in advanced Merkel cell carcinoma patients responding to first-line immunotherapy

Lisa M.Tachiki13LaurenZawacki2Daniel S.Hippe3YasmanMoshiri2NoraAlexander2TomokoAkaike2ColeyDoolittle-Amieva2ThomasPulliam2Lisa C.Zaba4ShailenderBhatia13PaulNghiem2

doi : 10.1016/j.jid.2022.08.024

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Merkel polyomavirus specific transgenic T cell receptor therapy in PD-1 inhibitor refractory Merkel cell carcinoma

JoshuaVeatch1KellyPaulson2YutaAsano1MeganMcAfee3LaurenMartin1BoLee1EvanHall4ShailenderBhatia4PaulNghiem4AudeChapuis1

doi : 10.1016/j.jid.2022.08.025

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Neoadjuvant systemic therapy for Merkel cell carcinoma: A Tertiary Referral Center Experience

Russell G.Witt1BrandonCope1RiyadSeervai2Yi-JuChiang1Sarah B.Fisher1AnthonyLucci1Jeffrey E.Gershenwald1Jennifer A.Wargo1Merrick I.Ross1Michael K.Wong3DevaratiMitra2Emily Z.Keung1

doi : 10.1016/j.jid.2022.08.026

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Navtemadlin (KRT-232) in combination with avelumab for patients with anti-PD-1/L1 treatment-naïve TP53WT Merkel cell carcinoma (MCC)

Michael K.Wong1MelissaBurgess2SunandanaChandra3DirkSchadendorf4AnnSilk5Anthony J.Olszanski6Jean-JacquesGrob7SekwonJang8Jaspreet SinghGrewal9Karl D.Lewis10LeslieFecher11GuilhermeRabinowits12CelesteLebbe13JuanMartin-Liberal14Anna MariaDi Giacomo15PhilipFriedlander16Andrew S.Brohl17BrandonCroft18…Ciara M.Kelly19

doi : 10.1016/j.jid.2022.08.027

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