Nature Biotechnology




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Insulin � the new battleground for drug pricing

doi : 10.1038/s41587-021-01203-z

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T-cell vaccines could top up immunity to COVID, as variants loom large

Elie Dolgin

doi : 10.1038/d41587-021-00025-3

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FDA go-ahead for myasthenia gravis agent

doi : 10.1038/s41587-021-01198-7

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Off-the-shelf, gene-edited CAR-T cells forge ahead, despite safety scare

Cormac Sheridan

doi : 10.1038/d41587-021-00027-1

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Synbio salvages alcohol-free beer

Lisa Melton 

doi : 10.1038/s41587-021-01202-0

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GABA-enriched tomato is first CRISPR-edited food to enter market

Emily Waltz

doi : 10.1038/d41587-021-00026-2

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The PROTAC gold rush

Ken Garber 

doi : 10.1038/s41587-021-01173-2

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Constructive principles for gene editing oversight

Mike May, L. Val Giddings, Charles DeLisi, Daniel Drell, Ari Patrinos, Stanley Hirsch & Richard J. Robertsآ

doi : 10.1038/s41587-021-01189-8

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The DxConnect Virtual Biobank connects diagnostic researchers to clinical samples

Stefano Ongarello, Marta Fernأ،ndez Suأ،rez & Fay Betsouآ

doi : 10.1038/s41587-021-01168-z

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Expanding global access to genetic therapies

Anne W. T. Muigai 

doi : 10.1038/s41587-021-01191-0

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The characteristics of patents impacting availability of biosimilars

Victor L. Van de Wiele, Reed F. Beall, Aaron S. Kesselheim & Ameet Sarpatwariآ

doi : 10.1038/s41587-021-01170-5

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Predicting disease variants using biodiversity and machine learning

Claudia Arnedo-Pac, Nuria Lopez-Bigas & Ferran Muiأ±osآ

doi : 10.1038/s41587-021-01187-w

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Forum: Drug delivery roundtable with Langer and Whitehead

doi : 10.1038/s41587-021-01177-y

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Single-cell immunology of SARS-CoV-2 infection

Yuan Tian, Lindsay N. Carpp, Helen E. R. Miller, Michael Zager, Evan W. Newell & Raphael Gottardoآ

doi : 10.1038/s41587-021-01131-y

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Multiplexed direct detection of barcoded protein reporters on a nanopore array

Nicolas Cardozo, Karen Zhang, Kathryn Doroschak, Aerilynn Nguyen, Zoheb Siddiqui, Nicholas Bogard, Karin Strauss, Luis Ceze & Jeff Nivalaآ

doi : 10.1038/s41587-021-01002-6

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Purification of multiplex oligonucleotide libraries by synthesis and selection

Hansol Choi, Yeongjae Choi, Jaewon Choi, Amos Chungwon Lee, Huiran Yeom, Jinwoo Hyun, Taehoon Ryu & Sunghoon Kwonآ

doi : 10.1038/s41587-021-00988-3

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Integrating T cell receptor sequences and transcriptional profiles by clonotype neighbor graph analysis (CoNGA)

Stefan A. Schattgen, Kate Guion, Jeremy Chase Crawford, Aisha Souquette, Alvaro Martinez Barrio, Michael J. T. Stubbington, Paul G. Thomas & Philip Br

doi : 10.1038/s41587-021-00989-2

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Single-cell measurement of higher-order 3D genome organization with scSPRITE

Mary V. Arrastia, Joanna W. Jachowicz, Noah Ollikainen, Matthew S. Curtis, Charlotte Lai, Sofia A. Quinodoz, David A. Selck, Rustem F. Ismagilov & Mit

doi : 10.1038/s41587-021-00998-1

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Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis

T. Lohoff, S. Ghazanfar, A. Missarova, N. Koulena, N. Pierson, J. A. Griffiths, E. S. Bardot, C.-H. L. Eng, R. C. V. Tyser, R. Argelaguet, C. Guibenti

doi : 10.1038/s41587-021-01006-2

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Identifying transcriptional programs underlying cancer drug response with TraCe-seq

Matthew T. Chang, Frances Shanahan, Thi Thu Thao Nguyen, Steven T. Staben, Lewis Gazzard, Sayumi Yamazoe, Ingrid E. Wertz, Robert Piskol, Yeqing Angel

doi : 10.1038/s41587-021-01005-3

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Efficient CRISPR editing with a hypercompact Cas12f1 and engineered guide RNAs delivered by adeno-associated virus

Do Yon Kim, Jeong Mi Lee, Su Bin Moon, Hyun Jung Chin, Seyeon Park, Youjung Lim, Daesik Kim, Taeyoung Koo, Jeong-Heon Ko & Yong-Sam Kimآ

doi : 10.1038/s41587-021-01009-z

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Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors

Alex Abramson, Morten Revsgaard Frederiksen, Andreas Vegge, Brian Jensen, Mette Poulsen, Brian Mouridsen, Mikkel Oliver Jespersen, Rikke Kaae Kirk, Je

doi : 10.1038/s41587-021-01024-0

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Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19

Jihoon W. Lee, Yapeng Su, Priyanka Baloni, Daniel Chen, Ana Jimena Pavlovitch-Bedzyk, Dan Yuan, Venkata R. Duvvuri, Rachel H. Ng, Jongchan Choi, Jingy

doi : 10.1038/s41587-021-01020-4

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Mapping single-cell data to reference atlases by transfer learning

Mohammad Lotfollahi, Mohsen Naghipourfar, Malte D. Luecken, Matin Khajavi, Maren Bأ¼ttner, Marco Wagenstetter, إ½iga Avsec, Adam Gayoso, Nir Yosef, Ma

doi : 10.1038/s41587-021-01001-7

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Publisher Correction: Top 20 translational researchers of 2020

Brady Huggett & Kathryn Paisnerآ

doi : 10.1038/s41587-021-01183-0

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Publisher Correction: Sickle cell gene therapies approach watershed

Cormac Sheridan 

doi : 10.1038/s41587-021-01193-y

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Publisher Correction: Treg engineers take aim at autoimmunity

Elie Dolgin 

doi : 10.1038/s41587-021-01200-2

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Virtual meetings promise to eliminate geographical and administrative barriers and increase accessibility, diversity and inclusivity

Juncheng Wu, Anushka Rajesh, Yu-Ning Huang, Karishma Chhugani, Rajesh Acharya, Kerui Peng, Ruth D. Johnson, Andrada Fiscutean, Carla Daniela Robles-Es

doi : 10.1038/s41587-021-01176-z

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