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Spotlight on the March 16 Issue
José G. Merino
doi : 10.1212/WNL.0000000000011627
March 16, 2021; 96 (11)
Recruiting Diverse Populations in Clinical TrialsHow Do We Overcome Selection Bias?
Rebecca F. Gottesman, Roy Hamilton
doi : 10.1212/WNL.0000000000011639
March 16, 2021; 96 (11)
Prevalence of Suicidality in Focal and Generalized Dystonia
Kirsten E. Zeuner, Jay A. van Gerpen
doi : 10.1212/WNL.0000000000011602
March 16, 2021; 96 (11)
N-of-1 Trials in Rare Genetic Neurodevelopmental Disorders
Adam L. Hartman
doi : 10.1212/WNL.0000000000011603
March 16, 2021; 96 (11)
Amyloid PET Imaging in Self-Identified Non-Hispanic Black Participants of the Anti-Amyloid in Asymptomatic Alzheimer's Disease (A4) Study
Kacie D. Deters, Valerio Napolioni, Reisa A. Sperling, Michael D. Greicius, Richard Mayeux, Timothy Hohman, Elizabeth C. Mormino
doi : 10.1212/WNL.0000000000011599
March 16, 2021; 96 (11)
Objective To examine whether amyloid PET in cognitively normal (CN) individuals screened for the Anti-Amyloid in Asymptomatic Alzheimer's Disease (A4) study differed across self-identified non-Hispanic White and Black (NHW and NHB) groups.
Association of Dilated Perivascular Spaces With Cognitive Decline and Incident Dementia
Matthew Paradise, John D. Crawford, Ben C.P. Lam, View ORCID ProfileWei Wen, Nicole A. Kochan, Steve Makkar, Laughlin Dawes, View ORCID ProfileJulian Trollor, Brian Draper, Henry Brodaty, View ORCID ProfilePerminder S. Sachdev
doi : 10.1212/WNL.0000000000011537
March 16, 2021; 96 (11)
Objective To determine whether severe perivascular space (PVS) dilation is associated with longitudinal cognitive decline and incident dementia over 4 and 8 years, respectively, we analyzed data from a prospective cohort study.
Low-Dose vs Standard-Dose Alteplase in Acute Lacunar Ischemic Stroke
Zien Zhou, Candice Delcourt, Chao Xia, View ORCID ProfileSohei Yoshimura, View ORCID ProfileCheryl Carcel, Takako Torii-Yoshimura, Shoujiang You, Alejandra Malavera, View ORCID ProfileXiaoying Chen, View ORCID ProfileMaree L. Hackett, Mark Woodward, John Chalmers, Jianrong Xu, Thompson G. Robinson, Mark W. Parsons, Andrew M. Demchuk, View ORCID ProfileRichard I. Lindley, Grant Mair, View ORCID ProfileJoanna M. Wardlaw, Craig S. Anderson
doi : 10.1212/WNL.0000000000011598
March 16, 2021; 96 (11)
Objective To determine any differential efficacy and safety of low- vs standard-dose IV alteplase for lacunar vs nonlacunar acute ischemic stroke (AIS), we performed post hoc analyzes from the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) alteplase dose arm.
Neurologic Syndromes Predict Higher In-Hospital Mortality in COVID-19
Emad Nader Eskandar, View ORCID ProfileDavid J. Altschul, Rafael de la Garza Ramos, View ORCID ProfilePhillip Cezayirli, View ORCID ProfileSantiago R. Unda, Joshua Benton, Joseph Dardick, Aureliana Toma, View ORCID ProfileNikunj Patel, Avinash Malaviya, David Flomenbaum, Jenelys Fernandez-Torres, Jenny Lu, Ryan Holland, Elisabetta Burchi, Richard Zampolin, Kevin Hsu, View ORCID ProfileAndrew McClelland, Judah Burns, View ORCID ProfileAmichai Erdfarb, Rishi Malhotra, Michelle Gong, Peter Semczuk, Jonathan Gursky, Victor Ferastraoaru, Jillian Rosengard, Daniel Antoniello, View ORCID ProfileDaniel Labovitz, Charles Esenwa, View ORCID ProfileMark Milstein, Alexis Boro, Mark F. Mehler
doi : 10.1212/WNL.0000000000011356
March 16, 2021; 96 (11)
Objective Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is protean in its manifestations, affecting nearly every organ system. However, nervous system involvement and its effect on disease outcome are poorly characterized. The objective of this study was to determine whether neurologic syndromes are associated with increased risk of inpatient mortality.
RHOBTB2 Mutations Expand the Phenotypic Spectrum of Alternating Hemiplegia of Childhood
Sara Zagaglia, Dora Steel, S. Krithika, Laura Hernandez-Hernandez, Helena Martins Custodio, Kathleen M. Gorman, Aikaterini Vezyroglou, View ORCID ProfileRikke S. M?ller, Mary D. King, Trine Bj?rg Hammer, View ORCID ProfileRobert Spaull, Walid Fazeli, Tobias Bartolomaeus, Diane Doummar, Boris Keren, Cyril Mignot, Nathalie Bednarek, J. Helen Cross, Andrew A. Mallick, Alba Sanchis-Juan, Anna Basu, F. Lucy Raymond, Bryan J. Lynch, Anirban Majumdar, Hannah Stamberger, Sarah Weckhuysen, Sanjay M. Sisodiya, Manju A. Kurian
doi : 10.1212/WNL.0000000000011543
March 16, 2021; 96 (11)
Objective To explore the phenotypic spectrum of RHOBTB2-related disorders and specifically to determine whether patients fulfill criteria for alternating hemiplegia of childhood (AHC), we report the clinical features of 11 affected individuals.
Suicidal Ideations and Attempts in Patients With Isolated Dystonia
Alexis Worthley, View ORCID ProfileKristina Simonyan
doi : 10.1212/WNL.0000000000011596
March 16, 2021; 96 (11)
Objective To evaluate the hypothesis that individuals with isolated dystonia are at an increased risk for suicidal behavior, we administered an anonymous electronic survey to patients with dystonia, asking them about their history of suicidal ideations and suicide attempt.
Association of Gray Matter Atrophy Patterns With Clinical Phenotype and Progression in Multiple Sclerosis
Maria A. Rocca, Paola Valsasina, Alessandro Meani, View ORCID ProfileClaudio Gobbi, View ORCID ProfileChiara Zecca, Alex Rovira, Jaume Sastre-Garriga, Hugh Kearney, Olga Ciccarelli, Lucy Matthews, Jacqueline Palace, Antonio Gallo, Alvino Bisecco, Carsten Lukas, View ORCID ProfileBarbara Bellenberg, View ORCID ProfileFrederik Barkhof, View ORCID ProfileHugo Vrenken, View ORCID ProfilePaolo Preziosa, View ORCID ProfileMassimo Filippi, on Behalf of the MAGNIMS Study Group
doi : 10.1212/WNL.0000000000011494
March 16, 2021; 96 (11)
Objectives Gay matter (GM) involvement is clinically relevant in multiple sclerosis (MS). Using source-based morphometry (SBM), we characterized GM atrophy and its 1-year evolution across different MS phenotypes.
Safety of Alemtuzumab and Autologous Hematopoietic Stem Cell Transplantation Compared to Noninduction Therapies for Multiple Sclerosis
Peter Alping, Joachim Burman, Jan Lycke, Thomas Frisell, Fredrik Piehl
doi : 10.1212/WNL.0000000000011545
March 16, 2021; 96 (11)
Objective To assess safety outcomes for the induction therapies alemtuzumab and autologous hematopoietic stem cell transplantation (AHSCT) compared to noninduction disease-modifying therapies.
What Is the Role of Sphingosine-1-Phosphate Receptors in Pain?
Eduardo E. Benarroch
doi : 10.1212/WNL.0000000000011605
March 16, 2021; 96 (11)
Systematic Review of N-of-1 Studies in Rare Genetic Neurodevelopmental Disorders
Annelieke R. Müller, Marion M.M.G. Brands, Peter M. van de Ven, View ORCID ProfileKit C.B. Roes, View ORCID ProfileMartina C. Cornel, View ORCID ProfileClara D.M. van Karnebeek, Frits A. Wijburg, View ORCID ProfileJoost G. Daams, View ORCID ProfileErik Boot, View ORCID ProfileAgnies M. van Eeghen
doi : 10.1212/WNL.0000000000011597
March 16, 2021; 96 (11)
Objective To improve the use of N-of-1 studies in rare genetic neurodevelopmental disorders, we systematically reviewed the literature and formulated recommendations for future studies.
Pediatric Parainfectious Encephalitis Associated With COVID-19
Maria Gaughan, Sean Connolly, Sean O'Riordan, Niall Tubridy, Chris McGuigan, Justin A. Kinsella
doi : 10.1212/WNL.0000000000011476
March 16, 2021; 96 (11)
Pearls & Oy-sters: The Myasthenic Double Humps
Brian D. Stephens, Min K. Kang
doi : 10.1212/WNL.0000000000011287
March 16, 2021; 96 (11)
Clinical Reasoning: A 36-Year-Old Woman Presenting With Headache Postpartum
Ahmad Nehme, View ORCID ProfileLaurent Létourneau-Guillon, View ORCID ProfileCéline Odier, View ORCID ProfileAlexandre Y. Poppe
doi : 10.1212/WNL.0000000000011318
March 16, 2021; 96 (11)
Teaching NeuroImages: Brain and Skin Involvement in Erdheim-Chester Disease
Adrian Budhram, Karen L. Rech, Johann M. Peikert, Scott H. Okuno, View ORCID ProfileRonald S. Go, Divyanshu Dubey, View ORCID ProfileW. Oliver Tobin
doi : 10.1212/WNL.0000000000011159
March 16, 2021; 96 (11)
Teaching NeuroImages: Trigeminal Ganglia Hypoplasia as Imaging Clue for the Diagnosis of G?mez-L?pez-Hern?ndez Syndrome
Eduardo Perrone, Stênio Burlin, View ORCID ProfileVânia D'Almeida, Ana Beatriz Alvarez Perez, View ORCID ProfileNara Lygia de Macena Sobreira, View ORCID ProfileVictor Rebelo Procaci, Marcela Amaral Avelino Jacobina, View ORCID ProfileOrlando G. Barsottini, View ORCID ProfileJosé Luiz Pedroso
doi : 10.1212/WNL.0000000000011158
March 16, 2021; 96 (11)
Editor's Note: A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City
Aravind Ganesh
doi : 10.1212/WNL.0000000000011604
March 16, 2021; 96 (11)
Reader Response: A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City
Anand Kumar, Neha Lall, View ORCID ProfileVarun Kumar Singh
doi : 10.1212/WNL.0000000000011614
March 16, 2021; 96 (11)
Author Response: A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City
Jennifer A. Frontera, Laura Balcer, Steven Galetta
doi : 10.1212/WNL.0000000000011609
March 16, 2021; 96 (11)
Reader Response: A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City
Eric M. Liotta, View ORCID ProfileAyush Batra, Igor J. Koralnik
doi : 10.1212/WNL.0000000000011613
March 16, 2021; 96 (11)
Author Response: A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City
Jennifer A. Frontera, Ariane Lewis, Laura Balcer, Steven Galetta
doi : 10.1212/WNL.0000000000011611
March 16, 2021; 96 (11)
Neurologic Syndromes Predict Higher In-Hospital Mortality in COVID-19
doi : 10.1212/WNL.0000000000011607
March 16, 2021; 96 (11)
