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Spotlight on the May 11 Issue
José G. Merino
doi : 10.1212/WNL.0000000000011889
May 11, 2021; 96 (19)
Pain Control in Aneurysmal Subarachnoid Hemorrhage Patients in the ICU
Gary L. Bernardini, John C.M. Brust
doi : 10.1212/WNL.0000000000011907
May 11, 2021; 96 (19)
Prevalent Nonmotor Symptoms Associated With Huntington Disease Challenging to Interpret and With Early Impact on Function
Elizabeth Anne McCusker, Clement T. Loy
doi : 10.1212/WNL.0000000000011888
May 11, 2021; 96 (19)
Physical Activity May Reduce Apolipoprotein E4-Associated Cognitive Decline in Parkinson Disease
Jacob Raber, Sirwan K.L. Darweesh,Rodolfo Savica
doi : 10.1212/WNL.0000000000011851
May 11, 2021; 96 (19)
Neighborhood Socioeconomic Differences in Stroke Risk?
Anita Lindmark
doi : 10.1212/WNL.0000000000011887
May 11, 2021; 96 (19)
Association of Refractory Pain in the Acute Phase After Subarachnoid Hemorrhage With Continued Outpatient Opioid Use
Matthew N. Jaffa, Jamie E. Podell, Madeleine C. Smith, Arshom Foroutan, Adam Kardon,Wan-Tsu W. Chang, Melissa Motta,Gunjan Y. Parikh, Kevin N. Sheth,Neeraj Badjatia, Michael J. Armahizer, J. Marc Simard,Nicholas A. Morris
doi : 10.1212/WNL.0000000000011906
May 11, 2021; 96 (19)
Objective Little is known about the prevalence of continued opioid use following aneurysmal subarachnoid hemorrhage (aSAH) despite guidelines recommending their use during the acute phase of disease. We sought to determine prevalence of opioid use following aSAH and test the hypothesis that acute pain and higher inpatient opioid dose increased outpatient opioid use.
Hematoma Expansion in Intracerebral Hemorrhage With Unclear Onset
Andrea Morotti,Gregoire Boulouis,Andreas Charidimou,Qi Li, Loris Poli, Paolo Costa, Valeria De Giuli, Eleonora Leuci, Federico Mazzacane, Giorgio Busto,Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Michele Laudisi, Giuseppe Micieli, Anna Cavallini, Elisa Candeloro, Massimo Gamba, Mauro Magoni, Andrew D. Warren, Christopher D. Anderson, M. Edip Gurol, Alessandro Biffi, Anand Viswanathan, Ilaria Casetta, Enrico Fainardi, Andrea Zini, Alessandro Pezzini, Alessandro Padovani, Steven M. Greenberg, Jonathan Rosand, Joshua N. Goldstein
doi : 10.1212/WNL.0000000000011895
May 11, 2021; 96 (19)
Objective To investigate the prevalence, predictors, and prognostic effect of hematoma expansion (HE) in patients with intracerebral hemorrhage (ICH) with unclear symptom onset (USO).
Early Neurologic Recovery, Practice Pattern Variation, and the Risk of Endotracheal Intubation Following Established Status Epilepticus
Eric S. Rosenthal, Jordan J. Elm, James Ingles,Alexander J. Rogers, Thomas E. Terndrup, Maija HolstiDanny G. Thomas,Lynn Babcock, Pamela J. Okada, Robert H. Lipsky, Joseph B. Miller, Robert W. Hickey, Megan E. Barra,Thomas P. Bleck, James C. Cloyd,Robert Silbergleit, Daniel H. Lowenstein, Lisa D. Coles,Jaideep Kapur, Shlomo Shinnar, James M. Chamberlain, ; on behalf of the Established Status Epilepticus Treatment Trial Study Group
doi : 10.1212/WNL.0000000000011879
May 11, 2021; 96 (19)
Objective To quantify the association between early neurologic recovery, practice pattern variation, and endotracheal intubation during established status epilepticus, we performed a secondary analysis within the cohort of patients enrolled in the Established Status Epilepticus Treatment Trial (ESETT).
Association of Gyrification Pattern, White Matter Changes, and Phenotypic Profile in Patients With Parkinson Disease
Xie Tang, Yuanchao Zhang, Daihong Liu, Yixin Hu, Liling Jiang,Jiuquan Zhang
doi : 10.1212/WNL.0000000000011894
May 11, 2021; 96 (19)
Objective To investigate the cortical gyrification changes as well as their relationships with white matter (WM) microstructural abnormalities in the akinetic-rigid (AR) and tremor-dominant (TD) subtypes of Parkinson disease (PD).
Timing and Impact of Psychiatric, Cognitive, and Motor Abnormalities in Huntington Disease
Branduff McAllister, James F. Gusella, G. Bernhard Landwehrmeyer, Jong-Min Lee, Marcy E. MacDonald, Michael Orth, Anne E. Rosser, Nigel M. Williams,Peter Holmans, Lesley Jones,Thomas H. Massey, on behalf of the REGISTRY Investigators of the European Huntington's Disease Network
doi : 10.1212/WNL.0000000000011893
May 11, 2021; 96 (19)
Objective To assess the prevalence, timing, and functional impact of psychiatric, cognitive, and motor abnormalities in Huntington disease (HD) gene carriers, we analyzed retrospective clinical data from individuals with manifest HD.
Association of CAG Repeat Length in the Huntington Gene With Cognitive Performance in Young Adults
Jordan L. Schultz, Carsten Saft, Peggy C. Nopoulos
doi : 10.1212/WNL.0000000000011823
May 11, 2021; 96 (19)
Objective To investigate the relationships between CAG repeat length in the huntingtin gene and cognitive performance in participants above and below the disease threshold for Huntington disease (HD), we performed a cross-sectional analysis of the Enroll-HD database.
Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease
Jing Qian, Rebecca A. Betensky, Bradley T. Hyman, Alberto Serrano-Pozo
doi : 10.1212/WNL.0000000000011883
May 11, 2021; 96 (19)
Objective To test the hypothesis that the APOE genotype is a significant driver of heterogeneity in Alzheimer disease (AD) clinical progression, which could have important implications for clinical trial design and interpretation.
Association of Physical Activity and APOE Genotype With Longitudinal Cognitive Change in Early Parkinson Disease
Ryul Kim, Sangmin Park, Dallah Yoo, Jin-Sun Jun, Beomseok Jeon
doi : 10.1212/WNL.0000000000011852
May 11, 2021; 96 (19)
Objective To determine whether greater physical activity could modify the negative association of APOE ?4 with longitudinal cognitive changes in early Parkinson disease (PD) and to uncover the disease-specific mechanism for explaining such benefits of physical activity.
Development of a New Quality of Life Measure for Duchenne Muscular Dystrophy Using Mixed Methods
Philip A. Powell,Jill Carlton, Donna Rowen, Fleur Chandler,Michela Guglieri, View ORCID ProfileJohn E. Brazier
doi : 10.1212/WNL.0000000000011896
May 11, 2021; 96 (19)
Objective Based on concerns about existing patient-reported outcome measures (PROMs) for assessing quality of life (QoL) in Duchenne muscular dystrophy (DMD), we describe the mixed methods development of a new QoL PROM for use in boys and men with DMD: the DMD-QoL.
What's Happening in Neurology® Clinical Practice
doi : 10.1212/WNL.0000000000011899
May 11, 2021; 96 (19)
What's Happening in Neurology® Neuroimmunology & Neuroinflammation
doi : 10.1212/WNL.0000000000011903
May 11, 2021; 96 (19)
The Quest for Covert Consciousness Bringing Neuroethics to the Bedside
Michael J. Young,Brian L. Edlow
doi : 10.1212/WNL.0000000000011734
May 11, 2021; 96 (19)
Neighborhood Socioeconomic Status and Stroke Incidence
Yeonwoo Kim,Erica Twardzik,Suzanne E. Judd, Natalie Colabianchi
doi : 10.1212/WNL.0000000000011892
May 11, 2021; 96 (19)
Objective To summarize overall patterns of the impact of neighborhood socioeconomic status (nSES) on stroke incidence and uncover potential gaps in the literature, we conducted a systematic review of studies examining the association between nSES and stroke incidence, independent of individual SES.
Absent Words, Present Person
Joan Yujae Lee
doi : 10.1212/WNL.0000000000011758
May 11, 2021; 96 (19)
Child Neurology: Late-Onset Vitamin B6–Dependent Epilepsy Identified by Rapid Genome Sequencing
A. Chris Espinoza, Melissa A. Wright, Meghan S. Candee, Cristina Trandafir, Gary R. Nelson
doi : 10.1212/WNL.0000000000011891
May 11, 2021; 96 (19)
Pearls & Oy-sters: “Quiet Nerve Paralysis” due to Symmetrical Neuropathy in Pure Neuritic Leprosy
Pratishtha Sengar, Ritu Verma,Varun Kumar Singh,Vimal Kumar Paliwal
doi : 10.1212/WNL.0000000000011880
May 11, 2021; 96 (19)
Teaching NeuroImages: Linear Radial Periventricular Enhancement in Glial Fibrillary Acidic Protein Astrocytopathy
Yongyao Kong, Andrew McKeon, Odelia S.Q. Koh, Yi Rong Chiew, Bela Purohit, Chee Fang Chin, Anastasia Zekeridou, Adeline S.L. Ng
doi : 10.1212/WNL.0000000000011496
May 11, 2021; 96 (19)
Teaching NeuroImages: Ohtahara Syndrome due to Unilateral Perisylvian Polymicrogyria
Sabarish Sekar, Pavankumar Rudrabhatla, Vinayagamani Selvadasan, Bejoy Thomas, Chandrasekharan Kesavadas
doi : 10.1212/WNL.0000000000011497
May 11, 2021; 96 (19)
Editors' Note: Association of Initial Imaging Modality and Futile Recanalization After Thrombectomy
Ariane Lewis, Steven Galetta
doi : 10.1212/WNL.0000000000011904
May 11, 2021; 96 (19)
Reader Response: Association of Initial Imaging Modality and Futile Recanalization After Thrombectomy
James E. Siegler, Jesse M. Thon
doi : 10.1212/WNL.0000000000011898
May 11, 2021; 96 (19)
Author Response: Association of Initial Imaging Modality and Futile Recanalization After Thrombectomy
Thomas Raphael Meinel, Johannes Kaesmacher, Urs Fischer
doi : 10.1212/WNL.0000000000011900
May 11, 2021; 96 (19)
Editors' Note: Comparison of Ice Pack Test and Single-Fiber EMG Diagnostic Accuracy in Patients Referred for Myasthenic Ptosis
Ariane Lewis, Steven Galetta
doi : 10.1212/WNL.0000000000011905
May 11, 2021; 96 (19)
Reader Response: Comparison of Ice Pack Test and Single-Fiber EMG Diagnostic Accuracy in Patients Referred for Myasthenic Ptosis
Nicholas Silvestri
doi : 10.1212/WNL.0000000000011901
May 11, 2021; 96 (19)
Author Response: Comparison of Ice Pack Test and Single-Fiber EMG Diagnostic Accuracy in Patients Referred for Myasthenic Ptosis
Maria Pia Giannoccaro, Rocco Liguori
doi : 10.1212/WNL.0000000000011902
May 11, 2021; 96 (19)
Lesion Evolution and Neurodegeneration in RVCL-S
doi : 10.1212/WNL.0000000000011323
May 11, 2021; 96 (19)
Apathy and Risk of Probable Incident Dementia Among Community-Dwelling Older Adults
doi : 10.1212/WNL.0000000000011756
May 11, 2021; 96 (19)
