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Issue Highlights page
doi : 10.1016/S0360-3016(21)03086-8
Volume 112, Issue 1, 1 January 2022, Pages A10-A12
Endings and Beginnings, and What Twists and Turns Could Lie on the Road Ahead
Sue S.YomMD, PhD, MAS, FASTRO
A Story of Hypofractionation and the Table on the Wall
RobertTimmermanMD
An Overview of Phase 2 Clinical Trial Designs
Pedro A.Torres-SaavedraPhDKathryn A.WinterMS
Back to the Future: Charting the Direction of Lower Grade Glioma Trials With Lessons From the Present and Past
Michelle M.KimMD*Jona A.Hattangadi-Gluth†Kristin J.Redmond‡Daniel M.Trifiletti§Scott G.Soltys‖Michael T.Milano¶
Synopsis of Supraclavicular Sarcoma: Synthesis of Stratagem and Solutions
JeremiahJohnsonMD, MSMaheshKudrimotiMDAradhanaKaushalMD
Treating the Unknown: First Refine the Diagnosis
David G.KirschMD, PhD, FASTRO
Radiation Without Endocrine Therapy in Older Women With Stage I Estrogen-Receptor-Positive Breast Cancer is Not Associated With a Higher Risk of Second Breast Cancer Events
Naamit K.GerberMD*HuiboShaoMS†ManjeetChadhaMD‡ParthaDebPhD§Heather T.GoldPhD||
Improving the Therapeutic Ratio Among Older Women With Early Stage Breast Cancer by Reevaluating Adjuvant Radiation Therapy and Hormone Therapy
Dean A.ShumwayMDKimberly S.CorbinMDRobert W.MutterMD
Final Analysis of a Phase 2 Trial of Once Weekly Hypofractionated Whole Breast Irradiation for Early-Stage Breast Cancer
Leonid B.ReshkoMD�JianminPanPhD†Shesh N.RaiPhD†NicolasAjkayMD‡AnthonyDragunMD§Teresa L.RobertsMBA, RN*Elizabeth C.RileyMD||Amy R.QuilloMD‡Charles R.ScogginsMD‡Kelly M.McMastersMD, PhD‡HarrietEldredge-HindyMD¶
Contemporary Outcomes After Multimodality Therapy in Patients With Breast Cancer Presenting With Ipsilateral Supraclavicular Node Involvement
KevinDiaoMD*Lauren M.AndringMD*Carlos H.BarcenasMD, MSc†PuneetSinghMD‡Huong(Carisa) Le-PetrossMD§Valerie K.ReedMD*Jay P.ReddyMD, PhD*Elizabeth S.BloomMD*Neelofur R.AhmadMD*Lauren L.MayoMD*George H.PerkinsMD*Melissa P.MitchellMD*Kevin T.NeadMD, MPhil*WelelaTereffeMD, MPH*Benjamin D.SmithMD*Wendy A.WoodwardMD, PhD*
Radiation Dose to the Intraprostatic Urethra Correlates Strongly With Urinary Toxicity After Prostate Stereotactic Body Radiation Therapy: A Combined Analysis of 23 Prospective Clinical Trials
Jonathan E.LeemanMD*Yu-HuiChenMS†PaulCatalanoScD†JeremyBredfeldtPhD*MartinKingMD, PhD*Kent W.MouwMD, PhD*Anthony V.D'AmicoMD, PhD*PeterOrioDO*Paul L.NguyenMD*NeilMartinMD, MPH*
Quality of Life Implications of Dose-Escalated External Beam Radiation for Localized Prostate Cancer: Results of a Prospective Randomized Phase 3 Clinical Trial, NRG/RTOG 0126
William A.HallMD�SnehalDeshmukhMS†Deborah W.BrunerPhD, RN‡Jeff M.MichalskiMD§James A.PurdyPhD||WalterBoschDSc§Jean-PaulBaharyMD¶Maltibehn P.PatelMD#Matthew B.ParliamentMD��Michael I.LockMD††Harold Y.LauMD‡‡LuisSouhamiMD§§Scot A.FisherMD||||YoungKwokMD¶¶Michael J.SeiderMD, PhD##EricVigneaultMD���Seth A.RosenthalMD†††Gary S.GustafsonMD‡‡‡…BenjaminMovsasMD||||||
FACE Value of Patient-Reported Outcomes in Dose-Escalated Radiation Therapy for Prostate Cancer
Rachel M.Glicksman�†AlejandroBerlin�†‡§
Exercise: A Treatment That Should Be Prescribed With Radiation Therapy
Nicholas G.ZaorskyMD, MS*†SaraGarrettPhD*Daniel E.SprattMD‡Paul L.NguyenMD§ChrisSciamannaMD, MPH†║KathrynSchmitzPhD, MPHâ€
Personalized Treatment Selection Leads to Low Rates of Local Salvage Therapy for Bone Metastases
Noah J.MathisBS*Connor J.DoyleBS*Daniel B.RosenMD*N. AriWijetungaMD, PhD�MaxVaynrubMD†MeredithBartelsteinMD†David M.GuttmannMD*Victoria S.BrennanMBBch, BAO*Yoshiya J.YamadaMD*Erin F.GillespieMD*DivyaYerramilliMD*Jonathan T.YangMD, PhD�
Phase 2 Clinical Trial of Separation Surgery Followed by Stereotactic Body Radiation Therapy for Metastatic Epidural Spinal Cord Compression
KeiItoMD, PhD*ShureiSugitaMD, PhD†YujiroNakajimaPhD*TomohisaFuruyaPhD*OgawaHiroakiMD*SaraHayakawaMD*TakahiroHozumiMD†MakotoSaitoMSc‡KatsuyukiKarasawaMD, PhD*
Thecal Sac Contouring as a Surrogate for the Cauda Equina and Intracanal Spinal Nerve Roots for Spine Stereotactic Body Radiation Therapy (SBRT): Contour Variability and Recommendations for Safe Practice
Emma M.DunneMBBS, PhD�Simon S.LoMD†Mitchell C.LiuMD*AlanahBergmanPhD*RobertKosztylaPhD*Eric L.ChangMD‡Ung-KyuChangMD§Samuel T.ChaoMD║NicolasDeaMD¶SalmanFaruqiMD#Amol J.GhiaMD��Kristin J.RedmondMD††Scott G.SoltysMD‡‡ArjunSahgalMD§§
Noninvasive Thalamotomy for Refractory Tremor by Frameless Radiosurgery
Mohamed H.KhattabMD*Anthony J.CmelakMD*Alexander D.SherryMD*GuozhenLuoPhD*LiWangMS†HongYuMD‡PeterHederaMD§║Fenna T.PhibbsMD, MPH§Christopher J.LindsellPhD†JosephNeimatMD, MS‡¶Austin N.KirschnerMD, PhD*
Pancreatic Stereotactic Body Radiation Therapy With or Without Hypofractionated Elective Nodal Irradiation
Jacob A.MillerMDDiego A.S.ToescaMDJ. Richelcyn M.BaclayMDLucas K.VitzthumMDPiotrDubrowskiMScErqi L.PollomMD, MSDaniel T.ChangMD
Elective Target Coverage for Pancreatic Cancer: When Less Does Not Clearly Achieve More
Michael D.ChuongMD�JordanKharofaMD†Nina N.SanfordMD‡
Long-Term Outcomes of NRG Oncology/RTOG 0529: A Phase 2 Evaluation of Dose-Painted Intensity Modulated Radiation Therapy in Combination With 5-Fluorouracil and Mitomycin-C for the Reduction of Acute Morbidity in Anal Canal Cancer
Lisa A.KachnicMD*Kathryn A.WinterMS†Robert J.MyersonMD‡Michael D.GoodyearMD§Andre A.AbitbolMD||Oscar E.StreeterMD¶Mark E.AugspurgerMD#Tracey E.SchefterMD��Alan W.KatzMD††Barbara J.FisherMD‡‡Lauren E.HenkeMD‡SamirNarayanMD§§Christopher H.CraneMD|| ||
Establishing Cost-Effective Allocation of Proton Therapy for Patients With Mediastinal Hodgkin Lymphoma
Raymond B.Mailhot VegaMD, MPH�HomanMohammadiMD†Samir I.PatelMD‡Adam L.HoltzmanMD*Natalie A.LockneyMD*James W.LynchMD§Manisha M.BansalMD||XiaoyingLiangPhD*William B.SlaytonMD||Susan K.ParsonsMD, MRP¶Bradford S.HoppeMD, MPH#Nancy P.MendenhallMD*
Fifty Shades of GyE: Interpreting the Cost-Effectiveness of Proton Beam Therapy for Mediastinal Hodgkin Lymphoma
David J.SherMD, MPH
Positron Emission Tomography-Guided Bone Marrow-Sparing Radiation Therapy for Locoregionally Advanced Cervix Cancer: Final Results From the INTERTECC Phase II/III Trial
Casey W.WilliamsonMD, MAS*IgorSirákMD, PhD†RonghuiXuPhD‡LorrainePortelanceMD§LichunWeiMD║RafalTarnawskiMD, PhD¶UmeshMahantshettyMD#Elena S.HeideBS��Catheryn M.YasharMD*Michael T.McHaleMD‡WalterBoschDSc††JessicaLowensteinMS‡‡Cheryl C.SaenzMD‡StevePlaxeMD‡RamezEskanderMD‡JohnEinckMD*Arno J.MundtMD*JyotiMayadevMD*§§Loren K.MellMD*§§
Secondary Infections After Diagnosis of Severe Radiation Pneumonitis (SRP) Among Patients With Non-Small Cell Lung Cancer: Pathogen Distributions, Choice of Empirical Antibiotics, and the Value of Empirical Antifungal Treatment
TingMeiMD�XuexiYangMD�YangYuMD�XiaomanTianMD†QianyueDengMD�YongXuMD�LinZhouMD, PhD�XiaojuanZhouMD�YongmeiLiuMD, PhD�BingwenZouMD, PhD�JianxinXueMD, PhD�MinQuanMD‡LiboYanMD‡YouLuMD�YoulingGongMD, PhD�
Coronary Artery Calcifications and Cardiac Risk After Radiation Therapy for Stage III Lung Cancer
KyleWangMD*Hayley E.MalkinMD, MPH†Nicholas D.PatchettMD‡Kevin A.PearlsteinMD†Hillary M.HeilingBS§Sean D.McCabePhD§Allison M.DealMS§PanayiotisMavroidisPhD†MaryOakeyMS†JeffreyFenoliMS†Carrie B.LeeMDâ•‘J. LarryKleinMD¶#Brian C.JensenMD¶Thomas E.StinchcombeMDâ�Žâ�ŽLawrence B.MarksMD†Ashley A.WeinerMD, PhDâ€
Low-Dose Lung Radiation Therapy for COVID-19 Lung Disease: A Preclinical Efficacy Study in a Bleomycin Model of Pneumonitis
Mark R.JacksonDPhil*KatrinaStevensonMSc*Sandeep K.ChahalMRes*EmerCurleyMSc†George E.FinneyMSc‡RodrigoGutierrez-QuintanaMVM*§EvarestOnwubikoMSc†AngieRuppDipECVP§KarenStrathdeeBSc*KarinWilliamsPhD*Megan K.L.MacLeodPhD‡CharlesMcSharryPhD‡Anthony J.ChalmersMD, PhD*
Gamma-H2AX Foci Decay Ratio as a Stronger Predictive Factor of Late Radiation Toxicity Than Dose-Volume Parameters in a Prospective Cohort of Prostate Cancer Patients
Anna C.NuijensMD*†Arlene L.OeiPhD*†Bregjevan OorschotPhD*†JorritVisserPhD*Rob M.van OsMSc*Perry D.MoerlandPhD‡Nicolaas A.P.FrankenPhD*†Coen R.N.RaschMD, PhD§Lukas J.A.StalpersMD, PhD�
Mechanisms and Review of Clinical Evidence of Variations in Relative Biological Effectiveness in Proton Therapy
HaraldPaganettiPhD
Correlation of LET With MRI Changes in Brain and Potential Implications for Normal Tissue Complication Probability for Patients With Meningioma Treated With Pencil Beam Scanning Proton Therapy
AlejandroBertoletPhD�†RaminAbolfathPhD�‡David J.CarlsonPhD�Robert A.LustigMD�ChristineHill-KayserMD�MichelleAlonso-BasantaMD�AlejandroCarabePhD�#
Dose-Based Radiomic Analysis (Dosiomics) for Intensity Modulated Radiation Therapy in Patients With Prostate Cancer: Correlation Between Planned Dose Distribution and Biochemical Failure
YuMurakamiMScâ�Žâ€ TakashiSoyanoMD‡TakuyoKozukaMD, PhD§MasaruUshijimaPhD‖YuukiKoizumiMSc*HikaruMiyauchiMScâ�ŽMasahiroKanekoBSc*MasahiroNakanoPhD*TatsuyaKamimaBSc*TakeoHashimotoBSc*YasuoYoshiokaMD, PhD*MasahikoOguchiMD, PhD*â€
In Regard to Roos et al.
ThiloSchulerMDShelleyWongMRTSarahBergaminMBBS, FRANZCRGeorgeHrubyMBChB, FRANZCRMichaelBackMBBS, MBA, PhD, FRANZCRStephanieRoderickMMedPhysThomasEadeMBChB, FRANZCR
In Regard to Ng et al.
Ahmed NadeemAbbasiMBBS, FFR, RCSINasirAliMBBS, FCPSAsimHafizMBBS, FCPSBilal MazharQureshiMBBS, FCPSSehrishAbrarMBBS, FCPSLaraibKhanMBBS
In Reply to Abbasi et al.
Wai-TongNgFRCRHoraceChoiPhDMelvin L.K.ChuaMBBS, FRCR, PhD, FAMSAnne W.M.LeeFRCR
