Journal of Investigative Dermatology




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Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease

William TylerFrantz12Craig J.Ceol12

doi : 10.1016/j.jid.2021.10.016

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SnapshotDx Quiz: March 2022

Jorge A.Lázaro-Escudero1Emily Y.Chu1

doi : 10.1016/j.jid.2021.12.011

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Cells to Surgery Quiz: March 2022

ShannonNugent1Harold WilliamHigginsII2

doi : 10.1016/j.jid.2021.12.002

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The Origins of Merkel Cell Carcinoma: Defining Paths to the Neuroendocrine Phenotype

Kenneth Y.Tsai12

doi : 10.1016/j.jid.2021.11.011

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New Key Players in Irritant Contact Dermatitis: Residential Skin Cells and Neutrophils Drive Inflammation

AnttiLauerma1PaulinaWerner2LukasWisgrill3NannaFyhrquist2

doi : 10.1016/j.jid.2021.09.002

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Exhausted Markers in Cutaneous T-Cell Lymphoma: The Face that Launched a Thousand Ships

Tony T.Jiang1Oleg E.Akilov1

doi : 10.1016/j.jid.2021.09.003

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Merkel Cell Polyomavirus‒Negative Merkel Cell Carcinoma Originating from In Situ Squamous Cell Carcinoma: A Keratinocytic Tumor with Neuroendocrine Differentiation

ThibaultKervarrec12318SilkeAppenzeller418MahtabSamimi25BhavishyaSarma3Eva-MariaSarosi3PatriciaBerthon2YannickLe Corre6EwaHainaut-Wierzbicka7AstridBlom8NathalieBenethon9GuidoBens10CharlineNardin11FrancoisAubin11MonicaDinulescu1213Marie-LaureJullie14�gnesPekár-Lukacs1516EduardoCalonje16SoumanthThanguturi1…DavidSchrama319

doi : 10.1016/j.jid.2021.07.175

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Genomic Progression of Precancerous Actinic Keratosis to Squamous Cell Carcinoma

Yoon-SeobKim123SunShin123Seung-HyunJung4Young MinPark5Gyeong SinPark6Sug HyungLee789Yeun-JunChung1239

doi : 10.1016/j.jid.2021.07.172

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Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes

NorihiroFujimoto1MinoruAkiyama1YasushiSatoh2ShingoTajima1

doi : 10.1016/j.jid.2021.04.038

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Immunocompromised Patients with Therapy-Refractory Chronic Skin Diseases Show Reactivation of Latent Epstein‒Barr Virus and Cytomegalovirus Infection

PhilippSpeth17ManjaJargosch17PeterSeiringer1KristinaSchwamborn2TanjaBauer3CoraScheerer1UlrikeProtzer3CarstenSchmidt-Weber4TiloBiedermann1StefanieEyerich48NatalieGarzorz-Stark1568

doi : 10.1016/j.jid.2021.07.171

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Tofacitinib Suppresses IL-10/IL-10R Signaling and Modulates Host Defense Responses in Human Macrophages

KristinKnoke1Robert R.Rongisch1Katarzyna M.Grzes2RomanSchwarz3BeateLorenz1NirYogev1Erika L.Pearce24Edward J.Pearce245David M.Kofler6MarioFabri1

doi : 10.1016/j.jid.2021.07.180

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CCL2‒CCR2 Signaling in the Skin Drives Surfactant-Induced Irritant Contact Dermatitis through IL-1β‒Mediated Neutrophil Accumulation

RintaroShibuya1YoshihiroIshida1ShoHanakawa23Tatsuki R.Kataoka4YasuhideTakeuchi5TeruasaMurata1ArisaAkagi1ZacharyChow23ToshiakiKogame1SatoshiNakamizo1SaekoNakajima1GyoheiEgawa1TakashiNomura1NaotomoKambe1AkihikoKitoh123KenjiKabashima123

doi : 10.1016/j.jid.2021.07.182

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Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation

MorganDragan1238PengSun18ZeyuChen145XianghuiMa1RemyVu12YulingShi56S. ArmandoVillalta37XingDai123

doi : 10.1016/j.jid.2021.08.397

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Specific β-Defensins Stimulate Pruritus through Activation of Sensory Neurons

Pang-YenTseng1Mark A.Hoon1

doi : 10.1016/j.jid.2021.07.178

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MicroRNA Regulation of T-Cell Exhaustion in Cutaneous T Cell Lymphoma

ZhenHan12Renee J.Estephan3XiweiWu24ChingyuSu12Yate-ChingYuan25HanjunQin24Sung HeeKil12CoreyMorales26DanielSchmolze7James F.Sanchez26LeiTian26JianhuaYu26MarcinKortylewski28Steven T.Rosen26ChristianeQuerfeld1267

doi : 10.1016/j.jid.2021.08.447

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Combined Cyclin-Dependent Kinase Inhibition Overcomes MAPK/Extracellular Signal–Regulated Kinase Kinase Inhibitor Resistance in Plexiform Neurofibroma of Neurofibromatosis Type I

WeiWang13Xi-WeiCui13Yi-HuiGu13Cheng-JiangWei1Yue-HuaLi1Jie-YiRen1Man-HonChung1Re-han-gu-liAimaier1Hai-BingZhang2Qing-FengLi14Zhi-ChaoWang14

doi : 10.1016/j.jid.2021.07.164

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Positive Allosteric Modulation of A2AR Alters Immune Cell Responses and Ameliorates Psoriasis-Like Dermatitis in Mice

AjithWelihinda1PujaRavikumar1ManmeetKaur1JordanMechanic1ShrutiYadav1Gyeong JinKang1EdwardAmento1

doi : 10.1016/j.jid.2021.07.174

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Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency

NicoleBerndt1ChristineWolf2KristinaFischer1EmanuelCura Costa3PeterKnuschke1NickZimmermann1FranziskaSchmidt1MartinMerkel1OsvaldoChara34Min AeLee-Kirsch2ClaudiaGünther1

doi : 10.1016/j.jid.2021.04.037

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Viral Status Predicts the Patterns of Genome Methylation and Decitabine Response in Merkel Cell Carcinoma

Paul W.Harms123410Monique E.Verhaegen410Josh N.Vo12Jean C.Tien12DrewPratt1FengyunSu12Saravana M.Dhanasekaran12XuhongCao125DorisMangelberger4JuliaVanGoor6Jae EunChoi12Vincent T.Ma7Andrzej A.Dlugosz348Arul M.Chinnaiyan12359

doi : 10.1016/j.jid.2021.07.173

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Activin A Sustains the Metastatic Phenotype of Tumor-Associated Macrophages and Is a Prognostic Marker in Human Cutaneous Melanoma

AlbaGutiérrez-Seijo12ElenaGarcía-Martínez12CeliaBarrio-Alonso12VerónicaParra-Blanco3José AntonioAvilés-Izquierdo4PalomaSánchez-Mateos256RafaelSamaniego16

doi : 10.1016/j.jid.2021.07.179

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Role of Exosomes in Dermal Wound Healing: A Systematic Review

AneshPrasai1Jayson W.Jay1DanielJupiter1Steven E.Wolf1AminaEl Ayadi1

doi : 10.1016/j.jid.2021.07.167

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Oncostatin M Improves Cutaneous Wound Re-Epithelialization and Is Deficient under Diabetic Conditions

AmitavaDas1Amit K.Madeshiya1NirupamBiswas1NandiniGhosh1MahadeoGorain1AtulRawat1Sanskruti P.Mahajan1SavitaKhanna1Chandan K.Sen1SashwatiRoy1

doi : 10.1016/j.jid.2021.04.039

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IL-10 Dysregulation Underlies Chemokine Insufficiency, Delayed Macrophage Response, and Impaired Healing in Diabetic Wounds

RuchiRoy12JanetZayas123Mohamed F.Mohamed12AnahitaAboonabi12KayleeDelgado12JennilleeWallace3MohammadBayat45Timothy M.Kuzel12JochenReiser1Sasha H.Shafikhani1236

doi : 10.1016/j.jid.2021.08.428

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Single-Cell Analysis Reveals Major Histocompatibility Complex II‒Expressing Keratinocytes in Pressure Ulcers with Worse Healing Outcomes

DongqingLi18ShangliCheng238YuPei29PehrSommar49JaanikaKärner59Eva K.Herter1Maria A.Toma1LetianZhang1KimPham1Yuen TingCheung1ZhuangLiu1XingqiChen6LivEidsmo57QiaolinDeng210NingXu Landén1310

doi : 10.1016/j.jid.2021.07.176

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Core Gene Signatures of Atopic Dermatitis Using Public RNA-Sequencing Resources: Comparison of Bulk Approach with Single-Cell Approach

Kyung BaeChung123JongwookOh123Won SeokRoh12Tae-GyunKim124Do-YoungKim124

doi : 10.1016/j.jid.2021.07.169

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Atopic Dermatitis and Frequency of Der p 11 Binding as a Major Allergen Revisited

RupertoGonzález-Pérez12PalomaPoza-Guedes12FernandoPineda3MiriamCastillo3VíctorMatheu1ElenaMederos-Luis1CristinaAlava-Cruz1InmaculadaSánchez-Machín1

doi : 10.1016/j.jid.2021.05.037

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Response to González-Pérez et al

PiaGattinger15Huey-JyHuang15RudolfValenta1234SusanneVrtala1

doi : 10.1016/j.jid.2021.09.006

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B Lymphocytes Accumulate and Proliferate in Human Skin at Sites of Cutaneous Antigen Challenge

Isioma U.Egbuniwe12Robert J.Harris1ManoNakamura1Frank O.Nestle13Arne N.Akbar4Sophia N.Karagiannis15Katie E.Lacy1

doi : 10.1016/j.jid.2021.06.038

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Itch in Lichen Simplex Chronicus Is Associated with Localized Small Fiber Neuropathy

MauricioSandoval1JulioParra1MauricioReyna-Jeldes23MaximilianoCuri-Tuma1FernandaEspinoza34DanielaMuñoz4María JesúsRojas-Lechuga1ClaudioCoddou23David L.H.Bennett5MargaritaCalvo34

doi : 10.1016/j.jid.2021.08.429

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Coexpression of MTH1 and PMS2 Is Associated with Advanced Disease and Disease Progression after Therapy in Melanoma

IshaniDas1RainerTuominen1ThomasHelleday23JohanHansson1UlrikaWarpman Berglund24SuzanneEgyházi Brage1

doi : 10.1016/j.jid.2021.07.166

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The Temporal Evolution of Distinct Skin Surface Microbiome in Asian Patients with Severe Hidradenitis Suppurativa during Effective Adalimumab Treatment

Ting-JungHsu13Hsu-HangYeh23Chih-HungLee1Han-ChiTseng1

doi : 10.1016/j.jid.2021.07.168

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A Personal Perspective on a Special Issue

Mark C.UdeyMD, PhD(Editor)

doi : 10.1016/j.jid.2021.12.001

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Autoantibody-Mediated Macrophage Responses Provide the Missing Link between Innate and Adaptive Immune Dysfunction in Hidradenitis Suppurativa

John W.Frew123

doi : 10.1016/j.jid.2021.08.400

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Antigen Processing, Presentation, and Tolerance: Role in Autoimmune Skin Diseases

Jörg ChristophPrinz1

doi : 10.1016/j.jid.2021.05.009

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Loss of AIRE-Mediated Immune Tolerance and the Skin

PärtPeterson1KaiKisand1NicolasKluger2AnnamariRanki2

doi : 10.1016/j.jid.2021.04.022

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CD1-Restricted T Cells in Inflammatory Skin Diseases

SamanthaGenardi1EvaMorgun1Chyung-RuWang1

doi : 10.1016/j.jid.2021.03.033

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Regulatory T Cells and Inflammatory Mediators in Autoimmune Disease

VictoireGouirand12IreneuszHabrylo12Michael D.Rosenblum1

doi : 10.1016/j.jid.2021.05.010

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Autoinflammation: Interferonopathies and Other Autoinflammatory Diseases

SinisaSavic123JamesCoe4PhilipLaws4

doi : 10.1016/j.jid.2021.07.189

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Type I Interferons in Autoimmunity

RuthFernandez-Ruiz1Timothy B.Niewold2

doi : 10.1016/j.jid.2021.11.031

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T-Cell‒Mediated Autoimmunity: Mechanisms and Future Directions

PeterSeiringer12NatalieGarzorz-Stark1345KilianEyerich1345

doi : 10.1016/j.jid.2021.04.032

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B- and Plasma Cell Subsets in Autoimmune Diseases: Translational Perspectives

Van DucDang123Ana-LuisaStefanski12Andreia C.Lino12ThomasDörner12

doi : 10.1016/j.jid.2021.05.038

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Neutrophils as Drivers of Immune Dysregulation in Autoimmune Diseases with Skin Manifestations

ShuichiroNakabo13JorgeRomo-Tena123Mariana J.Kaplan1

doi : 10.1016/j.jid.2021.04.014

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Skin Deep: The Role of the Microbiota in Cutaneous Autoimmunity

Márcia S.Pereira14SylvioRedanz14Martin A.Kriegel123

doi : 10.1016/j.jid.2021.12.005

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Neuron‒Mast Cell Cross-Talk in the Skin

ShiqunZhang123Tina L.Sumpter123Daniel H.Kaplan12

doi : 10.1016/j.jid.2021.10.006

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Mechanisms of Photosensitivity in Autoimmunity

Mitra P.Maz124JonMusai1J. MichelleKahlenberg13

doi : 10.1016/j.jid.2021.05.007

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Sex Bias and Autoimmune Diseases

EnzeXing1Allison C.Billi1Johann E.Gudjonsson12

doi : 10.1016/j.jid.2021.06.008

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Regulation of IL-17A–Producing Cells in Skin Inflammatory Disorders

PushpaPandiyan12Thomas S.McCormick3

doi : 10.1016/j.jid.2021.06.036

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Immunophenotypic Analysis Reveals Differences in Circulating Immune Cells in the Peripheral Blood of Patients with Segmental and Nonsegmental Vitiligo

MarcellaWillemsen1Nicoline F.Post1Nathalie O.P.van Uden1Vidhya S.Narayan1SaskiaChielie1E. HelenKemp2Marcel W.Bekkenk1Rosalie M.Luiten1

doi : 10.1016/j.jid.2021.05.022

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Mouse Models of Psoriasis: A Comprehensive Review

Roopesh SinghGangwar1Johann E.Gudjonsson2Nicole L.Ward1

doi : 10.1016/j.jid.2021.06.019

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Cytosolic DNA‒Mediated STING-Dependent Inflammation Contributes to the Progression of Psoriasis

YongshengYu15XiaochunXue25WendongTang35LiSu4LeiZhang1YuefanZhang1

doi : 10.1016/j.jid.2021.08.430

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Pemphigus and Pemphigoid: From Disease Mechanisms to Druggable Pathways

Christoph T.Ellebrecht1DamianMaseda1Aimee S.Payne1

doi : 10.1016/j.jid.2021.04.040

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Human Desmocollin 3‒Specific IgG Antibodies Are Pathogenic in a Humanized HLA Class II Transgenic Mouse Model of Pemphigus

ChristophHudemann18RobertoMaglie128MariaLlamazares-Prada13BenediktBeckert4DarioDidona1RitvaTikkanen4ThomasSchmitt5TakashiHashimoto6JensWaschke5MichaelHertl19RüdigerEming179

doi : 10.1016/j.jid.2021.06.017

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Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages

CarmeloCarmona-Rivera1Liam J.O’Neil2EduardoPatino-Martinez1William D.Shipman3ChengsongZhu4Quan-ZhenLi4Michelle L.Kerns5Leandra A.Barnes6Julie A.Caffrey7SewonKang5Mariana J.Kaplan1Ginette A.Okoye58Angel S.Byrd58

doi : 10.1016/j.jid.2021.07.187

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Cutaneous Lupus Erythematosus and Dermatomyositis: Utilizing Assessment Tools for Treatment Efficacy

Benjamin F.Chong1VictoriaWerth(Victoria)M.D.23

doi : 10.1016/j.jid.2021.09.036

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Applying Early Intervention Strategies to Autoimmune Skin Diseases. Is the Window of Opportunity Preclinical? A Dermato-Rheumatology Perspective

Lucy M.Carter1DennisMcGonagle12Edward M.Vital12MiriamWittmann12

doi : 10.1016/j.jid.2021.11.018

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Immune Checkpoint Blockade and Skin Toxicity Pathogenesis

BarbaraMa123NiroshanaAnandasabapathy234

doi : 10.1016/j.jid.2021.06.040

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Risk of Progression to Autoimmune Disease in Severe Drug Eruption: Risk Factors and the Factor-Guided Stratification

YoshikoMizukawa1YumiAoyama2HayatoTakahashi3RyoTakahashi4TetsuoShiohara1

doi : 10.1016/j.jid.2021.11.008

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Targeted Therapies in Autoimmune Skin Diseases

ChristineBraegelmann1DennisNiebel1JoergWenzel1

doi : 10.1016/j.jid.2021.08.439

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Senescent Progenitor Cells in the Skin of Patients with Cutaneous Lupus Erythematosus

XiaoyanWang13GillesDiercks2Wietske M.Lambers1JohannaWestra1HendrikaBootsma1Frans G.M.Kroese1Karinade Leeuw1SarahPringle1

doi : 10.1016/j.jid.2021.06.022

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Pathogenic Autoantibody Derived from Regulatory T Cell‒Deficient Scurfy Mice Targets Type VII Collagen and Leads to Epidermolysis Bullosa Acquisita‒Like Blistering Disease

ElisabethVicari1StefanieHaeberle1VanessaBolduan1TorbenRamcke1ArtemVorobyev23StephanieGoletz3HiroakiIwata4Ralf J.Ludwig23EnnoSchmidt23Alexander H.Enk16Eva N.Hadaschik156

doi : 10.1016/j.jid.2021.08.441

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A 1,035-Subject Study Suggesting a History of Bone Fracture as a Possible Factor Associated with the Development of Anti-BP180 Autoantibodies

YosukeMai1KentaroIzumi1KaoriSawada2EijiroAkasaka3ShokoMai1DaisukeSawamura3KazushigeIhara2ShigeyukiNakaji2WataruNishie1

doi : 10.1016/j.jid.2021.11.028

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