Diabetes




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Pima Indian Contributions to Our Understanding of Diabetic Kidney Disease

Robert G. Nelson; William C. Knowler; Matthias Kretzler; Kevin V. Lemley; Helen C. Looker; Michael Mauer; William E. Mitch; Behzad Najafian; Peter H. Bennett

doi : 10.2337/dbi20-0043

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Glycemic Variability and KIM-1–Induced Inflammation in the Diabetic Kidney

Katherine R. Tuttle; Radica Z. Alicic

doi : 10.2337/dbi21-0021

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Heal Thyself: SGLT2 Inhibition Limits Regenerative Cell Exhaustion and Heals Damaged Vessels

David A. Hess; Daniella C. Terenzi; Subodh Verma

doi : 10.2337/dbi21-0025

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The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence

Jessica L. Dunne; Jennifer L. Maizel; Amanda L. Posgai; Mark A. Atkinson; Linda A. DiMeglio

doi : 10.2337/db21-0052

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Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent

Darleen A. Sandoval; Laura C. Alonso; Maureen Gannon; Maike Sander; Lori Sussel; Jane E.B. Reusch

doi : 10.2337/dbi21-0023

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Women and the American Diabetes Association

Cynthia E. Munoz; Ruth S. Weinstock; Tracey D. Brown; Robert A. Gabbay

doi : 10.2337/dbi21-0024

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Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, With Decreased Expression of Growth Hormone–Releasing Hormone in the Hypothalamus

Takanori Hayashi; Tetsuya Kubota; Inoue Mariko; Iseki Takamoto; Masakazu Aihara; Yoshitaka Sakurai; Nobuhiro Wada; Takashi Miki; Toshimasa Yamauchi; Naoto Kubota; Takashi Kadowaki

doi : 10.2337/db20-0482

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HOXC10 Suppresses Browning to Maintain White Adipocyte Identity

H.Y. Angeline Tan; M.F. Michelle Sim; Shi-Xiong Tan; Yvonne Ng; Sin Yee Gan; Hongyu Li; Suat Peng Neo; Jayantha Gunaratne; Feng Xu; Weiping Han

doi : 10.2337/db21-0114

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Depletion of Prmt1 in Adipocytes Impairs Glucose Homeostasis in Diet-Induced Obesity

Seri Choi; Dahee Choi; Yun-Kyung Lee; Seung Hyun Ahn; Je Kyung Seong; Sung Wook Chi; Tae Jung Oh; Sung Hee Choi; Seung-Hoi Koo

doi : 10.2337/db20-1050

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An Intronic Risk SNP rs12454712 for Central Obesity Acts As an Allele-Specific Enhancer To Regulate BCL2 Expression

Shan-Shan Dong; Dong-Li Zhu; Xiao-Rong Zhou; Yu Rong; Mengqi Zeng; Jia-Bin Chen; Feng Jiang; Xiao-Mei Tuo; Zhihui Feng; Tie-Lin Yang; Yan Guo

doi : 10.2337/db20-1151

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Metformin Perturbs Pancreatic Differentiation From Human Embryonic Stem Cells

Linh Nguyen; Lillian Yuxian Lim; Shirley Suet Lee Ding; Nur Shabrina Amirruddin; Shawn Hoon; Shiao-Yng Chan; Adrian Kee Keong Teo

doi : 10.2337/db20-0722

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Nuclear Factor-Y in Mouse Pancreatic β-Cells Plays a Crucial Role in Glucose Homeostasis by Regulating β-Cell Mass and Insulin Secretion

Yin Liu; Siyuan He; Ruixue Zhou; Xueping Zhang; Shanshan Yang; Dan Deng; Caixia Zhang; Xiaoqian Yu; Yulong Chen; Zhiguang Su

doi : 10.2337/db20-1238

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Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function

Casey J. Bauchle; Kristen E. Rohli; Cierra K. Boyer; Vidhant Pal; Jonathan V. Rocheleau; Siming Liu; Yumi Imai; Eric B. Taylor; Samuel B. Stephens

doi : 10.2337/db21-0037

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The Repertoire of Newly Developing Regulatory T Cells in the Type 1 Diabetes–Prone NOD Mouse Is Very Diverse

Ariel Galindo-Albarrán; Sarah Castan; Jérémy C. Santamaria; Olivier P. Joffre; Bart Haegeman; Paola Romagnoli; Joost P.M. van Meerwijk

doi : 10.2337/db20-1072

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Tribbles Homolog 3 Mediates the Development and Progression of Diabetic Retinopathy

Priyamvada M. Pitale; Irina V. Saltykova; Yvonne Adu-Agyeiwaah; Sergio Li Calzi; Takashi Satoh; Shizuo Akira; Oleg Gorbatyuk; Michael E. Boulton; Machelle T. Pardue; W. Timothy Garvey; Mohammad Athar; Maria B. Grant; Marina S. Gorbatyuk

doi : 10.2337/db20-1268

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T-Cell Expression and Release of Kidney Injury Molecule-1 in Response to Glucose Variations Initiates Kidney Injury in Early Diabetes

Josephine M. Forbes; Domenica A. McCarthy; Andrew J. Kassianos; Tracey Baskerville; Amelia K. Fotheringham; Kurt T.K. Giuliani; Anca Grivei; Andrew J. Murphy; Michelle C. Flynn; Mitchell A. Sullivan; Preeti Chandrashekar; Rani Whiddett; Kristen J. Radford; Nicole Flemming; Sam S. Beard; Neisha D’Silva; Janelle Nisbet; Adam Morton; Stephanie Teasdale; Anthony Russell; Nicole Isbel; Timothy Jones; Jennifer Couper; Helen Healy; Mark Harris; Kim Donaghue; David W. Johnson; Andrew Cotterill; Helen L. Barrett; Trisha O’Moore-Sullivan

doi : 10.2337/db20-1081

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Inhibition of SGLT2 Rescues Bone Marrow Cell Traffic for Vascular Repair: Role of Glucose Control and Ketogenesis

Mattia Albiero; Serena Tedesco; Francesco Ivan Amendolagine; Marianna D’Anna; Ludovica Migliozzi; Gaia Zuccolotto; Antonio Rosato; Roberta Cappellari; Angelo Avogaro; Gian Paolo Fadini

doi : 10.2337/db20-1045

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Hijacking Dorsal Raphe to Improve Metabolism and Depression-Like Behaviors via BDNF Gene Transfer in Mice

Jianbo Xiu; Rongrong Han; Zeyue Liu; Jiayu Li; Shu Liu; Yan Shen; Yu-Qiang Ding; Qi Xu

doi : 10.2337/db20-1030

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Investigating the Neuroprotective Effect of Oral Omega-3 Fatty Acid Supplementation in Type 1 Diabetes (nPROOFS1): A Randomized Placebo-Controlled Trial

Alexis Ceecee Britten-Jones; Jordan T. Kamel; Leslie J. Roberts; Sabine Braat; Jennifer P. Craig; Richard J. MacIsaac; Laura E. Downie

doi : 10.2337/db21-0136

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Impact of Lower Versus Higher LDL Cholesterol Targets on Cardiovascular Events After Ischemic Stroke in Patients With Diabetes

Pierre Amarenco; Jong S. Kim; Julien Labreuche; Hugo Charles; Maurice Giroud; Byung-Chul Lee; Philippa C. Lavallée; Marie-Hélène Mahagne; Elena Meseguer; Norbert Nighoghossian; Philippe Gabriel Steg; Éric Vicaut; Eric Bruckert; Treat Stroke to Target investigators

doi : 10.2337/db21-0302

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Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles

Raymond Noordam; Kristi Läll; Roelof A.J. Smit; Triin Laisk; Andres Metspalu; Tõnu Esko; Lili Milani; Ruth J.F. Loos; Reedik Mägi; Ko Willems van Dijk; Diana van Heemst; Estonian Biobank Research Team

doi : 10.2337/db20-0602

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Tissue-Specific Splicing and Dietary Interaction of a Mutant As160 Allele Determine Muscle Metabolic Fitness in Rodents

Xinyu Yang; Qiaoli Chen; Qian Ouyang; Ping Rong; Weikuan Feng; Chao Quan; Min Li; Qing Jiang; Hui Liang; Tong-Jin Zhao; Hong Yu Wang; Shuai Chen

doi : 10.2337/db21-0039

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Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease

Susan Martin; Madeleine Cule; Nicolas Basty; Jessica Tyrrell; Robin N. Beaumont; Andrew R. Wood; Timothy M. Frayling; Elena Sorokin; Brandon Whitcher; Yi Liu; Jimmy D. Bell; E. Louise Thomas; Hanieh Yaghootkar

doi : 10.2337/db21-0129

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Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens

Weikang Cai; Xuemei Zhang; Thiago M. Batista; Rubén García-Martín; Samir Softic; Guoxiao Wang; Alfred K. Ramirez; Masahiro Konishi; Brian T. O’Neill; Jong Hun Kim; Jason K. Kim; C. Ronald Kahn

doi : 10.2337/db20-1119

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Genotype-Structure-Phenotype Correlations of Disease-Associated IGF1R Variants and Similarities to Those of INSR Variants

Jun Hosoe; Yuki Kawashima-Sonoyama; Fuyuki Miya; Hiroko Kadowaki; Ken Suzuki; Takashi Kato; Fumiko Matsuzawa; Sei-Ichi Aikawa; Yukinori Okada; Tatsuhiko Tsunoda; Keiichi Hanaki; Susumu Kanzaki; Nobuhiro Shojima; Toshimasa Yamauchi; Takashi Kadowaki

doi : 10.2337/db20-1145

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Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes

Helmut Hiller; Dawn E. Beachy; Joseph J. Lebowitz; Stefanie Engler; Justin R. Mason; Douglas R. Miller; Irina Kusmarteva; Laura M. Jacobsen; Amanda L. Posgai; Habibeh Khoshbouei; Richard A. Oram; Desmond A. Schatz; Andrew T. Hattersley; Bernd Bodenmiller; Mark A. Atkinson; Harry S. Nick; Clive H. Wasserfall

doi : 10.2337/db21-0070

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Metabolomics Profiling of Patients With A−β+ Ketosis-Prone Diabetes During Diabetic Ketoacidosis

Farook Jahoor; Jean W. Hsu; Paras B. Mehta; Kelly R. Keene; Ruchi Gaba; Surya Narayan Mulukutla; Eunice Caducoy; W. Frank Peacock; Sanjeet G. Patel; Rasmus Bennet; Ake Lernmark; Ashok Balasubramanyam

doi : 10.2337/db21-0066

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Statement of Retraction. Christopher Lipina, Clare Stretton, Simon Hastings, Jonathan S. Hundal, Ken Mackie, Andrew J. Irving, and Harinder S. Hundal. Regulation of MAP Kinase–Directed Mitogenic and Protein Kinase B–Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells. Diabetes 2010;59:375–385. DOI: 10.2337/db09-0979. PMID: 19933999. PMCID: PMC2809953

doi : 10.2337/db21-rt08a

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Statement of Retraction. Christopher Lipina, Katherine Macrae, Tamara Suhm, Cora Weigert, Agnieszka Blachnio-Zabielska, Marcin Baranowski, Jan Gorski, Karl Burgess, and Harinder S. Hundal. Mitochondrial Substrate Availability and Its Role in Lipid-Induced Insulin Resistance and Proinflammatory Signaling in Skeletal Muscle. Diabetes 2013;62:3426–3436. DOI: 10.2337/db13-0264. PMID: 23733201. PMCID: PMC3781443

doi : 10.2337/db21-rt08b

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Statement of Retraction. Qilong Wang, Zhonglin Xie, Wencheng Zhang, Jun Zhou, Yue Wu, Miao Zhang, Huaiping Zhu, and Ming-Hui Zou. Myeloperoxidase Deletion Prevents High-Fat Diet–Induced Obesity and Insulin Resistance. Diabetes 2014;63:4172–4185. DOI: 10.2337/db14-0026. PMID: 25024373. PMCID: PMC4238009

doi : 10.2337/db21-rt08c

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