American Journal of Psychiatry




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Neuroscientific Advances Supporting New Treatments for Major Depression

Ned H. Kalin, M.D.

doi : 10.1176/appi.ajp.20220445

Volume 179, Issue 7

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Digital Therapeutics to Enhance Cognition in Major Depression: How Can We Make the Cognitive Gains Translate Into Functional Improvements?

Philip D. Harvey, Ph.D.

doi : 10.1176/appi.ajp.20220441

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Understanding the Efficacy and Mechanism of Action of a Dextromethorphan-Bupropion Combination: Where Does It Fit in the NMDA Versus mu-Opioid Story?

Alan F. Schatzberg, M.D.

doi : 10.1176/appi.ajp.20220434

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Is Neuroplasticity Key to Treatment Response in Depression? Maybe So

Fabio Ferrarelli, M.D., Ph.D.

doi : 10.1176/appi.ajp.20220432

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The Amygdala and Depression: A Sober Reconsideration

Shannon E. Grogans, M.S., Andrew S. Fox, Ph.D., Alexander J. Shackman, Ph.D.

doi : 10.1176/appi.ajp.20220412

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Toward a Better Understanding of the Mechanisms and Pathophysiology of Anhedonia: Are We Ready for Translation?

Diego A. Pizzagalli, Ph.D.

doi : 10.1176/appi.ajp.20220423

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Longitudinal Trajectory of the Link Between Ventral Striatum and Depression in Adolescence

Pedro Mario Pan, M.D., Ph.D., Jo?o R. Sato, Ph.D., Marie-Laure Paillère Martinot, M.D., Ph.D., Jean-Luc Martinot, M.D., Ph.D., Eric Artiges, M.D., Ph.

doi : 10.1176/appi.ajp.20081180

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Digital Intervention for Cognitive Deficits in Major Depression: A Randomized Controlled Trial to Assess Efficacy and Safety in Adults

Richard S.E. Keefe, Ph.D., Elena Ca?adas, Ph.D., Deborah Farlow, Ph.D., Amit Etkin, M.D., Ph.D.

doi : 10.1176/appi.ajp.21020125

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Effect of AXS-05 (Dextromethorphan-Bupropion) in Major Depressive Disorder: A Randomized Double-Blind Controlled Trial

Herriot Tabuteau, M.D., Amanda Jones, Pharm.D., Ashley Anderson, B.S., Mark Jacobson, M.A., Dan V. Iosifescu, M.D.

doi : 10.1176/appi.ajp.21080800

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Predictive Value of Acute Neuroplastic Response to rTMS in Treatment Outcome in Depression: A Concurrent TMS-fMRI Trial

Ruiyang Ge, Ph.D., Afifa Humaira, B.Sc., Elizabeth Gregory, M.Sc., Golnoush Alamian, Ph.D., Erin L. MacMillan, Ph.D., Laura Barlow, R.T.R., R.T.M.R.,

doi : 10.1176/appi.ajp.21050541

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No Association Between Amygdala Responses to Negative Faces and Depressive Symptoms: Cross-Sectional Data from 28,638 Individuals in the UK Biobank Cohort

Sandra Tamm, M.D., Ph.D., Catherine J. Harmer, Ph.D., Julian Schiel, M.Sc., Florian Holub, B.Sc., Martin K. Rutter, M.B.Ch.B., M.D., Kai Spiegelhalder

doi : 10.1176/appi.ajp.21050466

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