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Survival After Implantable Cardioverter-Defibrillator Shocks
Mehmet K. Akta?, Arwa Younis, Wojciech Zareba, Valentina Kutyifa, ... Ilan Goldenberg
doi : 10.1016/j.jacc.2021.03.329
Volume 77, Issue 20, 25 May 2021, Pages 2453-2462
There are conflicting data on the impact of implantable cardioverter-defibrillator (ICD) shocks on subsequent mortality.
The “Shocking” Reality of ICD Therapies
Rajat Deo, Naga Venkata K. Pothineni
doi : 10.1016/j.jacc.2021.04.019
Volume 77, Issue 20, 25 May 2021, Pages 2463-2465
International Prospective Registry of Acute Coronary Syndromes in Patients With COVID-19
Thomas A. Kite, Peter F. Ludman, Chris P. Gale, Jianhua Wu, ... Anthony H. Gershlick
doi : 10.1016/j.jacc.2021.03.309
Volume 77, Issue 20, 25 May 2021, Pages 2466-2476
Published data suggest worse outcomes in acute coronary syndrome (ACS) patients and concurrent coronavirus disease 2019 (COVID-19) infection. Mechanisms remain unclear.
Resilience in the Face of Adversity: The Cardiology Community Comes Together?
Timothy D. Henry, Santiago Garcia
doi : 10.1016/j.jacc.2021.03.315
Volume 77, Issue 20, 25 May 2021, Pages 2477-2479
Integrated Clinical and Magnetic Resonance Imaging Assessments Late After Fontan Operation
Sophie L. Meyer, Nicole St. Clair, Andrew J. Powell, Tal Geva, Rahul H. Rathod
doi : 10.1016/j.jacc.2021.03.312
Volume 77, Issue 20, 25 May 2021, Pages 2480-2489
Several clinical and cardiac magnetic resonance (CMR)-derived parameters have been shown to be associated with death or heart transplant late after the Fontan operation.
The Fontan: “Straining” to Understand That “The Bigger They Come, The Harder They Fall”?
Mark A. Fogel
doi : 10.1016/j.jacc.2021.04.010
Volume 77, Issue 20, 25 May 2021, Pages 2490-2493
Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease
Nadia Akawi, Antonio Checa, Alexios S. Antonopoulos, Ioannis Akoumianakis, ... Charalambos Antoniades
doi : 10.1016/j.jacc.2021.03.314
Volume 77, Issue 20, 25 May 2021, Pages 2494-2513
Obesity is associated with increased cardiovascular risk; however, the potential role of dysregulations in the adipose tissue (AT) metabolome is unknown.
The Role of Adipose Tissue in Cardiovascular Disease: Decoding its Secret Language?
Michelle L. O’Donoghue, Nicholas A. Marston
doi : 10.1016/j.jacc.2021.04.017
Volume 77, Issue 20, 25 May 2021, Pages 2514-2516
Precision Medicine in Cardiovascular Disease: Genetics and Impact on Phenotypes: JACC Focus Seminar 1/5
Christopher Semsarian, Jodie Ingles, Samantha Barratt Ross, Sally L. Dunwoodie, ... Jason C. Kovacic
doi : 10.1016/j.jacc.2020.12.071
Volume 77, Issue 20, 25 May 2021, Pages 2517-2530
Our understanding of the genetic basis of cardiovascular diseases (CVDs) has evolved rapidly. This has resulted from a combination of dedicated research in well phenotyped CVD patients, the sequencing of the human genome, and the ready accessibility and decreasing cost of next-generation sequencing technologies.
Precision Medicine Approaches to Vascular Disease: JACC Focus Seminar 2/5
Clint L. Miller, Amy R. Kontorovich, Ke Hao, Lijiang Ma, ... Jason C. Kovacic
doi : 10.1016/j.jacc.2021.04.001
Volume 77, Issue 20, 25 May 2021, Pages 2531-2550
In this second of a 5-part Focus Seminar series, we focus on precision medicine in the context of vascular disease. The most common vascular disease worldwide is atherosclerosis, which is the primary cause of coronary artery disease, peripheral vascular disease, and a large proportion of strokes and other disorders.
Contemporary and Future Approaches to Precision Medicine in Inherited Cardiomyopathies: JACC Focus Seminar 3/5
Diane Fatkin, Hugh Calkins, Perry Elliott, Cynthia A. James, ... Jason C. Kovacic
doi : 10.1016/j.jacc.2020.12.072
Volume 77, Issue 20, 25 May 2021, Pages 2551-2572
Inherited cardiomyopathies are commonly occurring myocardial disorders that are associated with substantial morbidity and mortality. Clinical management strategies have focused on treatment of heart failure and arrhythmic complications in symptomatic patients according to standardized guidelines.
Precision Medicine Approaches to Cardiac Arrhythmias: JACC Focus Seminar 4/5
John R. Giudicessi, Michael J. Ackerman, Diane Fatkin, Jason C. Kovacic
doi : 10.1016/j.jacc.2021.03.325
Volume 77, Issue 20, 25 May 2021, Pages 2573-2591
In the initial 3 papers in this Focus Seminar series, the fundamentals and key concepts of precision medicine were reviewed, followed by a focus on precision medicine in the context of vascular disease and cardiomyopathy. For the remaining 2 papers, we focus on precision medicine in the context of arrhythmias. Specifically, in this fourth paper we focus on long QT syndrome, Brugada syndrome, and atrial fibrillation. The final (fifth) paper will deal with catecholaminergic polymorphic ventricular tachycardia.
Precision Medicine in Catecholaminergic Polymorphic Ventricular Tachycardia: JACC Focus Seminar 5/5
Silvia G. Priori, Andrea Mazzanti, Demetrio J. Santiago, Deni Kukavica, ... Jason C. Kovacic
doi : 10.1016/j.jacc.2020.12.073
Volume 77, Issue 20, 25 May 2021, Pages 2592-2612
In this final of a 5-part Focus Seminar series on precision medicine, we focus on catecholaminergic polymorphic ventricular tachycardia (CPVT). This focus on CPVT allows us to take a “deep dive” and explore the full extent of the precision medicine opportunities for a single cardiovascular condition at a level that was not possible in the preceding articles.
Paving the Way for Health Equity in Cardiology: Why Does it Matter?
Dipti Itchhaporia
doi : 10.1016/j.jacc.2021.04.025
Volume 77, Issue 20, 25 May 2021, Pages 2613-2616
Natural History and Clinical Characteristics of the First 10 Danish Families With Familial ST-Depression Syndrome
Alex H?rby Christensen, Benjamin Chris Nyholm, Christoffer Rasmus Vissing, Adrian Pietersen, ... Henning Bundgaard
doi : 10.1016/j.jacc.2021.03.313
Volume 77, Issue 20, 25 May 2021, Pages 2617-2619
The Real Offending Factor in Hypertension: Pressure or Flow?
Emre K. Aslanger
doi : 10.1016/j.jacc.2021.02.065
Volume 77, Issue 20, 25 May 2021, Page 2619
Hypertension Aggravates Atherosclerosis: A Matter of Pressure Remodeling of Myofibroblasts or LDL Accumulation?
Xinggang Wang, Junbo Ge
doi : 10.1016/j.jacc.2021.03.305
Volume 77, Issue 20, 25 May 2021, Pages 2619-2620
Reply: Hypertension-Accelerated Atherogenesis: Barely Scratching the Surface
Rozh H. Al-Mashhadi, Jacob F. Bentzon
doi : 10.1016/j.jacc.2021.03.306
Volume 77, Issue 20, 25 May 2021, Pages 2620-2621
Collateral Casualties of COVID-19
George Koulaouzidis, Dafni Charisopoulou, Anastasios Koulaouzidis
doi : 10.1016/j.jacc.2021.01.058
Volume 77, Issue 20, 25 May 2021, Pages 2621-2622
Reply: Collateral Casualties of COVID-19
Andrew J. Einstein, Joao V. Vitola, Michelle C. Williams, Leslee J. Shaw, Diana Paez
doi : 10.1016/j.jacc.2021.03.308
Volume 77, Issue 20, 25 May 2021, Pages 2622-2623
