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Should TIA and Minor Stroke Patients Be Kept Out of the Hospital?
Annemarei Ranta, View ORCID ProfileRachael Hunter
doi : 10.1212/WNL.0000000000011456
February 23, 2021; 96 (8)
Functional Connectivity to Predict Poststroke Cognition
Amy Brodtmann, Argye Hillis
doi : 10.1212/WNL.0000000000011501
February 23, 2021; 96 (8)
Traumatic Brain Injury
Masha G. Savelieff, Eva L. Feldman
doi : 10.1212/WNL.0000000000011455
February 23, 2021; 96 (8)
The Critical Role of the Neurology Diversity Officer in Serving Our Patients, Profession, and the Neurology Pipeline
Rachel Marie E. Salas, Charlene E. Gamaldo
doi : 10.1212/WNL.0000000000011457
February 23, 2021; 96 (8)
Specialized Outpatient Clinic vs Stroke Unit for TIA and Minor Stroke
Sidsel Hastrup, Soren P. Johnsen, Martin Jensen, Paul von Weitzel-Mudersbach, Claus Z. Simonsen, Niels Hjort, Anette T. M?ller, Thomas Harbo, Marika S. Poulsen, Helle K. Iversen, Dorte Damgaard, Grethe Andersen
doi : 10.1212/WNL.0000000000011453
February 23, 2021; 96 (8)
Objective To evaluate the effects of an outpatient clinic setup for minor stroke/TIA using subsequent admission of patients at high risk of recurrent stroke.
Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke
Dina Vojinovic, Marita Kalaoja, Stella Trompet, Krista Fischer, Martin J. Shipley, View ORCID ProfileShuo Li, Aki S. Havulinna, Markus Perola, Veikko Salomaa, Qiong Yang, Naveed Sattar, Pekka Jousilahti, Najaf Amin, View ORCID ProfileClaudia L. Satizabal, Nele Taba, View ORCID ProfileBehnam Sabayan, Ramachandran S. Vasan, M. Arfan Ikram, David J. Stott, View ORCID ProfileMika Ala-Korpela, J. Wouter Jukema, Sudha Seshadri, Johannes Kettunen, View ORCID ProfileMika Kivimaki, Tonu Esko, Cornelia M. van Duijn
doi : 10.1212/WNL.0000000000011236
February 23, 2021; 96 (8)
Objective To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings.
Association of Time of Day When Endovascular Therapy for Stroke Starts and Functional Outcome
Steven D. Hajdu, Johannes Kaesmacher, Patrik Michel, Gaia Sirimarco, Jean-Francois Knebel, View ORCID ProfileBruno Bartolini, Christoph C. Kurmann, Francesco Puccinelli, Pascal J. Mosimann, View ORCID ProfileChristophe Bonvin, Marcel Arnold, Julien Niederh?user, Ashraf Eskandari, Pasquale Mordasini, Jan Gralla, Urs Fischer, Guillaume Saliou
doi : 10.1212/WNL.0000000000011449
February 23, 2021; 96 (8)
Objective To investigate the association between endovascular therapy (EVT) start time in acute ischemic stroke (AIS) and midterm functional outcome.
Racial Differences in Atrial Cardiopathy Phenotypes in Patients With Ischemic Stroke
Hooman Kamel, Kathleen Alwell, View ORCID ProfileBrett M. Kissela, Heidi J. Sucharew, Daniel Woo, Matthew Flaherty, Simona Ferioli, Stacie L. Demel, Charles J. Moomaw, Kyle Walsh, Jason Mackey, Felipe De Los Rios La Rosa, View ORCID ProfileAdam Jasne, Sabreena Slavin, Sharyl Martini, Opeolu Adeoye, Tehniyat Baig, Monica L. Chen, View ORCID ProfileEmily B. Levitan, Elsayed Z. Soliman, Dawn O. Kleindorfer
doi : 10.1212/WNL.0000000000011197
February 23, 2021; 96 (8)
Objective To test the hypothesis that thrombogenic atrial cardiopathy may be relevant to stroke-related racial disparities, we compared atrial cardiopathy phenotypes between Black vs White patients with ischemic stroke.
Immigration Status, Ethnicity, and Long-term Outcomes Following Ischemic Stroke
View ORCID ProfileManav V. Vyas, View ORCID ProfilePeter C. Austin, View ORCID ProfileJiming Fang, View ORCID ProfileAndreas Laupacis, View ORCID ProfileFrank L. Silver, View ORCID ProfileMoira K. Kapral
doi : 10.1212/WNL.0000000000011451
February 23, 2021; 96 (8)
Objective To assess the association between immigration status and ethnicity and the outcomes of mortality and vascular event recurrence following ischemic stroke in Ontario, Canada.
Fatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke
Julie Bernhardt, Karen Borschmann, Janice M. Collier, Amanda G. Thrift, Peter Langhorne, Sandy Middleton, Richard I. Lindley, Helen M. Dewey, Philip Bath, Catherine M. Said, Leonid Churilov, Fiona Ellery, Christopher Bladin, Christopher M. Reid, Judith H. Frayne, Velandai Srikanth, Stephen J. Read, Geoffrey A. Donnan, ; on behalf of the AVERT Trialists Collaboration Group
doi : 10.1212/WNL.0000000000011106
February 23, 2021; 96 (8)
Objective This tertiary analysis from A Very Early Rehabilitation Trial (AVERT) examined fatal and nonfatal serious adverse events (SAEs) at 14 days.
Prediction of Long-term Cognitive Function After Minor Stroke Using Functional Connectivity
View ORCID ProfileRenaud Lopes, Clément Bournonville, View ORCID ProfileGrégory Kuchcinski, View ORCID ProfileThibaut Dondaine, Anne-Marie Mendyk, View ORCID ProfileRomain Viard, Jean-Pierre Pruvo, Hilde Hénon, View ORCID ProfileMarios K. Georgakis, View ORCID ProfileMarco Duering, View ORCID ProfileMartin Dichgans, View ORCID ProfileCharlotte Cordonnier, View ORCID ProfileXavier Leclerc, View ORCID ProfileRégis Bordet
doi : 10.1212/WNL.0000000000011452
February 23, 2021; 96 (8)
Objective To determine whether functional MRI connectivity can predict long-term cognitive function 36 months after minor stroke.
?-Amyloid PET and 123I-FP-CIT SPECT in Mild Cognitive Impairment at Risk for Lewy Body Dementia
View ORCID ProfileQin Chen, Val J. Lowe, Bradley F. Boeve, Scott A. Przybelski, Toji Miyagawa, View ORCID ProfileMatthew L. Senjem, Clifford R. Jack, Timothy G. Lesnick, Walter K. Kremers, Julie A. Fields, View ORCID ProfileHoon-Ki Min, View ORCID ProfileChristopher G. Schwarz, Jeffrey L. Gunter, Jonathan Graff-Radford, View ORCID ProfileRodolfo Savica, David S. Knopman, David Jones, Tanis J. Ferman, Neill R. Graff-Radford, Ronald C. Petersen, Kejal Kantarci
doi : 10.1212/WNL.0000000000011454
February 23, 2021; 96 (8)
Objective To determine the clinical phenotypes associated with the ?-amyloid PET and dopamine transporter imaging (123I-FP-CIT SPECT) findings in mild cognitive impairment (MCI) with the core clinical features of dementia with Lewy bodies (DLB; MCI-LB).
PM2.5 Associated With Gray Matter Atrophy Reflecting Increased Alzheimer Risk in Older Women
View ORCID ProfileDiana Younan, Xinhui Wang, Ramon Casanova, Ryan Barnard, Sarah A. Gaussoin, Santiago Saldana, Andrew J. Petkus, Daniel P. Beavers, Susan M. Resnick, JoAnn E. Manson, View ORCID ProfileMarc L. Serre, View ORCID ProfileWilliam Vizuete, Victor W. Henderson, Bonnie C. Sachs, Joel Salinas, View ORCID ProfileMargaret Gatz, Mark A. Espeland, Helena C. Chui, Sally A. Shumaker, Stephen R. Rapp, Jiu-Chiuan Chen, on behalf of the Women's Health Initiative
doi : 10.1212/WNL.0000000000011149
February 23, 2021; 96 (8)
Objective To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5 µm) contributes to progressive brain atrophy predictive of Alzheimer disease (AD) using a community-dwelling cohort of women (age 70–89 years) with up to 2 brain MRI scans (MRI-1, 2005–2006; MRI-2, 2010–2011).
Cell Therapy for Chronic TBI Interim Analysis of the Randomized Controlled STEMTRA Trial
View ORCID ProfileMasahito Kawabori, Alan H. Weintraub, Hideaki Imai, Iaroslav Zinkevych, Peter McAllister, Gary K. Steinberg, Benjamin M. Frishberg, Takao Yasuhara, Jefferson W. Chen, Steven C. Cramer, Achal S. Achrol, Neil E. Schwartz, Jun Suenaga, Daniel C. Lu, Ihor Semeniv, Hajime Nakamura, Douglas Kondziolka, Dai Chida, Takehiko Kaneko, Yasuaki Karasawa, Susan Paadre, Bijan Nejadnik, Damien Bates, Anthony H. Stonehouse, View ORCID ProfileR. Mark Richardson, David O. Okonkwo
doi : 10.1212/WNL.0000000000011450
February 23, 2021; 96 (8)
Objective To determine whether chronic motor deficits secondary to traumatic brain injury (TBI) can be improved by implantation of allogeneic modified bone marrow–derived mesenchymal stromal/stem cells (SB623).
Long-term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis
Giacomo Boffa, View ORCID ProfileLuca Massacesi, Matilde Inglese, View ORCID ProfileAlice Mariottini, Marco Capobianco, Lucia Moiola, Maria Pia Amato, Salvatore Cottone, Francesca Gualandi, Marco De Gobbi, Raffaella Greco, Rosanna Scimè, Jessica Frau, Giovanni Bosco Zimatore, View ORCID ProfileAntonio Bertolotto, Giancarlo Comi, Antonio Uccelli, Alessio Signori, Emanuele Angelucci, Chiara Innocenti, Fabio Ciceri, Anna Maria Repice, Maria Pia Sormani, Riccardo Saccardi, Gianluigi Mancardi, ; on behalf of the Italian BMT-MS Study Group
doi : 10.1212/WNL.0000000000011461
February 23, 2021; 96 (8)
Objective To determine whether autologous hematopoietic stem cell transplantation (aHSCT) is able to induce durable disease remission in people with multiple sclerosis (MS), we analyzed the long-term outcomes after transplantation in a large cohort of patients with MS.
Incidence, Prevalence, and Geographical Clustering of Motor Neuron Disease in the Netherlands
Adriaan D. de Jongh, View ORCID ProfileRuben P.A. van Eijk, Susan M. Peters, Michael A. van Es, Anja M.C. Horemans, Anneke J. van der Kooi, Nicol C. Voermans, Roel C.H. Vermeulen, View ORCID ProfileJan H. Veldink, Leonard H. van den Berg
doi : 10.1212/WNL.0000000000011467
February 23, 2021; 96 (8)
Objective To assess time trends in motor neuron disease (MND) incidence, prevalence, and mortality and to investigate geographic clustering of MND cases in the Netherlands from 1998 to 2017, we analyzed data from the Netherlands Personal Records database, the Netherlands MND Center, and the Netherlands Patient Association of Neuromuscular Diseases.
Seizures Among Patients With Brain Metastases A Population- and Institutional-Level Analysis
Nayan Lamba, Paul J. Catalano, Daniel N. Cagney, Daphne A. Haas-Kogan, Ellen J. Bubrick, Patrick Y. Wen, Ayal A. Aizer
doi : 10.1212/WNL.0000000000011459
February 23, 2021; 96 (8)
Objective To test the hypothesis that subets of patients with brain metastases (BrM) without seizures at intracranial presentation are at increased risk for developing seizures, we characterized the incidence and risk factors for seizure development among seizure-naive patients with BrMs.
Incidence, Prevalence, and Health Care Outcomes in Idiopathic Intracranial Hypertension
Latif Miah, Huw Strafford, Beata Fonferko-Shadrach, Joe Hollinghurst, Inder M.S. Sawhney, Savvas Hadjikoutis, Mark I. Rees, Rob Powell, Arron Lacey, View ORCID ProfileWilliam O. Pickrell
doi : 10.1212/WNL.0000000000011463
February 23, 2021; 96 (8)
Objective To characterize trends in incidence, prevalence, and health care outcomes in the idiopathic intracranial hypertension (IIH) population in Wales using routinely collected health care data.
What's Happening in Neurology® Clinical Practice
doi : 10.1212/WNL.0000000000011471
February 23, 2021; 96 (8)
What's Happening in Neurology® Neuroimmunology & Neuroinflammation
doi : 10.1212/WNL.0000000000011472
February 23, 2021; 96 (8)
Immigrant Neurologists in the United States
Abhimanyu Mahajan, Zachary London, View ORCID ProfileAndrew M. Southerland, Jaffar Khan, Erica A. Schuyler, and the Graduate Education Subcommittee and Education Committee of the American Academy of Neurology
doi : 10.1212/WNL.0000000000011196
February 23, 2021; 96 (8)
International medical graduates (IMGs), individuals who graduated from medical school outside of the United States or Canada, constitute 31.3% of active neurologists and one-third of current neurology trainees. Although three-fourths of IMG neurology trainees are not US citizens, they are an integral part of our trainee and practice workforce. IMGs play a vital role in providing greater access to health care for millions of patients, particularly in traditionally underserved regions and in the face of a current global health care crisis. With this article, we outline some of the unique challenges faced by immigrant, US-trained neurologists as they seek to provide neurologic care across the country, including preparing and applying for residency, securing authorization to remain in the United States to practice, and positioning themselves for successful careers in academic and private practice. We also call for advocacy and legislation to help reduce these barriers as a means to address the increasing physician workforce gap.
Developing the Neurology Diversity Officer
Nimish A. Mohile, View ORCID ProfileAndrew R. Spector, Ima M. Ebong, Charles Flippen, Camilo Gutierrez, Rodney O. Leacock, Erika Marulanda-Londo?o, Nicte I. Mejia, Reena Thomas, Roy H. Hamilton
doi : 10.1212/WNL.0000000000011460
February 23, 2021; 96 (8)
Academic neurology departments must confront the challenges of developing a diverse workforce, reducing inequity and discrimination within academia, and providing neurologic care for an increasingly diverse society. A neurology diversity officer should have a specific role and associated title within a neurology department as well as a mandate to focus their efforts on issues of equity, diversity, and inclusion that affect staff, trainees, and faculty. This role is expansive and works across departmental missions, but it has many challenges related to structural intolerance and cultural gaps. In this review, we describe the many challenges that diversity officers face and how they might confront them. We delineate the role and duties of the neurology diversity officer and provide a guide to departmental leaders on how to assess qualifications and evaluate progress. Finally, we describe the elements necessary for success. A neurology diversity officer should have the financial, administrative, and emotional support of leadership in order for them to carry out their mission and to truly have a positive influence.
Resident & Fellow Rounds
Roy E. Strowd, Whitley Aamodt
doi : 10.1212/WNL.0000000000011500
February 23, 2021; 96 (8)
Clinical Reasoning: A 48-Year-Old Man Presenting With Diplopia
Niranjan K. Pehere, Kebede Gofer
doi : 10.1212/WNL.0000000000011007
February 23, 2021; 96 (8)
Pearls & Oy-sters: Sturge-Weber Syndrome Unmasked by Traumatic Brain Injury
Jeetendra Sah, Clotilde Balucani, Aaron Abrams, Yoshimi Hisamoto, Geetha Chari, Vinodkumar Velayudhan, Steven G. Pavlakis
doi : 10.1212/WNL.0000000000011075
February 23, 2021; 96 (8)
Teaching Video NeuroImages: Spontaneous Third Ventriculostomy
Maud P. Tijssen, Erwin M.J. Cornips, Joost Nicolai
doi : 10.1212/WNL.0000000000010843
February 23, 2021; 96 (8)
Teaching Video NeuroImages: Bereitschaftspotential A Neurophysiologic Test for Functional or Voluntary Jerks
José Luiz Pedroso, Felipe Barbosa Magalh?es, View ORCID ProfileAgessandro Abrahao, Gilberto Mastrocola Manzano, Orlando G.P. Barsottini
doi : 10.1212/WNL.0000000000010846
February 23, 2021; 96 (8)
After a Stroke How Quickly Should Exercise Begin?
Steven Karceski
doi : 10.1212/WNL.0000000000011468
February 23, 2021; 96 (8)
Editors' Note: Telephone-Based Cognitive Behavioral Therapy for Depression in Parkinson Disease: A Randomized Controlled Trial
Ariane Lewis, Steven Galetta
doi : 10.1212/WNL.0000000000011539
February 23, 2021; 96 (8)
Reader Response: Telephone-Based Cognitive Behavioral Therapy for Depression in Parkinson Disease: A Randomized Controlled Trial
Alain Braillon
doi : 10.1212/WNL.0000000000011470
February 23, 2021; 96 (8)
Author Response: Telephone-based Cognitive Behavioral Therapy for Depression in Parkinson Disease: A Randomized Controlled Trial
Roseanne D. Dobkin
doi : 10.1212/WNL.0000000000011473
February 23, 2021; 96 (8)
