Journal of Allergy and Clinical Immunology




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Cover 1

doi : 10.1016/S0091-6749(21)01769-3

Volume 149, Issue 1, January 2022, Page OFC

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Emerging strategies for treating autoimmune disorders with genetically modified Treg cells

Dominic A.BoardmanPhDabMegan K.LevingsPhDabc

doi : 10.1016/j.jaci.2021.11.007

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Deconvoluting the heterogeneity of SLE: The contribution of ancestry

Katherine A.OwenPhDAmrie C.GrammerPhDPeter E.LipskyMD

doi : 10.1016/j.jaci.2021.11.005

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Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity

AristineChengMDabSteven M.HollandMDa

doi : 10.1016/j.jaci.2021.11.016

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News Beyond Our Pages

Marc E.RothenbergMD, PhD∗JeanBousquetMD∗

doi : 10.1016/j.jaci.2021.11.006

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Antibody-mediated neuropsychiatric disorders

JosepDalmauMD, PhD, FAANabcdeFrancescGrausMD, PhDa

doi : 10.1016/j.jaci.2021.11.008

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The epithelial barrier hypothesis proposes a comprehensive understanding of the origins of allergic and other chronic noncommunicable diseases

Cezmi A.AkdisMD

doi : 10.1016/j.jaci.2021.11.010

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Dynamic manifestation of autoimmune diseases in skin—cytokine hubs and paradoxic reactions

ShuaiShaoMD, PhDabAllison C.BilliMD, PhDbJohann E.GudjonssonMD, PhDb

doi : 10.1016/j.jaci.2021.11.014

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Autoimmune consequences of biologics

RashmiDhitalMDArthurKavanaughMD

doi : 10.1016/j.jaci.2021.11.011

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BCG vaccine’s off-target effects on allergic, inflammatory, and autoimmune diseases: Worth another shot?

AsimeniaAngelidouMD, PhDabcLaure F.PittetMD, PhDdefDeniseFaustmanMD, PhDcgNigelCurtisMBBS, PhDdhOferLevyMD, PhDbci

doi : 10.1016/j.jaci.2021.09.034

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Transcriptomic drug-response gene signatures are informative for the stratification of patients for clinical trials

Paul S.FosterPhD, DScacJessica L.BarnesBScacHock L.TayPhDacPeter G.GibsonMBBS, DMedbc

doi : 10.1016/j.jaci.2021.09.021

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Of mice and men, MMXXI: Anaphylaxis

Thomas A.E.Platts-MillsMD, PhDRyan C.EidMDBehnamKeshavarzPhD

doi : 10.1016/j.jaci.2021.08.029

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Immune checkpoint molecules on ILC2s as potential therapeutic targets for allergic diseases

HideakiMoritaMD, PhDabHirohisaSaitoMD, PhDaKenjiMatsumotoMD, PhDa

doi : 10.1016/j.jaci.2021.10.021

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COVID-19 as an infectome paradigm of autoimmunity

AradDotanBScabNaimMahroumMDabcDimitrios P.BogdanosMD, PhDdYehudaShoenfeldMDabef

doi : 10.1016/j.jaci.2021.11.009

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SARS-CoV-2–specific B- and T-cell immunity in a population-based study of young Swedish adults

SophiaBjörkanderPhDaLikunDuPhDbFangleiZuoPhDbSandraEkströmPhDcdYatingWangMScbHuiWanMScbNataliaSherinaPhDbLisanneSchoutensMScbJuniAndréllPhDeNiklasAnderssonMSccAntoniosGeorgelisPhDcdAnnaBergströmPhDcdHaroldMarcottePhDfIngerKullPhDagLennartHammarströmMD, PhDbErikMelénMD, PhDacgQiangPan-HammarströmMD, PhDb

doi : 10.1016/j.jaci.2021.10.014

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Impaired memory B-cell response to the Pfizer-BioNTech COVID-19 vaccine in patients with common variable immunodeficiency

AneFernandez SalinasBDabEvaPiano MortariPhDbSaraTerreriPhDbCinziaMilitoPhDaSalvatoreZaffinaMDcdCarlo FedericoPernoMDefFrancoLocatelliMDghIsabellaQuintiMDaRitaCarsettiMDbi

doi : 10.1016/j.jaci.2021.08.031

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Reply

DavidHaginMD, PhDabNatalia T.FreundPhDb

doi : 10.1016/j.jaci.2021.08.032

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TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk

Liza BronnerMurrisonPhDab∗XiaomengRenPhDb∗KristinaPreussePhDcHuaHeMSdJohnKronerMSbXiaotingChenPhDeSethJenkinsBSbElisabetJohanssonPhDbJocelyn M.BiaginiPhDabMatthew T.WeirauchPhDaefgRaphaelKopanPhDacLisa J.MartinPhDadGurjit K.Khurana HersheyMD, PhDab

doi : 10.1016/j.jaci.2021.05.033

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Mapping atopic dermatitis and anti–IL-22 response signatures to type 2–low severe neutrophilic asthma

Yusef EamonBadiMScabcAna B.PavelPhDde∗SteliosPavlidisPhDc‡John H.RileyPhDfStewartBatesPhDfNazanin ZounematKermaniPhDcRichardKnowlesPhDgJohanKolmertPhDhiCraig E.WheelockPhDiSallyWorsleyMScjMohibUddinPhDkKjellAlvingPhDlPer S.BakkeMDmAnnelieBehndigMD, PhDnMassimoCarusoMDoPascalChanezMDpLouise J.FlemingMDabStephen J.FowlerMD, PhDqr…Ian M.AdcockPhDab

doi : 10.1016/j.jaci.2021.04.010

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Metabolome subtyping of severe bronchiolitis in infancy and risk of childhood asthma

ZhaozhongZhuScDaCarlos A.CamargoJr.MD, DrPHaYoshihikoRaitaMD, MPH, MMScaMichimasaFujiogiMDaLimingLiangPhDbcEugene P.RheeMDdPrescott G.WoodruffMD, MPHeKoheiHasegawaMD, MPHa

doi : 10.1016/j.jaci.2021.05.036

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Dual role for CXCR3 and CCR5 in asthmatic type 1 inflammation

MarcGauthierMDa∗Sagar LaxmanKalePhDa∗Timothy B.OrissPhDabKathrynSchollBSaSudiptaDasPhDaHuijuanYuanPhDaSanmeiHuMSaJieChenMEaMatthewCamioloMD, PhDaPrabirRayPhDabSallyWenzelMDacAnuradhaRayPhDab

doi : 10.1016/j.jaci.2021.05.044

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Unraveling heterogeneity in pediatric atopic dermatitis: Identification of serum biomarker based patient clusters

Daphne S.BakkerMDabMarliesde GraafMD, PhDaStefanNierkensPhDbEveline M.DelemarreMD, PhDbEdwardKnolPhDbFemkevan WijkPhDbMarjolein S.de Bruin-WellerMD, PhDaJuliaDrylewiczPhDb∗Judith L.ThijsMD, PhDa∗

doi : 10.1016/j.jaci.2021.06.029

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High inflammation in hidradenitis suppurativa extends to perilesional skin and can be subdivided by lipocalin-2 expression

KristinaNavrazhinaBAabSandraGarcetPhDaXiuzhongZhengMScaHong BeomHurBScJohn W.FrewMBBSaJames G.KruegerMD, PhDa

doi : 10.1016/j.jaci.2021.05.027

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Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors

Christopher H.ArehartBSaMichelleDayaPhDaMonicaCampbellMSaMeher PreethiBoorgulaMSaNicholasRafaelsMSaSameerChavanMSaGloriaDavidPhDbJonHanifinMDcMark K.SlifkaPhDcRichard L.GalloMD, PhDdTissaHataMDdLynda C.SchneiderMDeAmy S.PallerMDfgPeck Y.OngMDhiJonathan M.SpergelMDjEmmaGuttman-YasskyMD, PhDkDonald Y.M.LeungMD, PhDlLisa A.BeckMDm…Kathleen C.BarnesPhDa∗

doi : 10.1016/j.jaci.2021.05.034

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Sirtuin 6 is a negative regulator of FcεRI signaling and anaphylactic responses

Hyun-YoungJangPhDaDo HyunHaBSbSo-YoungRahPhDaDong-HyunLeeMDcSang-MyeongLeeDVM, PhDdByung-HyunParkMD, PhDa

doi : 10.1016/j.jaci.2021.05.012

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Optimizing investigation of suspected allergy to polyethylene glycols

Maria AnnaBruusgaard-MouritsenMDabBettina MargretheJensenMSc, PhDbLars K.PoulsenPhD, DMScbJeanneDuus JohansenMD, DMScabLene HeiseGarveyMD, PhDbc

doi : 10.1016/j.jaci.2021.05.020

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Anti-TNF treatment corrects IFN-γ–dependent proinflammatory signatures in Blau syndrome patient–derived macrophages

YohkoKitagawaPhDaYuriKawasakiDVM, PhDaYuichiYamasakiMD, PhDbNaotomoKambeMD, PhDcdSyujiTakeiMD, PhDbMegumu K.SaitoMD, PhDa

doi : 10.1016/j.jaci.2021.05.030

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Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a phase 1 study

PhilippeGevaertMD, PhDa∗JarnoDe CraemerMDa∗NatalieDe RuyckMSaSylvieRotteyMD, PhDbJande HoonMD, PhDcPeter W.HellingsMDadeBramVolckaertMDfKristofLesneuckMSfJamie M.OrengoPhDgAmandaAtanasioMSgMohamed A.KamalPhDgHishamAbdallahPhDgVishalKamatPhDgRobertDingmanPhDgMichelleDeVeauxPhDgDivyaRameshPhDgLorahPerleePhDgClaire Q.WangPhDg…Meagan P.O’BrienMDg

doi : 10.1016/j.jaci.2021.05.039

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Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response

AmandaAtanasioMSaMatthew C.FranklinPhDaVishalKamatPhDaAnnabel RomeroHernandezPhDaAshokBadithePhDaLi-HongBenMSaJenniferJonesBSaJoannieBautistaBSaGeorge D.YancopoulosMD, PhDaWilliamOlsonPhDaAndrew J.MurphyPhDaMatthew A.SleemanPhDaJamie M.OrengoPhD, MPHa

doi : 10.1016/j.jaci.2021.05.038

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Allergoid–mannan conjugates reprogram monocytes into tolerogenic dendritic cells via epigenetic and metabolic rewiring

CristinaBenito-VillalvillaBScaMarioPérez-DiegoBScaAlbaAngelinaPhDaKaiKisandPhDbAnaRebanePhDbJosé LuisSubizaMD, PhDcOscarPalomaresPhDa

doi : 10.1016/j.jaci.2021.06.012

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LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity

Doumet GeorgesHelouPhDPedramShafiei-JahaniMSBenjamin P.HurrellPhDJacob D.PainterMSChristineQuachMSEmilyHowardBSOmidAkbariPhD

doi : 10.1016/j.jaci.2021.05.042

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Targeting androgen signaling in ILC2s protects from IL-33–driven lung inflammation, independently of KLRG1

EveBlanquartPhDaAudreyMandonnetBScaMarionMarsMScaClaireCenacMScaNinaAnesiMScaPascaleMercierMScbChristopheAudouardBSccStephaneRogaBScbGilbertoSerrano de AlmeidaPhDdCharlotte L.BevanPhDdJean-PhilippeGirardPhDbLucettePelletierMD, PhDaSophieLaffontPhDa∗Jean-CharlesGuéryPhDa∗

doi : 10.1016/j.jaci.2021.04.029

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Enhanced osteoclastogenesis in patients with MSMD due to impaired response to IFN-γ

MiyukiTsumuraPhDa∗MizukaMikiMDab∗‡YokoMizoguchiMD, PhDaOsamuHirataMD, PhDac‡ShihoNishimuraMD, PhDad‡MoeTamauraMD, PhDae‡ReikoKagawaMD, PhDaSeiichiHayakawaMD, PhDaMasaoKobayashiMD, PhDaf‡§SatoshiOkadaMD, PhDa§

doi : 10.1016/j.jaci.2021.05.018

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Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations

Jake A.GertieBSabBiyanZhangPhDabdElise G.LiuMDabcLaura R.HoytBAabXiangyunYinPhDabLanXuMSabLauren L.LongPhDeArielleSoldatenkoBSabUthamanGowthamanPhDabgAdamWilliamsPhDefStephanie C.EisenbarthMD, PhDabc

doi : 10.1016/j.jaci.2021.05.015

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P17 induces chemotaxis and differentiation of monocytes via MRGPRX2-mediated mast cell–line activation

KarthiDuraisamyPhDaKailashSinghPhDaMukeshKumarMS (Pharm)aBenjaminLefrancMSbElsaBonnaféPhDcMichelTreilhouPhDcJérômeLeprincePhDbBilly K.C.ChowPhDa

doi : 10.1016/j.jaci.2021.04.040

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Mast cells drive pathologic vascular lesions in Takayasu arteritis

AlexandreLe JoncourMD, MScabc∗Anne-ClaireDesboisMD, PhDabc∗Aurélie S.LeroyerPhDdEdwigeTellierPhDdPaulRégnierPhDabAnnaMaciejewski-DuvalPhDabCloéComarmondMD, PhDabcStéphaneBareteMD, PhDceMichelArockMD, PhDfgPatrickBrunevalMD, PhDhJean-MarieLaunayMD, PhDiPierreFouretMD, PhDjUlrichBlankMD, PhDkMichelleRosenzwajgMD, PhDabcDavidKlatzmannMD, PhDabcMohamedJarrayaMD, PhDlLaurentChicheMD, PhDmFabienKoskasMD, PhDm…DavidSaadounMD, PhDabc

doi : 10.1016/j.jaci.2021.05.003

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Cushing syndrome and glucocorticoids: T-cell lymphopenia, apoptosis, and rescue by IL-21

SuJinHwangPhDaChristinaTatsiMD, PhDbHye SunKuehnPhDaJulie E.NiemelaMS, MLSaJenniferStoddardBSaYanSuBSaMayaLodishMD, MHScbGulbuUzelMDcRosanneSpolskiPhDdWarren J.LeonardMDdSteven M.HollandMDcThomas A.FleisherMDaConstantine A.StratakisMD, D(Med)ScbSergio D.RosenzweigMD, PhDa

doi : 10.1016/j.jaci.2021.05.031

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Convergence of cytokine dysregulation and antibody deficiency in common variable immunodeficiency with inflammatory complications

Miranda L.AbyaziBSaKayla A.BellBSaGavinGyimesiBSbTurner S.BakerBScMinjiByunPhDcHuaibin M.KoMDeCharlotteCunningham-RundlesMD, PhDcFengFengPhDdPaul J.MaglioneMD, PhDa

doi : 10.1016/j.jaci.2021.06.008

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Molecular diagnosis of childhood immune dysregulation, polyendocrinopathy, and enteropathy, and implications for clinical management

Sarah K.BaxterMD, PhDabcTomWalshPhDcSilviaCasadeiPhDcMary M.EckertBSbEric J.AllenspachMD, PhDabDavidHaginMD, PhDbdGesmarSegundoMD, PhDeMing K.LeePhDcSuleymanGulsunerMD, PhDcBrian H.ShirtsMD, PhDfKathleen E.SullivanMD, PhDgMichael D.KellerMDhTroy R.TorgersonMD, PhDabMary-ClaireKingPhDc

doi : 10.1016/j.jaci.2021.04.005

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DEP-induced ZEB2 promotes nasal polyp formation via epithelial-to-mesenchymal transition

MingyuLeePhDabcdSuhaLimBScabcYi SookKimBScabcRozaKhalmuratovaMD, PhDaSeung-HyunShinPhDbcIljinKimMD, PhDeHyun-JikKimMD, PhDfDong-YoungKimMD, PhDfChae-SeoRheeMD, PhDfJong-WanParkMD, PhDbcgHyun-WooShinMD, PhDabcfg

doi : 10.1016/j.jaci.2021.04.024

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Neutralizing anti–IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease

Justin A.JarrellPhDabcMatthew C.BakerMD, MSaCory A.PeruginoDOdHangLiuMDdMichelle S.BloomPhDabcTakashiMaeharaDDS, PhDdHeidi H.WongBSabcTobias V.LanzMDabceJulia Z.AdamskaBAabcSarahKongpachithPh.DabcJeremySokoloveMDabcJohn H.StoneMD, MPHdShiv S.PillaiMBBS, PhDdWilliam H.RobinsonMD, PhDabc

doi : 10.1016/j.jaci.2021.05.002

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Curation and expansion of Human Phenotype Ontology for defined groups of inborn errors of immunity

MatthiasHaimelPhDabc∗JuliaPazmandiMScabc∗Raúl JiménezHerediaMScabcJasminDmytrusMScabcSevgi KöstelBalMD, PhDabcSamanehZoghiPhDabcPaulvan DaeleMDdTracy A.BriggsPhDefCarineWoutersMDghBrigitteBader-MeunierMDijFlorence A.AeschlimannMDijRobertaCaorsiMDkDespinaEleftheriouMDlmEstherHoppenreijsMDnElisabethSalzerMD, PhDabcalShahrzadBakhtiarMDoBeataDerfalviMDpFrancescoSaettiniMDq…KaanBoztugMDabcakal‡

doi : 10.1016/j.jaci.2021.04.033

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Comprehensive analysis of ADA2 genetic variants and estimation of carrier frequency driven by a function-based approach

HyukJeeBSaZhengpingHuangMDbcSamanthaBaxterMS, CGCdYuelongHuangPhDcMaria L.TaylorBSaLauren A.HendersonMD, MMscaSofiaRosenzweigBSeAmanSharmaMD, FRCPfEugene P.ChambersMDghMichael S.HershfieldMDiQingZhouPhDjFatmaDedeogluMDaIvonaAksentijevichMDePeter A.NigrovicMDacAnneO’Donnell-LuriaMD, PhDdkPui Y.LeeMD, PhDac

doi : 10.1016/j.jaci.2021.04.034

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Rubella vaccine–induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity

MiriamGroßMScabCarstenSpeckmannMDacAnnetteMayMDdTaniaGajardo-CarrascoMScefKatharinaWustrauMDgSarah LenaMaierMDgMarcusPanningMDhDanielaHuzlyMDhAbbasAgaimyMDiYenan T.BrycesonPhDjkSharonChooMDlC.W.ChowMDmGregorDückersMDnAndersFasthMD, PhDoSylvieFraitagMDpKatjaGräweMTAaSabineHaxelmansTAqDirkHolzingerMDr…StephanEhlMDa

doi : 10.1016/j.jaci.2021.05.007

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Nodular regenerative hyperplasia in X-linked agammaglobulinemia: An underestimated and severe complication

Cristiane J.Nunes-SantosMDa∗ChristopherKohMD, MHScb∗AnjaliRaiMDb∗KeithSaccoMDc∗Beatriz E.MarcianoMDcDavid E.KleinerMD, PhDdJamieMarkoMDeJenna R.E.BergersonMD, MPHcMichaelStackBSccMaria M.RiveraMDbGregoryConstantineMDfWarrenStroberMDgGulbuUzelMDcIvan J.FussMDgLuigi D.NotarangeloMDc‡Steven M.HollandMDc‡Sergio D.RosenzweigMD, PhDa‡TheoHellerMDb‡

doi : 10.1016/j.jaci.2021.05.028

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International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome

DimanaDimitrovaMDa∗ZohrehNademiMD, PhDbc∗Maria ElenaMaccariMDdeStephanEhlMDdeGulbuUzelMDfTakahiroTomodaMDgTsubasaOkanoMDgKohsukeImaiMD, PhDhBenjaminCarpenterMDiWinnieIpMDjkKanchanRaoMDlAusten J.J.WorthMD, PhDjkAlexandraLaberkoMDmAnnaMukhinaMDmBénédicteNévenMD, PhDnopDespinaMoshousMD, PhDnopCarstenSpeckmannMDdeKlausWarnatzMDe…Jennifer A.KanakryMDa‡

doi : 10.1016/j.jaci.2021.04.036

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Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma

GroTjalvinMD, PhDabØisteinSvanesMDbcJannickeIglandPhDdeRandi JacobsenBertelsenPhDcfBryndísBenediktsdóttirMDghShyamaliDharmageMD, PhDiBertilForsbergPhDjMathiasHolmMD, PhDkChristerJansonMD, PhDlNils OskarJõgiMDbcmAneJohannessenPhDaAndreiMalinovschiMD, PhDnKathrinePapePhDopFrancisco GomezRealMD, PhDcqTorbenSigsgaardMD, PhDpKjellTorénMD, PhDkHilde KristinVindenesMDbcJan-PaulZockPhDrst…CecilieSvanesMD, PhDbu

doi : 10.1016/j.jaci.2021.08.025

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Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS

Caspar I.van der MadeMDabJudithPotjewijdMDcAnnemiekHoogstinsMDdHuub P.J.WillemsMDeArjan J.KwakernaakMD, PhDfRuud G.L.de SevauxMD, PhDagPaul L.A.van DaeleMD, PhDhAnnetSimonsPhDbMarloesHeijstekMD, PhDiDavid B.BeckMD, PhDjMihai G.NeteaMD, PhDaPietervan PaassenMD, PhDcA.Elizabeth HakMD, PhDfLars T.van der VekenPhDkMarielle E.van GijnPhDlAlexanderHoischenPhDabFrank L.van de VeerdonkMD, PhDaHelen L.LeavisMD, PhDi∗AbrahamRutgersMD, PhDd∗

doi : 10.1016/j.jaci.2021.05.014

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Effect of vitamin D supplementation on total and allergen-specific IgE in children with asthma and low vitamin D levels

Franziska J.RosserMD, MPHaYueh-YingHanPhDaErickFornoMD, MPHaLeonard B.BacharierMDbWandaPhipatanakulMD, MScTheresa W.GuilbertMD, MSdMichael D.CabanaMD, MPHeKristieRossMD, MSfJoshuaBlatterMD, MPHgSandyDurraniMDdJamesLutherMAhStephen R.WisniewskiPhDhJuan C.CeledónMD, DrPH, FAAAAIa

doi : 10.1016/j.jaci.2021.05.037

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Distinct immune trajectories in patients with chromosome 22q11.2 deletion syndrome and immune-mediated diseases

T. BlaineCrowleyaIan M.CampbellMD, PhDabEmily J.LieblingMDcMichele P.LambertMD, MSTRdLorraine E.Levitt KatzMDeJenniferHeimallMDfAliceBaileyBSaDaniel E.McGinnBSaDonna M.McDonald McGinnMS, CGCaKathleen E.SullivanMD, PhDf

doi : 10.1016/j.jaci.2021.06.007

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Potential role of advanced glycation end products in the TH2 adjuvant effect of peanut protein

Jeffrey D.MillerMD

doi : 10.1016/j.jaci.2021.08.033

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Reply

BertRuiterPhDabWayne G.ShrefflerMD, PhDabc

doi : 10.1016/j.jaci.2021.08.034

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Allergists are critical in actively guiding schools in the development of food allergy policies

Alice E.W.HoytMDabJennifer E.Goertzbc

doi : 10.1016/j.jaci.2021.10.005

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