Diabetes




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In This Issue of Diabetes

Max Bingham, PhD

doi : 10.2337/db22-ti09

Volume 71, Issue 9

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Sorting Out the Receptor Isoforms Underlying Dopamine Inhibition of Insulin Secretion

Melkam A. Kebede; David W. Piston

doi : 10.2337/dbi22-0018

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Regulation of Hepatic Lipid and Glucose Metabolism by INSP3R1

Rachel J. Perry

doi : 10.2337/dbi22-0003

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Cross Talk Between Insulin and Glucagon Receptor Signaling in the Hepatocyte

Kirk M. Habegger

doi : 10.2337/dbi22-0002

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The Liver–α-Cell Axis in Health and in Disease

Michael M. Richter; Katrine D. Galsgaard; Emilie Elmelund; Filip K. Knop; Malte P. Suppli; Jens J. Holst; Marie Winther-Sørensen; Sasha A.S. Kjeldsen; Nicolai J. Wewer Albrechtsen

doi : 10.2337/dbi22-0004

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CHCHD10 Modulates Thermogenesis of Adipocytes by Regulating Lipolysis

Meng Ding; Yin-jun Ma; Ruo-qi Du; Wei-yu Zhou; Xin Dou; Qi-qi Yang; Yan Tang; Shu-wen Qian; Yun Liu; Dong-ning Pan; Qi-Qun Tang; Yang Liu

doi : 10.2337/db21-0999

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Insulin Response to Oral Glucose and Cardiometabolic Disease: A Mendelian Randomization Study to Assess Potential Causality

Anthony Nguyen; Rana Khafagy; Ameena Meerasa; Delnaz Roshandel; Andrew D. Paterson; Satya Dash

doi : 10.2337/db22-0138

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Total Postprandial Hepatic Nonesterified and Dietary Fatty Acid Uptake Is Increased and Insufficiently Curbed by Adipose Tissue Fatty Acid Trapping in Prediabetes With Overweight

Run Zhou Ye; Émilie Montastier; Christophe Noll; Frédérique Frisch; Mélanie Fortin; Lucie Bouffard; Serge Phoenix; Brigitte Guérin; Éric E. Turcotte; André C. Carpentier

doi : 10.2337/db21-1097

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Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin

Yoshihiro Ito; Runan Sun; Hiroshi Yagimuma; Keigo Taki; Akira Mizoguchi; Tomoko Kobayashi; Mariko Sugiyama; Takeshi Onoue; Taku Tsunekawa; Hiroshi Takagi; Daisuke Hagiwara; Shintaro Iwama; Hidetaka Suga; Hiroyuki Konishi; Hiroshi Kiyama; Hiroshi Arima; Ryoichi Banno

doi : 10.2337/db21-0953

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Long Noncoding RNA lncRHL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis

Xuan Shen; Yajun Zhang; Xuetao Ji; Bo Li; Yuzhu Wang; Yun Huang; Xu Zhang; Jingxian Yu; Ruihan Zou; Dongdong Qin; Hongwen Zhou; Qian Wang; John Zhong Li

doi : 10.2337/db21-1145

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Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts

Abraham S. Meijnikman; Casper C. van Olden; Ömrüm Aydin; Hilde Herrema; Dorota Kaminska; Dimitra Lappa; Ville Männistö; Valentina Tremaroli; Louise E. Olofsson; Maurits de Brauw; Arnold van de Laar; Joanne Verheij; Victor E.A. Gerdes; Thue W. Schwartz; Jens Nielsen; Fredrik Bäckhed; Päivi Pajukanta; Jussi Pihlajamäki; Tamar Tchkonia; James L. Kirkland; Folkert Kuipers; Max Nieuwdorp; Albert K. Groen

doi : 10.2337/db21-1076

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Fat Distribution Patterns and Future Type 2 Diabetes

Hajime Yamazaki; Shinichi Tauchi; Jürgen Machann; Tobias Haueise; Yosuke Yamamoto; Mitsuru Dohke; Nagisa Hanawa; Yoshihisa Kodama; Akio Katanuma; Norbert Stefan; Andreas Fritsche; Andreas L. Birkenfeld; Róbert Wagner; Martin Heni

doi : 10.2337/db22-0315

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Dopamine Negatively Regulates Insulin Secretion Through Activation of D1-D2 Receptor Heteromer

Fumiya Uefune; Toru Aonishi; Tetsuya Kitaguchi; Harumi Takahashi; Susumu Seino; Daisuke Sakano; Shoen Kume

doi : 10.2337/db21-0644

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Heterogeneous Development of β-Cell Populations in Diabetes-Resistant and -Susceptible Mice

Pascal Gottmann; Thilo Speckmann; Mandy Stadion; Erika Zuljan; Heja Aga; Michael Sterr; Maren Büttner; Patrícia Martínez Santos; Markus Jähnert; Stefan R. Bornstein; Fabian J. Theis; Heiko Lickert; Annette Schürmann

doi : 10.2337/db21-1030

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Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Mei-Ling Yang; Sean E. Connolly; Renelle J. Gee; TuKiet T. Lam; Jean Kanyo; Jian Peng; Perrin Guyer; Farooq Syed; Hubert M. Tse; Steven G. Clarke; Catherine F. Clarke; Eddie A. James; Cate Speake; Carmella Evans-Molina; Peter Arvan; Kevan C. Herold; Li Wen; Mark J. Mamula

doi : 10.2337/db21-0989

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Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells

Sherman S. Leung; Danielle J. Borg; Domenica A. McCarthy; Tamar E. Boursalian; Justen Cracraft; Aowen Zhuang; Amelia K. Fotheringham; Nicole Flemming; Thomas Watkins; John J. Miles; Per-Henrik Groop; Jean L. Scheijen; Casper G. Schalkwijk; Raymond J. Steptoe; Kristen J. Radford; Mikael Knip; Josephine M. Forbes

doi : 10.2337/db22-0177

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NRF2 Genetic Polymorphism Modifies the Association of Plasma Selenium Levels With Incident Coronary Heart Disease Among Individuals With Type 2 Diabetes

Chengyong Jia; Ruixin Wang; Tengfei Long; Yali Xu; Ying Zhang; Rong Peng; Xiaomin Zhang; Huan Guo; Handong Yang; Tangchun Wu; Meian He

doi : 10.2337/db21-1124

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Fibronectin–Integrin α5 Signaling in Vascular Complications of Type 1 Diabetes

Minghao Chen; Rui Hu; Cristina Cavinato; Zhenwu W. Zhuang; Jiasheng Zhang; Sanguk Yun; Pablo Fernandez Tussy; Abhishek Singh; Sae-Il Murtada; Keiichiro Tanaka; Min Liu; Carlos Fernández-Hernando; Jay D. Humphrey; Martin A. Schwartz

doi : 10.2337/db21-0958

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PATAS, a First-in-Class Therapeutic Peptide Biologic, Improves Whole-Body Insulin Resistance and Associated Comorbidities In Vivo

Edwige Schreyer; Cathy Obringer; Nadia Messaddeq; Bruno Kieffer; Paul Zimmet; Alexander Fleming; Tarekegn Geberhiwot; Vincent Marion

doi : 10.2337/db22-0058

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Changes in the Coexpression of Innate Immunity Genes During Persistent Islet Autoimmunity Are Associated With Progression of Islet Autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY)

Patrick M. Carry; Kathleen Waugh; Lauren A. Vanderlinden; Randi K. Johnson; Teresa Buckner; Marian Rewers; Andrea K. Steck; Ivana Yang; Tasha E. Fingerlin; Katerina Kechris; Jill M. Norris

doi : 10.2337/db21-1111

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A Novel Intron-Encoded Neuropilin-1 Isoform in Pancreatic Islets Associated With Very Young Age of Onset of Type 1 Diabetes

Michael J. MacDonald; Israr-ul H. Ansari; Amy S. Riedemann; Scott W. Stoker; Jens C. Eickhoff; Peter J. Chlebeck; Luis A. Fernandez; Melissa J. Longacre

doi : 10.2337/db21-1070

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Comment on Colclough et al. and Saint-Martin et al. Syndromic Monogenic Diabetes Genes Should Be Tested in Patients With a Clinical Suspicion of Maturity-Onset Diabetes of the Young. Diabetes 2022;71:530–537, and Gene Panel Sequencing of Patients With Monogenic Diabetes Brings to Light Genes Typically Associated With Syndromic Presentations. Diabetes 2022;71:578–584

Su Fen Ang; Su Chi Lim

doi : 10.2337/db22-0305

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Response to Comment on Colclough et al. and Saint-Martin et al. Syndromic Monogenic Diabetes Genes Should Be Tested in Patients With a Clinical Suspicion of Maturity-Onset Diabetes of the Young. Diabetes 2022;71:530–537, and Gene Panel Sequencing of Patients With Monogenic Diabetes Brings to Light Genes Typically Associated With Syndromic Presentations. Diabetes 2022;71:578–584

Kevin Colclough; Kashyap Patel

doi : 10.2337/db22-0400

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Comment on D’Addio et al. Immunogenicity and Safety of SARS-CoV-2 mRNA Vaccines in a Cohort of Patients With Type 1 Diabetes. Diabetes 2022;71:1800–1806

Pathum Sookaromdee; Viroj Wiwanitkit

doi : 10.2337/db22-0468

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Response to Comment on D’Addio et al. Immunogenicity and Safety of SARS-CoV-2 mRNA Vaccines in a Cohort of Patients With Type 1 Diabetes. Diabetes 2022;71:1800–1806

Francesca D’Addio; Paolo Fiorina

doi : 10.2337/dbi22-0020

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