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Eruptive Calcified Nodules as a Potential Mechanism of Acute Coronary Thrombosis and Sudden Death
ShoToriiMD, PhDa?YuSatoMDa?FumiyukiOtsukaMDabFrank D.KolodgiePhDaHiroyukiJinnouchiMDaAtsushiSakamotoMD, PhDaJoohyungParkMDaKazuyukiYahagiMDaKenichiSakakuraMDaAnneCornelissenMDaRikaKawakamiMDaMasayukiMoriMDaKenjiKawaiMDaFaloneAmoaMDaLiangGuoPhDaMatthewKutynaMSaRaquelFernandezBSaMaria E.RomeroMDaDavidFowlerMDcAloke V.FinnMDadRenuVirmaniMDa
doi : 10.1016/j.jacc.2021.02.016
Volume 77, Issue 13, 6 April 2021, Pages 1599-1611
Calcified nodule (CN) has a unique plaque morphology, in which an area of nodular calcification causes disruption of the fibrous cap with overlying luminal thrombus. CN is reported to be the least frequent cause of acute coronary thrombosis, and the pathogenesis of CN has not been well studied.
On the Shades of Coronary Calcium and Plaque Instability?
EloisaArbustiniMDaYuliyaVengrenyukPhDbJagatNarulaMD, PhDb
doi : 10.1016/j.jacc.2021.02.011
Volume 77, Issue 13, 6 April 2021, Pages 1612-1615
Long Working Hours and Risk of Recurrent Coronary Events
XavierTrudelPhDabChantalBrissonPhDabDenisTalbotPhDabMahéeGilbert-OuimetPhDbcAlainMilotMDbd
doi : 10.1016/j.jacc.2021.02.012
Volume 77, Issue 13, 6 April 2021, Pages 1616-1625
Evidence from prospective studies has suggested that long working hours are associated with incident coronary heart disease (CHD) events. However, no previous study has examined whether long working hours are associated with an increased risk of recurrent CHD events among patients returning to work after a first myocardial infarction (MI).
Occupational Risks of Recurrent Coronary Heart Disease?
JianLiMD, PhDaJohannesSiegristPhDb
doi : 10.1016/j.jacc.2021.02.020
Volume 77, Issue 13, 6 April 2021, Pages 1626-1628
Infective Endocarditis in Patients on Chronic Hemodialysis
Juan M.PericàsMD, PhD, MPHa?JaumeLlopisMD, PhDb?Maria Jes?sJiménez-ExpositoMD, PhDaWissam M.KouranyMDcBenitoAlmiranteMD, PhDdGiampieroCarosiMD, PhDeEmanueleDurante-MangoniMD, PhDfClaudio QueridoFortesMDgEfthymiaGiannitsiotiMD, PhDhStamatiosLerakisMDiRodrigoMontagna-MellaMDjJuanAmbrosioniMD, PhDaRu-SanTanMDkCarlos A.MestresMD, PhDlDannahWrayMDmOrathaiPachiratMD, PhDnAsuncionMorenoMD, PhDaVivian H.ChuMD, MHScElisade LazzariMScaVance G.FowlerJr.MD, MHScJose M.Mir?MD, PhDaand the
doi : 10.1016/j.jacc.2021.02.014
Volume 77, Issue 13, 6 April 2021, Pages 1629-1640
Infective endocarditis (IE) is a common and serious complication in patients receiving chronic hemodialysis (HD).
Dialysis and Endocarditis: Proving What We Know, Learning What We Didn’t?
Neel R.SodhaMD
doi : 10.1016/j.jacc.2021.02.034
Volume 77, Issue 13, 6 April 2021, Pages 1641-1643
COVID-19 in Adults With Congenital Heart Disease
Craig S.BrobergMD, MCRaAdrienne H.KovacsPhDaSorayaSadeghiBSbMarlon S.RosenbaumMDcMatthew J.LewisMD, MPHcMatthew R.CarazoMDdFred H.RodriguezIIIMDdDan G.HalpernMDeJodiFeinbergNPeFrancisca ArancibiaGalileaMDfFernandoBaraonaMDfAri M.CedarsMDgJong M.KoBSgPrashobPorayetteMDhJenniferMaldonadoBShBerardoSarubbiMDiFlaviaFuscoMDiAlexandra A.FrogoudakiMD, PhDj…Jamil A.AboulhosnMDb
doi : 10.1016/j.jacc.2021.02.023
Volume 77, Issue 13, 6 April 2021, Pages 1644-1655
Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications.
ACHD-Specific Risk Factors for Severe COVID-19?
Elisa A.BradleyMDOmerCavusMD
doi : 10.1016/j.jacc.2021.02.024
Volume 77, Issue 13, 6 April 2021, Pages 1656-1659
Therapeutic Potential of Ketone Bodies for Patients With Cardiovascular Disease: JACC State-of-the-Art Review
Salva R.YuristaMD, PhDaCher-RinChongPhDbcJuan J.BadimonPhDdDaniel P.KellyMDeRudolf A.de BoerMD, PhDaB. DaanWestenbrinkMD, PhDa
doi : 10.1016/j.jacc.2020.12.065
Volume 77, Issue 13, 6 April 2021, Pages 1660-1669
Metabolic perturbations underlie a variety of cardiovascular disease states; yet, metabolic interventions to prevent or treat these disorders are sparse. Ketones carry a negative clinical stigma as they are involved in diabetic ketoacidosis. However, evidence from both experimental and clinical research has uncovered a protective role for ketones in cardiovascular disease. Although ketones may provide supplemental fuel for the energy-starved heart, their cardiovascular effects appear to extend far beyond cardiac energetics. Indeed, ketone bodies have been shown to influence a variety of cellular processes including gene transcription, inflammation and oxidative stress, endothelial function, cardiac remodeling, and cardiovascular risk factors. This paper reviews the bioenergetic and pleiotropic effects of ketone bodies that could potentially contribute to its cardiovascular benefits based on evidence from animal and human studies.
Cardiovascular Risk in Patients With Psoriasis: JACC Review Topic of the Week
Michael S.GarshickMD, MSaNicole L.WardPhDbJames G.KruegerMD, PhDcJeffrey S.BergerMD, MSade
doi : 10.1016/j.jacc.2021.02.009
Volume 77, Issue 13, 6 April 2021, Pages 1670-1680
Psoriasis is a chronic inflammatory skin disease that affects 2% to 3% of the U.S. population. The immune response in psoriasis includes enhanced activation of T cells and myeloid cells, platelet activation, and up-regulation of interferons, tumor necrosis factor-?, and interleukins (ILs) IL-23, IL-17, and IL-6, which are linked to vascular inflammation and atherosclerosis development. Patients with psoriasis are up to 50% more likely to develop cardiovascular disease (CV) disease, and this CV risk increases with skin severity. Major society guidelines now advocate incorporating a psoriasis diagnosis into CV risk prediction and prevention strategies. Although registry data suggest treatment targeting psoriasis skin disease reduces vascular inflammation and coronary plaque burden, and may reduce CV risk, randomized placebo-controlled trials are inconclusive to date. Further studies are required to define traditional CV risk factor goals, the optimal role of lipid-lowering and antiplatelet therapy, and targeted psoriasis therapies on CV risk.
Competency-Based Medical Education for Fellowship Training During the COVID-19 Pandemic
James A.ArrighiMDaLisa A.MendesMDbShannonMcConnaugheyMDcACC Competency Management Committee
doi : 10.1016/j.jacc.2021.02.022
Volume 77, Issue 13, 6 April 2021, Pages 1681-1683
Taking a Stand Against Air Pollution—The Impact on Cardiovascular Disease: A Joint Opinion from the World Heart Federation, American College of Cardiology, American Heart Association, and the European Society of Cardiology
MichaelBrauerabBarbaraCasadeicRobert A.HarringtondRichardKovacseKarenSliwaf
doi : 10.1016/j.jacc.2020.12.003
Volume 77, Issue 13, 6 April 2021, Pages 1684-1688
Although the attention of the world and the global health community specifically is deservedly focused on the COVID-19 pandemic, other determinants of health continue to have large impacts and may also interact with COVID-19. Air pollution is one crucial example. Established evidence from other respiratory viruses and emerging evidence for COVID-19 specifically indicates that air pollution alters respiratory defense mechanisms leading to worsened infection severity. Air pollution also contributes to co-morbidities that are known to worsen outcomes amongst those infected with COVID-19, and air pollution may also enhance infection transmission due to its impact on more frequent coughing. Yet despite the massive disruption of the COVID-19 pandemic, there are reasons for optimism: broad societal lockdowns have shown us a glimpse of what a future with strong air pollution measures could yield. Thus, the urgency to combat air pollution is not diminished, but instead heightened in the context of the pandemic.
Professor Bernard Lown: An Inventor Who Saved Lives, a Man Who Fought Against Nuclear War
AntoniBayes-GenisMD, PhDabAntoniBayes de LunaMD, PhDc
doi : 10.1016/j.jacc.2021.02.050
Volume 77, Issue 13, 6 April 2021, Pages 1689-1690
Pulmonary Embolism Response Team: Additional Call Burden or a Valuable Learning Opportunity?
YevgeniyBrailovskyDO, MScaVladimirLakhterDOb
doi : 10.1016/j.jacc.2021.02.036
Volume 77, Issue 13, 6 April 2021, Pages 1691-1696
RESPONSE: Do Pulmonary Embolism Response Teams Result in Improved Outcomes in Patients With Pulmonary Embolism?
Jeffrey W.OlinDO
doi : 10.1016/j.jacc.2021.02.037
Volume 77, Issue 13, 6 April 2021, Pages 1695-1696
Trends in Ischemic Heart Disease and Cerebrovascular Disease Mortality in Europe: An Observational Study 1990–2017
MatthewHammond-HaleyMBBS, MScAdamHartleyMBBS, BScMohammedEssaMDAugustin J.DeLagoMDDominic C.MarshallMBBS, BScJustin D.SalciccioliMBBS, MAJosephShalhoubMBBS, PhD
doi : 10.1016/j.jacc.2021.02.013
Volume 77, Issue 13, 6 April 2021, Pages 1697-1698
Peculiar Paradoxical Results That Puzzle Me
Allan D.SnidermanMD
doi : 10.1016/j.jacc.2020.12.067
Volume 77, Issue 13, 6 April 2021, Pages 1698-1699
Reply: Peculiar Paradoxical Results That Puzzle Me
ShoaibAfzalMD, PhD, DMSMieBallingMDAnneLangstedMD, PhDGeorgeDavey SmithMD, DSB?rge G.NordestgaardMD, DMS
doi : 10.1016/j.jacc.2021.01.042
Volume 77, Issue 13, 6 April 2021, Pages 1699-1700
Delivering Ethnic and Racial Diversity in Cardiac Imaging Studies of COVID-19 Patients
William E.MoodyPhDRichard P.SteedsMD
doi : 10.1016/j.jacc.2020.12.069
Volume 77, Issue 13, 6 April 2021, Page 1701
Reply: Delivering Ethnic and Racial Diversity in Cardiac Imaging Studies of COVID-19 Patients
JiwonKimMDHannah W.MitlakBAJonathan W.WeinsaftMD
doi : 10.1016/j.jacc.2021.02.015
Volume 77, Issue 13, 6 April 2021, Pages 1701-1702
