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20 years of precision medicine in oncology
The Lancet
doi : 10.1016/S0140-6736(21)01099-0
EDITORIAL| VOLUME 397, ISSUE 10287, P1781, MAY 15, 2021
R21/Matrix-M: a second malaria vaccine?
Vasee Moorthy,Fred Binka
doi : 10.1016/S0140-6736(21)01065-5
COMMENT| VOLUME 397, ISSUE 10287, P1782-1783, MAY 15, 2021
COVID-19 vaccine impact in Israel and a way out of the pandemic
Eyal Leshem,Annelies Wilder-Smith
doi : 10.1016/S0140-6736(21)01018-7
COMMENT| VOLUME 397, ISSUE 10287, P1783-1785, MAY 15, 2021
Gain in survival after metabolic–bariatric surgery
Geltrude Mingrone,Stefan R Bornstein
doi : 10.1016/S0140-6736(21)00952-1
COMMENT| VOLUME 397, ISSUE 10287, P1785-1787, MAY 15, 2021
Recovering from Trump: Biden's first 100 days
David U Himmelstein,Steffie Woolhandler
doi : 10.1016/S0140-6736(21)00979-X
COMMENT| VOLUME 397, ISSUE 10287, P1787-1791, MAY 15, 2021
A global pandemic treaty should aim for deep prevention
Jorge Vinuales,Suerie Moon,Ginevra Le Moli,Gian-Luca Burci
doi : 10.1016/S0140-6736(21)00948-X
COMMENT| VOLUME 397, ISSUE 10287, P1791-1792, MAY 15, 2021
Health and climate change MJA–Lancet Countdown report: Australia gets another failing grade in 2020 but shows signs of progress
Nicholas J Talley,Fiona Stanley,Tamara Lucas,Richard Horton
doi : 10.1016/S0140-6736(20)32632-5
COMMENT| VOLUME 397, ISSUE 10287, E12-E14, MAY 15, 2021
Serbia begins paying citizens to receive a COVID-19 vaccine
Ed Holt
doi : 10.1016/S0140-6736(21)01097-7
WORLD REPORT| VOLUME 397, ISSUE 10287, P1793, MAY 15, 2021
COVID-19 in Turkey: a nation on edge
Kaya Genç
doi : 10.1016/S0140-6736(21)01098-9
WORLD REPORT| VOLUME 397, ISSUE 10287, P1794-1796, MAY 15, 2021
A call to arms to change capitalism
Joseph Stiglitz
doi : 10.1016/S0140-6736(21)01004-7
PERSPECTIVES|BOOK| VOLUME 397, ISSUE 10287, P1797-1799, MAY 15, 2021
Facts and values in the history of spina bifida
Bart Lutters,Thomas Schlich
doi : 10.1016/S0140-6736(21)01005-9
PERSPECTIVES|THE ART OF MEDICINE| VOLUME 397, ISSUE 10287, P1800-1801, MAY 15, 2021
Peter MacNaughton Dunn
Geoff Watts
doi : 10.1016/S0140-6736(21)01006-0
OBITUARY| VOLUME 397, ISSUE 10287, P1802, MAY 15, 2021
Canada is no global health leader on COVID-19 vaccine equity
Adam R Houston,Srinivas Murthy
doi : 10.1016/S0140-6736(21)00888-6
CORRESPONDENCE| VOLUME 397, ISSUE 10287, P1803, MAY 15, 2021
Working upstream
Mary Owen,Michael Westerhaus,Amy Finnegan,Laalitha Surapaneni,Winona LaDuke
doi : 10.1016/S0140-6736(21)00923-5
CORRESPONDENCE| VOLUME 397, ISSUE 10287, P1803-1804, MAY 15, 2021
Vaccine scarcity in LMICs is a failure of global solidarity and multilateral instruments
Irene Torres,Daniel Lopez-Cevallos,Osvaldo Artaza,Barbara Profeta,JaHyun Kang,Cristiani Vieira Machado
doi : 10.1016/S0140-6736(21)00893-X
CORRESPONDENCE| VOLUME 397, ISSUE 10287, P1804, MAY 15, 2021
Global COVID-19 vaccine roll-out: time to randomise vaccine allocation?
Samuel I Watson,Richard J Lilford
doi : 10.1016/S0140-6736(21)00895-3
CORRESPONDENCE| VOLUME 397, ISSUE 10287, P1804-1805, MAY 15, 2021
Peruvian research: striving for the highest standards
Jorge Arévalo,Francisco C Villafuerte,Martin Montes,Theresa J Ochoaon behalf of researchers from Facultad de Ciencias y Filosof?a and from Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia
doi : 10.1016/S0140-6736(21)00890-4
CORRESPONDENCE| VOLUME 397, ISSUE 10287, P1805-1806, MAY 15, 2021
Venezuela is collapsing without COVID-19 vaccines
Enrique S L?pez Loyo,Marino J Gonz?lez,José Esparza
doi : 10.1016/S0140-6736(21)00924-7
CORRESPONDENCE| VOLUME 397, ISSUE 10287, P1806, MAY 15, 2021
Long-term effects of COVID-19 on kidney function
Philipp Enghard,Jan-Hendrik Hardenberg,Helena Stockmann,Christian Hinze,Kai-Uwe Eckardt,Kai M Schmidt-Ott
doi : 10.1016/S0140-6736(21)00880-1
CORRESPONDENCE| VOLUME 397, ISSUE 10287, P1806-1807, MAY 15, 2021
Long-term effects of COVID-19 on kidney function
Pierre Delanaye,Justine Huart,Antoine Bouquegneau,François Jouret
doi : 10.1016/S0140-6736(21)00881-3
CORRESPONDENCE| VOLUME 397, ISSUE 10287, P1807, MAY 15, 2021
Long-term effects of COVID-19 on kidney function – Authors' reply
Lixue Huang,Xiaoying Gu,Yeming Wang,Chaolin Huang,Bin Cao
doi : 10.1016/S0140-6736(21)00875-8
CORRESPONDENCE| VOLUME 397, ISSUE 10287, P1807-1808, MAY 15, 2021
Department of Error
doi : 10.1016/S0140-6736(21)01067-9
DEPARTMENT OF ERROR| VOLUME 397, ISSUE 10287, P1808, MAY 15, 2021
Department of Error
doi : 10.1016/S0140-6736(21)01008-4
DEPARTMENT OF ERROR| VOLUME 397, ISSUE 10287, P1808, MAY 15, 2021
Department of Error
doi : 10.1016/S0140-6736(21)01011-4
DEPARTMENT OF ERROR| VOLUME 397, ISSUE 10287, P1808, MAY 15, 2021
Department of Error
doi : 10.1016/S0140-6736(21)01012-6
DEPARTMENT OF ERROR| VOLUME 397, ISSUE 10287, P1808, MAY 15, 2021
Department of Error
doi : 10.1016/S0140-6736(21)01010-2
DEPARTMENT OF ERROR| VOLUME 397, ISSUE 10287, P1808, MAY 15, 2021
Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial
Mehreen S Datoo,Magloire H Natama,Athanase Somé,Ousmane Traoré,Toussaint Rouamba,Duncan Bellamy,Prisca Yameogo,Daniel Valia,Moubarak Tegneri,Florence Ouedraogo,Rachidatou Soma,Seydou Sawadogo,Faizatou Sorgho,Karim Derra,Eli Rouamba,Benedict Orindi,Fernando Ramos Lopez,Amy Flaxman,Federica Cappuccini,Reshma Kailath,Sean Elias,Ekta Mukhopadhyay,Andres Noe,Matthew Cairns,Alison Lawrie,Rachel Roberts,Innocent Valéa,Hermann Sorgho,Nicola Williams,Gregory Glenn,Louis Fries,Jenny Reimer,Katie J Ewer,Umesh Shaligram,Adrian V S Hill,Halidou Tinto
doi : 10.1016/S0140-6736(21)00943-0
ARTICLES| VOLUME 397, ISSUE 10287, P1809-1818, MAY 15, 2021
Stalled progress in controlling Plasmodium falciparum malaria highlights the need for an effective and deployable vaccine. RTS,S/AS01, the most effective malaria vaccine candidate to date, demonstrated 56% efficacy over 12 months in African children. We therefore assessed a new candidate vaccine for safety and efficacy.
Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data
Eric J Haas,Frederick J Angulo,John M McLaughlin,Emilia Anis,Shepherd R Singer,Farid Khan,Nati Brooks,Meir Smaja,Gabriel Mircus,Kaijie Pan,Jo Southern,David L Swerdlow,Luis Jodar,Yeheskel Levy,Sharon Alroy-Preis
doi : 10.1016/S0140-6736(21)00947-8
ARTICLES| VOLUME 397, ISSUE 10287, P1819-1829, MAY 15, 2021
Following the emergency use authorisation of the Pfizer–BioNTech mRNA COVID-19 vaccine BNT162b2 (international non-proprietary name tozinameran) in Israel, the Ministry of Health (MoH) launched a campaign to immunise the 6·5 million residents of Israel aged 16 years and older. We estimated the real-world effectiveness of two doses of BNT162b2 against a range of SARS-CoV-2 outcomes and to evaluate the nationwide public-health impact following the widespread introduction of the vaccine.
Association of metabolic–bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174?772 participants
Nicholas L Syn,David E Cummings,Louis Z Wang,Daryl J Lin,Joseph J Zhao,Marie Loh,Zong Jie Koh,Claire Alexandra Chew,Ying Ern Loo,Bee Choo Tai,Guowei Kim,Jimmy Bok-Yan So,Lee M Kaplan,John B Dixon,Asim Shabbir
doi : 10.1016/S0140-6736(21)00591-2
ARTICLES| VOLUME 397, ISSUE 10287, P1830-1841, MAY 15, 2021
Metabolic–bariatric surgery delivers substantial weight loss and can induce remission or improvement of obesity-related risks and complications. However, more robust estimates of its effect on long-term mortality and life expectancy—especially stratified by pre-existing diabetes status—are needed to guide policy and facilitate patient counselling. We compared long-term survival outcomes of severely obese patients who received metabolic–bariatric surgery versus usual care.
Pulmonary embolism and thrombocytopenia following ChAdOx1 vaccination
Viktoria Muster,Thomas Gary,Reinhard B Raggam,Albert W?lfler,Marianne Brodmann
doi : 10.1016/S0140-6736(21)00871-0
CLINICAL PICTURE| VOLUME 397, ISSUE 10287, P1842, MAY 15, 2021
Gout
Nicola Dalbeth,Anna L Gosling,Angelo Gaffo,Abhishek Abhishek
doi : 10.1016/S0140-6736(21)00569-9
SEMINAR| VOLUME 397, ISSUE 10287, P1843-1855, MAY 15, 2021
Gout is a common and treatable disease caused by the deposition of monosodium urate crystals in articular and non-articular structures. Increased concentration of serum urate (hyperuricaemia) is the most important risk factor for the development of gout. Serum urate is regulated by urate transporters in the kidney and gut, particularly GLUT9 (SLC2A9), URAT1 (SLC22A12), and ABCG2. Activation of the NLRP3 inflammasome by monosodium urate crystals with release of IL-1? plays a major role in the initiation of the gout flare; aggregated neutrophil extracellular traps are important in the resolution phase. Although presenting as an intermittent flaring condition, gout is a chronic disease. Long-term urate lowering therapy (eg, allopurinol) leads to the dissolution of monosodium urate crystals, ultimately resulting in the prevention of gout flares and tophi and in improved quality of life. Strategies such as nurse-led care are effective in delivering high-quality gout care and lead to major improvements in patient outcomes.
Problems with traffic light approaches to public health emergencies of international concern
Clare Wenham,Matthew Kavanagh,Alexandra Phelan,Simon Rushton,Maike Voss,Sam Halabi,Mark Eccleston-Turner,Mara Pillinger
doi : 10.1016/S0140-6736(21)00474-8
VIEWPOINT| VOLUME 397, ISSUE 10287, P1856-1858, MAY 15, 2021
