Nature Biotechnology




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COVID-19 vaccine makers chase variant-ready vaccines

Cormac Sheridan

doi : 10.1038/d41587-022-00001-5

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Fashion’s microbial dyeing machines

Lisa Melton 

doi : 10.1038/s41587-022-01237-x

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Rejuvenation by controlled reprogramming is the latest gambit in anti-aging

Michael Eisenstein

doi : 10.1038/d41587-022-00002-4

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African coronavirus surveillance network provides early warning for world

Paul Adepoju

doi : 10.1038/d41587-022-00003-3

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Drug pipeline 4Q21

Laura DeFrancesco 

doi : 10.1038/s41587-022-01216-2

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2021 � the bubble’s hangover

Laura DeFrancesco 

doi : 10.1038/s41587-022-01215-3

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Fresh from the biotech pipeline: too much, too fast?

Melanie Senior 

doi : 10.1038/s41587-022-01208-2

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A Python library for probabilistic analysis of single-cell omics data

Adam Gayoso, Romain Lopez, Galen Xing, Pierre Boyeau, Valeh Valiollah Pour Amiri, Justin Hong, Katherine Wu, Michael Jayasuriya, Edouard Mehlman, Maxi

doi : 10.1038/s41587-021-01206-w

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Recent Orange and Purple Book legislation suggests a need to bridge drug and biologic patent regimes

Bryan S. Walsh, Jonathan J. Darrow & Aaron S. Kesselheimآ

doi : 10.1038/s41587-021-01204-y

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Dreaming ideal protein structures

Noelia Ferruz & Birte Hأ¶ckerآ

doi : 10.1038/s41587-021-01196-9

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Back and forth with nanopore peptide sequencing

Meni Wanunu 

doi : 10.1038/s41587-021-01205-x

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Identification of tumor antigens with immunopeptidomics

Chloe Chong, George Coukos & Michal Bassani-Sternbergآ

doi : 10.1038/s41587-021-01038-8

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CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells

Karl Petri, Weiting Zhang, Junyan Ma, Andrea Schmidts, Hyunho Lee, Joy E. Horng, Daniel Y. Kim, Ibrahim C. Kurt, Kendell Clement, Jonathan Y. Hsu, Luc

doi : 10.1038/s41587-021-00901-y

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Compact RNA editors with small Cas13 proteins

Soumya Kannan, Han Altae-Tran, Xin Jin, Victoria J. Madigan, Rachel Oshiro, Kira S. Makarova, Eugene V. Koonin & Feng Zhangآ

doi : 10.1038/s41587-021-01030-2

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Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Claudia Kathe, Frأ©dأ©ric Michoud, Philipp Schأ¶nle, Andreas Rowald, Noأ© Brun, Jimmy Ravier, Ivan Furfaro, Valentina Paggi, Kyungjin Kim, Sadaf Solou

doi : 10.1038/s41587-021-01019-x

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Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer

Tamara Ouspenskaia, Travis Law, Karl R. Clauser, Susan Klaeger, Siranush Sarkizova, Franأ§ois Aguet, Bo Li, Elena Christian, Binyamin A. Knisbacher, P

doi : 10.1038/s41587-021-01021-3

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Precise genomic deletions using paired prime editing

Junhong Choi, Wei Chen, Chase C. Suiter, Choli Lee, Florence M. Chardon, Wei Yang, Anh Leith, Riza M. Daza, Beth Martin & Jay Shendureآ

doi : 10.1038/s41587-021-01025-z

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Deletion and replacement of long genomic sequences using prime editing

Tingting Jiang, Xiao-Ou Zhang, Zhiping Weng & Wen Xueآ

doi : 10.1038/s41587-021-01026-y

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Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin

Martina Tedesco, Francesca Giannese, Dejan Lazareviؤ‡, Valentina Giansanti, Dalia Rosano, Silvia Monzani, Irene Catalano, Elena Grassi, Eugenia R. Zan

doi : 10.1038/s41587-021-01031-1

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Differential abundance testing on single-cell data using k-nearest neighbor graphs

Emma Dann, Neil C. Henderson, Sarah A. Teichmann, Michael D. Morgan & John C. Marioniآ

doi : 10.1038/s41587-021-01033-z

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Multiscale and integrative single-cell Hi-C analysis with Higashi

Ruochi Zhang, Tianming Zhou & Jian Maآ

doi : 10.1038/s41587-021-01034-y

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A small and highly sensitive red/far-red optogenetic switch for applications in mammals

Yang Zhou, Deqiang Kong, Xinyi Wang, Guiling Yu, Xin Wu, Ningzi Guan, Wilfried Weber & Haifeng Yeآ

doi : 10.1038/s41587-021-01036-w

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Author Correction: CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells

Karl Petri, Weiting Zhang, Junyan Ma, Andrea Schmidts, Hyunho Lee, Joy E. Horng, Daniel Y. Kim, Ibrahim C. Kurt, Kendell Clement, Jonathan Y. Hsu, Luc

doi : 10.1038/s41587-021-00939-y

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Assessing workforce needs for the emerging CAR-T cell therapy industry

Linda D. Ho, Hadassah L. Robbins & Aaron D. Levineآ

doi : 10.1038/s41587-022-01212-6

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Fourth-quarter biotech job picture

Michael Francisco 

doi : 10.1038/s41587-022-01214-4

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