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Spotlight on the March 30 Issue
José G. Merino
doi : 10.1212/WNL.0000000000011695
March 30, 2021; 96 (13)
Old Methods for Young People?Toward Addressing Unique Needs of Young Stroke Survivors
Can Ozan Tan, Howard Kirshner
doi : 10.1212/WNL.0000000000011652
March 30, 2021; 96 (13)
A Good Start to Shed More Light on the Relationship Between Glycemic Traits, Diabetes Mellitus, and Cerebrovascular Disease
Markus Arnold,Dipender Gill, Mira Katan
doi : 10.1212/WNL.0000000000011557
March 30, 2021; 96 (13)
Young Stroke Survivors' Preferred Methods of Meeting Their Unique Needs
Jessica Keating,Karen Borschmann, Hannah Johns,Leonid Churilov,Julie Bernhardt
doi : 10.1212/WNL.0000000000011647
March 30, 2021; 96 (13)
Objective To determine how young stroke survivors want their unmet needs to be addressed, we undertook an international online survey of people living with stroke.
Nationwide Trends in Incidence and Mortality of Stroke Among Younger and Older Adults in Denmark
Nils Skajaa, Kasper Adelborg, Erzsébet Horv?th-Puh?, Kenneth J. Rothman, Victor W. Henderson, Lau Casper Thygesen, Henrik Toft S?rensen
doi : 10.1212/WNL.0000000000011636
March 30, 2021; 96 (13)
Objective To investigate the extent to which the incidence and mortality of a first-time stroke among younger and older adults changed from 2005 to 2018 in Denmark using nationwide registries.
Microbleeds, Cerebral Hemorrhage, and Functional Outcome After Endovascular Thrombectomy
Imad Derraz, Federico Cagnazzo, Nicolas Gaillard, Riccardo Morganti, Cyril Dargazanli, Raed Ahmed, Pierre-Henri Lefevre, Carlos Riquelme, Isabelle Mourand, Gregory Gascou,Alain Bonafe, Caroline Arquizan, Vincent Costalat
doi : 10.1212/WNL.0000000000011566
March 30, 2021; 96 (13)
Objective To determine whether pretreatment cerebral microbleeds (CMBs) presence and burden are correlated with an increased risk of intracranial hemorrhage (ICH) or poor functional outcome following endovascular thrombectomy (EVT) for acute ischemic stroke (AIS).
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease
Marios K. Georgakis, Eric L. Harshfield,Rainer Malik, Nora Franceschini,Claudia Langenberg, Nicholas J. WarehamHugh S. Markus, Martin Dichgans
doi : 10.1212/WNL.0000000000011555
March 30, 2021; 96 (13)
Objective We employed Mendelian randomization to explore the effects of genetic predisposition to type 2 diabetes (T2D), hyperglycemia, insulin resistance, and pancreatic ?-cell dysfunction on risk of stroke subtypes and related cerebrovascular phenotypes.
Clinical and Biological Correlates of White Matter Hyperintensities in Patients With Behavioral-Variant Frontotemporal Dementia and Alzheimer Disease
Katharine Huynh, Olivier Piguet,John Kwok, Carol Dobson-Stone,Glenda M. Halliday, John R. Hodges,Ram?n Landin-Romero
doi : 10.1212/WNL.0000000000011638
March 30, 2021; 96 (13)
Objective To test the hypothesis that white matter hyperintensities (WMH) in behavioral-variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD) are associated with disease variables such as disease severity, cortical atrophy, and cognition, we conducted a cross-sectional brain MRI study with volumetric and voxel-wise analyses.
Association of Mitochondrial DNA Genomic Variation With Risk of Pick Disease
Rebecca R. Valentino, Michael G. Heckman,Patrick W. Johnson, Matthew C. Baker, Alexandra I. Soto-Beasley, Ronald L. Walton,Shunsuke Koga, Shanu F. Roemer, EunRan Suh, Ryan J. Uitti, John Q. Trojanowski, Murray Grossman, Vivianna M. Van Deerlin, Rosa Rademakers, Zbigniew K. Wszolek,Dennis W. Dickson, View ORCID ProfileOwen A. Ross
doi : 10.1212/WNL.0000000000011649
March 30, 2021; 96 (13)
Objective To determine whether stable polymorphisms that define mitochondrial haplogroups in mitochondrial DNA (mtDNA) are associated with Pick disease risk, we genotyped 52 pathologically confirmed cases of Pick disease and 910 neurologically healthy controls and performed case-control association analysis.
Machine Learning–Based Automatic Rating for Cardinal Symptoms of Parkinson Disease
Kye Won Park, Eun-Jae Lee, Jun Seong Lee, Jinhoon Jeong, Nari Choi, Sungyang Jo, Mina Jung, Ja Yeon Do, Dong-Wha Kang, June-Goo Lee, Sun Ju Chung
doi : 10.1212/WNL.0000000000011654
March 30, 2021; 96 (13)
Objective We developed and investigated the feasibility of a machine learning–based automated rating for the 2 cardinal symptoms of Parkinson disease (PD): resting tremor and bradykinesia.
Diagnostic Yield of Whole Genome Sequencing After Nondiagnostic Exome Sequencing or Gene Panel in Developmental and Epileptic Encephalopathies
Elizabeth Emma Palmer, Rani Sachdev, Rebecca Macintosh, Uir? Souto Melo, Stefan Mundlos,Sarah Righetti, Tejaswi Kandula, Andre E. Minoche, Clare Puttick, Velimir Gayevskiy, Luke Hesson, Senel Idrisoglu,Cheryl Shoubridge,Monica Hong Ngoc Thai,Ryan L. Davis, Alexander P. Drew, Hugo Sampaio, Peter Ian Andrews, John Lawson, Michael Cardamone, David Mowat, Alison Colley, Sarah Kummerfeld,Marcel E. Dinger,Mark J. Cowley, Tony Roscioli,Ann Bye, Edwin Kirk
doi : 10.1212/WNL.0000000000011655
March 30, 2021; 96 (13)
Objective To assess the benefits and limitations of whole genome sequencing (WGS) compared to exome sequencing (ES) or multigene panel (MGP) in the molecular diagnosis of developmental and epileptic encephalopathies (DEE).
Association of De Novo RNF213 Variants With Childhood Onset Moyamoya Disease and Diffuse Occlusive Vasculopathy
Amélie Pinard, Maximillian D.J. Fiander, Alana C. Cecchi, Andrea L. Rideout, Mohamed Azouz, Stuart M. Fraser, P. Daniel McNeely, Simon Walling, Sarah C. Novara, Anna C.E. Hurst, Dongchuan Guo, Sandhya Parkash, Michael J. Bamshad, Deborah A. Nickerson, Anthony M. Vandersteen, Dianna M. Milewicz
doi : 10.1212/WNL.0000000000011653
March 30, 2021; 96 (13)
Objective To test the hypothesis that de novo genetic variants are responsible for moyamoya disease (MMD) in children with unaffected relatives, we performed exome sequencing of 28 affected children and their unaffected parents.
Traumatic Brain Injury and Incidence Risk of Sleep Disorders in Nearly 200,000 US Veterans
Yue Leng, Amy L. Byers, Deborah E. Barnes, Carrie B. Peltz, Yixia Li, Kristine Yaffe
doi : 10.1212/WNL.0000000000011656
March 30, 2021; 96 (13)
Objective To test the hypothesis that veterans with traumatic brain injury (TBI) have an increased subsequent risk of sleep disorders, we studied the longitudinal association between TBI and incident sleep disorders in nearly 200,000 veterans.
What's Happening in Neurology® Clinical Practice
doi : 10.1212/WNL.0000000000011674
March 30, 2021; 96 (13)
What's Happening in Neurology® Neuroimmunology & Neuroinflammation
doi : 10.1212/WNL.0000000000011673
March 30, 2021; 96 (13)
Publication Rate and Consistency of Registered Trials of Motor-Based Stroke Rehabilitation
Raabeae Aryan, David Jagroop, Cynthia J. Danells,Gabriela Rozanski, Janelle Unger,Andrew H. Huntley,Avril Mansfield
doi : 10.1212/WNL.0000000000011660
March 30, 2021; 96 (13)
Objective To determine the publication rate of motor-rehabilitation trials poststroke and the consistency between registry records and their corresponding main publications in trial design, primary objectives and outcomes, eligibility criteria, and sample size.
Cervical Spondylotic Myelopathy Secondary to Ochronotic Vertebral Arthropathy
Wladimir Bocca Vieira de Rezende Pinto, Igor Braga Farias, Bruno de Mattos Lombardi Badia, José Marcos Vieira de Albuquerque Filho, Roberta Ismael Lacerda Machado, Paulo Victor Sgobbi de Souza, Acary Souza Bulle Oliveira
doi : 10.1212/WNL.0000000000011663
March 30, 2021; 96 (13)
Resident & Fellow Rounds
Roy E. Strowd, Whitley Aamodt
doi : 10.1212/WNL.0000000000011666
March 30, 2021; 96 (13)
Pearls & Oy-sters: A Journey Through Reversible Cerebral Vasoconstriction Syndrome
Maksim Son, David Dongkyung Kim, Ruba Kiwan, Michael Mayich, Alexander V. Khaw
doi : 10.1212/WNL.0000000000011194
March 30, 2021; 96 (13)
Teaching NeuroImages: Parkinsonism Secondary to a Metastatic Lesion Involving the Substantia Nigra
Kosei Hirata, Takanori Yokota, Yoshiharu Miura
doi : 10.1212/WNL.0000000000011162
March 30, 2021; 96 (13)
Teaching Video NeuroImages: A Triad of Tremor, Ataxia, and Cognitive Impairment
Lisa W.C. Au,Ko Ho, Joshua J.X. Li, Vincent C.T. Mok
doi : 10.1212/WNL.0000000000011288
March 30, 2021; 96 (13)
Training in Neurology: Diagnostic Accuracy Among Neurology Residents
Emily M. Schorr, Rachel Brandstadter, Peter Jin, Christine Stahl, Stephen Krieger
doi : 10.1212/WNL.0000000000011232
March 30, 2021; 96 (13)
Objective To describe cases presented by junior neurology residents and to evaluate resident diagnostic patterns to help address individual and systemic educational needs.
Preferences of Young Stroke Survivors to Meet Their Unique Needs
Christa O'Hana S. Nobleza
doi : 10.1212/WNL.0000000000011665
March 30, 2021; 96 (13)
Editors' Note: Challenges to Successful Research Careers in Neurology: How Gender Differences May Play a Role
Ariane Lewis, Steven Galetta
doi : 10.1212/WNL.0000000000011662
March 30, 2021; 96 (13)
Reader Response 1a: Challenges to Successful Research Careers in Neurology: How Gender Differences May Play a Role
Ayushi Aggarwal, Divya Singhal, Michelle Guo, Julie K. Silver
doi : 10.1212/WNL.0000000000011664
March 30, 2021; 96 (13)
Reader Response 1b: Challenges to Successful Research Careers in Neurology: How Gender Differences May Play a Role
Heidi Moawad
doi : 10.1212/WNL.0000000000011657
March 30, 2021; 96 (13)
Author Response 1b: Challenges to Successful Research Careers in Neurology: How Gender Differences May Play a Role
Mia T. Minen
doi : 10.1212/WNL.0000000000011661
March 30, 2021; 96 (13)
Editors' Note: Does Screening for Adverse Effects Improve Health Outcomes in Epilepsy? A Randomized Trial
Ariane Lewis, Steven Galetta
doi : 10.1212/WNL.0000000000011658
March 30, 2021; 96 (13)
Reader Response: Does Screening for Adverse Effects Improve Health Outcomes in Epilepsy? A Randomized Trial
Maria Bruzzone
doi : 10.1212/WNL.0000000000011672
March 30, 2021; 96 (13)
Author Response: Does Screening for Adverse Effects Improve Health Outcomes in Epilepsy? A Randomized Trial
Valentina Franco, Emilio Perucca
doi : 10.1212/WNL.0000000000011659
March 30, 2021; 96 (13)
Acute Symptomatic Seizures in Cerebral Venous Thrombosis
doi : 10.1212/WNL.0000000000011322
March 30, 2021; 96 (13)
Cultural Disparities in Deep Brain Stimulation (DBS) Decision Making in Patients With Parkinson Disease (PD) (1713)
doi : 10.1212/WNL.0000000000011240
March 30, 2021; 96 (13)
