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Targeting the Pancreatic α-Cell to Prevent Hypoglycemia in Type 1 Diabetes
Julia K. Panzer; Alejandro Caicedo
doi : 10.2337/dbi20-0048
COVID-19–Induced New-Onset Diabetes: Trends and Technologies
Ahmed A. Metwally; Pranav Mehta; Brian S. Johnson; Anvith Nagarjuna; Michael P. Snyder
doi : 10.2337/dbi21-0029
Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19
Jihoon Shin; Shinichiro Toyoda; Shigeki Nishitani; Atsunori Fukuhara; Shunbun Kita; Michio Otsuki; Iichiro Shimomura
doi : 10.2337/db20-1094
Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function
Jee Hyung Sohn; Yul Ji; Chang-Yun Cho; Hahn Nahmgoong; Sangsoo Lim; Yong Geun Jeon; Sang Mun Han; Ji Seul Han; Isaac Park; Hyun-Woo Rhee; Sun Kim; Jae Bum Kim
doi : 10.2337/db21-0272
Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner
Maria M. Glavas; Ann Y. Lee; Ian Miao; Fan Yang; Majid Mojibian; Shannon M. O’Dwyer; Timothy J. Kieffer
doi : 10.2337/db21-0310
Different Effects of Lifestyle Intervention in High- and Low-Risk Prediabetes: Results of the Randomized Controlled Prediabetes Lifestyle Intervention Study (PLIS)
Andreas Fritsche; Robert Wagner; Martin Heni; Kostantinos Kantartzis; Jürgen Machann; Fritz Schick; Rainer Lehmann; Andreas Peter; Corinna Dannecker; Louise Fritsche; Vera Valenta; Renate Schick; Peter Paul Nawroth; Stefan Kopf; Andreas F.H. Pfeiffer; Stefan Kabisch; Ulrike Dambeck; Michael Stumvoll; Matthias Blüher; Andreas L. Birkenfeld; Peter Schwarz; Hans Hauner; Julia Clavel; Jochen Seißler; Andreas Lechner; Karsten Müssig; Katharina Weber; Michael Laxy; Stefan Bornstein; Annette Schürmann; Michael Roden; Martin Hrabe de Angelis; Norbert Stefan; Hans-Ulrich Häring
doi : 10.2337/db21-0526
Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1
Christian de Wendt; Lena Espelage; Samaneh Eickelschulte; Christian Springer; Laura Toska; Anna Scheel; Awovi Didi Bedou; Tim Benninghoff; Sandra Cames; Torben Stermann; Alexandra Chadt; Hadi Al-Hasani
doi : 10.2337/db21-0587
Empagliflozin Treatment Is Associated With Improvements in Cardiac Energetics and Function and Reductions in Myocardial Cellular Volume in Patients With Type 2 Diabetes
Sharmaine Thirunavukarasu; Nicholas Jex; Amrit Chowdhary; Imtiaz Ul Hassan; Sam Straw; Thomas P. Craven; Miroslawa Gorecka; David Broadbent; Peter Swoboda; Klaus K. Witte; Richard M. Cubbon; Hui Xue; Peter Kellman; John P. Greenwood; Sven Plein; Eylem Levelt
doi : 10.2337/db21-0270
Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9
Ryan P. Ceddia; Dianxin Liu; Fubiao Shi; Mark K. Crowder; Sumita Mishra; David A. Kass; Sheila Collins
doi : 10.2337/db21-0100
Syntaxin 4 Enrichment in β-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice
Eunjin Oh; Erika M. McCown; Miwon Ahn; Pablo A. Garcia; Sergio Branciamore; Shanshan Tang; De-Fu Zeng; Bart O. Roep; Debbie C. Thurmond
doi : 10.2337/db21-0170
The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice
Nathalie Jouvet; Khalil Bouyakdan; Scott A. Campbell; Cindy Baldwin; Shannon E. Townsend; Maureen A. Gannon; Vincent Poitout; Thierry Alquier; Jennifer L. Estall
doi : 10.2337/db21-0147
Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms
Neetu Srivastava; Hao Hu; Anthony N. Vomund; Orion J. Peterson; Rocky L. Baker; Kathryn Haskins; Luc Teyton; Xiaoxiao Wan; Emil R. Unanue
doi : 10.2337/db21-0513
Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect
Virginia M. Stone; Marta Butrym; Minna M. Hankaniemi; Amir-Babak Sioofy-Khojine; Vesa P. Hytönen; Heikki Hyöty; Malin Flodström-Tullberg
doi : 10.2337/db21-0193
CD8+ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes
Marie Eliane Azoury; Fatoumata Samassa; Mijke Buitinga; Laura Nigi; Noemi Brusco; Aïsha Callebaut; Matthieu Giraud; Magali Irla; Ana Ines Lalanne; Alexia Carré; Georgia Afonso; Zhicheng Zhou; Barbara Brandao; Maikel L. Colli; Guido Sebastiani; Francesco Dotta; Maki Nakayama; Decio L. Eizirik; Sylvaine You; Sheena Pinto; Mark J. Mamula; Yann Verdier; Joelle Vinh; Soren Buus; Chantal Mathieu; Lut Overbergh; Roberto Mallone
doi : 10.2337/db21-0259
Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes
Andrea Vecchione; Tatiana Jofra; Jolanda Gerosa; Kimberly Shankwitz; Roberta Di Fonte; Giuseppe Galvani; Elio Ippolito; Maria Pia Cicalese; Andrew R. Schultz; Howie R. Seay; Mariagrazia Favellato; Giulia Milardi; Angela Stabilini; Francesca Ragogna; Pauline Grogan; Eleonora Bianconi; Andrea Laurenzi; Amelia Caretto; Rita Nano; Raffaela Melzi; Nichole Danzl; Emanuele Bosi; Lorenzo Piemonti; Alessandro Aiuti; Todd Brusko; Constantinos Petrovas; Manuela Battaglia; Georgia Fousteri
doi : 10.2337/db21-0091
Diabetes, Drug Treatment, and Mortality in COVID-19: A Multinational Retrospective Cohort Study
Jennifer E. Nyland; Nazia T. Raja-Khan; Kerstin Bettermann; Philippe A. Haouzi; Douglas L. Leslie; Jennifer L. Kraschnewski; Leslie J. Parent; Patricia Sue Grigson
doi : 10.2337/db21-0385
Diabetes and the Risk of Long-term Post-COVID Symptoms
César Fernández-de-las-Peñas; Carlos Guijarro; Juan Torres-Macho; MarÃa Velasco-Arribas; Susana Plaza-Canteli; ValentÃn Hernández-Barrera; José A. Arias-Navalón
doi : 10.2337/db21-0329
The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes
Emily K. Sims; David Cuthbertson; Kevan C. Herold; Jay M. Sosenko
doi : 10.2337/db21-0519
Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism
Ruifang Li-Gao; David A. Hughes; Jan B. van Klinken; Renée de Mutsert; Frits R. Rosendaal; Dennis O. Mook-Kanamori; Nicholas J. Timpson; Ko Willems van Dijk
doi : 10.2337/db21-0397
Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus
Qing-Rong Liu; Min Zhu; Pingbo Zhang; Caio H. Mazucanti; Nicholas S. Huang; Doyle L. Lang; Qinghua Chen; Pavan Auluck; Stefano Marenco; Jennifer F. O’Connell; Luigi Ferrucci; Chee W. Chia; Josephine M. Egan
doi : 10.2337/db21-0198
