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Pooled Analysis of PFO Occluder Device Trials in Patients With PFO and Migraine
Mohammad K.MojadidiMDa?PreethamKumarMDb?Ahmed N.MahmoudMDcIslam Y.ElgendyMDdHilaryShapiroMDbBrianWestMDeAndrew C.CharlesMDfHeinrich P.MattleMDgShermanSorensenMDhBernhardMeierMDiStephen D.SilbersteinMDjJonathan M.TobisMDb
doi : 10.1016/j.jacc.2020.11.068
Volume 77, Issue 6, 16 February 2021, Pages 667-676
Although observational studies have shown percutaneous patent foramen ovale (PFO) closure to be a safe means of reducing the frequency and duration of migraine, randomized clinical trials have not met their primary efficacy endpoints.
Reassessing the PFO-Migraine Trials: Are We Closer to Closure??
ZubairAhmedMDaRobert J.SommerMDb
doi : 10.1016/j.jacc.2020.12.017
Volume 77, Issue 6, 16 February 2021, Pages 677-679
Intracranial Atherosclerotic Plaque as a Potential Cause of Embolic Stroke of Undetermined Source
LinTaoMMaXiao-QiuLiMDaXiao-WenHouMDaBen-QiangYangMDbChengXiaMDaGeorgeNtaiosMD, PhDcHui-ShengChenMDa
doi : 10.1016/j.jacc.2020.12.015
Volume 77, Issue 6, 16 February 2021, Pages 680-691
Previous studies investigated the potential mechanism of embolic stroke of undetermined source (ESUS) from extracranial artery plaque, but there has been no study other than a case report on high-risk intracranial plaque in ESUS.
Intracranial Atherosclerotic Plaque and Embolic Stroke of Undetermined Source: Another Piece of the Puzzle?
Robert G.HartMDaKanjana S.PereraMBBSb
doi : 10.1016/j.jacc.2020.12.041
Volume 77, Issue 6, 16 February 2021, Pages 692-694
Natriuretic Equation to Predict Loop Diuretic Response in Patients With Heart Failure
Veena S.RaoPhDa?Juan B.Ivey-MirandaMDab?Zachary L.CoxPharmDcRalphRielloPharmDdMatthewGriffinMDaJamesFlemingBAaRichardSoucierMDaPrasamaSangkachandMSN, RNdMargaretO’BrienRNdFrancineLoRussoRNdJulieD’AmbrosiPharmDdKeithChurchwellMDdDevinMahoneyBSaLavanyaBellumkondaMDaJennifer L.AsherDVM, MSeChristopherMaulionMDaJeffrey M.TurnerMDfF. PerryWilsonMD, MSCEg…Jeffrey M.TestaniMD, MTRa
doi : 10.1016/j.jacc.2020.12.022
Volume 77, Issue 6, 16 February 2021, Pages 695-708
Most acute decompensated heart failure admissions are driven by congestion. However, residual congestion is common and often driven by the lack of reliable tools to titrate diuretic therapy. The authors previously developed a natriuretic response prediction equation (NRPE), which predicts sodium output using a spot urine sample collected 2 h after loop diuretic administration.
Improving In-Hospital Diuretic Therapy for Heart Failure: The Need for High-Quality Evidence?
G. MichaelFelkerMD, MHSStephen J.GreeneMD
doi : 10.1016/j.jacc.2020.12.018
Volume 77, Issue 6, 16 February 2021, Pages 709-712
Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation
Philippe B.BertrandMD, PhDa?Jessica R.OverbeyDrPHb?XinZengMD, PhDaRobert A.LevineMDaGoravAilawadiMDcMichael A.AckerMDdPeter K.SmithMDeVinod H.ThouraniMDfEmiliaBagiellaPhDbMarissa A.MillerDVM, MPHgLopaGuptaMPHbMichael J.MackMDhA. MarcGillinovMDiGennaroGiustinoMDbAlan J.MoskowitzMDbAnnetine C.GelijnsPhDbMichael E.BowdishMDjPatrick T.O’GaraMDk…YanneToulgoat-Dubois
doi : 10.1016/j.jacc.2020.11.066
Volume 77, Issue 6, 16 February 2021, Pages 713-724
Whether to repair nonsevere tricuspid regurgitation (TR) during surgery for ischemic mitral valve regurgitation (IMR) remains uncertain.
The Tricuspid Valve: No Longer Forgotten But Still Not Well Understood?
Stephanie L.MickMD
doi : 10.1016/j.jacc.2020.12.012
Volume 77, Issue 6, 16 February 2021, Pages 725-727
Absolute Coronary Blood Flow Measured by Continuous Thermodilution in Patients With Ischemia and Nonobstructive Disease
Regina E.KonstMDaSuzette E.Elias-SmaleMD, PhDaDarioPellegriniMDbMariëlleHartzema-MeijerMScaBas J.C.van UdenRNaTijn P.J.JansenMDaPriyaVartPhDacHelmutGehlmannMDaAngela H.E.M.MaasMD, PhDaNielsvan RoyenMD, PhDaPeterDammanMD, PhDa
doi : 10.1016/j.jacc.2020.12.019
Volume 77, Issue 6, 16 February 2021, Pages 728-741
Intracoronary continuous thermodilution is a novel technique to quantify absolute coronary flow (Q) and resistance (R) and has potential advantages over current methods such as coronary flow reserve (CFR) and index of microvascular resistance (IMR). However, no data are available in patients with ischemia and nonobstructive coronary artery disease (INOCA).
Measurement of Absolute Coronary Blood Flow and Microvascular Resistance: A New Window to Coronary Microcirculation?
Nico H.J.PijlsMD, PhDAnnemiek M.J.de VosMDDaniëlle C.J.KeulardsMD
doi : 10.1016/j.jacc.2020.12.016
Volume 77, Issue 6, 16 February 2021, Pages 742-744
Leptin in Leanness and Obesity: JACC State-of-the-Art Review
NikolaosPerakakisMDOlivia M.FarrPhDChristos S.MantzorosMD
doi : 10.1016/j.jacc.2020.11.069
Volume 77, Issue 6, 16 February 2021, Pages 745-760
Leptin has emerged over the past 2 decades as a key hormone secreted by adipose tissue that conveys information on energy stores. Leptin is considered an important regulator of both neuroendocrine function and energy homeostasis. Numerous studies (mainly preclinical and much less in humans) have investigated the mechanisms of leptin’s actions both in the healthy state as well as in a wide range of metabolic diseases. In this review, the authors present leptin physiology and review the main findings from animal studies, observational and interventional studies, and clinical trials in humans that have investigated the role of leptin in metabolism and cardiometabolic diseases (energy deficiency, obesity, diabetes, cardiovascular diseases, nonalcoholic fatty liver disease). The authors discuss the similarities and discrepancies between animal and human biology and present clinical applications of leptin, directions for future research, and current approaches for the development of the next-generation leptin analogs.
Preventing Arrhythmic Death in Patients With Tetralogy of Fallot: JACC Review Topic of the Week
Mitchell I.CohenMDaPaulKhairyMD, PhDbKatjaZeppenfeldMD, PhDcGeorge F.Van HareMDdDhanunjaya R.LakkireddyMDeJohn K.TriedmanMDf
doi : 10.1016/j.jacc.2020.12.021
Volume 77, Issue 6, 16 February 2021, Pages 761-771
Patients with tetralogy of Fallot are at risk for ventricular arrhythmias and sudden cardiac death. These abnormalities are associated with pulmonary regurgitation, right ventricular enlargement, and a substrate of discrete, slowly-conducting isthmuses. Although these arrhythmic events are rare, their prediction is challenging. This review will address contemporary risk assessment and prevention strategies. Numerous variables have been proposed to predict who would benefit from an implantable cardioverter-defibrillator. Current risk stratification models combine independently associated factors into risk scores. Cardiac magnetic resonance imaging, QRS fragmentation assessment, and electrophysiology testing in selected patients may refine some of these models. Interaction between right and left ventricular function is emerging as a critical factor in our understanding of disease progression and risk assessment. Multicenter studies evaluating risk factors and risk mitigating strategies such as pulmonary valve replacement, ablative strategies, and use of implantable cardiac-defibrillators are needed moving forward.
2021 Update to the 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart Failure Treatment: Answers to 10 Pivotal Issues About Heart Failure With Reduced Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee
Writing CommitteeThomas M.MaddoxMD, MSc, FACC(Chair)James L.JanuzziJr.MD, FACC(Vice Chair)Larry A.AllenMD, MHS, FACCKhadijahBreathettMD, MS, FACCJavedButlerMD, MBA, MPH, FACCLeslie L.DavisPhD, RN, ANP-BC, FACCGregg C.FonarowMD, FACCNasrien E.IbrahimMD, FACCJoAnnLindenfeldMD, FACCFrederick A.MasoudiMD, MSPH, FACCShweta R.MotiwalaMD, MPHEstefaniaOliverosMD, MScJ. HerbertPattersonPharmDMary NorineWalshMD, MACCAlanWassermanMD, FACCClyde W.YancyMD, MSc, MACCQuentin R.YoumansMD
doi : 10.1016/j.jacc.2020.11.022
Volume 77, Issue 6, 16 February 2021, Pages 772-810
2021 ACC Expert Consensus Decision Pathway on Same-Day Discharge After Percutaneous Coronary Intervention: A Report of the American College of Cardiology Solution Set Oversight Committee
Writing CommitteeSunil V.RaoMD, FACC(Chair)Mladen I.VidovichMD, FACC(Vice Chair)Ian C.GilchristMD, FACCRajivGulatiMD, PhD, FACCJ. AntonioGutierrezMD, MHSConnie N.HessMD, MHS, FACCPrashantKaulMD, FACCSara C.MartinezMD, PhD, FACCJenniferRymerMD, MBA
doi : 10.1016/j.jacc.2020.11.013
Volume 77, Issue 6, 16 February 2021, Pages 811-825
Acute and Healed Myocardial Infarctions as Cause of Sudden Death: Age and Sex Differences
Bj?rn O.M?hleMD, PhDTorill M.BarrettMDGretheAlbrektsenPhDEinarSvendsenMD, PhD†Peer K.LillengMD, PhDIngeMorildMD, PhD
doi : 10.1016/j.jacc.2020.11.070
Volume 77, Issue 6, 16 February 2021, Pages 826-827
Multimodal Strategy for Myocardial Protection During Cardiac Surgery: The ProCCard Study
PascalChiariMD, PhDNathanMewtonMD, PhDDelphineMaucort-BoulchMD, PhDOlivierDesebbeMDMichelDurandMDMarc-OlivierFischerMD, PhDDianeLena-QuintardMDJean-CharlesPalaoMDMichelOvizeMD, PhDJean-LucFellahiMD, PhD
doi : 10.1016/j.jacc.2020.12.020
Volume 77, Issue 6, 16 February 2021, Pages 827-829
Impact of Sex Differences in Incident and Recurrent Coronary Events and All-Cause Mortality
CelestinoSarduMD, MSc, PhDGiuseppePaolissoMDRaffaeleMarfellaMD, PhD
doi : 10.1016/j.jacc.2020.10.059
Volume 77, Issue 6, 16 February 2021, Pages 829-830
Sex Differences in Coronary Risk on Both Absolute and Relative Scales
HideakiKanedaMD, PhD
doi : 10.1016/j.jacc.2020.11.064
Volume 77, Issue 6, 16 February 2021, Pages 831-832
Reply: Sex Differences in Coronary Risk on the Absolute and Relative Scale and Underlying Mechanisms
Sanne A.E.PetersPhDPaulMuntnerPhDMarkWoodwardPhD
doi : 10.1016/j.jacc.2020.12.010
Volume 77, Issue 6, 16 February 2021, Page 832
TAVR Versus SAVR or Valve Versus Valve?
DritanUseiniMD
doi : 10.1016/j.jacc.2020.11.065
Volume 77, Issue 6, 16 February 2021, Pages 832-833
Reply: TAVR Versus SAVR or Valve Versus Valve?
JulienTernacleMD, PhDPhilippePibarotDVM, PhDRebecca T.HahnMD
doi : 10.1016/j.jacc.2020.12.011
Volume 77, Issue 6, 16 February 2021, Pages 833-834
