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ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?
Colin G. Nichols; Nathaniel W. York; Maria S. Remedi
doi : 10.2337/db21-0755
Imeglimin to the Rescue: Enhanced CHOP/GADD34/eIF2α Signaling Axis Promotes β-Cell Survival
Seokwon Jo; Emilyn U. Alejandro
doi : 10.2337/dbi21-0035
The Need to Increase Clinical Skills and Change the Genetic Testing Strategy for Monogenic Diabetes
Rosa Di Paola; Antonella Marucci; Vincenzo Trischitta
doi : 10.2337/dbi21-0037
Adipose Tissue Inflammation Is Not Related to Adipose Insulin Resistance in Humans
Ana Elena Espinosa De Ycaza; Esben Søndergaard; Maria Morgan-Bathke; Kelli Lytle; Danae A. Delivanis; Paola Ramos; Barbara Gisella Carranza Leon; Michael D. Jensen
doi : 10.2337/db21-0609
Obesity-Induced miR-455 Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway
Qianxing Hu; Jinming Mu; Yuhong Liu; Yue Yang; Yue Liu; Yi Pan; Yanfeng Zhang; Ling Li; Dechen Liu; Jianqiu Chen; Fangfang Zhang; Liang Jin
doi : 10.2337/db21-0134
A Cycle of Inflammatory Adipocyte Death and Regeneration in Murine Adipose Tissue
Akio Monji; Yang Zhang; G.V. Naveen Kumar; Christelle Guillermier; Soomin Kim; Benjamin Olenchock; Matthew L. Steinhauser
doi : 10.2337/db20-1306
Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway
Jinghe Li; Ryota Inoue; Yu Togashi; Tomoko Okuyama; Aoi Satoh; Mayu Kyohara; Kuniyuki Nishiyama; Takahiro Tsuno; Daisuke Miyashita; Tatsuya Kin; A.M. James Shapiro; Resilind Su Ern Chew; Adrian Kee Keong Teo; Seiichi Oyadomari; Yasuo Terauchi; Jun Shirakawa
doi : 10.2337/db21-0123
The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum
Xiaoxi Xu; Yumeng Huang; Xin Li; Peter Arvan; Ming Liu
doi : 10.2337/db21-0638
Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy
Tal Israeli; Yael Riahi; Perla Garzon; Ruy Andrade Louzada; Joao Pedro Werneck-de-Castro; Manuel Blandino-Rosano; Roni Yeroslaviz-Stolper; Liat Kadosh; Sharona Tornovsky-Babeay; Gilad Hacker; Nitzan Israeli; Orly Agmon; Boaz Tirosh; Erol Cerasi; Ernesto Bernal-Mizrachi; Gil Leibowitz
doi : 10.2337/db21-0281
Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes
Kathryn C.S. Locker; Kritika Kachapati; Yuehong Wu; Kyle J. Bednar; David Adams; Caroline Patel; Hiroki Tsukamoto; Luke S. Heuer; Bruce J. Aronow; Andrew B. Herr; William M. Ridgway
doi : 10.2337/db21-0426
Tolerogenic Delivery of a Hybrid Insulin Peptide Markedly Prolongs Islet Graft Survival in the NOD Mouse
Braxton L. Jamison; James E. DiLisio; K. Scott Beard; Tobias Neef; Brenda Bradley; Jessica Goodman; Ronald G. Gill; Stephen D. Miller; Rocky L. Baker; Kathryn Haskins
doi : 10.2337/db20-1170
Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target
MarÃa Garranzo-Asensio; Guillermo SolÃs-Fernández; Ana Montero-Calle; José Manuel GarcÃa-MartÃnez; Maria Carmen Fiuza; Pilar Pallares; Nuria Palacios-Garcia; Custodia GarcÃa-Jiménez; Ana Guzman-Aranguez; Rodrigo Barderas
doi : 10.2337/db20-1206
SGLT2 Inhibition Increases Fasting Glucagon but Does Not Restore the Counterregulatory Hormone Response to Hypoglycemia in Participants With Type 1 Diabetes
Schafer C. Boeder; Justin M. Gregory; Erin R. Giovannetti; Jeremy H. Pettus
doi : 10.2337/db21-0769
Clinical Predictors and Long-term Impact of Acute Kidney Injury on Progression of Diabetic Kidney Disease in Chinese Patients With Type 2 Diabetes
Guozhi Jiang; Andrea O. Luk; Claudia H.T. Tam; Risa Ozaki; Cadmon K.P. Lim; Elaine Y.K. Chow; Eric S. Lau; Alice P.S. Kong; Baoqi Fan; Hong Kong Diabetes Register TRS Study Group; Ka Fai Lee; Shing Chung Siu; Grace Hui; Chiu Chi Tsang; Kam Piu Lau; Jenny Y. Leung; Man-wo Tsang; Grace Kam; Ip Tim Lau; June K. Li; Vincent T. Yeung; Emmy Lau; Stanley Lo; Samuel Fung; Yuk Lun Cheng; Chun Chung Chow; Hong Kong Diabetes Biobank Study Group; Nelson L.S. Tang; Yu Huang; Hui-yao Lan; Richard A. Oram; Cheuk Chun Szeto; Wing Yee So; Juliana C.N. Chan; Ronald C.W. Ma
doi : 10.2337/db21-0694
Syndromic Monogenic Diabetes Genes Should Be Tested in Patients With a Clinical Suspicion of Maturity-Onset Diabetes of the Young
Kevin Colclough; Sian Ellard; Andrew Hattersley; Kashyap Patel
doi : 10.2337/db21-0517
Functional Gly297Ser Variant of the Physiological Dysglycemic Peptide Pancreastatin Is a Novel Risk Factor for Cardiometabolic Disorders
Prasanna K.R. Allu; Malapaka Kiranmayi; Sromona D. Mukherjee; Venkat R. Chirasani; Richa Garg; Durairajpandian Vishnuprabu; Sudesh Ravi; Lakshmi Subramanian; Bhavani S. Sahu; Dhanya R. Iyer; Sakthisree Maghajothi; Saurabh Sharma; Marimuthu S. Ravi; Madhu Khullar; Arasambattu K. Munirajan; Jiaur R. Gayen; Sanjib Senapati; Ajit S. Mullasari; Viswanathan Mohan; Venkatesan Radha; Sathyamangala V. Naga Prasad; Nitish R. Mahapatra
doi : 10.2337/db21-0289
Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes
Mark J. O’Connor; Philip Schroeder; Alicia Huerta-Chagoya; Paula Cortés-Sánchez; SilvÃa Bonà s-Guarch; Marta Guindo-MartÃnez; Joanne B. Cole; Varinderpal Kaur; David Torrents; Kumar Veerapen; Niels Grarup; Mitja Kurki; Carsten F. Rundsten; Oluf Pedersen; Ivan Brandslund; Allan Linneberg; Torben Hansen; Aaron Leong; Jose C. Florez; Josep M. Mercader
doi : 10.2337/db21-0545
Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4+ T Cells That Mark Progression to Type 1 Diabetes
Naiara G. Bediaga; Alexandra L. Garnham; Gaetano Naselli; Esther Bandala-Sanchez; Natalie L. Stone; Joanna Cobb; Jessica E. Harbison; John M. Wentworth; Annette-G. Ziegler; Jennifer J. Couper; Gordon K. Smyth; Leonard C. Harrison
doi : 10.2337/db21-0612
Gene Panel Sequencing of Patients With Monogenic Diabetes Brings to Light Genes Typically Associated With Syndromic Presentations
Cécile Saint-Martin; Delphine Bouvet; Mathilda Bastide; Christine Bellanné-Chantelot; on behalf of the Monogenic Diabetes Study Group of the Société Francophone du Diabète*
doi : 10.2337/db21-0520
Comment on De Wendt et al. Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1. Diabetes 2021;70:2796–2809
Rasmus Kjøbsted; Jørgen F.P. Wojtaszewski
doi : 10.2337/db21-1036
Response to Comment on Wendt et al. Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1. Diabetes 2021;70:2796–2809
Alexandra Chadt; Hadi Al-Hasani
doi : 10.2337/dbi21-0038
