Diabetes, Obesity and Metabolism




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A novel hypothesis linking low-grade ketonaemia to cardio-renal benefits with sodium-glucose cotransporter-2 inhibitors

Preethika Ekanayake MD, Sunder Mudaliar MD

doi : 10.1111/dom.14562

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Effects of canagliflozin on major adverse cardiovascular events by baseline estimated glomerular filtration rate: Pooled Hispanic subgroup analyses from the CANVAS Program and CREDENCE trial

Matthew R. Weir MD, Jagadish Gogate PhD, C.V. Damaraju PhD, Ricardo Correa-Rotter MD, Kenneth W. Mahaffey MD

doi : 10.1111/dom.14539

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A single bout of cycling exercise induces nucleosome repositioning in the skeletal muscle of lean and overweight/obese individuals

Prasad P. Devarshi PhD, Andrea S. Pereyra MD, PhD, Jessica M. Ellis PhD, Tara M. Henagan PhD

doi : 10.1111/dom.14541

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Efficacy of iGlarLixi in adults with type 2 diabetes inadequately controlled (glycated haemoglobin ≥8%, ≥64 mmol/mol) on two oral antidiabetes drugs: Post hoc analysis of the LixiLan-O randomized trial

Melanie J. Davies MD, Julio Rosenstock MD, Amar Ali MBChB (Hons), David Russell-Jones MD, Elisabeth Souhami MD, Karen Palmer BSc (Hons), Chen Ji PhD, Elisabeth Niemoeller MD, Neil Skolnik MD

doi : 10.1111/dom.14543

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Degludec hospital trial: A randomized controlled trial comparing insulin degludec U100 and glargine U100 for the inpatient management of patients with type 2 diabetes

Rodolfo J. Galindo MD, Francisco J. Pasquel MD, Priyathama Vellanki MD, Radica Alicic MD, David W. Lam MD, Maya Fayfman MD, Alexandra L. Migdal MD, Georgia M. Davis MD, Saumeth Cardona MD, Maria A. Urrutia MD, Citlalli Perez-Guzman MD, Karla Walkiria Zamudio-Coronado MD, Limin Peng PhD, Katherine R. Tuttle MD, Guillermo E. Umpierrez MD

doi : 10.1111/dom.14544

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Antiobesity therapeutics with complementary dual-agonist activities at glucagon and glucagon-like peptide 1 receptors

Bong Gyu Park PhD, Gyeong Min Kim PhD candidate, Hye-Jin Lee MS, Jae Ha Ryu PhD, Dong-Hoon Kim PhD, Jae-Young Seong PhD, Soojeong Kim PhD, Zee-Yong Park PhD, Young-Joon Kim PhD, Jaemin Lee PhD, Jae Il Kim PhD

doi : 10.1111/dom.14546

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Long-term effects of dapagliflozin plus saxagliptin versus glimepiride on a background of metformin in patients with type 2 diabetes: Results of a 104-week extension to a 52-week randomized, phase 3 study and liver fat MRI substudy

Juan P. Frías MD, Jill Maaske MD, Lisa Suchower MA, Lars Johansson PhD, Paul D. Hockings PhD, Nayyar Iqbal MD, John P. H. Wilding DM

doi : 10.1111/dom.14548

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Switching the basal insulin to insulin glargine 300 U/ml in people with type 2 diabetes under basal insulin supported oral therapy: Observational trial on effectiveness and safety

Jochen Seufert MD, Peter Wiesli MD, Andreas Fritsche MD, Helmut Anderten MD, Katrin Pegelow PhD, Stefan Pscherer MD, Martin Pfohl MD

doi : 10.1111/dom.14549

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Relationship between blood glucose variability in ambulatory glucose profile and standardized continuous glucose monitoring metrics: Subanalysis of a prospective cohort study

Akemi Tokutsu MD, Yosuke Okada MD, Tomoya Mita MD, Keiichi Torimoto MD, Satomi Wakasugi MD, Naoto Katakami MD, Hidenori Yoshii MD, Kohei Uryu MD, Keiko Nishida MD, Tadashi Arao MD, Yoshiya Tanaka MD, Masahiko Gosho PhD, Iichiro Shimomura MD, Hirotaka Watada MD

doi : 10.1111/dom.14550

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Gastrointestinal tolerability of once-weekly semaglutide 2.4 mg in adults with overweight or obesity, and the relationship between gastrointestinal adverse events and weight loss

Sean Wharton MD, Salvatore Calanna MD, Melanie Davies MD, Dror Dicker MD, Bryan Goldman MS, Ildiko Lingvay MD, Ofri Mosenzon MD, Domenica M. Rubino MD, Mette Thomsen MD, Thomas A. Wadden PhD, Sue D. Pedersen MD

doi : 10.1111/dom.14551

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Sotagliflozin for patients with type 2 diabetes: A systematic review and meta-analysis

Ioannis Avgerinos MD, Thomas Karagiannis MD, Panagiota Kakotrichi MD, Theodoros Michailidis MD, Aris Liakos MD, David R. Matthews MD, Apostolos Tsapas MD, Eleni Bekiari MD

doi : 10.1111/dom.14555

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Postprandial renal haemodynamic effects of the dipeptidyl peptidase-4 inhibitor linagliptin versus the sulphonylurea glimepiride in adults with type 2 diabetes (RENALIS): A predefined substudy of a randomized, double-blind trial

Marcel H. A. Muskiet MD, Lennart Tonneijck MD, Mark M. Smits MD, Mark H. H. Kramer MD, D. Margriet Ouwens PhD, Bolette Hartmann PhD, Jens J. Holst PhD, A. H. Jan Danser MD, Jaap A. Joles DVM, Daniël H. van Raalte MD

doi : 10.1111/dom.14557

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Efficacy and safety of finerenone in patients with chronic kidney disease and type 2 diabetes by GLP-1RA treatment: A subgroup analysis from the FIDELIO-DKD trial

Peter Rossing MD, Rajiv Agarwal MD, Stefan D. Anker MD, Gerasimos Filippatos MD, Bertram Pitt MD, Luis M. Ruilope MD, Aslam Amod MD, Michel Marre MD, Amer Joseph MBBS, Andrea Lage MD, Charlie Scott MSc, George L. Bakris MD, on behalf of the FIDELIO-DKD Investigators

doi : 10.1111/dom.14558

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Empagliflozin and uric acid metabolism in diabetes: A post hoc analysis of the EMPA-REG OUTCOME trial

João Pedro Ferreira MD, Silvio E. Inzucchi MD, Michaela Mattheus Dipl. Biomath, Thomas Meinicke MD, Dominik Steubl MD, Christoph Wanner MD, Bernard Zinman MD

doi : 10.1111/dom.14559

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Glucose-dependent insulinotropic polypeptide induces lipolysis during stable basal insulin substitution and hyperglycaemia in men with type 1 diabetes: A randomized, double-blind, placebo-controlled, crossover clinical trial

Sebastian M.N. Heimburger MSc, Chris N. Nielsen MD, Salvatore Calanna MD, PhD, Professor Jens J. Holst MD, DMSc, Professor Tina Vilsbøll MD, DMSc, Professor Filip K. Knop PhD, MD, Associate Professor Mikkel B. Christensen MD, PhD

doi : 10.1111/dom.14545

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The dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist tirzepatide improves cardiovascular risk biomarkers in patients with type 2 diabetes: A post hoc analysis

Jonathan M. Wilson, Yanzhu Lin, M. Jane Luo, Gary Considine, Amy L. Cox, Lenden M. Bowsman, Deborah A. Robins, Axel Haupt, Kevin L. Duffin, Giacomo Ruotolo

doi : 10.1111/dom.14553

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Are novel glucose-lowering agents' cardiorenal benefits generalizable to individuals of Black race? A meta-trial sequential analysis to address disparities in cardiovascular and renal outcome trials enrolment

Huilin Tang MSc, Stephen E. Kimmel MD, Inmaculada Hernandez PharmD, PhD, Maria M. Brooks PhD, Kenneth Cusi MD, Steven M. Smith PharmD, Weilong Shi MSc, Almut G. Winterstein PhD, Jared W. Magnani MD, Jingchuan Guo MD, PhD

doi : 10.1111/dom.14540

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Does poor glycaemic control affect the immunogenicity of the COVID-19 vaccination in patients with type 2 diabetes: The CAVEAT study

Raffaele Marfella MD, Nunzia D'Onofrio BiolD, Celestino Sardu MD, Lucia Scisciola BiolD, Paolo Maggi MD, Nicola Coppola MD, Ciro Romano MD, Vincenzo Messina MD, Fabrizio Turriziani MD, Mario Siniscalchi MD, Mauro Maniscalco MD, Marco Boccalatte MD, Giovanni Napolitano MD, Luigi Salemme MD, Ludovica Vittoria Marfella st, Eugenio Basile MD, Maria Vittoria Montemurro MD, Carmela Papa st, Francesco Frascaria MD, Antonio Papa MD, Ferdinando Russo MD, Virginia Tirino MD, Gianpaolo Papaccio MD, Marilena Galdiero MD, Ferdinando Carlo Sasso MD, Michelangela Barbieri MD, Maria Rosaria Rizzo MD, Maria Luisa Balestrieri BiolD, Italo Francesco Angelillo DDS, MPH, Claudio Napoli MD, Giuseppe Paolisso MD

doi : 10.1111/dom.14547

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Pharmacodynamics and pharmacokinetics of extended-release metformin in patients with type 2 diabetes and chronic kidney disease stage 3B

Jean-Daniel Lalau MD, Youssef Bennis MD, Abdallah Al-Salameh MD, Anne-Sophie Hurtel-Lemaire MD, Salha Fendri MD

doi : 10.1111/dom.14554

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Off-label use of sodium glucose co-transporter inhibitors among adults in type 1 diabetes exchange registry

Michael S. Hughes MD, Ryan Bailey MS, Peter Calhoun PhD, Viral N. Shah MD, Sarah K. Lyons MD, Daniel J. DeSalvo MD

doi : 10.1111/dom.14556

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From insulin injections to islet transplantation: An overview of the journey

Michelle B. Paget BSc(Hons), PhD, Hilary E. Murray BSc, PhD, Clifford J. Bailey PhD, Richard Downing BSc, MD, FRCS

doi : 10.1111/dom.14526

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The ongoing evolution of basal insulin therapy over 100 years and its promise for the future

Ravi Retnakaran, Bernard Zinman

doi : 10.1111/dom.14552

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Insulin Centennial: Milestones influencing the development of insulin preparations since 1922

David R. Owens MD, Louis Monnier MD, Antonio Ceriello MD, Geremia B. Bolli MD

doi : 10.1111/dom.14587

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The automated pancreas: A review of technologies and clinical practice

Torben Biester MD, Martin Tauschmann PhD, Agata Chobot PhD, Olga Kordonouri MD, Thomas Danne MD, Thomas Kapellen MD, Klemen Dovc PhD

doi : 10.1111/dom.14576

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Pushing the limits of insulin delivery 100 years later: A case study of a race across Canada

Lauren V. Turner BSc, Michael C. Riddell PhD

doi : 10.1111/dom.14629

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Rapid-acting insulin analogues: Theory and best clinical practice in type 1 and type 2 diabetes

Christophe E. M. De Block MD, Jolijn Van Cauwenberghe MD, Niels Bochanen MD, Eveline Dirinck MD

doi : 10.1111/dom.14713

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