Neurology




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Planning for Prevention of Parkinson Disease: Now Is the Time.

Crotty, Grace F. MBBChBAO, MD; Keavney, Jessi L. MBA; Alcalay, Roy N. MD, MS; Marek, Kenneth MD; Marshall, Gad A. MD; Rosas, H. Diana MD, MSc; Schwarzschild, Michael A. MD, PhD

doi : 10.1212/WNL.0000000000200789

Volume 99(7_Supplement_1) Supplement 1 pgs. 1-83 August 16, 2022

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Who to Enroll in Parkinson Disease Prevention Trials?: The Case for Genetically At-Risk Cohorts.

Niotis, Kellyann MD; West, Andrew B. PhD; Saunders-Pullman, Rachel MD, MPH

doi : 10.1212/WNL.0000000000200812

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Neuroprotective Trials in REM Sleep Behavior Disorder: The Way Forward Becomes Clearer.

Postuma, Ronald B. MD, MSc

doi : 10.1212/WNL.0000000000200235

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Who to Enroll in Parkinson Disease Prevention Trials?: The Case for Composite Prodromal Cohorts.

Molsberry, Samantha A. PhD; Hughes, Katherine C. ScD; Schwarzschild, Michael A. MD, PhD; Ascherio, Alberto MD, DrPH

doi : 10.1212/WNL.0000000000200788

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What to Test in Parkinson Disease Prevention Trials?: Repurposed, Low-Risk, and Gene-Targeted Drugs.

Crotty, Grace F. MBBChBAO, MD; Schwarzschild, Michael A. MD, PhD

doi : 10.1212/WNL.0000000000200238

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Lifestyle Interventions for the Prevention of Parkinson Disease: A Recipe for Action.

Janssen Daalen, Jules M. MD; Schootemeijer, Sabine MSc; Richard, Edo MD, PhD; Darweesh, Sirwan K.L. MD, PhD; Bloem, Bastiaan R. MD, PhD

doi : 10.1212/WNL.0000000000200787

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Outcome Assessment in Parkinson Disease Prevention Trials: Utility of Clinical and Digital Measures.

Mirelman, Anat PhD; Siderowf, Andrew MD; Chahine, Lana MD

doi : 10.1212/WNL.0000000000200236

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What Is the Role of Dopamine Transporter Imaging in Parkinson Prevention Clinical Trials?.

Seibyl, John Peter MD; Kuo, Phillip MD, PhD

doi : 10.1212/WNL.0000000000200786

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Statistical Considerations in the Design of Clinical Trials Targeting Prodromal Parkinson Disease.

Macklin, Eric A. PhD *; Coffey, Christopher S. PhD *; Brumm, Michael C. MS; Seibyl, John Peter MD

doi : 10.1212/WNL.0000000000200897

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Path to Parkinson Disease Prevention: Conclusion and Outlook.

Berg, Daniela MD; Crotty, Grace F. MD; Keavney, Jessi L. MBA; Schwarzschild, Michael A. MD, PhD; Simuni, Tanya MD, FAAN; Tanner, Caroline MD, PhD

doi : 10.1212/WNL.0000000000200793

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Spotlight on the August 23 Issue.

Merino, Jose G. MD, MPhil; Editor-in-Chief, Neurology(R)

doi : 10.1212/WNL.0000000000200972

Volume 99(8) pgs. 317-358,e751-e864 August 23, 2022

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Trends in Antiseizure Medication Use: Implications for Practice and Clinical Care.

Bensken, Wyatt P. BS; Sanchez Fernandez, Ivan MD, MPH, MBI

doi : 10.1212/WNL.0000000000200852

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First Human In Vivo Neuroelectrophysiology Recordings of Uncrossed Dentatothalamocortical White-Matter Connections: On the Fast Tract.

Brogna, Christian MD; Perera, Noemia MSc; Ghimire, Prajwal MBBS, MRCSEd, MSc; Bruchhage, Muriel M.K.; Abela, Eugenio; Richardson, Mark P.; Vergani, Francesco PhD; Bhangoo, Ranjeev FRCS; Ashkan, Keyoumars FRCS

doi : 10.1212/WNL.0000000000200990

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Reversible Dysexecutive Syndrome From CSF Overshunting in a Patient With Normal Pressure Hydrocephalus.

Maneval, Jeffrey MD *; Dmytriw, Adam A. MD, MPH *; Acar, Diler MD *

doi : 10.1212/WNL.0000000000200942

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Stable Leukoencephalopathy in a Patient With ACTA2-Associated Multisystem Smooth Muscle Disorder.

Bieber, David MD; Port, John D. MD; Renaud, Deborah L. MD

doi : 10.1212/WNL.0000000000200961

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Child Neurology: Neurodegenerative Encephalomyelopathy Associated With ACOX1 Gain-of-Function Variation Partially Responsive to Immunotherapy.

Jafarpour, Saba MD *; Khoshnood, Mellad MD *; Santoro, Jonathan D. MD

doi : 10.1212/WNL.0000000000200935

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Clinical Reasoning: A 68-Year-Old Man With Palmar Rash, Leg Pain, and Inability to Walk.

Yoon, Joseph YoungHun MD, MSc, MAEd; Solomon, Jacqueline Madeleine MD; Li, Yijia MD; Prasad, Sashank MD

doi : 10.1212/WNL.0000000000200933

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Teaching NeuroImage: Subacute Encephalopathy With Seizures in Alcoholics (SESA)-Related Abnormalities on EEG and MRI.

Suh, Jimmy MD; Chen, Denise MD; Albin, Catherine MD

doi : 10.1212/WNL.0000000000200915

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Teaching Video NeuroImage: Hung-Up Reflex in Stiff Limb Syndrome.

Lopez-Jimenez, Alejandro MD; Gutierrez-Gutierrez, Gerardo MD; Guerra-Hiraldo, Juan Diego MD; Kurtis, Monica M. MD; Parees, Isabel MD, PhD

doi : 10.1212/WNL.0000000000200938

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Editors' Note: Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults.

Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD

doi : 10.1212/WNL.0000000000201078

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Reader Response: Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults.

Kawada, Tomoyuki

doi : 10.1212/WNL.0000000000201079

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Author Response: Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults.

Siow, Tiing Yee; Toh, Cheng Hong; Hsu, Jung-Lung; Liu, Geng-Hao; Lee, Shwu-Hua; Chen, Ning-Hung; Fu, Changjui James; Castillo, Mauricio; Fang, Ji-Tseng

doi : 10.1212/WNL.0000000000201080

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Changes in the Use of Brand Name and Generic Medications and Total Prescription Cost Among Medicare Beneficiaries With Epilepsy.

Terman, Samuel W. MD, MS; Lin, Chun C. PhD, MBA; Kerr, Wesley T. MD, PhD; DeLott, Lindsey B. MD, MS; Callaghan, Brian C. MD, MS; Burke, James F. MD, MS

doi : 10.1212/WNL.0000000000200779

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Long-term Treatment With Ponesimod in Relapsing-Remitting Multiple Sclerosis: Results From Randomized Phase 2b Core and Extension Studies.

Freedman, Mark S. MD; Pozzilli, Carlo MD; Havrdova, Eva Kubala MD; Lemle, Alexandre PharmD, MSc; Burcklen, Michel PhD; Larbalestier, Anna MSc; Hennessy, Brian MSc; Sidorenko, Tatiana MD, PhD; Vaclavkova, Andrea MD; Olsson, Tomas MD; on behalf of the Ponesimod Phase II Study Group

doi : 10.1212/WNL.0000000000200606

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Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease.

Billette, Ornella V. PhD *; Ziegler, Gabriel PhD *; Aruci, Merita MSc; Schutze, Hartmut PhD; Kizilirmak, Jasmin M. PhD; Richter, Anni PhD; Altenstein, Slawek Dipl-Psych; Bartels, Claudia PhD; Brosseron, Frederic PhD; Cardenas-Blanco, Arturo PhD; Dahmen, Philip MSc; Dechent, Peter PhD; Dobisch, Laura MSc; Fliessbach, Klaus MD; Freiesleben, Silka Dawn MSc; Glanz, Wenzel MD; Goer[latin sharp s], Doreen MD; Haynes, John Dylan PhD; Heneka, Michael T. MD; Kilimann, Ingo MD; Kimmich, Okka MD; Kleineidam, Luca PhD; Laske, Christoph PhD; Lohse, Andrea; Rostamzadeh, Ayda MD; Metzger, Coraline MD; Munk, Matthias H. PhD; Peters, Oliver MD; Preis, Lukas MSc; Priller, Josef MD; Scheffler, Klaus PhD; Schneider, Anja MD; Spottke, Annika MD; Spruth, Eike Jakob MD; Ramirez, Alfredo MD; Roske, Sandra PhD; Roy, Nina PhD; Teipel, Stefan MD; Wagner, Michael MD; Wiltfang, Jens MD; Wolfsgruber, Steffen PhD; Yakupov, Renat PhD; Zeidman, Peter PhD; Jessen, Frank MD; Schott, Bjorn H. MD; Duzel, Emrah MD; Maass, Anne PhD; on behalf of the DELCODE Study Group

doi : 10.1212/WNL.0000000000200667

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Effects of Sex, APOE4, and Lifestyle Activities on Cognitive Reserve in Older Adults.

Pa, Judy PhD; Aslanyan, Vahan BS; Casaletto, Kaitlin B. PhD; Renteria, Miguel Arce PhD; Harrati, Amal PhD; Tom, Sarah E. PhD; Armstrong, Nicole PhD; Rajan, Kumar PhD; Avila-Rieger, Justina PhD; Gu, Yian PhD; Schupf, Nicole PhD; Manly, Jennifer J. PhD; Brickman, Adam PhD; Zahodne, Laura PhD

doi : 10.1212/WNL.0000000000200675

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Physical and Mental Activity, Disease Susceptibility, and Risk of Dementia: A Prospective Cohort Study Based on UK Biobank.

Zhu, Jianwei MD, PhD *; Ge, Fenfen PhD *; Zeng, Yu MD; Qu, Yuanyuan MA; Chen, Wenwen MD; Yang, Huazhen MD; Yang, Lei PhD; Fang, Fang MD, PhD; Song, Huan MD, PhD

doi : 10.1212/WNL.0000000000200701

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Association of Olfactory Performance With Motor Decline and Age at Onset in People With Parkinson Disease and the LRRK2 G2019S Variant.

Saunders-Pullman, Rachel MD, MPH; Ortega, Roberto Angel MS; Wang, Cuiling PhD; Raymond, Deborah MS; Elango, Sonya MS; Leaver, Katherine MD; Urval, Nikita MD; Katsnelson, Viktoriya MD; Gerber, Rachel BS; Swan, Matthew MD; Shanker, Vicki MD; Alcalay, Roy N. MD, MS; Mirelman, Anat PhD; Brumm, Michael C. MS; Mejia-Santana, Helen MS; Coffey, Christopher S. PhD; Marek, Kenneth MD; Ozelius, Laurie J. PhD; Giladi, Nir MD; Marder, Karen S. MD, MPH; Bressman, Susan B. MD

doi : 10.1212/WNL.0000000000200737

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Normobaric Hyperoxia Combined With Endovascular Treatment for Patients With Acute Ischemic Stroke: A Randomized Controlled Clinical Trial.

Li, Weili MD *; Qi, Zhifeng MD *; Ma, Qingfeng MD; Ding, Jiayue MD; Wu, Chuanjie MD; Song, Haiqing MD; Yang, Qi MD; Duan, Jiangang MD; Liu, Lan PhD; Kang, Huining PhD; Wu, Longfei MD; Ji, Kangxiang MD; Zhao, Wenbo MD; Li, Chuanhui MD; Sun, Chenghe MD; Li, Na MD; Fisher, Marc MD; Ji, Xunming MD; Liu, Ke Jian PhD

doi : 10.1212/WNL.0000000000200775

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Brain Abscess and Risk of Cancer: A Nationwide Population-Based Cohort Study.

Bodilsen, Jacob MD, PhD; Sogaard, Kirstine Kobberoe MD, PhD; Nielsen, Henrik MD, PhD; Omland, Lars Haukali MD, PhD, DMSc

doi : 10.1212/WNL.0000000000200769

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Prognostic Factors and Treatments Efficacy in Spontaneous Spinal Epidural Hematoma: A Multicenter Retrospective Study.

Peng, Deqing MD *; Yan, Min MD *; Liu, Tianjian MD; Yang, Kaichuang MD; Ma, Yuyuan MD; Hu, Xinben MD; Ying, Guangyu MD; Zhu, Yongjian MD

doi : 10.1212/WNL.0000000000200844

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Frequency of Asymptomatic Optic Nerve Enhancement in a Large Retrospective Cohort of Patients With Aquaporin-4+ NMOSD.

Shah, Shailee S. MD; Morris, Pearse MBBCh; Buciuc, Marina MD; Tajfirouz, Deena MD; Wingerchuk, Dean M. MD; Weinshenker, Brian G. MD; Eggenberger, Eric R. DO; Di Nome, Marie MD; Pittock, Sean J. MD; Flanagan, Eoin P. MBBCh; Bhatti, M. Tariq MD; Chen, John J. MD, PhD

doi : 10.1212/WNL.0000000000200838

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Adult Neurology Rotations for Child Neurology Residents: A Survey of Program Directors.

Marshall, Cullen S. MD; Deng, Stella MD; Jackson, Hannah S. BA; Horn, Paul S. PhD; Wolf, David S. MD, PhD; Thompson-Stone, Robert MD; Gilbert, Donald L. MD, MS

doi : 10.1212/WNL.0000000000200759

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