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Tenecteplase Prior to Mechanical Thrombectomy
Michelle P. Lin, Kameshwar Prasad
doi : 10.1212/WNL.0000000000011519
March 02, 2021; 96 (9)
Neuroimaging for Spontaneous Intracranial Hypotension Turned on Its Side
Ian Richard Carroll, Deborah I. Friedman
doi : 10.1212/WNL.0000000000011518
March 02, 2021; 96 (9)
Tenecteplase vs Alteplase Before Endovascular Therapy in Basilar Artery Occlusion
Fana Alemseged, Felix C. Ng, Cameron Williams, Volker Puetz, View ORCID ProfileGregoire Boulouis, Timothy John Kleinig, Alessandro Rocco, View ORCID ProfileTeddy Y. Wu, Darshan Shah, View ORCID ProfileFrancesco Arba, View ORCID ProfileDaniel Kaiser, View ORCID ProfileFrancesca Di Giuliano, View ORCID ProfileAndrea Morotti, Fabrizio Sallustio, View ORCID ProfileHelen M. Dewey, Peter Bailey, Billy O'Brien, Gagan Sharma, Steven Bush, Richard Dowling, Marina Diomedi, Leonid Churilov, Bernard Yan, Mark William Parsons, Stephen M. Davis, Peter J. Mitchell, Nawaf Yassi, View ORCID ProfileBruce C.V. Campbell, ; on behalf of the BATMAN study group and EXTEND IA TNK study group
doi : 10.1212/WNL.0000000000011520
March 02, 2021; 96 (9)
Objective To investigate the efficacy of tenecteplase (TNK), a genetically modified variant of alteplase with greater fibrin specificity and longer half-life than alteplase, prior to endovascular thrombectomy (EVT) in patients with basilar artery occlusion (BAO).
Brain Histopathology of Adult Decedents After Extracorporeal Membrane Oxygenation
Imad R. Khan, Yang Gu, View ORCID ProfileBenjamin P. George, Laura Malone, View ORCID ProfileKyle S. Conway, Fabienne Francois, Jack Donlon, Nadim Quazi, View ORCID ProfileAshwin Reddi, View ORCID ProfileCheng-Ying Ho, View ORCID ProfileDaniel L. Herr, Mahlon D. Johnson, View ORCID ProfileGunjan Y. Parikh
doi : 10.1212/WNL.0000000000011525
March 02, 2021; 96 (9)
Objective To test the hypothesis that brain injury is more common and varied in patients receiving extracorporeal membrane oxygenation (ECMO) than radiographically observed, we described neuropathology findings of ECMO decedents and associated clinical factors from 3 institutions.
Association of Bone Mineral Density to Cerebral Small Vessel Disease Burden
Jeong-Min Kim, Kwang-Yeol Park, Hye Ryoun Kim, Hwa Young Ahn, Leonardo Pantoni, Moo-Seok Park, Su-Hyun Han, Hae-Bong Jung, Jaehan Bae
doi : 10.1212/WNL.0000000000011526
March 02, 2021; 96 (9)
Objective To test the hypothesis that bone mineral loss is mechanistically related to cerebral small vessel disease (SVD), we investigated the relationship between bone mineral density and the prevalence and intensity of SVD among patients with stroke.
Prevalence of Imaging Targets in Patients With Minor Stroke Selected for IV tPA Treatment Using MRI
Amie W. Hsia, Marie L. Luby, Richard Leigh, John K. Lynch, Zurab Nadareishvili, Richard T. Benson, Chandni Kalaria, Shannon P. Burton, Larry Latour
doi : 10.1212/WNL.0000000000011527
March 02, 2021; 96 (9)
Objective To determine the IV tissue plasminogen activator (tPA) treatment rate of patients with minor acute ischemic stroke (mAIS) at our centers and compare the frequency of MRI targets by treatment stratification and clinical severity, we evaluated clinical characteristics and baseline MRIs for tPA-treated and untreated patients.
Diagnostic Yield of Lateral Decubitus Digital Subtraction Myelogram Stratified by Brain MRI Findings
Dong Kun Kim, Carrie M. Carr, John C. Benson, Felix E. Diehn, Vance T. Lehman, Greta B. Liebo, Jonathan M. Morris, P. Pearse Morris, Jared T. Verdoorn, View ORCID ProfileJeremy K. Cutsforth-Gregory, John L. D. Atkinson, Waleed Brinjikji
doi : 10.1212/WNL.0000000000011522
March 02, 2021; 96 (9)
Objective To assess the diagnostic yield of lateral decubitus digital subtraction myelography (LDDSM) and stratify LDDSM diagnostic yield by the Bern spontaneous intracranial hypotension (SIH) score of preprocedure brain MRI.
Basal Ganglia Dysmorphism in Patients With Aicardi Syndrome
Silvia Masnada, Anna Pichiecchio, Manuela Formica, Filippo Arrigoni, Paola Borrelli, Patrizia Accorsi, Paolo Bonanni, Renato Borgatti, Bernardo Dalla Bernardina, Alberto Danieli, Francesca Darra, Nicolas Deconinck, Valentina De Giorgis, Olivier Dulac, Svetlana Gataullina, Lucio Giordano, Renzo Guerrini, Francesca La Briola, Massimo Mastrangelo, Martino Montomoli, Marzia Mortilla, Elisa Osanni, View ORCID ProfilePasquale Parisi, Emilio Perucca, Lorenzo Pinelli, Romina Romaniello, View ORCID ProfileMariasavina Severino, Federico Vigevano, Aglaia Vignoli, Nadia Bahi-Buisson, Mara Cavallin, Andrea Accogli, Marie Burgeois, Valeria Capra, Virgine Chaves-Vischer, Luisa Chiapparini, GiovannaStefania Colafati, Stefano D'Arrigo, Isabelle Desguerre, Martine Doco-Fenzy, Giuseppe d'Orsi, Nino Epitashvili, Elisa Fazzi, Alessandro Ferretti, Elena Fiorini, Melanie Fradin, Carlo Fusco, Tiziana Granata, View ORCID ProfileKatrine Marie Johannesen, Sebastien Lebon, Philippe Loget, View ORCID ProfileRikke Steensjerre Moller, Domenico Montanaro, Simona Orcesi, Chloe Quelin, Erika Rebessi, View ORCID ProfileAntonino Romeo, View ORCID ProfileRoberta Solazzi, Carlotta Spagnoli, Christian Uebler, Federico Zara, View ORCID ProfileAlexis Arzimanoglou, Pierangelo Veggiotti, The Aicardi Syndrome International Study Group
doi : 10.1212/WNL.0000000000011237
March 02, 2021; 96 (9)
Objective Aiming to detect associations between neuroradiologic and EEG evaluations and long-term clinical outcome in order to detect possible prognostic factors, a detailed clinical and neuroimaging characterization of 67 cases of Aicardi syndrome (AIC), collected through a multicenter collaboration, was performed.
Role of the Nucleus Basalis as a Key Network Node in Temporal Lobe Epilepsy
View ORCID ProfileHern?n F.J. Gonz?lez, View ORCID ProfileSaramati Narasimhan, View ORCID ProfileGraham W. Johnson, View ORCID ProfileKristin E. Wills, Kevin F. Haas, Peter E. Konrad, View ORCID ProfileCatie Chang, View ORCID ProfileVictoria L. Morgan, Mikail Rubinov, View ORCID ProfileDario J. Englot
doi : 10.1212/WNL.0000000000011523
March 02, 2021; 96 (9)
Objective To determine whether the nucleus basalis of Meynert (NBM) may be a key network structure of altered functional connectivity in temporal lobe epilepsy (TLE), we examined fMRI with network-based analyses.
Temporal Dynamics of ?-Amyloid Accumulation in Aging and Alzheimer Disease
William J. Jagust, Susan M. Landau, for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1212/WNL.0000000000011524
March 02, 2021; 96 (9)
Objective To understand the time course of ?-amyloid (A?) deposition in the brain, which is crucial for planning therapeutic trials of A?-lowering therapies in Alzheimer disease (AD).
Validation of the Alzheimer Disease Dementia Conversion-Related Pattern as an ATN Biomarker of Neurodegeneration
Ganna Blazhenets, View ORCID ProfileLars Frings, Yilong Ma, Arnd S?rensen, David Eidelberg, Jens Wiltfang, Philipp T. Meyer, for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1212/WNL.0000000000011521
March 02, 2021; 96 (9)
Objective To determine whether the Alzheimer disease (AD) dementia conversion-related pattern (ADCRP) on [18F]FDG PET can serve as a valid predictor for the development of AD dementia, the individual expression of the ADCRP (subject score) and its prognostic value were examined in patients with mild cognitive impairment (MCI) and biologically defined AD.
Natural History, Phenotypic Spectrum, and Discriminative Features of Multisystemic RFC1 Disease
Andreas Traschütz, Andrea Cortese, Selina Reich, Natalia Dominik, Jennifer Faber, Heike Jacobi, View ORCID ProfileAnnette M. Hartmann, Dan Rujescu, Solveig Montaut, Andoni Echaniz-Laguna, Sevda Erer, Valerie Cornelia Schütz, Alexander A. Tarnutzer, Marc Sturm, Tobias B. Haack, Nadège Vaucamps-Diedhiou, Helene Puccio, Ludger Sch?ls, Thomas Klockgether, Bart P. van de Warrenburg, Martin Paucar, View ORCID ProfileDagmar Timmann, View ORCID ProfileRalf-Dieter Hilgers, Jose Gazulla, Michael Strupp, German Moris, Alessandro Filla, View ORCID ProfileHenry Houlden, Mathieu Anheim, Jon Infante, A. Nazli Basak, Matthis Synofzik, on behalf of the RFC1 Study Group
doi : 10.1212/WNL.0000000000011528
March 02, 2021; 96 (9)
Objective To delineate the full phenotypic spectrum, discriminative features, piloting longitudinal progression data, and sample size calculations of replication factor complex subunit 1 (RFC1) repeat expansions, recently identified as causing cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS).
What's Happening in Neurology® Equity, Diversity, & Inclusion
doi : 10.1212/WNL.0000000000011530
March 02, 2021; 96 (9)
Building the Neurology Pipeline With Undergraduate Students in Research and Clinical Practice
Mia T. Minen, Christina L. Szperka, Michael S. Cartwright, Rebecca Erwin Wells
doi : 10.1212/WNL.0000000000011351
March 02, 2021; 96 (9)
There is currently a shortage of neurologists in the United States. Multiple efforts are underway to increase the strength of the neurology workforce. One potential approach is early exposure to neurology research and clinical care to pique interest and promote the specialty as a career choice. This study details the rewarding experience of working with undergraduate students, both in clinical research and clinical care. The logistics, benefits to students, and positive aspects for neurologists are outlined. Examples provided by undergraduate students who have participated in neurology research and clinical care are presented. The ultimate goals of this work are to encourage and inspire academic neurologists to involve undergraduate students in research and clinical care, to facilitate this process by outlining the steps needed to make this pairing successful, and to ultimately promote a pathway to build the neurology pipeline.
High-Frequency Oscillations in Epilepsy
Zhuying Chen, View ORCID ProfileMatias I. Maturana, View ORCID ProfileAnthony N. Burkitt, View ORCID ProfileMark J. Cook, View ORCID ProfileDavid B. Grayden
doi : 10.1212/WNL.0000000000011465
March 02, 2021; 96 (9)
For the past 2 decades, high-frequency oscillations (HFOs) have been enthusiastically studied by the epilepsy community. Emerging evidence shows that HFOs harbor great promise to delineate epileptogenic brain areas and possibly predict the likelihood of seizures. Investigations into HFOs in clinical epilepsy have advanced from small retrospective studies relying on visual identification and correlation analysis to larger prospective assessments using automatic detection and prediction strategies. Although most studies have yielded promising results, some have revealed significant obstacles to clinical application of HFOs, thus raising debate about the reliability and practicality of HFOs as clinical biomarkers. In this review, we give an overview of the current state of HFO research and pinpoint the conceptual and methodological issues that have hampered HFO translation. We highlight recent insights gained from long-term data, high-density recordings, and multicenter collaborations and discuss the open questions that need to be addressed in future research.
Saccadic Hypermetria From a Selective Lesion of the Fastigial Oculomotor Region
Ivan Milenkovic, Gregor Kasprian, View ORCID ProfileGerald Wiest
doi : 10.1212/WNL.0000000000011462
March 02, 2021; 96 (9)
Painful Recurrent Diplopia Caused by Medial Rectus Cysticercosis
Emmanuelle Moret, View ORCID ProfileFrançois-Xavier Borruat
doi : 10.1212/WNL.0000000000011466
March 02, 2021; 96 (9)
Pearls & Oy-sters: When Genetic Generalized Epilepsy Becomes Progressive
Priya Purushothaman, Erin M. McGinnis, Monica Aldulescu, View ORCID ProfileCynthia V. Stack, View ORCID ProfileTracy S. Gertler
doi : 10.1212/WNL.0000000000011293
March 02, 2021; 96 (9)
Child Neurology: A Case of FHL1-Related Disease Presenting as Inflammatory Myopathy
André Macedo Serafim Silva, View ORCID ProfileClara Gontijo Camelo, View ORCID ProfileCiro Matsui-J?nior, View ORCID ProfileRodrigo de Holanda Mendonça, L?cia Maria Campos, Adriana Maluf Elias, Clovis Artur Silva, View ORCID ProfileUmbertina Conti Reed, View ORCID ProfileEdmar Zanoteli
doi : 10.1212/WNL.0000000000011320
March 02, 2021; 96 (9)
Teaching NeuroImages: The Trigeminal Pontine Sign
Fajun Wang, View ORCID ProfileHesham Abboud
doi : 10.1212/WNL.0000000000010845
March 02, 2021; 96 (9)
Teaching Video NeuroImages: Posterior Cortical Atrophy Presenting With Balint Syndrome
Roberto Rodr?guez-Rivas, Mariana Marc?n-Sierra, Carlos Carde?a-Arredondo
doi : 10.1212/WNL.0000000000010849
March 02, 2021; 96 (9)
We present the case of a 68-year-old woman who developed progressive visuospatial deficits in a period of 18 months, leading to the loss of her independence for activities of daily living. After examination, she showed signs of Balint syndrome with optic ataxia, oculomotor apraxia, and simultanagnosia without visual acuity impairment. After brain imaging showing severe bilateral parieto-occipital association cortex atrophy, a diagnosis of posterior cortical atrophy was made according to the 2017 International Consortium's criteria.
Editors' Note: Prediction of Regaining Consciousness Despite an Early Epileptiform EEG After Cardiac Arrest
James E. Siegler, Steven Galetta
doi : 10.1212/WNL.0000000000011549
March 02, 2021; 96 (9)
Reader Response: Prediction of Regaining Consciousness Despite an Early Epileptiform EEG After Cardiac Arrest
Nitin K. Sethi
doi : 10.1212/WNL.0000000000011532
March 02, 2021; 96 (9)
Author Response: Prediction of Regaining Consciousness Despite an Early Epileptiform EEG After Cardiac Arrest
Andrea O. Rossetti, Giuseppina Barbella
doi : 10.1212/WNL.0000000000011536
March 02, 2021; 96 (9)
Editors' Note: Acute Hypokinetic-Rigid Syndrome After SARS-CoV-2 Infection
James E. Siegler, Steven Galetta
doi : 10.1212/WNL.0000000000011551
March 02, 2021; 96 (9)
Reader Response: Acute Hypokinetic-Rigid Syndrome Following SARS-CoV-2 Infection
Joseph R. Berger
doi : 10.1212/WNL.0000000000011535
March 02, 2021; 96 (9)
Reader Response: Acute Hypokinetic-Rigid Syndrome After SARS-CoV-2 Infection
Khichar Shubhakaran
doi : 10.1212/WNL.0000000000011534
March 02, 2021; 96 (9)
Author Response: Acute Hypokinetic-Rigid Syndrome After SARS-CoV-2 Infection
Antonio Méndez-Guerrero, V?ctor Antonio Blanco-Palmero, Mar?a Isabel Laespada-Garc?a, Francisco Javier Azc?rate-D?az, View ORCID ProfileJes?s Gonz?lez de la Aleja
doi : 10.1212/WNL.0000000000011533
March 02, 2021; 96 (9)
