Diabetes Care




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In This Issue of Diabetes

Max Bingham, PhD

doi : 10.2337/dc22-ti10

Volume 45, Issue 10

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Innovative Designs and Logistical Considerations for Expedited Clinical Development of Combination Disease-Modifying Treatments for Type 1 Diabetes

Randy L. Anderson; Linda A. DiMeglio; Adrian P. Mander; Colin M. Dayan; Peter S. Linsley; Kevan C. Herold; Marjana Marinac; Simi T. Ahmed

doi : 10.2337/dc22-0308

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To Correct or Not to Correct: Lost in Inpatient Translation

Amisha Wallia; Jane Jeffrie Seley

doi : 10.2337/dci22-0023

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A New Bar for Pharmacologic Weight Loss: Type 2 Diabetes Prevention

Kathleen M. Dungan

doi : 10.2337/dci22-0019

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Professor Juliana Chung Ngor Chan: Tireless Trailblazer for Diabetes Research, Care, and Education in Asia

Ronald C.W. Ma; Wing Yee So; Andrea O.Y. Luk

doi : 10.2337/dci22-0016

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Efficacy and Safety of Intensive Versus Nonintensive Supplemental Insulin With a Basal-Bolus Insulin Regimen in Hospitalized Patients With Type 2 Diabetes: A Randomized Clinical Study

Priyathama Vellanki; Saumeth Cardona; Rodolfo J. Galindo; Maria A. Urrutia; Francisco J. Pasquel; Georgia M. Davis; Maya Fayfman; Alexandra Migdal; Limin Peng; Guillermo E. Umpierrez

doi : 10.2337/dc21-1606

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Effects of Patient-Driven Lifestyle Modification Using Intermittently Scanned Continuous Glucose Monitoring in Patients With Type 2 Diabetes: Results From the Randomized Open-label PDF Study

Hun Jee Choe; Eun-Jung Rhee; Jong Chul Won; Kyong Soo Park; Won-Young Lee; Young Min Cho

doi : 10.2337/dc22-0764

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Targeting Technology in Underserved Adults With Type 1 Diabetes: Effect of Diabetes Practice Transformations on Improving Equity in CGM Prescribing Behaviors

Priyanka Mathias; Lakshmi Priyanka Mahali; Shivani Agarwal

doi : 10.2337/dc22-0555

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First STEPS: Primary Outcomes of a Randomized, Stepped-Care Behavioral Clinical Trial for Parents of Young Children With New-Onset Type 1 Diabetes

Marisa E. Hilliard; Carrie Tully; Maureen Monaghan; Tom Hildebrandt; Christine H. Wang; John R. Barber; Lauren Clary; Katherine Gallagher; Wendy Levy; Fran Cogen; Celia Henderson; Lefkothea Karaviti; Randi Streisand

doi : 10.2337/dc21-2704

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Thirty-Year Time Trends in Diabetic Retinopathy and Macular Edema in Youth With Type 1 Diabetes

Digby W. Allen; Gerald Liew; Yoon Hi Cho; Alison Pryke; Janine Cusumano; Stephen Hing; Albert K. Chan; Maria E. Craig; Kim C. Donaghue

doi : 10.2337/dc21-1652

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Effect of State-Led Delivery System and Payment Reforms on Population-Level Detection and Management of Diabetes

Hector P. Rodriguez; Brent D. Fulton; Aryn Z. Phillips; Karl Rubio

doi : 10.2337/dc21-2425

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The Transition From a Compensatory Increase to a Decrease in C-peptide During the Progression to Type 1 Diabetes and Its Relation to Risk

Heba M. Ismail; David Cuthbertson; Stephen E. Gitelman; Jay S. Skyler; Andrea K. Steck; Henry Rodriguez; Mark Atkinson; Brandon M. Nathan; Maria J. Redondo; Kevan C. Herold; Carmella Evans-Molina; Linda A. DiMeglio; Jay Sosenko; on behalf of DPT-1 and TrialNet Study Groups

doi : 10.2337/dc22-0167

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Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study

Jeffrey P. Krischer; Xiang Liu; Ã…ke Lernmark; William A. Hagopian; Marian J. Rewers; Jin-Xiong She; Jorma Toppari; Anette-G. Ziegler; Beena Akolkar; TEDDY Study Group ; on behalf of the TEDDY Study Group

doi : 10.2337/dc21-2612

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Health Beliefs Associated With Metformin Use Among Insured Adults With Prediabetes

Laura N. McEwen; Thomas E. Hurst; Kevin L. Joiner; William H. Herman

doi : 10.2337/dc21-2316

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Incretin-Based Drugs and the Risk of Acute Liver Injury Among Patients With Type 2 Diabetes

Richeek Pradhan; Hui Yin; Oriana H.Y. Yu; Laurent Azoulay

doi : 10.2337/dc22-0712

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Evolution of Clinical Complexity, Treatment Burden, Health Care Use, and Diabetes-Related Outcomes Among Commercial and Medicare Advantage Plan Beneficiaries With Diabetes in the U.S., 2006–2018

Tyler J. Benning; Herbert C. Heien; Rozalina G. McCoy

doi : 10.2337/dc21-2623

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Early-Phase Changes in Serum Free Fatty Acid Levels After Glucose Intake Are Associated With Type 2 Diabetes Incidence: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases

Nobuo Sasaki; Ryo Maeda; Ryoji Ozono; Kenichi Yoshimura; Yukiko Nakano; Yukihito Higashi

doi : 10.2337/dc21-2554

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Trends in Prescribing Preferences for Antidiabetic Medications Among Patients With Type 2 Diabetes in the U.K. With and Without Chronic Kidney Disease, 2006–2020

Julia Liaw; Meera Harhay; Soko Setoguchi; Tobias Gerhard; Chintan V. Dave

doi : 10.2337/dc22-0224

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Range of Risk Factor Levels, Risk Control, and Temporal Trends for Nephropathy and End-stage Kidney Disease in Patients With Type 1 and Type 2 Diabetes

Janita Halminen; Naveed Sattar; Araz Rawshani; Björn Eliasson; Katarina Eeg-Olofsson; Deepak L. Bhatt; Aidin Rawshani

doi : 10.2337/dc22-0926

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Racial Disparities in Health Care With Timing to Amputation Following Diabetic Foot Ulcer

Taavy A. Miller; James H. Campbell; Nick Bloom; Shane R. Wurdeman

doi : 10.2337/dc21-2693

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Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests

Kendra Vehik; David Boulware; Michael Killian; Marian Rewers; Richard McIndoe; Jorma Toppari; Ã…ke Lernmark; Beena Akolkar; Anette-G. Ziegler; Henry Rodriguez; Desmond A. Schatz; Jeffrey P. Krischer; William Hagopian; The TEDDY Study Group Colorado Clinical Center ; for the TrialNet Study Group and TEDDY Study Group

doi : 10.2337/dc22-0828

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Dapagliflozin and Prevention of Kidney Disease Among Patients With Type 2 Diabetes: Post Hoc Analyses From the DECLARE-TIMI 58 Trial

Ofri Mosenzon; Itamar Raz; Stephen D. Wiviott; Meir Schechter; Erica L. Goodrich; Ilan Yanuv; Aliza Rozenberg; Sabina A. Murphy; Thomas A. Zelniker; Anna Maria Langkilde; Ingrid A.M. Gause-Nilsson; Martin Fredriksson; Peter A. Johansson; John P.H. Wilding; Darren K. McGuire; Deepak L. Bhatt; Lawrence A. Leiter; Avivit Cahn; Jamie P. Dwyer; Hiddo J.L. Heerspink; Marc S. Sabatine

doi : 10.2337/dc22-0382

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Glycemic Variability Patterns Strongly Correlate With Partial Remission Status in Children With Newly Diagnosed Type 1 Diabetes

Olivier G. Pollé; Antoine Delfosse; Manon Martin; Jacques Louis; Inge Gies; Marieke den Brinker; Nicole Seret; Marie-Christine Lebrethon; Thierry Mouraux; Laurent Gatto; Philippe A. Lysy; on behalf of the DIATAG Working Group

doi : 10.2337/dc21-2543

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Continuous Glucose Monitoring–Guided Insulin Administration in Hospitalized Patients With Diabetes: A Randomized Clinical Trial

Elias K. Spanakis; Agustina Urrutia; Rodolfo J. Galindo; Priyathama Vellanki; Alexandra L. Migdal; Georgia Davis; Maya Fayfman; Thaer Idrees; Francisco J. Pasquel; Walkiria Zamudio Coronado; Bonnie Albury; Emmenlin Moreno; Lakshmi G. Singh; Isabel Marcano; Sergio Lizama; Chikara Gothong; Kashif Munir; Catalina Chesney; Rebecca Maguire; William H. Scott; M. Citlalli Perez-Guzman; Saumeth Cardona; Limin Peng; Guillermo E. Umpierrez

doi : 10.2337/dc22-0716

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The Association of Measures of Cardiovascular Autonomic Function, Heart Rate, and Orthostatic Hypotension With Incident Glucose Disorders: The Cardiovascular Health Study

Joshua I. Barzilay; William Tressel; Mary L. Biggs; Phyllis K. Stein; Jorge R. Kizer; Sanyog G. Shitole; Yakubu Bene-Alhasan; Kenneth J. Mukamal

doi : 10.2337/dc22-0553

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Optimal Frequency of Retinopathy Screening in Adolescents With Type 1 Diabetes: Markov Modeling Approach Based on 30 Years of Data

Andrzej S. Januszewski; Vallimayil Velayutham; Paul Z. Benitez-Aguirre; Maria E. Craig; Janine Cusumano; Alison Pryke; Stephen Hing; Gerald Liew; Yoon Hi Cho; Emily Y. Chew; Alicia J. Jenkins; Kim C. Donaghue

doi : 10.2337/dc22-0071

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Cardiac Autonomic Nerve Dysfunction Predicts Incident Retinopathy and Early Kidney Dysfunction in Adolescents With Type 1 Diabetes

Vallimayil Velayutham; Paul Benitez-Aguirre; Maria Craig; Yoon Hi Cho; Gerald Liew; Kim Donaghue

doi : 10.2337/dc22-0349

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Changes in Glucose Metabolism and Glycemic Status With Once-Weekly Subcutaneous Semaglutide 2.4 mg Among Participants With Prediabetes in the STEP Program

Leigh Perreault; Melanie Davies; Juan P. Frias; Peter Nørkjaer Laursen; Ildiko Lingvay; Sriram Machineni; Anette Varbo; John P.H. Wilding; Signe Olrik Rytter Wallenstein; Carel W. le Roux

doi : 10.2337/dc21-1785

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COVID-19 Exacerbates Insulin Resistance During Diabetic Ketoacidosis in Pediatric Patients With Type 1 Diabetes

Elizabeth S. Keiner; James C. Slaughter; Karishma A. Datye; Alan D. Cherrington; Daniel J. Moore; Justin M. Gregory

doi : 10.2337/dc22-0396

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Use of the Steno T1 Risk Engine Identifies Preclinical Atherosclerosis Better Than Use of ESC/EASD-2019 in Adult Subjects With Type 1 Diabetes at High Risk

Tonet Serés-Noriega; Marga Giménez; Verónica Perea; Laura Boswell; Clara Viñals; Jesús Blanco; Irene Vinagre; Adriana Pané; Enric Esmatjes; Ignacio Conget; Antonio J. Amor

doi : 10.2337/dc22-0118

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Associations of New-Onset Atrial Fibrillation With Risks of Cardiovascular Disease, Chronic Kidney Disease, and Mortality Among Patients With Type 2 Diabetes

Tingting Geng; Yi Wang; Qi Lu; Yan-Bo Zhang; Jun-Xiang Chen; Yan-Feng Zhou; Zhenzhen Wan; Kunquan Guo; Kun Yang; Liegang Liu; Gang Liu; An Pan

doi : 10.2337/dc22-0717

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Measurement of Serum N-Glycans in the Assessment of Early Vascular Aging (Arterial Stiffness) in Adults With Type 1 Diabetes

Gemma Llauradó; Núria Amigó; Rocío Fuertes-Martín; Ana Romero; Albert Cano; Lara Albert; Olga Giménez-Palop; Eugenio Berlanga; Sonia Fernández-Veledo; Xavier Correig; Joan Vendrell; José-Miguel González-Clemente

doi : 10.2337/dc22-0331

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The Fast-Glycator Phenotype, Skin Advanced Glycation End Products, and Complication Burden Among People With Type 1 Diabetes

Alberto Maran; Mario Luca Morieri; Daniele Falaguasta; Angelo Avogaro; Gian Paolo Fadini

doi : 10.2337/dc22-0980

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Association of Estimated Time-in-Range Capillary Glucose Levels Versus HbA1c With Progression of Microvascular Complications in the Diabetes Control and Complications Trial

John M. Lachin; Ionut Bebu; Xiaoyu Gao; David M. Nathan; Bernard Zinman; the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group

doi : 10.2337/dc21-2298

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Noninvasive Fibrosis Screening in Fatty Liver Disease Among Vulnerable Populations: Impact of Diabetes and Obesity on FIB-4 Score Accuracy

Rebecca G. Kim; Jasmine Deng; Jewel N. Reaso; James P. Grenert; Mandana Khalili

doi : 10.2337/dc22-0556

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Impact of a Novel Diabetes Prevention Intervention for Early Slow Weight Loss Responders Among Adults With Prediabetes: An Adaptive Trial

Carla K. Miller; Haikady N. Nagaraja; Jennifer Cheavens; Kentaro Fujita; Sophie Lazarus

doi : 10.2337/dc22-0824

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Symptoms of Anxiety and Depression Are Independently Associated With Impaired Awareness of Hypoglycemia in Type 1 Diabetes

Beatrice A. Pieri; Gabriella A.I. Bergin-Cartwright; Anna Simpson; Julian Collins; Anna Reid; Janaka Karalliedde; Anna Brackenridge; Matthew Hotopf; Sufyan Hussain

doi : 10.2337/dc21-2482

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Cardiovascular Autonomic Neuropathy Is Associated With Increased Glucose Variability in People With Type 1 Diabetes

Sara H. Naaman; Hatice I. Mizrak; Nanna Lind; Jens C. Laursen; Huda Kufaishi; Marie M.B. Christensen; Ajenthen G. Ranjan; Kirsten Nørgaard; Christian S. Hansen

doi : 10.2337/dc22-0117

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Systematic Review and Network Meta-analysis of Neurostimulation for Painful Diabetic Neuropathy

Rui V. Duarte; Sarah Nevitt; Sue Copley; Michelle Maden; Cecile C. de Vos; Rod S. Taylor; Sam Eldabe

doi : 10.2337/dc22-0932

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Erratum. Patients With Type 2 Diabetes Have an Increased Demand for Pacemaker Treatment: A Comparison With Age- and Sex-Matched Control Subjects From the General Population. Diabetes Care 2020;44:2853–2858

Elina Rautio; Fredrik Gadler; Soffia Gudbjörnsdottir; Stefan Franzén; Lars Rydén; Ann-Marie Svensson; Linda G. Mellbin

doi : 10.2337/dc22-er10

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Concomitant Use of Sulfonylureas and Warfarin and the Risk of Severe Hypoglycemia: Population-Based Cohort Study

Jenny Dimakos; Ying Cui; Robert W. Platt; Christel Renoux; Kristian B. Filion; Antonios Douros

doi : 10.2337/dc21-2383

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Effect of Insulin Delivery Strategies on Glycemic Control and Nursing Exposure in Critically Ill Patients With COVID-19: An Observational Cohort Study

Carolyn T. Hua; Rachelle L. Firestone; Jeremiah J. Duby

doi : 10.2337/dc21-2602

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Can the Artificial Intelligence System for Urine Microalbuminuria Detection Monitor the Progression of Diabetic Kidney Disease in the Clinical Laboratory?

Xiaozhe Lin; Yingxiu Xiao; Yaqiong Tian; Bizhen Cheng; Xiaoyang Jiao; Xinran Yang; Yongni Wang; Wenjing Xiong; Wenyan Guo; Qingyu Wu; Qiaoxin Zhang

doi : 10.2337/dc22-0966

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Painful Diabetic Neuropathy: Myofascial Pain Makes the Difference

Fabiola Escolano-Lozano; Felix Buehling-Schindowski; Heidrun H. Krämer; Frank Birklein; Christian Geber

doi : 10.2337/dc22-1023

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Acute and Chronic Diabetes-Related Complications Among Patients With Diabetes Receiving Care in Community Health Centers

Irina Chamine; Jun Hwang; Steele Valenzuela; Miguel Marino; Annie E. Larson; Joanna Georgescu; Michaella Latkovic-Taber; Heather Angier; Jennifer E. DeVoe; Nathalie Huguet

doi : 10.2337/dc22-0420

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The At-Risk Diabetic Foot: Time to Focus on Prevention

Robert G. Frykberg; Loretta Vileikyte; Andrew J.M. Boulton; David G. Armstrong

doi : 10.2337/dc22-1111

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Dulaglutide and a Composite Outcome Reflecting Atherosclerosis in the REWIND Trial: A Post Hoc Analysis

Giulia Ferrannini; Linda G. Mellbin; Faith Kirabo; Chinthanie Ramasundarahettige; Hertzel C. Gerstein; Lars Rydén

doi : 10.2337/dc22-0903

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Activation of the Tubulo-Glomerular Feedback by SGLT2 Inhibitors in Patients With Type 2 Diabetes and Advanced Chronic Kidney Disease: Toward the End of a Myth?

Alexandre O. Gérard; Audrey Laurain; Guillaume Favre; Milou-Daniel Drici; Vincent L.M. Esnault

doi : 10.2337/dc22-0921

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Comment on Mone et al. Empagliflozin Improves Cognitive Impairment in Frail Older Adults With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction. Diabetes Care 2022;45:1247–1251

Bo Liang; Ning Gu

doi : 10.2337/dc22-0778

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Response to Comment on Mone et al. Empagliflozin Improves Cognitive Impairment in Frail Older Adults With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction. Diabetes Care 2022;45:1247–1251

Gaetano Santulli; Salvatore Frullone; Maria Morgante; Gaetano Macina; Antonella Pansini; Jessica Gambardella; Angela Lombardi; Pasquale Mone

doi : 10.2337/dci22-0025

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