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In Memoriam: Jim Toole, MD: Ahead of His Time.

Howard, Virginia J. PhD; Spence, J. David MD

doi : 10.1161/STROKEAHA.122.037401

Volume 53(9) pgs. 2713-2990,e407-e441 September 2022

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September 2022 Stroke Highlights.

Romero, Jose Rafael MD

doi : 10.1161/STROKEAHA.122.040699

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Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Multicenter Randomized Phase II Trial.

Uphaus, Timo MD; Richards, Toby MD; Weimar, Christian MD; Neugebauer, Hermann MD; Poli, Sven MD; Weissenborn, Karin MD; Imray, Christopher MD; Michalski, Dominik MD; Rashid, Hisham MD; Loftus, Ian MD; Rummey, Christian PhD; Ritter, Martin MD; Hauser, Till-Karsten MD; Munch, Gotz MD; Groschel, Klaus MD ,*; Poppert, Holger MD ,*

doi : 10.1161/STROKEAHA.121.037006

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Patient-Centered Outcomes in a Randomized Trial Investigating a Multimodal Prevention Program After Transient Ischemic Attack or Minor Stroke: The INSPiRE-TMS Trial.

Ihl, Thomas MD; Ahmadi, Michael MD; Laumeier, Inga MD; Steinicke, Maureen MD; Ferse, Caroline MD; Klyscz, Philipp MD; Endres, Matthias MD; Hastrup, Sidsel MD; Poppert, Holger MD; Palm, Frederick MD; Kandil, Farid I. PhD; Weber, Joachim E. MD; von Weitzel-Mudersbach, Paul MD; Wimmer, Martin L.J. MD; Audebert, Heinrich J. MD

doi : 10.1161/STROKEAHA.120.037503

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Transdural Revascularization by Multiple Burrhole After Erythropoietin in Stroke Patients With Cerebral Hypoperfusion: A Randomized Controlled Trial.

Hong, Ji Man MD, PhD; Choi, Mun Hee MD; Park, Geun Hwa PhD; Shin, Hee Sun PhD Candidate; Lee, Seong-Joon MD, PhD; Lee, Jin Soo MD, PhD; Lim, Yong Cheol MD

doi : 10.1161/STROKEAHA.122.038650

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Effects of Semaglutide on Stroke Subtypes in Type 2 Diabetes: Post Hoc Analysis of the Randomized SUSTAIN 6 and PIONEER 6.

Strain, W. David MD; Frenkel, Ofir MD; James, Martin A. FRCP; Leiter, Lawrence A. MD; Rasmussen, Soren PhD; Rothwell, Peter M. FMedSci; Sejersten Ripa, Maria DMSc; Truelsen, Thomas C. TC, DMSc; Husain, Mansoor MD

doi : 10.1161/STROKEAHA.121.037775

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Use of Clinical Pathway Simulation and Machine Learning to Identify Key Levers for Maximizing the Benefit of Intravenous Thrombolysis in Acute Stroke.

Allen, Michael PhD; James, Charlotte PhD; Frost, Julia PhD; Liabo, Kristin PhD; Pearn, Kerry BSc; Monks, Thomas PhD; Everson, Richard PhD; Stein, Ken MD; James, Martin MD

doi : 10.1161/STROKEAHA.121.038454

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Simulation and Machine Learning Provide New Approaches to Examine Quality of Acute Stroke Management.

Kamal, Noreen PhD; Lakshminarayan, Kamakshi MBBS, PhD, MS

doi : 10.1161/STROKEAHA.122.039954

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Perfusion Imaging for Endovascular Thrombectomy in Acute Ischemic Stroke Is Associated With Improved Functional Outcomes in the Early and Late Time Windows.

Dhillon, Permesh Singh MD; Butt, Waleed MD; Podlasek, Anna MD; McConachie, Norman MD; Lenthall, Robert MD; Nair, Sujit MD; Malik, Luqman MD; Booth, Thomas C. PhD; Bhogal, Pervinder PhD; Makalanda, Hegoda Levansri Dilrukshan MD; Spooner, Oliver MD, MRCP; Mortimer, Alex PhD; Lamin, Saleh MD; Chavda, Swarupsinh MD; Chew, Han Seng MD; Nader, Kurdow MD; Al-Ali, Samer MD; Butler, Benjamin MD; Rajapakse, Dilina MD; Appleton, Jason P. PhD, MRCP; Krishnan, Kailash PhD, MRCP; Sprigg, Nikola PhD; Smith, Aubrey MD; Lobotesis, Kyriakos PhD; White, Phil PhD; James, Martin A. PhD; Bath, Philip M. DSc, FMedSci; Dineen, Robert A. PhD; England, Timothy J. PhD

doi : 10.1161/STROKEAHA.121.038010

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Stenting and Angioplasty in Neurothrombectomy: Matched Analysis of Rescue Intracranial Stenting Versus Failed Thrombectomy.

Mohammaden, Mahmoud H. MD, MSc; Haussen, Diogo C. MD; Al-Bayati, Alhamza R. MD; Hassan, Ameer DO; Tekle, Wondwossen MD; Fifi, Johanna MD; Matsoukas, Stavros MD; Kuybu, Okkes MD; Gross, Bradley A. MD; Lang, Michael J. MD; Narayanan, Sandra MD; Cortez, Gustavo M. MD; Hanel, Ricardo A. MD; Aghaebrahim, Amin MD; Sauvageau, Eric MD; Farooqui, Mudassir MD; Ortega-Gutierrez, Santiago MD, MSc; Zevallos, Cynthia MD; Galecio-Castillo, Milagros MD; Sheth, Sunil A. MD; Nahhas, Michael MD; Salazar-Marioni, Sergio MD; Nguyen, Thanh N. MD; Abdalkader, Mohamad MD; Klein, Piers; Hafeez, Muhammad MD; Kan, Peter MD; Tanweer, Omar MD; Khaldi, Ahmad MD; Li, Hanzhou MD; Jumaa, Mouhammad MD; Zaidi, Syed MD; Oliver, Marion MD; Salem, Mohamed M. MD, MPH; Burkhardt, Jan-Karl MD; Pukenas, Bryan A. MD; Alaraj, Ali MD; Peng, Sophia MD; Kumar, Rahul; Lai, Michael; Siegler, James MD; Nogueira, Raul G. MD

doi : 10.1161/STROKEAHA.121.038248

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Determinants and Temporal Dynamics of Cerebral Small Vessel Disease: 14-Year Follow-Up.

Cai, Mengfei MD, PhD ,*; Jacob, Mina A. MD ,*; van Loenen, Mark R. MSc; Bergkamp, Mayra MD; Marques, Jose PhD; Norris, David G. PhD; Duering, Marco MD; Tuladhar, Anil M. MD, PhD; de Leeuw, Frank-Erik MD, PhD

doi : 10.1161/STROKEAHA.121.038099

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Effect of Hypertension on Efficacy and Safety of Ticagrelor-Aspirin Versus Clopidogrel-Aspirin in Minor Stroke or Transient Ischemic Attack.

Wang, Anxin PhD ,,*; Meng, Xia MD ,,*; Tian, Xue PhD; Johnston, S. Claiborne MD, PhD; Li, Hao MD, PhD; Bath, Philip M. DSc, FMedSci; Zuo, Yingting PhD; Xie, Xuewei MD, PhD; Jing, Jing MD, PhD; Lin, Jinxi MD, PhD; Wang, Yilong MD, PhD; Zhao, Xingquan MD, PhD; Li, Zixiao MD, PhD; Jiang, Yong MD, PhD; Liu, Liping MD, PhD; Wang, Feng MD, PhD; Wang, Yanxia MM; Huang, Panbing BS; Chen, Guofang MD; Wang, Yongjun MD; for the CHANCE-2 Investigators

doi : 10.1161/STROKEAHA.122.038662

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TAGE Score for Symptomatic Intracranial Hemorrhage Prediction After Successful Endovascular Treatment in Acute Ischemic Stroke.

Janvier, Paul MD; Kerleroux, Basile MD; Turc, Guillaume MD, PhD; Pasi, Marco MD, PhD; Farhat, Wassim MD; Bricout, Nicolas MD; Benzakoun, Joseph MD, PhD; Legrand, Laurence MD; Clarencon, Frederic MD, PhD; Bracard, Serge MD, PhD; Oppenheim, Catherine MD, PhD; Boulouis, Gregoire MD, PhD; Henon, Hilde MD, PhD; Naggara, Olivier MD, PhD ,*; Ben Hassen, Wagih MD, PhD ,*

doi : 10.1161/STROKEAHA.121.038088

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Determinants of Symptomatic Intracranial Hemorrhage After Endovascular Stroke Treatment: A Retrospective Cohort Study.

van der Steen, Wouter MD; van der Ende, Nadinda A.M. MD; van Kranendonk, Katinka R. MD; Chalos, Vicky MD; van Oostenbrugge, Robert J. MD, PhD; van Zwam, Wim H. MD, PhD; Roos, Yvo B.W.E.M. MD, PhD; van Doormaal, Pieter J. MD; van Es, Adriaan C.G.M. MD, PhD; Lingsma, Hester F. PhD; Majoie, Charles B.L.M. MD, PhD; van der Lugt, Aad MD, PhD; Dippel, Diederik W.J. MD, PhD; Roozenbeek, Bob MD, PhD; on behalf of the MR CLEAN Trial and MR CLEAN Registry Investigators

doi : 10.1161/STROKEAHA.121.036195

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How Much of the Thrombectomy Related Improvement in Functional Outcome Is Already Apparent at 24 Hours and at Hospital Discharge?.

Kniep, Helge MD, Dipl.-Ing; Meyer, Lukas MD; Bechstein, Matthias MD; Broocks, Gabriel MD; Guerreiro, Helena MD; van Horn, Noel MD; Brekenfeld, Caspar MD; Flottmann, Fabian MD; Deb-Chatterji, Milani MD; Alegiani, Anna MD; Thomalla, Gotz MD; Hanning, Uta MD, MHBA; Fiehler, Jens MD; Gelli[latin sharp s]en, Susanne MD; for the GSR-ET (German Stroke Registry-Endovascular Treatment)

doi : 10.1161/STROKEAHA.121.037888

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Natural History of Asymptomatic Moderate Carotid Artery Stenosis in a Large Community-Based Cohort.

Gologorsky, Rebecca C. MD; Lancaster, Elizabeth MD, MAS; Tucker, Lue-Yen BA; Nguyen-Huynh, Mai N. MD, MAS; Rothenberg, Kara A. MD; Avins, Andrew L. MD, MPH; Kuang, Hui C. NP; Chang, Robert W. MD

doi : 10.1161/STROKEAHA.121.038426

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Longitudinal Study Reveals Long-Term Proinflammatory Proteomic Signature After Ischemic Stroke Across Subtypes.

Stanne, Tara M. PhD; Angerfors, Annelie MScEng; Andersson, Bjorn PhD; Brannmark, Cecilia MD, PhD; Holmegaard, Lukas MD; Jern, Christina MD, PhD

doi : 10.1161/STROKEAHA.121.038349

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Associations of Life's Simple 7 With Cerebral Small Vessel Disease.

Liu, Dandan MSc ,,*; Cai, Xueli MD, PhD ,*; Yang, Yingying PhD; Wang, Suying PhD; Yao, Dongxiao MD; Mei, Lerong MD; Jing, Jing MD, PhD; Li, Shan MD; Yan, Hongyi MD; Meng, Xia MD, PhD; Li, Hao PhD; Wei, Tiemin MD; Wang, Yongjun MD; Pan, Yuesong PhD; Wang, Yilong MD, PhD

doi : 10.1161/STROKEAHA.122.038838

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Simple Interventions: A Clue to Tackle Cerebral Small Vessel Disease.

Romero, Jose Rafael MD

doi : 10.1161/STROKEAHA.122.039953

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Sex Hormones and Risk of Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Study.

Molenberg, Rob BSc; Thio, Chris H.L. PhD; Aalbers, Marlien W. MD, PhD; Uyttenboogaart, Maarten MD, PhD; ISGC Intracranial Aneurysm Working Group; Larsson, Susanna C. PhD; Bakker, Mark K. MSc; Ruigrok, Ynte M. MD, PhD; Snieder, Harold PhD; van Dijk, J. Marc C. MD, PhD

doi : 10.1161/STROKEAHA.121.038035

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Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis.

Kuramatsu, Joji B. MD ,*; Gerner, Stefan T. MD ,*; Ziai, Wendy MD ,*; Bardutzky, Jurgen MD; Sembill, Jochen A. MD; Sprugel, Maximilian I. MD; Mrochen, Anne MD; Kolbl, Kathrin MD; Ram, Malathi PhD; Avadhani, Radhika MS; Falcone, Guido J. MD; Selim, Magdy H. MD; Lioutas, Vasileios-Arsenios MD; Endres, Matthias MD; Zweynert, Sarah MD; Vajkoczy, Peter MD; Ringleb, Peter A. MD; Purrucker, Jan C. MD; Volkmann, Jens MD; Neugebauer, Hermann MD; Erbguth, Frank MD; Schellinger, Peter D. MD; Knappe, Ulrich J. MD; Fink, Gereon R. MD; Dohmen, Christian MD; Minnerup, Jens MD; Reichmann, Heinz MD; Schneider, Hauke MD; Rother, Joachim MD; Reimann, Gernot MD; Schwarz, Michael MD; Bazner, Hansjorg MD; Cla[latin sharp s]en, Joseph MD; Michalski, Dominik MD; Witte, Otto W. MD; Gunther, Albrecht MD; Hamann, Gerhard F. MD; Lucking, Hannes MD; Dorfler, Arnd MD; Ishfaq, Muhammad Fawad MD; Chang, Jason J. MD; Testai, Fernando D. MD; Woo, Daniel MD; Alexandrov, Andrei V. MD; Staykov, Dimitre MD; Goyal, Nitin MD; Tsivgoulis, Georgios MD; Sheth, Kevin N. MD; Awad, Issam A. MD; Schwab, Stefan MD ,+; Hanley, Daniel F. MD ,+; Huttner, Hagen B. MD ,+

doi : 10.1161/STROKEAHA.121.038455

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Silent Infarcts, White Matter Integrity, and Oxygen Metabolic Stress in Young Adults With and Without Sickle Cell Trait.

Wang, Yan MD; Guilliams, Kristin P. MD, MSCI; Fields, Melanie E. MD, MSCI; Fellah, Slim PhD; Binkley, Michael M. PhD, MS; Reis, Martin MD; Vo, Katie D. MD; Chen, Yasheng DSc; Ying, Chunwei BS; Blinder, Morey MD; King, Allison A. MD, PhD, MPH; Hulbert, Monica L. MD; An, Hongyu DSc; Lee, Jin-Moo MD, PhD; Ford, Andria L. MD, MSCI

doi : 10.1161/STROKEAHA.121.036567

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Automatic Segmentation in Acute Ischemic Stroke: Prognostic Significance of Topological Stroke Volumes on Stroke Outcome.

Wong, Kelvin K. PhD ,,,*; Cummock, Jonathon S. BS ,,*; Li, Guihua MD ,*; Ghosh, Rahul MS; Xu, Pingyi MD, PhD; Volpi, John J. MD; Wong, Stephen T.C. PhD

doi : 10.1161/STROKEAHA.121.037982

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Association of RNF213 Variants With Periventricular Anastomosis in Moyamoya Disease.

Xue, Yimeng MD ,,,,,,*; Zeng, Chaofan MD ,,,,,*; Ge, Peicong MD; Liu, Chenglong MD; Li, Junsheng MD; Zhang, Yan MD; Zhang, Dong MD; Zhang, Qian MD; Zhao, Jizong MD

doi : 10.1161/STROKEAHA.121.038066

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Diagnostic Utility of Computed Tomography Perfusion in the Telestroke Setting.

Arora, Kshitij BMed, BSc(Med)Hons; Gaekwad, Aaron MBBS; Evans, James MBBS; O'Brien, William MB, BAO, BCh; Ang, Timothy MD; Garcia-Esperon, Carlos MD; Blair, Christopher MBBS, PhD; Edwards, Leon S. MBBS; Chew, Beng L.A. MBBS; Delcourt, Candice MD, PhD; Spratt, Neil J. MD, PhD; Parsons, Mark W. MD, PhD; Butcher, Ken S. MD, PhD

doi : 10.1161/STROKEAHA.122.038798

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Comparison of Computed Tomography Perfusion and Multiphase Computed Tomography Angiogram in Predicting Clinical Outcomes in Endovascular Thrombectomy.

Tan, Zefeng MD, PhD; Parsons, Mark MD, PhD; Bivard, Andrew MD, PhD; Sharma, Gagan MD, PhD; Mitchell, Peter MD, PhD; Dowling, Richard MD, PhD; Bush, Steven MD, PhD; Churilov, Leonid MD, PhD; Xu, Anding MD, PhD; Yan, Bernard MD, PhD

doi : 10.1161/STROKEAHA.122.038576

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Lithium and Stroke Recovery: A Systematic Review and Meta-Analysis of Stroke Models in Rodents and Human Data.

Almeida, Osvaldo P. MD, PhD ,*; Singulani, Monique P. PhD ,*; Ford, Andrew H. MD; Hackett, Maree L. PhD; Etherton-Beer, Christopher MBBS, PhD; Flicker, Leon MBBS, PhD; Hankey, Graeme J. MBBS, MD; De Paula, Vanessa J.R. PhD; Penteado, Camila T. MD; Forlenza, Orestes V. MD, PhD

doi : 10.1161/STROKEAHA.122.039203

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Normalization of Aperiodic Electrocorticography Components Indicates Fine Motor Recovery After Sensory Cortical Stroke in Mice.

Biskamp, Jonatan MD; Isla Cainzos, Sara MSc; Higgen, Focko L. MD; Gerloff, Christian MD; Magnus, Tim MD

doi : 10.1161/STROKEAHA.122.039335

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High Incidence and Unique Features of Cerebral Venous Sinus Thrombosis in Hospitalized Patients With COVID-19 Infection.

McCullough-Hicks, Margy E. MD; Halterman, Daniel J. MS; Anderson, David BSAE; Cohen, Kenneth MD; Lakshminarayan, Kamakshi MBBS, PhD

doi : 10.1161/STROKEAHA.122.038955

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Targeted Plasma Proteomics to Predict the Development of Carotid Plaques.

Baragetti, Andrea PhD; Mattavelli, Elisa BSc; Grigore, Liliana MD, PhD; Pellegatta, Fabio MD, PhD; Magni, Paolo MD, PhD; Catapano, Alberico Luigi MDhc, PhD

doi : 10.1161/STROKEAHA.122.038887

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Treatment and 1-Year Prognosis of Ischemic Stroke in China in 2018: A Hospital-Based Study From Bigdata Observatory Platform for Stroke of China.

Tu, Wen-Jun PhD; Yan, Feng MD; Chao, Bao-Hua MD; Cao, Lei MD; Wang, Longde MD

doi : 10.1161/STROKEAHA.121.038260

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Pilot Deployment of Viz-Intracranial Hemorrhage for Intracranial Hemorrhage Detection: Real-World Performance in a Stroke Code Cohort.

Matsoukas, Stavros MD; Chennareddy, Susmita BA; Kalagara, Roshini BA; Scaggiante, Jacopo MD; Smith, Colton J. BS; Bazil, Maximilian J. BS; Reford, Emma BA; Liu, Kayla; Delman, Bradley N. MD, MS; Selim, Magdy H. MD, PhD; Mocco, J MD, MS; Fifi, Johanna T. MD; Kellner, Christopher P. MD

doi : 10.1161/STROKEAHA.122.039711

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Small Cerebral Infarcts Mimicked by Nuchal Lymph Nodes in Accelerated High-Resolution Diffusion Magnetic Resonance Imaging.

Sundermann, Benedikt MD; Kluner, Claudia MD; Bosenberg, Holger MD; Gerdes, Maike; Mathys, Christian MD

doi : 10.1161/STROKEAHA.122.039481

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Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Hidden by Another Stroke.

Yoon, Joseph Y. MD, MSc, MAEd; Klein, Joshua P. MD, PhD

doi : 10.1161/STROKEAHA.122.039829

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Neurocritical Care Updates in Cerebrovascular Disease.

Jha, Ruchira M. MD, MSc; Sheth, Kevin N. MD

doi : 10.1161/STROKEAHA.122.038881

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Nursing Care of the Acute Ischemic Stroke Endovascular Thrombectomy Patient.

Hill, Michelle , MS, RN, AGCNS-BC, CNRN, SCRN; Baumann, JJ MS, RN, CCNS-BC, FNCS; Newcommon, Nancy RN, MN

doi : 10.1161/STROKEAHA.122.034536

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Digital Health-Enabled Clinical Trials in Stroke: Ready for Prime Time?.

Berwanger, Otavio MD, PhD; Machline-Carrion, M. Julia MD, MHS, PhD

doi : 10.1161/STROKEAHA.122.037378

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David G. Sherman Lecture Award: 15-Year Experience of the Nationwide Multicenter Stroke Registry in Korea.

Bae, Hee-Joon MD, PhD; on behalf of the CRCS-K Investigators

doi : 10.1161/STROKEAHA.122.039212

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The Problem of Restrictive Thrombectomy Trial Eligibility Criteria.

Nguyen, Thanh N. MD; Raymond, Jean MD; Nogueira, Raul G. MD; Fischer, Urs MD, MSc; Siegler, James E. MD

doi : 10.1161/STROKEAHA.122.040006

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Screening for Aspiration Risk Associated With Dysphagia in Acute Stroke.

Boaden, Elizabeth PhD; Burnell, Jane MSc; Hives, Lucy MSc; Dey, Paola MD; Clegg, Andrew PhD; Lyons, Mary W. MPH; Lightbody, C. Elizabeth PhD; Hurley, Margaret A. PhD; Roddam, Hazel PhD; McInnes, Elizabeth PhD; Alexandrov, Anne W. PhD; Watkins, Caroline L. PhD

doi : 10.1161/STROKEAHA.122.037998

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Selective Serotonin Reuptake Inhibitors for Stroke Recovery.

Hua, Xing MBBS; Wu, Simiao PhD; Legg, Lynn A. PhD; Rudberg, Ann-Sofie PhD; Hackett, Maree L. PhD; Tilney, Russel PhD; Lindgren, Linnea MSc; Kutlubaev, Mansur A. PhD; Hsieh, Cheng-Fang MD; Barugh, Amanda J. PhD; Hankey, Graeme J. MD; Lundstrom, Erik PhD; Dennis, Martin MD; Mead, Gillian E. PhD

doi : 10.1161/STROKEAHA.121.038149

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September Literature Synopsis.

Quinn, Terence J. MD; Kelbling, Eline

doi : 10.1161/STROKEAHA.122.040206

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Science Visualization: Approaches and Resources for Making Communication Simple but Not Simplistic.

Hayward, Kathryn PhD; Davis, Aaron PhD

doi : 10.1161/STROKEAHA.122.037668

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Progressive Vertebrobasilar Vasculopathy and Stroke Secondary to Giant Cell Arteritis.

Mahjoub, Yasamin MD; McKenzie, Erica D. MD; Raouf, Saher; Almekhlafi, Mohammed MD

doi : 10.1161/STROKEAHA.122.039503

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Correction to: Diagnostic Utility of Computed Tomography Perfusion in the Telestroke Setting.

doi : 10.1161/STR.0000000000000412

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Correction to: Clonal Hematopoiesis Is Associated With Higher Risk of Stroke.

doi : 10.1161/STR.0000000000000413

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Correction to: Nursing Care of the Acute Ischemic Stroke Endovascular Thrombectomy Patient.

doi : 10.1161/STR.0000000000000414

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