Neurology




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Spotlight on the April 13 Issue

José G. Merino

doi : 10.1212/WNL.0000000000011741

April 13, 2021; 96 (15) 

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Can Biomarkers Differentiate Between Ischemic and Hemorrhagic Stroke in the Prehospital Setting?

Glen C. Jickling, Katja E. Wartenberg

doi : 10.1212/WNL.0000000000011738

April 13, 2021; 96 (15) 

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Teleneurology for Determination of Death by Neurologic Criteria

 View ORCID ProfileBrittany Bolduc Lachance, Nicholas A. Morris, John C.M. Brust

doi : 10.1212/WNL.0000000000011740

April 13, 2021; 96 (15) 

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Blood Biomarkers to Differentiate Ischemic and Hemorrhagic Strokes

Alejandro Bustamante, Anna Penalba, Cyrille Orset, Leire Azurmendi,V?ctor Llombart, Alba Simats, Emili Pecharroman, Oriol Ventura,Marc Rib?, Denis Vivien, Jean Charles Sanchez, Joan Montaner

doi : 10.1212/WNL.0000000000011742

April 13, 2021; 96 (15) 

Objective To validate a panel of blood biomarkers to differentiate between ischemic stroke (IS) and intracerebral hemorrhage (ICH) in patients with suspected stroke.

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Quality of Plant-Based Diet and Risk of Total, Ischemic, and Hemorrhagic Stroke

Megu Y. Baden, Zhilei Shan, Fenglei Wang,Yanping Li, JoAnn E. Manson, Eric B. Rimm, Walter C. Willett, Frank B. Hu, Kathryn M. Rexrode

doi : 10.1212/WNL.0000000000011713

April 13, 2021; 96 (15) 

Objective To determine whether a healthful plant-based diet is related to lower stroke risk, we examined the associations of plant-based diet quality with risk of total, ischemic, and hemorrhagic stroke.

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Cerebral Small Vessel Disease and Functional Outcome Prediction After Intracerebral Hemorrhage

Isabel C. Hostettler,Ghil Schwarz, Gareth Ambler, Duncan Wilson, Gargi Banerjee,David J. Seiffge, Clare Shakeshaft, Surabhika Lunawat, Hannah Cohen, Tarek A. Yousry,Rustam Al-Shahi Salman,Gregory Y.H. Lip, Martin M. Brown,  View ORCID ProfileKeith W. Muir,Henry Houlden, Hans Rolf J?ger, David J. Werring, on behalf of the CROMIS-2 Collaborators

doi : 10.1212/WNL.0000000000011746

April 13, 2021; 96 (15) 

Objective To determine whether CT-based cerebral small vessel disease (SVD) biomarkers are associated with 6-month functional outcome after intracerebral hemorrhage (ICH) and whether these biomarkers improve the performance of the preexisting ICH prediction score.

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Association of Depression and Anxiety With Cognitive Impairment 6 Months After Stroke

Owen A. Williams, Nele Demeyere

doi : 10.1212/WNL.0000000000011748

April 13, 2021; 96 (15) 

Objective To investigate the associations between general cognitive impairment and domain-specific cognitive impairment with depression and anxiety at 6 months poststroke.

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Association of Memory Impairment With Concomitant Tau Pathology in Patients With Cerebral Amyloid Angiopathy

Dorothee Schoemaker, Andreas Charidimou, Maria Clara Zanon Zotin,Nicolas Raposo, Keith A. Johnson, Justin S. Sanchez, Steven M. Greenberg, Anand Viswanathan

doi : 10.1212/WNL.0000000000011745

April 13, 2021; 96 (15) 

Objective Relying on tau-PET imaging, this cross-sectional study explored whether memory impairment is linked to the presence of concomitant tau pathology in individuals with cerebral amyloid angiopathy (CAA).

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Temporal Cognitive and Brain Changes in Korsakoff Syndrome

Angéline Maillard, Alice Laniepce, Nicolas Cabé, Céline Boudehent, Gael Chételat, Laurent Urso, Francis Eustache, François Vabret,  Shailendra Segobin,Anne-Lise Pitel

doi : 10.1212/WNL.0000000000011749

April 13, 2021; 96 (15) 

Objective To investigate cognitive and brain changes in patients with Korsakoff syndrome (KS) over months and up to 10 years after the diagnosis.

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Teleneurology-Enabled Determination of Death by Neurologic Criteria After Cardiac Arrest or Severe Neurologic Injury

Marcelo Matiello, Ashby C. Turner, Juan Estrada, Cynthia M. Whitney, Barrett T. Kitch, Patrick T. Lee, Uma Girkar,Rafael Palacios,Pooja Singla, Lee Schwamm

doi : 10.1212/WNL.0000000000011751

April 13, 2021; 96 (15) 

Objective To determine whether providing teleneurology (TN) consultations aiding in determination of death by neurologic criteria (DNC) to a bedside intensivist is feasible and whether timely access and expert input increase the quality of the DNC examination and identification of potential organ donors, we reviewed retrospective data related to outcomes of such consultations.

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Pregnancy in Patients With AQP4-Ab, MOG-Ab, or Double-Negative Neuromyelitis Optica Disorder

Nicolas Collongues, Cecilia Alves Do Rego, Bertrand Bourre, Damien Biotti, Romain Marignier,  View ORCID ProfileAna Martins da Silva,Ernestina Santos,Elisabeth Maillart, Caroline Papeix, Jacqueline Palace, Maria Isabel S. Leite, Jerome De Seze

doi : 10.1212/WNL.0000000000011744

April 13, 2021; 96 (15) 

Objective To analyze the effects of pregnancy on neuromyelitis optica spectrum disorder (NMOSD) according to patients' serostatus and immunosuppressive therapy (IST).

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Olfactory Testing in Parkinson Disease and REM Behavior Disorder

Christine Lo, Siddharth Arora,Yoav Ben-Shlomo,Thomas R. Barber,Michael Lawton,Johannes C. Klein, Sofia Kanavou, Annette Janzen, Elisabeth Sittig,Wolfgang H. Oertel, Donald G. Grosset,Michele T. Hu

doi : 10.1212/WNL.0000000000011743

April 13, 2021; 96 (15) 

Objective We sought to identify an abbreviated test of impaired olfaction amenable for use in busy clinical environments in prodromal (isolated REM sleep behavior disorder [iRBD]) and manifest Parkinson disease (PD).

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What's Happening in Neurology® Clinical Practice

doi : 10.1212/WNL.0000000000011777

April 13, 2021; 96 (15) 

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What's Happening in Neurology® Genetics

doi : 10.1212/WNL.0000000000011778

April 13, 2021; 96 (15) 

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What's Happening in Neurology® Neuroimmunology & Neuroinflammation

doi : 10.1212/WNL.0000000000011779

April 13, 2021; 96 (15) 

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CSF and Blood Neurofilament Levels in Athletes Participating in Physical Contact Sports

Carl Verduyn, Maria Bjerke, Johnny Duerinck,Sebastiaan Engelborghs, Koenraad Peers, Jan Versijpt, Miguel D'haeseleer

doi : 10.1212/WNL.0000000000011750

April 13, 2021; 96 (15) 

Objective To evaluate whether participating in physical contact sports is associated with a release of neurofilaments and whether such release is related to future clinical neurologic and/or psychiatric impairment.

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Microglia

Beverly Greenspan

doi : 10.1212/WNL.0000000000011670

April 13, 2021; 96 (15) 

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Medulla Compression by Bilateral Aberrant Vertebral Artery With Mild Chiari Malformation

Zongli Han, Yanli Du, Peng Hu, Hongqi Zhang

doi : 10.1212/WNL.0000000000011752

April 13, 2021; 96 (15) 

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Pearls & Oy-sters: Anisocoria Greater in the Dark: It's Not Just All About Horner Pupil

Emily Witsberger, Sasha A. Mansukhani, John J. Chen, M. Tariq Bhatti

doi : 10.1212/WNL.0000000000011221

April 13, 2021; 96 (15) 

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Education Research: Challenges Faced by Neurology Trainees in a Neuro-Intervention Career Track

Conrad W. Liang, Saurav Das, Santiago Ortega-Gutierrez, David S. Liebeskind, James C. Grotta, Tudor G. Jovin, Thanh N. Nguyen, Raul G. Nogueira, Hesham Masoud, Lucas Elijovich, Osama O. Zaidat, Ameer E. Hassan, Italo Linfante, Johanna T. Fifi, Sunil A. Sheth

doi : 10.1212/WNL.0000000000011629

April 13, 2021; 96 (15) 

Objective The widespread adoption of endovascular therapy (EVT) for emergent large vessel occlusion has led to increased nationwide demand for neurointerventionalists, heightened interest among neurology residents to pursue neurointervention as a career, and increased importance of neurointervention exposure for all neurologists who care for patients with acute ischemic stroke. Exposure to neurointervention and its career path are not well-defined for neurology trainees.

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Teaching NeuroImages: Hutchinson Sign in Herpes Zoster Ophthalmicus

Eiichiro Amano, Akira Machida

doi : 10.1212/WNL.0000000000011285

April 13, 2021; 96 (15) 

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Teaching NeuroImages: Neurocysticercosis With Unilateral Vision Loss

Ramanuj Samanta, Sreeram Jayaraj, Shalaka Ramesh Waghamare, Athul S. Puthalath, Niraj Kumar

doi : 10.1212/WNL.0000000000011319

April 13, 2021; 96 (15) 

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Editors' Note: First-Ever Ischemic Stroke and Increased Risk of Incident Heart Disease in Older Adults

James E. Siegler, Steven Galetta

doi : 10.1212/WNL.0000000000011780

April 13, 2021; 96 (15) 

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Reader Response: First-Ever Ischemic Stroke and Increased Risk of Incident Heart Disease in Older Adults

Chrissa Sioka, Andreas Fotopoulos,Sotirios Giannopoulos

doi : 10.1212/WNL.0000000000011782

April 13, 2021; 96 (15) 

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Author Response: First-Ever Ischemic Stroke and Increased Risk of Incident Heart Disease in Older Adults

Luciano A. Sposato, Gustavo Saposnik

doi : 10.1212/WNL.0000000000011785

April 13, 2021; 96 (15) 

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Editors' Note: Exosomal Neurofilament Light: A Prognostic Biomarker for Remote Symptoms After Mild Traumatic Brain Injury?

James E. Siegler, Steven Galetta

doi : 10.1212/WNL.0000000000011787

April 13, 2021; 96 (15) 

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Reader Response: Exosomal Neurofilament Light: A Prognostic Biomarker for Remote Symptoms After Mild Traumatic Brain Injury?

Tomoyuki Kawada

doi : 10.1212/WNL.0000000000011784

April 13, 2021; 96 (15) 

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Author Response: Exosomal Neurofilament Light: A Prognostic Biomarker for Remote Symptoms After Mild Traumatic Brain Injury?

Kimbra Kenney, Vivian A. Guedes, Jessica M. Gill

doi : 10.1212/WNL.0000000000011786

April 13, 2021; 96 (15) 

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