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Cardiovascular comorbidity in rheumatic and musculoskeletal diseases: Where we are and how can we move forward?
George D. Kitas Theodoros Dimitroulas
doi : 10.1111/1756-185X.14112
Volume 24, Issue 4 p. 473-476
Cardiovascular morbidity and mortality in patients with spondyloarthritis: A meta?analysis
Ji Hyoun Kim In Ah Choi
doi : 10.1111/1756-185X.13970
Volume 24, Issue 4 p. 477-486
Cardiovascular (CV) risk and mortality associated with spondyloarthritis (SpA) remain controversial. Herein, we performed a meta?analysis of the latest large?scale population?based studies to demonstrate the elevated risk of CV disease and mortality in patients with SpA than in the general population.
Epigenetics of ankylosing spondylitis: Recent developments
Hui Yang Yuting Chen Wei Xu Ming Shao Jixiang Deng Shanshan Xu Xing Gao Shiyang Guan Jinian Wang Shengqian Xu Zongwen Shuai Faming Pan
doi : 10.1111/1756-185X.14080
Volume 24, Issue 4 p. 487-493
Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease which mainly affects the spine, sacroiliac joint and peripheral joints. To date, the exact causes and pathogenesis of AS still remain unknown. It is considered that the pathogenesis of AS is associated with genetic, infection, environment, immunity and other factors. Among them, the role of genetic factors in the pathogenesis of AS has been studied most deeply. However, over the past few years, the function of environmental predisposition and epigenetic modification in the pathogenesis of AS has received extensive attention. This paper summarizes the recent progress in the epigenetics of AS, including abnormal epigenetic modifications at AS?associated genomic loci, such as DNA methylation, histone modification, microRNA, and so on. In summary, the findings of this review attempt to explain the role of epigenetic modification in the occurrence and development of AS. Nevertheless, there are still unknown and complicated aspects worth exploring to deepen our understanding of the pathogenesis of AS.
Disease severity affects myocardial functions in patients with treatment?naive early rheumatoid arthritis
Ender ?zgün ?akmak U?ur F?nd?kç?o?lu Mehmet Engin Tezcan
doi : 10.1111/1756-185X.13992
Volume 24, Issue 4 p. 494-501
The cross?sectional study aimed to assess myocardial functions using global longitudinal strain (GLS) echocardiography and arrhythmia parameters with treatment naive newly diagnosed rheumatoid arthritis (RA) and no clinical evidence of cardiovascular disease (CVD).
Subclinical atherosclerosis in systemic sclerosis: Different risk profiles among patients according to clinical manifestations
Iliana Sciarra Massimiliano Vasile Alessia Carboni Katia Stefanantoni Nicoletta Iannace Carlotta Angelelli Antongiulio G. Scarno Guido Valesini Valeria Riccieri
doi : 10.1111/1756-185X.14002
Volume 24, Issue 4 p. 502-509
Like other autoimmune diseases, systemic sclerosis (SSc) has been described to be associated with accelerated atherosclerosis (ATS). Before clinical manifestations of cardiovascular disease (CVD) occur, subclinical ATS can be investigated in different ways.
Left ventricular hypertrophy predicts poorer cardiovascular outcome in normotensive normoglycemic patients with rheumatoid arthritis
Giovanni Cioffi Ombretta Viapiana Giovanni Orsolini Federica Ognibeni Sonographer Andrea Dalbeni Davide Gatti Giovanni Adami Angelo Fassio Maurizio Rossini Alessandro Giollo
doi : 10.1111/1756-185X.14082
Volume 24, Issue 4 p. 510-518
Patients with rheumatoid arthritis (RA) develop early changes in left ventricular (LV) geometry and experience cardiovascular events in excess than in the general population. This study was designed to assess prevalence, predictors and prognostic role of LV hypertrophy (LVH) in a selected group of RA patients with normal blood pressure and glycemia who should be at low risk for LVH.
Tonsillitis as a possible predisposition to synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome
Yirong Xiang Yutong Wang Yihan Cao Zhaohui Li Dingkun Xiong Lun Wang Wen Zhang Xiaofeng Zeng Yi Wang Chen Li
doi : 10.1111/1756-185X.14064
Volume 24, Issue 4 p. 519-525
To present the prevalence of tonsillitis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) patients, to compare the clinical characteristics and disease activities between SAPHO patients with and without tonsillitis and to preliminarily explore the efficacy of tonsillectomy in SAPHO syndrome.
A rheumatologic approach to granulomatous mastitis: A case series and review of the literature
Sarah Ringsted Marcia Friedman
doi : 10.1111/1756-185X.14065
Volume 24, Issue 4 p. 526-532
Idiopathic granulomatous mastitis (IGM) is an enigmatic inflammatory breast disorder. IGM responds to immunomodulatory treatment and may be associated with systemic manifestations such as arthritis and erythema nodosum. These patients are increasingly referred to rheumatologists for management, but IGM is rarely discussed in the rheumatology literature. The objective of this report is to familiarize rheumatologists with the treatment and systemic manifestations of IGM. We report here a case series of IGM at our institution, and a literature review of IGM treated with methotrexate (MTX).
Musculoskeletal sarcoidosis: A single center experience over 15 years
Sanjeev Patil Carolyn A. Hilliard Masumi Arakane Sreedevi Koppisetti Jenigiri Elizabeth H. Field Namrata Singh
doi : 10.1111/1756-185X.14068
Volume 24, Issue 4 p. 533-541
Musculoskeletal (MSK) sarcoidosis presents with a variety of clinical phenotypes. Four subtypes of MSK sarcoidosis have been identified to date: Lofgren syndrome, chronic sarcoid arthritis, osseous sarcoidosis, sarcoid myopathy. Each subtype has been reported with varying incidence mainly due to lack of universal classification criteria.
Comparison of baseline laboratory findings of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis and multisystem inflammatory syndrome in children
Fatma Ayd?n Elif ?elikel Zahide Ekici Tekin Serkan Co?kun Müge Sezer Cüneyt Karag?l Melike Mehve? Kaplan Nilüfer Tekg?z Tuba Kurt Serhan ?zcan Ahmet Vedat Kavurt … See all authors
doi : 10.1111/1756-185X.14078
Volume 24, Issue 4 p. 542-547
Recently, multisystem inflammatory syndrome in children (MIS?C) has been recognized in association with coronavirus disease 2019 as a cytokine storm syndrome. MIS?C presents with symptoms similar to Kawasaki disease and macrophage activation syndrome (MAS). We aimed to better understand this cytokine storm syndrome by comparing the initial laboratory findings of MIS?C and MAS.
Association between core stability and physical function, functional performance in patients with systemic sclerosis
Hazal Yakut Sevgi ?zalevli Ahmet Merih Birlik
doi : 10.1111/1756-185X.14067
Volume 24, Issue 4 p. 548-554
To investigate the association of core stability with physical function and functional performance in patients with systemic sclerosis (SSc).
Increased malignancies in our Waikato cohort of patients with systemic sclerosis
Monique S. Rees Chris Frampton Douglas H. N. White Kamal K. Solanki
doi : 10.1111/1756-185X.14091
Volume 24, Issue 4 p. 555-561
Systemic sclerosis (SSc) has been associated with an increased risk of malignancy (especially in the skin, lung, breast, and hematological system).
Comparison of relapse rates in Behçet’s disease with venous involvement on different doses of azathioprine therapy, a retrospective observational study
Sinem Girgin Seda Yurumez Ahmet Omma Selda Celik Ozan Cemal Icacan Cemal Bes Nilufer Alpay?Kanitez
doi : 10.1111/1756-185X.14075
Volume 24, Issue 4 p. 562-566
The aim of this study was to investigate relapse rates in azathioprine (AZA) maintenance therapy at different doses in Behçet's disease (BD) with venous involvement.
Association of the genetic variants in the endoplasmic reticulum aminopeptidase 2 gene with ankylosing spondylitis susceptibility
Mehrdad Ebrazeh Fatemeh Ezzatifar Shahram Torkamandi Fatemeh Sadat Mohammadi Sevda Salimifard Arezoo Gowhari Shabgah Maryam Hemmatzadeh Saeed Aslani Farhad Babaie Farhad Jadidi?Niaragh Jamshid Gholizadeh Navashenaq Hamed Mohammadi
doi : 10.1111/1756-185X.14079
Volume 24, Issue 4 p. 567-581
Genetic polymorphisms in the endoplasmic reticulum aminopeptidase gene ERAP2 has been attributed with the etiopathogenesis of ankylosing spondylitis (AS). Here we assessed the association of ERAP2 gene single nucleotide polymorphisms (SNPs) with AS predisposition in Iranian patients and determined their effect on the inflammatory state of the patients.
Utility of magnetic resonance imaging in Crohn's associated sacroiliitis: A cross?sectional study
Fardina Malik Ellen Scherl Ulrich Weber John A. Carrino Madeline Epsten Stephanie Wichuk Susanne J. Pedersen Joel Paschke Sergio Schwartzman Georg Kroeber Walter P. Maksymowych Randy Longman Lisa A. Mandl
doi : 10.1111/1756-185X.14081
Volume 24, Issue 4 p. 582-590
Prevalence of sacroiliitis in Crohn's disease (CD) is variable depending on defining criteria. This study utilized standardized sacroiliac joint (SIJ) magnetic resonance imaging (MRI) to identify sacroiliitis in CD patients and its association with clinical and serological markers.
Identification of serum interleukin?13 and interleukin?13 receptor subunit expressions: Rheumatoid arthritis–associated interstitial lung disease
Manal Shawky Hussein Amal Mohamad El?Barbary Doaa Waseem Nada Rasha Ahmad Gaber Reham Mohamed Elkolaly Marwa Ahmed Aboelhawa
doi : 10.1111/1756-185X.14084
Volume 24, Issue 4 p. 591-598
To identify the role of serum IL?13, and its receptor subunit expressions as a serologic marker of rheumatoid arthritis (RA)?associated ILD (RA?ILD).
MiR?223?3p and miR?22?3p inhibit monosodium urate?induced gouty inflammation by targeting NLRP3
Xiang Wang Jingwei Chi Bingzi Dong Lili Xu Yue Zhou Yajing Huang Shengnan Sun Fanxiang Wei Yuzhao Liu Chuanfeng Liu Kui Che Wenshan Lv Ying Chen Yangang Wang
doi : 10.1111/1756-185X.14089
Volume 24, Issue 4 p. 599-607
MicroRNAs (miRNAs) have been shown to play a crucial role in inflammation regulation; however, their relationship with inflammation in acute gouty arthritis has not been fully elucidated. Herein, we conducted a study to explore the regulatory roles of miR?223?3p and miR?22?3p in gouty?associated inflammation.
Recent advances in pediatric rheumatology: October to December 2020
Gummadi Anjani Himanshi Chaudhary Surjit Singh
doi : 10.1111/1756-185X.14090
Volume 24, Issue 4 p. 608-610
Are non?steroidal anti?inflammatory drugs effective for acute low back pain? A Cochrane Review summary with commentary
Farooq Azam Rathore Ayesha Afridi
doi : 10.1111/1756-185X.14088
Volume 24, Issue 4 p. 611-614
Your help is needed in the fight against COVID?19: Please contribute to the COVID?19 Global rheumatology alliance registry
doi : 10.1111/1756-185X.14113
Volume 24, Issue 4 p. 615-615
