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When Adipose Tissue Lets You Down: Understanding the Functions of Genes Disrupted in Lipodystrophy
Justin J. Rochford
doi : 10.2337/dbi21-0006
Keeping It Local in Metabolic Disease: Adipose Tissue Paracrine Signaling and Insulin Resistance
Darcy E. Kahn; Bryan C. Bergman
doi : 10.2337/dbi21-0020
Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective
Emily K. Sims; Rachel E.J. Besser; Colin Dayan; Cristy Geno Rasmussen; Carla Greenbaum; Kurt J. Griffin; William Hagopian; Mikael Knip; Anna E. Long; Frank Martin; Chantal Mathieu; Marian Rewers; Andrea K. Steck; John M. Wentworth; Stephen S. Rich; Olga Kordonouri; Anette-Gabriele Ziegler; Kevan C. Herold; for the NIDDK Type 1 Diabetes TrialNet Study Group
doi : 10.2337/dbi20-0054
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Lucile Dollet; Michael Kuefner; Elena Caria; David Rizo-Roca; Logan Pendergrast; Ahmed M. Abdelmoez; Håkan K.R. Karlsson; Marie Bjrnholm; Emilie Dalbram; Jonas T. Treebak; Jun Harada; Erik Näslund; Mikael Rydén; Juleen R. Zierath; Nicolas J. Pillon; Anna Krook
doi : 10.2337/db20-0814
Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue
Yijun Lin; Meijuan Bai; Shuo Wang; Lingling Chen; Zixuan Li; Chenchen Li; Peijuan Cao; Yan Chen
doi : 10.2337/db21-0535
PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes
Bernat Elvira; Valerie Vandenbempt; Julia Bauzá-Martinez; Raphaël Crutzen; Javier Negueruela; Hazem Ibrahim; Matthew L. Winder; Manoja K. Brahma; Beata Vekeriotaite; Pieter-Jan Martens; Sumeet Pal Singh; Fernando Rossello; Pascale Lybaert; Timo Otonkoski; Conny Gysemans; Wei Wu; Esteban N. Gurzov
doi : 10.2337/db21-0443
Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention
Jeanne M. McCaffery; Kathleen A. Jablonski; Qing Pan; Arne Astrup; Malene Revsbech Christiansen; Dolores Corella; Lauren M.L. Corso; Jose C. Florez; Paul W. Franks; Christopher Gardner; Torben Hansen; Tuomas O. Kilpeläinen; William C. Knowler; Jaana Lindström; Wim H.M. Saris; Thorkild I.A. Sørensen; Jaakko Tuomilehto; Matti Uusitupa; Rena R. Wing; Tanya Agurs-Collins
doi : 10.2337/db21-0741
Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism
Qianyi Yang; Jameson Hinkle; Jordan N. Reed; Redouane Aherrahrou; Zhiwen Xu; Thurl E. Harris; Erin J. Stephenson; Kiran Musunuru; Susanna R. Keller; Mete Civelek
doi : 10.2337/db21-0674
Rare Variant Analysis of Obesity-Associated Genes in Young Adults With Severe Obesity From a Consanguineous Population of Pakistan
Sadia Saeed; Qasim M. Janjua; Attiya Haseeb; Roohia Khanam; Emmanuelle Durand; Emmanuel Vaillant; Lijiao Ning; Alaa Badreddine; Lionel Berberian; Mathilde Boissel; Souhila Amanzougarene; Mickaël Canouil; Mehdi Derhourhi; Amélie Bonnefond; Muhammad Arslan; Philippe Froguel
doi : 10.2337/db21-0373
Hyperglycemia and Not Hyperinsulinemia Mediates Diabetes-Induced Memory CD8 T-Cell Dysfunction
Inga Kavazović; Mia Krapić; Ammarina Beumer-Chuwonpad; Bojan Polić; Tamara Turk Wensveen; Niels A. Lemmermann; Klaas P.J.M. van Gisbergen; Felix M. Wensveen
doi : 10.2337/db21-0209
Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes
Yuk-Fun Liu; Jake Powrie; Sefina Arif; Jennie H.M. Yang; Evangelia Williams; Leena Khatri; Mamta Joshi; Loic Lhuillier; Nikolaos Fountoulakis; Emma Smith; Craig Beam; Anna Lorenc; Mark Peakman; Timothy Tree
doi : 10.2337/db21-0728
Differentiating Microaneurysm Pathophysiology in Diabetic Retinopathy Through Objective Analysis of Capillary Nonperfusion, Inflammation, and Pericytes
Dong An; Bryan Tan; Dao-Yi Yu; Chandrakumar Balaratnasingam
doi : 10.2337/db21-0737
Pathogenic Role of Diabetes-Induced Overexpression of Kallistatin in Corneal Wound Healing Deficiency Through Inhibition of Canonical Wnt Signaling
Wentao Liang; Li Huang; Xiang Ma; Lijie Dong; Rui Cheng; Marcus Dehdarani; Dimitrios Karamichos; Jian-xing Ma
doi : 10.2337/db21-0740
Single-Cell Transcriptomics Reveals Novel Role of Microglia in Fibrovascular Membrane of Proliferative Diabetic Retinopathy
Zizhong Hu; Xiying Mao; Mingkang Chen; Xinjing Wu; Tianye Zhu; Yu Liu; Zhengyu Zhang; Wen Fan; Ping Xie; Songtao Yuan; Qinghuai Liu
doi : 10.2337/db21-0551
GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression
Vanessa Königs; Sandra Pierre; Martin Schicht; Jessica Welss; Lisa Hahnefeld; Vittoria Rimola; Elke Lütjen-Drecoll; Gerd Geisslinger; Klaus Scholich
doi : 10.2337/db21-0711
Hyperglycemia, Reduced Hematopoietic Stem Cells, and Outcome of COVID-19
Benedetta Maria Bonora; Paola Fogar; Jenny Zuin; Daniele Falaguasta; Roberta Cappellari; Annamaria Cattelan; Serena Marinello; Anna Ferrari; Angelo Avogaro; Mario Plebani; Daniela Basso; Gian Paolo Fadini
doi : 10.2337/db21-0965
Methazolamide Attenuates the Development of Diabetic Cardiomyopathy by Promoting β-Catenin Degradation in Type 1 Diabetic Mice
Xiaoqing Chen; Yilang Li; Xun Yuan; Wenchang Yuan; Conglin Li; Yue Zeng; Yuling Lian; Xiaoxia Qiu; Yuan Qin; Guiping Zhang; Xiawen Liu; Chengfeng Luo; Jian-Dong Luo; Ning Hou
doi : 10.2337/db21-0506
Randomized Controlled Trial of the Hemodynamic Effects of Empagliflozin in Patients With Type 2 Diabetes at High Cardiovascular Risk: The SIMPLE Trial
Emil Wolsk; Mikkel Jürgens; Morten Schou; Mads Ersbøll; Philip Hasbak; Andreas Kjær; Bo Zerahn; Niels Høgh Brandt; Peter Haulund Gæde; Peter Rossing; Jens Faber; Silvio E. Inzucchi; Caroline Michaela Kistorp; Finn Gustafsson
doi : 10.2337/db21-0721
Babies of South Asian and European Ancestry Show Similar Associations With Genetic Risk Score for Birth Weight Despite the Smaller Size of South Asian Newborns
Suraj S. Nongmaithem; Robin N. Beaumont; Akshay Dedaniya; Andrew R. Wood; Babatunji-William Ogunkolade; Zahid Hassan; Ghattu V. Krishnaveni; Kalyanaraman Kumaran; Ramesh D. Potdar; Sirazul A. Sahariah; Murali Krishna; Chiara Di Gravio; Inder D. Mali; Alagu Sankareswaran; Akhtar Hussain; Biswajit W. Bhowmik; Abdul Kalam A. Khan; Bridget A. Knight; Timothy M. Frayling; Sarah Finer; Caroline H.D. Fall; Chittaranjan S. Yajnik; Rachel M. Freathy; Graham A. Hitman; Giriraj R. Chandak
doi : 10.2337/db21-0479
Sulfated Progesterone Metabolites That Enhance Insulin Secretion via TRPM3 Are Reduced in Serum From Women With Gestational Diabetes Mellitus
Hei Man Fan; Alice L. Mitchell; Elena Bellafante; Saraid McIlvride; Laura I. Primicheru; Mirko Giorgi; Ivano Eberini; Argyro Syngelaki; Anita Lövgren-Sandblom; Peter Jones; David McCance; Nithya Sukumar; Nishanthi Periyathambi; Yonas Weldeselassie; Katharine F. Hunt; Kypros H. Nicolaides; David Andersson; Stuart Bevan; Paul T. Seed; Gavin A. Bewick; James E. Bowe; Franca Fraternali; Ponnusamy Saravanan; Hanns-Ulrich Marschall; Catherine Williamson
doi : 10.2337/db21-0702
Monocyte miRNAs Are Associated With Type 2 Diabetes
Daniel C. Parker; Ma Wan; Kurt Lohman; Li Hou; Anh Tram Nguyen; Jingzhong Ding; Alain Bertoni; Steve Shea; Gregory L. Burke; David R. Jacobs, Jr.; Wendy Post; David Corcoran; Ina Hoeschele; John S. Parks; Yongmei Liu
doi : 10.2337/db21-0704
Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells
Manuel Carrasco; Chencheng Wang; Anne M. Søviknes; Yngvild Bjørlykke; Shadab Abadpour; Joao A. Paulo; Erling Tjora; Pål Njølstad; Jonas Ghabayen; Ingrid Nermoen; Valeriya Lyssenko; Simona Chera; Luiza M. Ghila; Marc Vaudel; Hanne Scholz; Helge Ræder
doi : 10.2337/db20-1279
Erratum. Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes. Diabetes 2021;70:2580–2594
Maroof Alam; Anoop Arunagiri; Leena Haataja; Mauricio Torres; Dennis Larkin; John Kappler; Niyun Jin; Peter Arvan
doi : 10.2337/db22-er04a
Comment On Espinosa De Ycaza et al. Adipose Tissue Inflammation Is Not Related to Adipose Insulin Resistance in Humans. Diabetes 2022;71:381–393
Inez Trouwborst; Gijs H. Goossens
doi : 10.2337/db21-1141
Response to Comment on Espinosa De Ycaza et al. Adipose Tissue Inflammation Is Not Related to Adipose Insulin Resistance in Humans. Diabetes 2022;71:381–393
Ana Elena Espinosa De Ycaza; Esben Søndergaard; Michael D. Jensen
doi : 10.2337/dbi22-0005
