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Spotlight on the April 20 Issue
José G. Merino
doi : 10.1212/WNL.0000000000011794
April 20, 2021; 96 (16)
The Phial of Galadriel
Radoslav Raychev, Warren D. Lo
doi : 10.1212/WNL.0000000000011824
April 20, 2021; 96 (16)
Seeing the Finish Line Can Baseline OCT Values Predict Long-term Disability and Therapeutic Management in Multiple Sclerosis?
Pablo Villoslada,Steven L. Galetta, Ahmed Toosy
doi : 10.1212/WNL.0000000000011793
April 20, 2021; 96 (16)
The Role of Immune Checkpoint Therapy in Propagating Neurologic Immune-Related Adverse Events
Tova Gardin, Erin E. Longbrake
doi : 10.1212/WNL.0000000000011812
April 20, 2021; 96 (16)
Temporal Trends in Case Fatality, Discharge Destination, and Admission to Long-term Care After Acute Stroke
Raed A. Joundi, Eric E. Smith,Amy Y.X. Yu, Mohammed Rashid, Jiming Fang,Moira K. Kapral
doi : 10.1212/WNL.0000000000011791
April 20, 2021; 96 (16)
Objective To determine contemporary trends in case fatality, discharge destination, and admission to long-term care after acute ischemic stroke and intracerebral hemorrhage (ICH) using a large, population-based cohort.
Detection of Cerebral Microbleeds With Venous Connection at 7-Tesla MRI
Johanna Rotta, Valentina Perosa, Renat Yakupov,Hugo J. Kuijf,Frank Schreiber, Laura Dobisch, Jan Oltmer, Anne Assmann, Oliver Speck, Hans-Jochen Heinze,Julio Acosta-Cabronero, Emrah Duzel, Stefanie Schreiber
doi : 10.1212/WNL.0000000000011790
April 20, 2021; 96 (16)
Objective Cerebral microbleeds (MBs) are a common finding in patients with cerebral small vessel disease (CSVD) and Alzheimer disease as well as in healthy elderly people, but their pathophysiology remains unclear. To investigate a possible role of veins in the development of MBs, we performed an exploratory study, assessing in vivo presence of MBs with a direct connection to a vein.
Association of Spectral-Domain OCT With Long-term Disability Worsening in Multiple Sclerosis
Jeffrey Lambe,Kathryn C. Fitzgerald,Olwen C. Murphy,Angeliki G. Filippatou,Elias S. Sotirchos,Grigorios Kalaitzidis,Elena Vasileiou, Nicole Pellegrini, Esther Ogbuokiri, Brandon Toliver, Nicholas J. Luciano, Simidele Davis, Nicholas Fioravante, Ohemaa Kwakyi, Hunter Risher, Ciprian M. Crainiceanu,Jerry L. Prince, Scott D. Newsome,Ellen M. Mowry,Shiv Saidha,Peter A. Calabresi
doi : 10.1212/WNL.0000000000011788
April 20, 2021; 96 (16)
Objective To evaluate whether a retinal spectral-domain optical coherence tomography (SD-OCT) assessment at baseline is associated with long-term disability worsening in people with multiple sclerosis (PwMS), we performed SD-OCT and Expanded Disability Status Scale (EDSS) assessments among 132 PwMS at baseline and at a median of 10 years later.
Evaluation of the Diagnostic Criteria for Anti-NMDA Receptor Encephalitis in Japanese Children
Hiroya Nishida, Kuniko Kohyama, Satoko Kumada, Jun-ichi Takanashi, Akihisa Okumura, Asako Horino, Kengo Moriyama, Hiroshi Sakuma
doi : 10.1212/WNL.0000000000011789
April 20, 2021; 96 (16)
Objective To evaluate the validity of the 2016 clinical diagnostic criteria proposed for probable anti-NMDA receptor (NMDAR) encephalitis in children, we tested the criteria in a Japanese pediatric cohort.
Expanding the Spectrum of Chronic Immune Sensory Polyradiculopathy
Shahar Shelly, Kamal Shouman, Pritikanta Paul, JaNean Engelstad, Kimberly K. Amrami, Robert J. Spinner, Divyanshu Dubey, Rocio Vazquez Do Campo, Peter J. Dyck, Christopher J. Klein, P. James B. Dyck
doi : 10.1212/WNL.0000000000011792
April 20, 2021; 96 (16)
Objective Sensory loss with normal nerve conduction studies (NCS) from focal sensory root inflammatory demyelination is characteristic of chronic immune sensory polyradiculopathy (CISP). However, nonpure cases involving motor and distal sensory nerves exist (CISP-plus). We hypothesize that CISP-plus and CISP are fundamentally part of the same syndrome through comparison of clinical, neurophysiologic, and pathologic features.
Association of Cortical Hyperexcitability and Cognitive Impairment in Patients With Amyotrophic Lateral Sclerosis
Mana Higashihara, Nathan Pavey,Mehdi van den Bos, Parvathi Menon, Matthew C. Kiernan, Steve Vucic
doi : 10.1212/WNL.0000000000011798
April 20, 2021; 96 (16)
Objective To determine whether cortical hyperexcitability was more prominent in cognitively impaired patients with amyotrophic lateral sclerosis (ALS).
Lumbosacral Radiculoplexus Neuropathy
Marcus V. Pinto, Peng-Soon Ng, Benjamin M. Howe, Ruple S. Laughlin, Prabin Thapa, Peter J. Dyck, P. James B. Dyck
doi : 10.1212/WNL.0000000000011799
April 20, 2021; 96 (16)
Objective To determine whether patients in the community with lumbosacral radiculoplexus neuropathy (LRPN) have milder neuropathy than referral patients, we characterized the outcomes and survival of population-based compared to referral-based LRPN cohorts.
Impact of Coronavirus Disease 2019 in a French Cohort of Myasthenia Gravis
Guilhem Solé, Stéphane Mathis, Diane Friedman,Emmanuelle Salort-Campana, Céline Tard, Françoise Bouhour, Armelle Magot, Djillali Annane, Bernard Clair, Gwendal Le Masson, Antoine Soulages, Fanny Duval, Louis Carla, Marie-Hélène Violleau, Tiphaine Saulnier, Sandrine Segovia-Kueny, Léa Kern, Jean-Christophe Antoine, Guillemette Beaudonnet, Frédérique Audic, Laurent Kremer, Jean-Baptiste Chanson, Aleksandra Nadaj-Pakleza, Tanya Stojkovic, Pascal Cintas, Marco Spinazzi, Alexandra Foubert-Samier,Shahram Attarian
doi : 10.1212/WNL.0000000000011669
April 20, 2021; 96 (16)
Objective To describe the clinical characteristics and outcomes of coronavirus disease 2019 (COVID-19) among patients with myasthenia gravis (MG) and identify factors associated with COVID-19 severity in patients with MG.
Perivascular Spaces in the Basal Ganglia and Long-term Motor Prognosis in Newly Diagnosed Parkinson Disease
Seok Jong Chung, Han Soo Yoo, Na-Young Shin, Yae Won Park, Hye Sun Lee, Ji-Man Hong,Yun Joong Kim, Seung-Koo Lee, Phil Hyu Lee, Young H. Sohn
doi : 10.1212/WNL.0000000000011797
April 20, 2021; 96 (16)
Objective To investigate the association between enlarged perivascular spaces (PVS) in the basal ganglia (BG-PVS) and long-term motor outcomes in Parkinson disease (PD).
Five-Year Trends in Payments for Neurologist-Prescribed Drugs in Medicare Part D
Adam de Havenon, Alen Delic, Sarah Dehoney, Presley Whetman, Nazanin Sheibani, Brian Callaghan, John Ney, Gregory J. Esper, Brandon Magliocco, Kavita V. Nair
doi : 10.1212/WNL.0000000000011712
April 20, 2021; 96 (16)
Objective To determine whether there was an increase in payments for neurologist-prescribed drugs, we performed a retrospective analysis of prescription claims in the Medicare Part D Prescriber Public Use Files from 2013 to 2017.
What's Happening in Neurology® Clinical Practice
doi : 10.1212/WNL.0000000000011800
April 20, 2021; 96 (16)
What's Happening in Neurology® Neuroimmunology & Neuroinflammation
doi : 10.1212/WNL.0000000000011801
April 20, 2021; 96 (16)
What Is the Clinical Correlation of Cardiac Noradrenergic Denervation in Parkinson Disease?
Guillaume Lamotte, Eduardo E. Benarroch
doi : 10.1212/WNL.0000000000011805
April 20, 2021; 96 (16)
Neurologic Adverse Events of Immune Checkpoint Inhibitors
Alessandro Marini, Andrea Bernardini, Gian Luigi Gigli, Mariarosaria Valente,Sergio Mu?iz-Castrillo, Jérôme Honnorat, Alberto Vogrig
doi : 10.1212/WNL.0000000000011795
April 20, 2021; 96 (16)
Objective To define the clinical characteristics, management, and outcome of neurologic immune-related adverse events (n-irAEs) of immune checkpoint inhibitors (ICIs).
Multiple Sclerosis Relapse Presenting as Sensorineural Hearing Loss
Parth Bansal, Birinder S. Paul, Gagandeep Singh
doi : 10.1212/WNL.0000000000011796
April 20, 2021; 96 (16)
Teaching NeuroImages: Glossopharyngeal Nerve Focal Pressure Atrophy in Glossopharyngeal Neuralgia
Luying Li, Heng Zhang
doi : 10.1212/WNL.0000000000011321
April 20, 2021; 96 (16)
Journal Club: Diffusion-Weighted MRI in Transient Global Amnesia and Its Diagnostic Implications
Daniel Talmasov, Arjun V. Masurkar
doi : 10.1212/WNL.0000000000011352
April 20, 2021; 96 (16)
Pearls & Oy-sters: Primary CNS Burkitt Lymphoma in Pregnancy
Angel Miraclin, Ajith Sivadasan, S. Rima, Pavithra Mannam, Ankush Gupta, Anup J. Devasia, A.T. Prabhakar, Vivek Mathew
doi : 10.1212/WNL.0000000000011495
April 20, 2021; 96 (16)
Teaching Video Neuroimages: Spontaneous Nystagmus Reversal in Acute Attack of Ménière Disease
Anand K. Bery, Tzu-Pu Chang
doi : 10.1212/WNL.0000000000011053
April 20, 2021; 96 (16)
Editors' Note: Clinical Characterization of Delayed Alcohol-Induced Headache: A Study of 1,108 Participants
Ariane Lewis, Steven Galetta
doi : 10.1212/WNL.0000000000011804
April 20, 2021; 96 (16)
Reader Response: Clinical Characterization of Delayed Alcohol-Induced Headache: A Study of 1,108 Participants
Vinod K. Gupta
doi : 10.1212/WNL.0000000000011802
April 20, 2021; 96 (16)
Author Response: Clinical Characterization of Delayed Alcohol-Induced Headache: A Study of 1,108 Participants
David Garc?a-Azor?n, Henrik W. Schytz, ?ngel L. Guerrero
doi : 10.1212/WNL.0000000000011803
April 20, 2021; 96 (16)
Reader Response: Clinical Characterization of Delayed Alcohol-Induced Headache: A Study of 1,108 Participants
Peter J. Goadsby
doi : 10.1212/WNL.0000000000011807
April 20, 2021; 96 (16)
Author Response: Clinical Characterization of Delayed Alcohol-Induced Headache: A Study of 1,108 Participants
David Garc?a-Azor?n, ?ngel L. Guerrero
doi : 10.1212/WNL.0000000000011809
April 20, 2021; 96 (16)
Reader Response: Clinical Characterization of Delayed Alcohol-Induced Headache: A Study of 1,108 Participants
Jonathan H. Smith
doi : 10.1212/WNL.0000000000011808
April 20, 2021; 96 (16)
Author Response: Clinical Characterization of Delayed Alcohol-Induced Headache: A Study of 1,108 Participants
David Garc?a-Azor?n, ?ngel L. Guerrero
doi : 10.1212/WNL.0000000000011810
April 20, 2021; 96 (16)
