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Spotlight on the April 27 Issue
José G. Merino
doi : 10.1212/WNL.0000000000011831
April 27, 2021; 96 (17)
Lateropulsion An Overlooked Driver of Balance and Gait Deficits in Stroke?
Joyce Gomes-Osman, Anne Kloos
doi : 10.1212/WNL.0000000000011156
April 27, 2021; 96 (17)
White Matter HyperintensitiesHow Much (and What Shape) Is Too Much?
Nawaf Yassi, Bruce C.V. Campbell
doi : 10.1212/WNL.0000000000011829
April 27, 2021; 96 (17)
The Benign Course of PLS A Strong Point in Favor of an Earlier Differentiation From ALS
Federica Agosta,Massimo Filippi
doi : 10.1212/WNL.0000000000011773
April 27, 2021; 96 (17)
Manfred D. Muenter, MD (1934–2021)
J. Eric Ahlskog, Charles H. Adler, Ryan J. Uitti
doi : 10.1212/WNL.0000000000011830
April 27, 2021; 96 (17)
Balance, Lateropulsion, and Gait Disorders in Subacute Stroke
Shenhao Dai, Céline Piscicelli, Emmanuelle Clarac,Monica Baciu,Marc Hommel,Dominic Pérennou
doi : 10.1212/WNL.0000000000011152
April 27, 2021; 96 (17)
Objective To test the hypothesis that impaired body orientation with respect to gravity (lateropulsion) would play a key role in poststroke balance and gait disorders.
Lateropulsion After Hemispheric Stroke A Form of Spatial Neglect Involving Graviception
Shenhao Dai, Céline Piscicelli, Emmanuelle Clarac, Monica Baciu, View ORCID ProfileMarc Hommel,Dominic Pérennou
doi : 10.1212/WNL.0000000000011826
April 27, 2021; 96 (17)
Objective To test the hypothesis that lateropulsion is an entity expressing an impaired body orientation with respect to gravity in relation to a biased graviception and spatial neglect.
Association of White Matter Hyperintensity Markers on MRI and Long-term Risk of Mortality and Ischemic Stroke
Rashid Ghaznawi, Mirjam I. Geerlings,Myriam Jaarsma-Coes, Jeroen Hendrikse,Jeroen de Bresser, on behalf of the UCC-Smart Study Group
doi : 10.1212/WNL.0000000000011827
April 27, 2021; 96 (17)
Objective To determine whether white matter hyperintensity (WMH) markers on MRI are associated with long-term risk of mortality and ischemic stroke.
Risk and Predictors of Depression Following Acute Ischemic Stroke in the Elderly
Naomi Mayman, Laura Katherine Stein, John Erdman, Alana Kornspun, Stanley Tuhrim, Nathalie Jette, Mandip S. Dhamoon
doi : 10.1212/WNL.0000000000011828
April 27, 2021; 96 (17)
Objective We sought to comprehensively evaluate predictors of poststroke depression (PSD) in the United States and to compare PSD to post–myocardial infarction (MI) depression to determine whether ischemic stroke uniquely elevates risk of depression.
Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities
Danielle Kerkhofs, Sau May Wong, Eleana Zhang, Julie Staals, View ORCID ProfileJacobus F.A. Jansen, Robert J. van Oostenbrugge, Walter H. Backes
doi : 10.1212/WNL.0000000000011783
April 27, 2021; 96 (17)
Objective To investigate the 2-year change in parenchymal diffusivity, a quantitative marker of microstructural tissue condition, and the relationship with baseline blood-brain barrier (BBB) permeability, in tissue at risk, i.e., the perilesional zone surrounding white matter hyperintensities (WMH) in patients with cerebral small vessel disease (cSVD).
Amyloid Positivity in the Alzheimer/Subcortical-Vascular Spectrum
Sung Hoon Kang, Monica Eunseo Kim, Hyemin Jang, Hojeong Kwon,Hyejoo Lee, Hee Jin Kim, Sang Won Seo, Duk L. Na
doi : 10.1212/WNL.0000000000011833
April 27, 2021; 96 (17)
Objective We investigated the frequency of ?-amyloid (A?) positivity in 9 groups classified according to a combination of 3 different cognition states and 3 distinct levels of white matter hyperintensities (WMH) (minimal, moderate, and severe) and aimed to determine which factors were associated with A? after controlling for WMH and vice versa.
Cardiovascular Risk Factors Across the Life Course and Cognitive Decline
Kristine Yaffe, Eric Vittinghoff, Tina Hoang, Karen Matthews, Sherita H. Golden, Adina Zeki Al Hazzouri
doi : 10.1212/WNL.0000000000011747
April 27, 2021; 96 (17)
Objective Cardiovascular risk factors (CVRFs) are associated with increased risk of cognitive decline, but little is known about how early adult CVRFs and those across the life course might influence late-life cognition. To test the hypothesis that CVRFs across the adult life course are associated with late-life cognitive changes, we pooled data from 4 prospective cohorts (n = 15,001, ages 18–95).
Long-term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality
Hong Xu, Sara Garcia-Ptacek, Linus J?nsson, Anders Wimo, Peter Nordstr?m, Maria Eriksdotter
doi : 10.1212/WNL.0000000000011832
April 27, 2021; 96 (17)
Objective To investigate whether cholinesterase inhibitors (ChEIs) are associated with slower cognitive decline in Alzheimer dementia and decreased risk of severe dementia or death.
Natural History of “Pure” Primary Lateral Sclerosis
Anhar Hassan,Shivam Om Mittal,William T. Hu, Keith A. Josephs, Eric J. Sorenson, J. Eric Ahlskog
doi : 10.1212/WNL.0000000000011771
April 27, 2021; 96 (17)
Objective To assess whether primary lateral sclerosis (PLS), classified as pure when the EMG is normal, converts to amyotrophic lateral sclerosis (ALS) after longitudinal follow-up.
What's Happening in Neurology® Clinical Practice
doi : 10.1212/WNL.0000000000011835
April 27, 2021; 96 (17)
What's Happening in Neurology® Neuroimmunology & Neuroinflammation
doi : 10.1212/WNL.0000000000011836
April 27, 2021; 96 (17)
New Ethical and Clinical Challenges in “Closed-Loop” Neuromodulation
Manu Hegde, Winston Chiong, Vikram R. Rao
doi : 10.1212/WNL.0000000000011834
April 27, 2021; 96 (17)
Neurostimulation provides a new dimension in the treatment of neurologic disorders. For patients with drug-resistant epilepsy, the Responsive Neurostimulation (RNS) System (NeuroPace, Inc.) provides treatment of seizures with a closed-loop device that continuously records brain activity and provides stimulation designed to reduce seizure frequency over time. The presence of a chronic implanted device that can provide an electrographic record of neural activity provides great opportunities for treatment of seizure disorders and neuroscience research. However, our experience with this device indicates that a number of ethical and clinical challenges arise, and these issues may be applicable to neurotechnology developed for other disease states in the future. We present clinical scenarios based on cases from our center that present clinical or ethical dilemmas. The dilemmas revolve around 4 core themes: (1) electroclinical correlation and dissociation; (2) patient concerns about device capabilities; (3) clinician opportunities and burdens; and (4) data ownership and access. Developing a framework for understanding these issues will be critical as closed-loop neuromodulation is applied to a growing range of neuropsychiatric disorders.
Incidence and Prevalence of Drug-Resistant Epilepsy
Bushra Sultana, Marie-Andrée Panzini, Ariane Veilleux Carpentier, Jacynthe Comtois, Bastien Rioux, Geneviève Gore,Prisca R. Bauer, Churl-Su Kwon, Nathalie Jetté, Colin B. Josephson, Mark R. Keezer
doi : 10.1212/WNL.0000000000011839
April 27, 2021; 96 (17)
Objective To evaluate the incidence and prevalence of drug-resistant epilepsy (DRE) as well as its predictors and correlates, we conducted a systematic review and meta-analysis of observational studies.
Residents & Fellows Rounds
Roy E. Strowd, Whitley Aamodt
doi : 10.1212/WNL.0000000000011890
April 27, 2021; 96 (17)
Education Research: Neurology Resident EEG Education
F?bio A. Nascimento, Jay R. Gavvala
doi : 10.1212/WNL.0000000000011354
April 27, 2021; 96 (17)
Objective To better understand the EEG education provided to adult neurology residents by surveying program directors of adult neurology residency programs in the United States.
Pearls & Oy-sters: Nonmotor Seizures as Presenting Feature of Hodgkin Lymphoma CNS Involvement
Dioselina Panam? Trist?n-Samaniego,Miguel Garc?a-Grimshaw,Rogelio Dom?nguez-Moreno, Fernanda Sof?a Garc?a-Miranda,Griselda Teresa Romero-S?nchez, Orlando Emmanuel Falc?n-Antonio, Oswaldo Alan Ch?vez-Mart?nez, Gladys Patricia Agreda-V?squez,Carlos Cant?-Brito
doi : 10.1212/WNL.0000000000011238
April 27, 2021; 96 (17)
Teaching Video NeuroImages: Cluster Breathing in Brainstem-Sparing Bihemispheric Cerebral and Cerebellar Lesions
Roger M. Meza, Hans Schulz, Diego Alva, Alberto J. Espay
doi : 10.1212/WNL.0000000000011215
April 27, 2021; 96 (17)
Teaching Video NeuroImages: Paroxysmal Dysarthria-Ataxia in Multiple Sclerosis
Shailee Shah, Bryan T. Klassen,Eoin P. Flanagan
doi : 10.1212/WNL.0000000000011498
April 27, 2021; 96 (17)
The Effects of Long-term Medication Use in Alzheimer Disease
Steven Karceski
doi : 10.1212/WNL.0000000000011843
April 27, 2021; 96 (17)
Editors' Note: Determination of Death by Neurologic Criteria Around the World
Aravind Ganesh, Steven Galetta
doi : 10.1212/WNL.0000000000011844
April 27, 2021; 96 (17)
Reader Response: Determination of Death by Neurologic Criteria Around the World
Nitin K. Sethi
doi : 10.1212/WNL.0000000000011838
April 27, 2021; 96 (17)
Author Response: Determination of Death by Neurologic Criteria Around the World
Ariane Lewis, Sam D. Shemie, Gene Sung, Sylvia Torrance, David Greer
doi : 10.1212/WNL.0000000000011841
April 27, 2021; 96 (17)
Reader Response: Determination of Death by Neurologic Criteria Around the World
Calixto Machado
doi : 10.1212/WNL.0000000000011840
April 27, 2021; 96 (17)
Author Response: Determination of Death by Neurologic Criteria Around the World
Ariane Lewis, Sam D. Shemie, Gene Sung, Sylvia Torrance, David Greer
doi : 10.1212/WNL.0000000000011842
April 27, 2021; 96 (17)
Stroke Reperfusion Therapy Following Dabigatran Reversal With Idarucizumab in a National Cohort
doi : 10.1212/WNL.0000000000009542
April 27, 2021; 96 (17)
Leisure Activity Participation and Risk of Dementia
doi : 10.1212/WNL.0000000000011447
April 27, 2021; 96 (17)
An Alternative to Vitamin D Supplementation to Prevent Fractures in Patients With MS
doi : 10.1212/WNL.0000000000011856
April 27, 2021; 96 (17)
