Journal of Ethnopharmacology




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New mechanisms of ginseng saponin-mediated anti-inflammatory action via targeting canonical inflammasome signaling pathways

Young-SuYi

doi : 10.1016/j.jep.2021.114292

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Findings of Russian literature on the clinical application of Eleutherococcus senticosus (Rupr. & Maxim.): A narrative review

SophiaGerontakosaAmyTaylorbAlena YuAvdeevacVeronika A.ShikovadOlga N.PozharitskayaeDavidCasteleijnfJonWardleaAlexander N.Shikovc

doi : 10.1016/j.jep.2021.114274

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Phlomoides umbrosa (Turcz.) Kamelin & Makhm: A review of its traditional uses, botany, phytochemistry, pharmacology and clinical research

HangLiaQiansongLiuaXirongZhouaHongSuiabXueyanFuab

doi : 10.1016/j.jep.2021.114252

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Role of herbal products in animal production – An updated review

PrajaktaKuralkaraS.V.Kuralkarb

doi : 10.1016/j.jep.2021.114246

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A review on Moroccan Thymus species: Traditional uses, essential oils chemical composition and biological effects

MohamedEl YaagoubiaHichamMechqoqaAbdellahEl HamdaouiaVenugopalJrv MukkubAbdelhamidEl MousadikaFouadMsandaaNoureddineEl Aouadac

doi : 10.1016/j.jep.2021.114205

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Mechanisms of traditional Chinese medicine in modulating gut microbiota metabolites-mediated lipid metabolism

YingyingLia1XinyuJib1HaonanWuaXiangLicHuaminZhangd2DanliTanga2

doi : 10.1016/j.jep.2021.114207

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Therapeutic indications, chemical composition and biological activity of native Brazilian species from Psidium genus (Myrtaceae): A review

Julimery GonçalvesFerreira MacedoaJuliana MeloLinhares RangelaMariade Oliveira SantosaCicera JanaineCamilobJosé GalbertoMartins da CostabMartaMaria de Almeida Souzaa

doi : 10.1016/j.jep.2021.114248

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Galla Chinensis, a Traditional Chinese Medicine: Comprehensive review of botany, traditional uses, chemical composition, pharmacology and toxicology

Yuan-yuanRen1Xiao-ruiZhang1Ting-naLiYi-jiaZengJinWangQin-wanHuang

doi : 10.1016/j.jep.2021.114247

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Genus Pterocarpus: A review of ethnopharmacology, phytochemistry, biological activities, and clinical evidence

Dаyаr�rbаinaGita AyuSaputriaGhalib SyukrilahSyahputraaYuliWidiyastutibDenySusanticMuhammadTaherd

doi : 10.1016/j.jep.2021.114316

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The ethnopharmacology, phytochemistry, pharmacology and toxicology of the genus Erycibe (Convolvulaceae)

LongFanacLeiWuacXu-HuaYuacYuan-BinChenacLinLinacShuo-GuoLib

doi : 10.1016/j.jep.2021.114312

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Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicological profile of Glycosmis pentaphylla (Retz.) DC.: A review

LabonyKhandokaraMd. SazzadulBaribVeroniqueSeidelcMd. AreefulHaquede

doi : 10.1016/j.jep.2021.114313

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Chemical composition, quality control, pharmacokinetics, pharmacological properties and clinical applications of Fufang Danshen Tablet: A systematic review

XuanZengYuyingZhengYulingLiuWeiweiSu

doi : 10.1016/j.jep.2021.114310

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Khaya grandifoliola C. DC. (Meliaceae: Sapindales): Ethnobotany, phytochemistry, pharmacological properties, and toxicology

Yusuf OlaMukailaaAbdulwakeel Ayokun-nunAjaobAnnah NtsamaeengMoteeteeb

doi : 10.1016/j.jep.2021.114253

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The traditional uses, phytochemistry and pharmacology of spearmint (Mentha spicata L.): A review

GanesanMahendranSanjeet KumarVermaLaiq-UrRahman

doi : 10.1016/j.jep.2021.114266

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The traditional uses, phytochemistry, and pharmacological properties of Paris L. (Liliaceae): A review

Yu-GangDingabYan-LiZhaoaJiZhangaZhi-TianZuoaQing-ZhiZhangbYuan-ZhongWanga

doi : 10.1016/j.jep.2021.114293

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Ethnomedicine and neuropsychopharmacology in Mesoamerica

Matthias S.GeckabDanieleLeccaaGiorgioMarchesecLauraCasudMarcoLeontia

doi : 10.1016/j.jep.2021.114243

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From forest to pharmacy: Should we be depressed about a sustainable Griffonia simplicifolia (Fabaceae) seed supply chain?

A.B.CunninghamabJ.A.BrinckmanncD.E.V.Harterd

doi : 10.1016/j.jep.2021.114202

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Transcriptomic study of the mechanism by which the Kai Yu Zhong Yu recipe improves oocyte quality in a stressed mouse model

XiaoliZhaoa1RuihongMaa1XiaoyuZhanga2BaojuanWanga2BeileiRongaNanJiangaWeihuaFengaMingliChenaZhipengHuobShumingLicTianXiaa

doi : 10.1016/j.jep.2021.114298

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Protective effect of pogostone on murine norovirus infected-RAW264.7 macrophages through inhibition of NF-κB/NLRP3-dependent pyroptosis

QingyanYea1QihuaLingb1JianShenaLeiShicJianjieChendTaoYangeZhijunHoubJunZhaoaHuaZhoue

doi : 10.1016/j.jep.2021.114250

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Systems pharmacological study based on UHPLC-Q-Orbitrap-HRMS, network pharmacology and experimental validation to explore the potential mechanisms of Danggui-Shaoyao-San against atherosclerosis

YimingBibXinHanbYiguiLaiaYingchangFuaKongzhengLiaWeiZhangaQiangWangaXuefengJiangabYingchunZhoubHongfengLiangaHuijieFanabc

doi : 10.1016/j.jep.2021.114278

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Angelica sinensis extract promotes neuronal survival by enhancing p38 MAPK–mediated hippocampal neurogenesis and dendritic growth in the chronic phase of transient global cerebral ischemia in rats

Chin-YiChengabHui-ChiHuangcShung-TeKaodYu-ChenLeeefg

doi : 10.1016/j.jep.2021.114301

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Comparisons of the anti-inflammatory, antiviral, and hemostatic activities and chemical profiles of raw and charred Schizonepetae Spica

XindanLiuadZihanHuangaJinjuZhangaYuZhouaYingZhangabcMenghuaWuabcZhiguoMaabcHuiCaoabc

doi : 10.1016/j.jep.2021.114275

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Autophagy is involved in the neuroprotective effect of nicotiflorin

YeqingWanga1ShanshanZhanga1HailaiNib1YanjieZhangaXiaodongYanaYueGaoaBeixuanHeaWenzhengWangcChongLiudMeiliGuoa

doi : 10.1016/j.jep.2021.114279

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Baccharin and p-coumaric acid from green propolis mitigate inflammation by modulating the production of cytokines and eicosanoids

Juliana C.FerreiraaMouzarllem B.ReisaGiovanna D.P.CoelhoaGabriel H.GastaldelloaAna Paula F.PetibDébora M.RodriguesbJairo K.BastosbVanessa L.CampoabCarlos A.SorgicLúcia H.FacciolibLuiz G.GardinassidCristianeTefé-SilvaaKarina F.Zoccala

doi : 10.1016/j.jep.2021.114255

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Methanol extract of Ficus platyphylla decreases cerebral ischemia induced injury in mice

AxelBeckeraMartinHelmuthaDorisTrzeczakaBen A.Chindobc

doi : 10.1016/j.jep.2021.114219

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Inhibition effect of oxyepiberberine isolated from Coptis chinensis franch. On non-small cell lung cancer based on a network pharmacology approach and experimental validation

YingZhangaYunfengYaoaYingjieFuaZixinYuanaXingpanWuaTianshunWangaZongchaoHongaYanfangYangabHezhenWuab

doi : 10.1016/j.jep.2021.114267

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Shenzhiling oral liquid protects the myelin sheath against Alzheimer's disease through the PI3K/Akt-mTOR pathway

MingcuiZhengab1ZhenhongLiuabc1LuluManaabd1GaofengQinabShuaiyangHuangabZhuoyanGongabMeijingTianabYannanHeabPengwenWangab

doi : 10.1016/j.jep.2021.114264

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Multi-omics analysis of brain tissue metabolome and proteome reveals the protective effect of gross saponins of Tribulus terrestris L. fruit against ischemic stroke in rat

YangWangaWenjunGuobcShengxuXiecYueLiucDandanXucGengChendYajuanXuc

doi : 10.1016/j.jep.2021.114280

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Modulation of the transport of valproic acid through the blood-brain barrier in rats by the Gastrodia elata extracts

LingYangaI-HsinLinaChin-TsungTingbTung-HuTsaiacd

doi : 10.1016/j.jep.2021.114276

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Optimization of ultrasound extraction of Tribulus terrestris L. leaves saponins and their HPLC-DAD-ESI-MSn profiling, anti-inflammatory activity and mechanism in vitro and in vivo

ChunlianTianabYuChangaRuxiaWangaZhiruoKangaQiWangaZhifanTongaAohuaZhouaCancanCuiaMingchunLiua

doi : 10.1016/j.jep.2021.114225

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Positive effects of Lianhuaqingwen granules in COVID-19 patients: A retrospective study of 248 cases

PanShena1JingLia1ShenghaoTuaYanranWuaYongtiaoPengbGangChenaChaoChenc

doi : 10.1016/j.jep.2021.114220

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Anti-inflammatory, and anti-arthritic effects by the twigs of Cinnamomum cassia on complete Freund's adjuvant-induced arthritis in rats

JiSukLeeaSabinaLimb

doi : 10.1016/j.jep.2021.114209

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Applying cooperative module pair analysis to uncover compatibility mechanism of Fangjis: An example of Wenxin Keli decoction

PengqianWangab1TianmaiHea1RuiZhengaYangSunaRuijinQiuaXiaoyuZhangaYanweiXingcHongcaiShanga

doi : 10.1016/j.jep.2021.114214

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Investigation of antinociceptive, antipyretic, antiasthmatic, and spasmolytic activities of Brazilian Cannabis sativa L. roots in rodents

Pedro Modesto NascimentoMenezesaTarcísio Cícero de LimaAraújobEmanuella Chiara ValençaPereiraaJanaine AlmeidaNetobDavid SouzaSilvabMariana CoelhoBritocKátia Simoni BezerraLimadAlane Pains Oliveira doMontedMaria Helena Tavares deMatosdRicardo Santana deLimadLuciano Augusto de AraújoRibeirobdFabrício SouzaSilvabcdLarissa AraújoRolimabd

doi : 10.1016/j.jep.2021.114259

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Effectiveness of the polyphenols-rich Sedum dendroideum infusion on gastric ulcer healing in rats: Roles of protective endogenous factors and antioxidant and anti-inflammatory mechanisms

Bruna Barbosada LuzaDanieleMaria-FerreiraaeJorge LuizDallazenaAna Fláviade OliveirabJosé EderaldoQueiroz TellescOlair CarlosBeltramedThales RicardoCiprianibMaria Fernandade Paula Wernera

doi : 10.1016/j.jep.2021.114260

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Vernicia fordii (Hemsl.) Airy Shaw extract stimulates insulin secretion in pancreatic β-cells and improves insulin sensitivity in diabetic mice

JiminHyuna1Mi HyeonParkb1Yo HanLeea1YoungeunLeeaSu JiJeongaSun SilChoiaKeon WooKhimaHye JinEomaJin-HoeHurcChan YoungParkaJae-IckKimaJiyoungParkaHyung WonRyubHyun-JunJangaSei-RyangOhbJang HyunChoia

doi : 10.1016/j.jep.2021.114238

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Association between Traditional Chinese medicine and a lower risk of dementia in patients with major depression: A case-control study

Shun-KuLinabc†Pin-HsuanWangbe†Ching-HsuanHuangdYu-HsienKuodJung-NienLaief1JamesCheng-Chung Weighi1

doi : 10.1016/j.jep.2021.114291

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Identification of neolignans with PCSK9 downregulatory and LDLR upregulatory activities from Penthorum chinense and the potential in cholesterol uptake by transcriptional regulation of LDLR via SREBP2

Hee-SungChaea1PiseyPela1JinwooChoaYoung-MiKimaChae-YeongAnaJungmooHuhaYoung HeeChoibJinwoongKimaYoung-WonChina

doi : 10.1016/j.jep.2021.114265

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Novel antidepressant mechanism of ginsenoside Rg1: Regulating biosynthesis and degradation of connexin43

Hui-QinWangabSong-WeiYangaYanGaobYing-JiaoLiuaXunLiaQi-DiAiaMei-YuLinaYan-TaoYangaQiZengaYiZhangcZhen-ZhenWangbNai-HongChenab

doi : 10.1016/j.jep.2021.114212

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Total saponins from Tupistra chinensis baker inhibits growth of human gastric cancer cells in vitro and in vivo

ZheWangaJingwenXuabYihaiWangabLiminXiangabXiangjiuHeab

doi : 10.1016/j.jep.2021.114323

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Binding activity of Valeriana fauriei root extract on GABAA receptor flunitrazepam sites and distribution of its active ingredients in the brain of mice – A comparison with that of V. officinalis root

MisatoOtaabHaoNiaYasuhitoMakiabDaikiKatobShoheiMoriguchibShutoNakayamabYukiOiwabKan'ichiroIshiuchiaToshiakiMakinoa

doi : 10.1016/j.jep.2021.114262

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Comparative study on the pharmacodynamic difference of oral administration of Xiaojin Pills accompanied with Chinese Baijiu and water

JiaoSongaBiFengaDingkunZhangaMinQiuaFeiRanaBoCaoaHongXucJunzhiLinbRunchunXuaLiHana

doi : 10.1016/j.jep.2021.114284

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Metabolomics of Spleen-Yang deficiency syndrome and the therapeutic effect of Fuzi Lizhong pill on regulating endogenous metabolism

ZhenZhangabShashaYangaXiaLinaYouHuangaXinyiWeiaJinweiZhouaRuiLiaBinDengcChaomeiFua

doi : 10.1016/j.jep.2021.114281

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Anti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves

Elisangela dosSantosaSaulo EuclidesSilva-FilhobJoyce AlencarSantos RadaiaArielle CristinaArenacThiago LeiteFragadCláudia AndreaLima CardosoeJulioCrodafghCândida AparecidaLeite Kassuyaa

doi : 10.1016/j.jep.2021.114308

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Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agents

JieMeiaYatongZhouaXinpingYangaFanZhangaXiufengLiuabcBoyangYuabc

doi : 10.1016/j.jep.2021.114303

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An integrated approach to discriminate the quality markers of Traditional Chinese medicine preparation based on multi-dimensional characteristic network: Shenqi Jiangtang Granule as a case

HuiZhangaRuoyuChenaCongXuaGuiminZhangbcYongxiaGuanbcQunFengbcJingchunYaobcJizhongYana

doi : 10.1016/j.jep.2021.114277

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Novel promising reproductive and metabolic effects of Cicer arietinum L. extract on letrozole induced polycystic ovary syndrome in rat model

Sara E.AliaShymaa A.El BadawybSherif H.ElmosalamyaShimaa R.EmambAsmaa A.AzouzbMona K.GalalcReham M.Abd-ElsalamdMarwa Y.IssaeBardes B.Hassand

doi : 10.1016/j.jep.2021.114318

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Antinociceptive effect of the hydroethanolic leaf extract of Calotropis procera (Ait) R. Br. (Apocynaceae): Possible involvement of glutamatergic, cytokines, opioidergic and adenosinergic pathways

ErnestObeseaRobert P.BineyaIsaac T.HennehaDanielAnokwahaEmmanuel A.AdakuduguaEricWoodebElvis O.Ameyawa

doi : 10.1016/j.jep.2021.114261

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Anneslea fragrans Wall. ameliorates ulcerative colitis via inhibiting NF-κB and MAPK activation and mediating intestinal barrier integrity

XiaocuiDenga1YudanWanga1LeiTianaMeilianYangaShuyueHeaYapingLiuaAfsarKhancYanpingLibJianxinCaoaGuiguangChenga

doi : 10.1016/j.jep.2021.114304

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Exploring the synergistic mechanism of Gegen Qinlian Decoction on the Wnt signaling pathway using an integrated strategy of network pharmacology and RNA-seq

YanpingLiaYitingGongaXinZhangaJiaxinWangbYaruChengbFenLiubXiujiaShiaWenjuanXubLingDongb

doi : 10.1016/j.jep.2021.114283

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Investigating the hemostatic effect of medicinal plant Arnebia euchroma (Royle) I.M.Johnst extract in a mouse model

NuramatjanAblatabcMihrayAblimitdAbudourehemanAbudoukadiereBuhaiqiemuKadeerfLeiYangg

doi : 10.1016/j.jep.2021.114306

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Integration of transcriptomics and system pharmacology to reveal the therapeutic mechanism underlying Qingfei Xiaoyan Wan to treat allergic asthma

Jing-YiHouaJia-RongWuaDongXuaYi-BingChenbDan-DanShangcShuLiucGuan-WeiFanbYuan-LuCuia

doi : 10.1016/j.jep.2021.114302

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Potentiation of flutamide-induced hepatotoxicity in mice by Xian-Ling-Gu-Bao through induction of CYP1A2

YannanDingabHonghongMaaYashaXuaFengYangaYiLiaFuguoShiaYuanfuLua

doi : 10.1016/j.jep.2021.114299

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Monascus ruber fermented Panax ginseng ameliorates lipid metabolism disorders and modulate gut microbiota in rats fed a high-fat diet

ChongyanZhaoa1QingsongQub1FangYangaZhixunLiaPengshuoYangaLuHanbXinyuanShibc

doi : 10.1016/j.jep.2021.114300

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Understanding the effects of Moringa oleifera in chronic unpredictable stressed zebrafish using metabolomics analysis

Muhammad ShazlyRosdyabMohd SallehRofieeacNurdianaSamsulrizalbMohd ZakiSallehaLay KekTehad

doi : 10.1016/j.jep.2021.114290

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Unfolding the apoptotic mechanism of antioxidant enriched-leaves of Tabebuia pallida (lindl.) miers in EAC cells and mouse model

Md MahbuburRahmanaA.S.M. AliRezabMuhammad AliKhancKhaled MahmudSujondRokshanaSharmineMamunurRashidfMd GolamSadikfMd AbuRezadToshifumiTsukaharagRaffaeleCapassohAshikMosaddikfGlenda C.GobecAHM KhurshidAlamf

doi : 10.1016/j.jep.2021.114297

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Discovery of eight alkaloids with D1 and D2 antagonist activity in leaves of Nelumbo nucifera Gaertn. Using FLIPR assays

HanZhouaTaoHouabZhenhuaGaocXiujieGuobChaoranWangabJixiaWangaYanfangLiuaXinmiaoLianga

doi : 10.1016/j.jep.2021.114335

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Digestive promoting effect and mechanism of Jiao Sanxian in rats

YingLiuaWentingLiaoaXingranLiubYunweiHuaXiaoxiaZhubLongtaoJucFengFengbdWeiQubWenyuanLiuaJianXue

doi : 10.1016/j.jep.2021.114334

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Leojaponin inhibits NLRP3 inflammasome activation through restoration of autophagy via upregulating RAPTOR phosphorylation

Xing-JieZhang1KunShang1Yu-KunPuQiWangTing-TingWangYanZouYong-MeiWangYao-JunXuXiao-LiLiRui-HanZhangWei-LieXiao

doi : 10.1016/j.jep.2021.114322

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The inhibition of inducible nitric oxide production in lipopolysaccharide-stimulated rat macrophages and in silico studies by flavonoids from Iris spuria L. rhizomes

Iman S.A.KhallafaSoad A.L.BayoumiaLourin G.MalakaAbeer M.R.HusseinbAnber F.MohammedcMohamed A.El-MokhtardSalwa F.Faragae

doi : 10.1016/j.jep.2021.114311

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Effects of Salvianolic acid B on RNA expression and co-expression network of lncRNAs in brown adipose tissue of obese mice

BohanLva1YanxiangWua1JuanLiana1NaYuacTianAnaTingyeWangaXueliBaodFangfangMoaDandanZhaoaXiuyanYangaJingZhangbZhiyongZhangbSihuaGaoaGuangjianJianga

doi : 10.1016/j.jep.2021.114289

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Role of taraxerone isolated from Leucas lavandulifolia, as an immunomodulator

SonyJayaramanE. JayadeviVariyar(Associate Professor)

doi : 10.1016/j.jep.2021.114307

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The network pharmacology integrated with pharmacokinetics to clarify the pharmacological mechanism of absorbed components from Viticis fructus extract

XuanhaoChenabXiaoyanWangab1LinMaac1ShimingFangabJinLiabEvans OwusuBoadiabJunHeabXiu-meiGaoabYuWangacYan-xuChangab

doi : 10.1016/j.jep.2021.114336

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Documenting and protecting traditional knowledge in the era of open science: Insights from two Spanish initiatives

VictoriaReyes-GarcíaabcPetraBenyeibLauraAceituno-MatadAiryGraseMaríaMolinadJavierTardíodManuelPardo-de-Santayanafg

doi : 10.1016/j.jep.2021.114295

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The influence of chemical composition of potent inhibitors in the hydrolyzed extracts of anti-hyperuricemic plants to their xanthine oxidase activities

Kheng LeongOoiaRahimahZakariabMei LanTanaShaida FarizaSulaimana

doi : 10.1016/j.jep.2021.114294

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Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation

PriyaPathakabPrachiShuklaaJitendra S.KanshanaaKumaraveluJagaveluaNeelam S.SangwanPh.Dd1Anil K.DwivedicMadhuDikshitae

doi : 10.1016/j.jep.2021.114296

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Corrigendum to Polytrichumcommune Lex Hedw ethyl acetat extract-triggered perturbations in intracellular Ca2+ homeostasis regulates mitochondrial-dependent apoptosis [J. of Ethnopharmacol. 172 (2015) 410–420]

WenjuanYuana1XiaoxiaChengb1PanWangaYaliJiaaQuanhongLiuaWeiTangbXiaobingWanga

doi : 10.1016/j.jep.2021.114319

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