Nature Biotechnology




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First soluble TCR therapy opens ‘new universe’ of cancer targets

Elie Dolgin 

doi : 10.1038/s41587-022-01282-6

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In Antarctica, diesel is for dinner

Lisa Melton 

doi : 10.1038/s41587-022-01285-3

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Broad defeats Berkeley CRISPR patent

Catherine Shaffer

doi : 10.1038/d41587-022-00004-2

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Glyco-immune checkpoints for cancer reach clinic

doi : 10.1038/s41587-022-01295-1

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Pyrukynd ushers in new era for rare cellular metabolic disease

Charlotte Harrison 

doi : 10.1038/s41587-022-01286-2

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Innovators take cover as market bubble bursts

Melanie Senior 

doi : 10.1038/s41587-022-01277-3

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Differentiated dollars

Daniel L. Alvarez & Andrew W. Loآ

doi : 10.1038/s41587-022-01260-y

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Who will oversee the ethical limits of human embryo research?

Eli Y. Adashi & I. Glenn Cohenآ

doi : 10.1038/s41587-022-01274-6

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European patent protection for medical uses of known products and drug repurposing

Mateo Aboy, Kathleen Liddell, Matthew Jordan, Cristina Crespo & Johnathon Liddicoatآ

doi : 10.1038/s41587-022-01269-3

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Enhanced cancer detection from cell-free DNA

Peiyong Jiang & Y. M. Dennis Loآ

doi : 10.1038/s41587-021-01207-9

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Super-resolved spatial transcriptomics by deep data fusion

Ludvig Bergenstrأ¥hle, Bryan He, Joseph Bergenstrأ¥hle, Xesأ؛s Abalo, Reza Mirzazadeh, Kim Thrane, Andrew L. Ji, Alma Andersson, Ludvig Larsson, Natha

doi : 10.1038/s41587-021-01075-3

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Remote smartphone monitoring of Parkinson’s disease and individual response to therapy

Larsson Omberg, Elias Chaibub Neto, Thanneer M. Perumal, Abhishek Pratap, Aryton Tediarjo, Jamie Adams, Bastiaan R. Bloem, Brian M. Bot, Molly Elson,

doi : 10.1038/s41587-021-00974-9

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T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes

Muhammad Ali, Eirini Giannakopoulou, Yingqian Li, Madeleine Lehander, Stina Virding Culleton, Weiwen Yang, Cathrine Knetter, Mete Can Odabasi, Ravi Ch

doi : 10.1038/s41587-021-01089-x

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Improved prediction of immune checkpoint blockade efficacy across multiple cancer types

Diego Chowell, Seong-Keun Yoo, Cristina Valero, Alessandro Pastore, Chirag Krishna, Mark Lee, Douglas Hoen, Hongyu Shi, Daniel W. Kelly, Neal Patel, V

doi : 10.1038/s41587-021-01070-8

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Fast and accurate metagenotyping of the human gut microbiome with GT-Pro

Zhou Jason Shi, Boris Dimitrov, Chunyu Zhao, Stephen Nayfach & Katherine S. Pollardآ

doi : 10.1038/s41587-021-01102-3

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Robust decomposition of cell type mixtures in spatial transcriptomics

Dylan M. Cable, Evan Murray, Luli S. Zou, Aleksandrina Goeva, Evan Z. Macosko, Fei Chen & Rafael A. Irizarryآ

doi : 10.1038/s41587-021-00830-w

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Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data

Duanchen Sun, Xiangnan Guan, Amy E. Moran, Ling-Yun Wu, David Z. Qian, Pepper Schedin, Mu-Shui Dai, Alexey V. Danilov, Joshi J. Alumkal, Andrew C. Ade

doi : 10.1038/s41587-021-01091-3

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RNA-responsive elements for eukaryotic translational control

Evan M. Zhao, Angelo S. Mao, Helena de Puig, Kehan Zhang, Nathaniel D. Tippens, Xiao Tan, F. Ann Ran, Isaac Han, Peter Q. Nguyen, Emma J. Chory, Tiffa

doi : 10.1038/s41587-021-01068-2

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Locus-specific expression of transposable elements in single cells with CELLO-seq

Rebecca V. Berrens, Andrian Yang, Christopher E. Laumer, Aaron T. L. Lun, Florian Bieberich, Cheuk-Ting Law, Guocheng Lan, Maria Imaz, Joseph S. Bowne

doi : 10.1038/s41587-021-01093-1

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Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning

Noah F. Greenwald, Geneva Miller, Erick Moen, Alex Kong, Adam Kagel, Thomas Dougherty, Christine Camacho Fullaway, Brianna J. McIntosh, Ke Xuan Leow,

doi : 10.1038/s41587-021-01094-0

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Deep distributed computing to reconstruct extremely large lineage trees

Naoki Konno, Yusuke Kijima, Keito Watano, Soh Ishiguro, Keiichiro Ono, Mamoru Tanaka, Hideto Mori, Nanami Masuyama, Dexter Pratt, Trey Ideker, Wataru

doi : 10.1038/s41587-021-01111-2

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Personalized phosphoproteomics identifies functional signaling

Elise J. Needham, Janne R. Hingst, Benjamin L. Parker, Kaitlin R. Morrison, Guang Yang, Johan Onslev, Jonas M. Kristensen, Kurt Hأ¸jlund, Naomi X. Y.

doi : 10.1038/s41587-021-01099-9

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Inferring gene expression from cell-free DNA fragmentation profiles

Mohammad Shahrokh Esfahani, Emily G. Hamilton, Mahya Mehrmohamadi, Barzin Y. Nabet, Stefan K. Alig, Daniel A. King, Chloأ© B. Steen, Charles W. Macaul

doi : 10.1038/s41587-022-01222-4

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Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging

Kanuj Mishra, Juan Pablo Fuenzalida-Werner, Francesca Pennacchietti, Robert Janowski, Andriy Chmyrov, Yuanhui Huang, Christian Zakian, Uwe Klemm, Ilar

doi : 10.1038/s41587-021-01100-5

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Sparse deconvolution improves the resolution of live-cell super-resolution fluorescence microscopy

Weisong Zhao, Shiqun Zhao, Liuju Li, Xiaoshuai Huang, Shijia Xing, Yulin Zhang, Guohua Qiu, Zhenqian Han, Yingxu Shang, De-en Sun, Chunyan Shan, Runlo

doi : 10.1038/s41587-021-01092-2

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Helping others enhances graduate student wellness and mental health

Tracey O. Hermanstyne, Lauren Johnson, Kristine M. Wylie & James B. Skeathآ

doi : 10.1038/s41587-022-01275-5

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