JAMA Internal Medicine




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Fulfilling the Mandate of the US Food and Drug Administration’s Accelerated Approval PathwayThe Need for Reforms

Bishal Gyawali, MD, PhD; Joseph S. Ross, MD, MHS; Aaron S. Kesselheim, MD, JD, MPH

doi : 10.1001/jamainternmed.2021.4604

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Approval of Aducanumab for Alzheimer Disease—The FDA’s Perspective

Billy Dunn, MD; Peter Stein, MD; Patrizia Cavazzoni, MD

doi : 10.1001/jamainternmed.2021.4607

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Medicare and the Shocking US Food and Drug Administration Approval of AducanumabCrisis or Opportunity?

Francis J. Crosson, MD; Kenneth Covinsky, MD, MPH; Rita F. Redberg, MD, MSc

doi : 10.1001/jamainternmed.2021.4610

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Reassessing the Role of Routine Urine Drug Screening in Opioid Use Disorder Treatment

Michael A. Incze, MD, MSEd

doi : 10.1001/jamainternmed.2021.4109

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Effectiveness of App-Delivered, Tailored Self-management Support for Adults With Lower Back Pain–Related DisabilityA selfBACK Randomized Clinical Trial

Louise Fleng Sandal, PhD; Kerstin Bach, PhD; Cecilie K. Øverås, MS; et al.

doi : 10.1001/jamainternmed.2021.4097

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Association Between Neighborhood Disadvantage and Functional Well-being in Community-Living Older Persons

Thomas M. Gill, MD; Emma X. Zang, PhD; Terrence E. Murphy, PhD; et al.

doi : 10.1001/jamainternmed.2021.4260

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Association of BNT162b2 mRNA and mRNA-1273 Vaccines With COVID-19 Infection and Hospitalization Among Patients With Cirrhosis

Binu V. John, MD, MPH; Yangyang Deng, MS; Andrew Scheinberg, MD; et al.

doi : 10.1001/jamainternmed.2021.4325

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Association Between Prison Crowding and COVID-19 Incidence Rates in Massachusetts Prisons, April 2020-January 2021

Abigail I. Leibowitz, BA; Mark J. Siedner, MD, MPH; Alexander C. Tsai, MD, PhD; et al.

doi : 10.1001/jamainternmed.2021.4392

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Association of Surprise-Billing Legislation with Prices Paid to In-Network and Out-of-Network Anesthesiologists in California, Florida, and New YorkAn Economic Analysis

Ambar La Forgia, PhD; Amelia M. Bond, PhD; Robert Tyler Braun, PhD; et al.

doi : 10.1001/jamainternmed.2021.4564

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Association Between Prenatal Exposure to Antipsychotics and Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Preterm Birth, and Small for Gestational Age

Zixuan Wang, MSc; Adrienne Y. L. Chan, MPH; David Coghill, MD; et al.

doi : 10.1001/jamainternmed.2021.4571

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COVID-19 Transmission Dynamics Among Close Contacts of Index Patients With COVID-19A Population-Based Cohort Study in Zhejiang Province, China

Yang Ge, MS; Leonardo Martinez, PhD; Shengzhi Sun, PhD; et al.

doi : 10.1001/jamainternmed.2021.4686

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Evaluation of Gender Inequity in Thyroid Cancer DiagnosisDifferences by Sex in US Thyroid Cancer Incidence Compared With a Meta-analysis of Subclinical Thyroid Cancer Rates at Autopsy

Karissa LeClair, BS; Katy J. L. Bell, MBChB, MMed, PhD; Luis Furuya-Kanamori, MBBS, MEpi, MPH, PhD; et al.

doi : 10.1001/jamainternmed.2021.4804

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Accounting for Age in the Definition of Chronic Kidney Disease

Ping Liu, PhD; Rob R. Quinn, MD, PhD; Ngan N. Lam, MD, MSc; et al.

doi : 10.1001/jamainternmed.2021.4813

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Efficacy of Blended Collaborative Care for Patients With Heart Failure and Comorbid DepressionA Randomized Clinical Trial

Bruce L. Rollman, MD, MPH; Amy M. Anderson, MS; Scott D. Rothenberger, PhD; et al.

doi : 10.1001/jamainternmed.2021.4978

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Updated USPSTF Screening Recommendations for DiabetesIdentification of Abnormal Glucose Metabolism in Younger Adults

Richard W. Grant, MD, MPH; Anjali Gopalan, MD, MS; Marc G. Jaffe, MD

doi : 10.1001/jamainternmed.2021.4886

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Overuse of Levothyroxine in Patients With Subclinical HypothyroidismTime to “Leve�-Out-Thyroxine

William K. Silverstein, MD; Deborah Grady, MD, MPH

doi : 10.1001/jamainternmed.2021.2690

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The Fundamental Unfairness of Active Life Span Disparity

Blair Golden, MD, MS; Amy J. H. Kind, MD, PhD

doi : 10.1001/jamainternmed.2021.4269

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Avoiding COVID-19 Outbreaks in Carceral Settings

A. Asa Clemenzi-Allen, MD, MAS; Lisa A. Pratt, MD, MPH

doi : 10.1001/jamainternmed.2021.4389

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Continuation of Antipsychotic Treatment in Pregnancy—Do Not Panic

Amanda Yeaton-Massey, MD; Elizabeth Fitelson, MD; Patricia Robertson, MD

doi : 10.1001/jamainternmed.2021.4562

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Overdiagnosis of Chronic Kidney Disease in Older Adults—An Inconvenient Truth

Ann M. O’Hare, MA, MD; Rudolph A. Rodriguez, MD; Andrew D. Rule, MD, MS

doi : 10.1001/jamainternmed.2021.4823

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Moving Toward Fully Blended Collaborative CareIntegrating Medical and Social Care

Christopher M. Callahan, MD

doi : 10.1001/jamainternmed.2021.4993

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Underuse of Electronic Health Record Features—The Case for CancelRx

Scott D. Nelson, PharmD, MS; Yaa Kumah-Crystal, MD, MPH, MS

doi : 10.1001/jamainternmed.2021.4878

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The Accelerated Approval of Aducanumab for Treatment of Patients With Alzheimer Disease

Robert Steinbrook, MD

doi : 10.1001/jamainternmed.2021.4622

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Protection Because of Prior SARS-CoV-2 Infection

Mitchell H. Katz, MD

doi : 10.1001/jamainternmed.2021.2966

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Electronic Health Record Interoperability—Why Electronically Discontinued Medications Are Still Dispensed

Saira Shervani, MD; William Madden, PharmD; Lauren J. Gleason, MD, MPH

doi : 10.1001/jamainternmed.2021.4881

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Early Hospital Compliance With Federal Requirements for Price Transparency

Suhas Gondi, BA; Adam L. Beckman, BS; Avery A. Ofoje, BA; et al.

doi : 10.1001/jamainternmed.2021.2531

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American Board of Medical Specialties Board Examination Lactation Accommodation Policies

Kevin T. Nead, MD, MPhil; Candice L. Hinkston, MPH; Eleni Linos, MD, MPH, DrPH; et al.

doi : 10.1001/jamainternmed.2021.2536

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Association of Changes in Seasonal Respiratory Virus Activity and Ambulatory Antibiotic Prescriptions With the COVID-19 Pandemic

Alexander J. Lepak, MD; Lindsay N. Taylor, MD; Carolyn A. Stone, PharmD; et al.

doi : 10.1001/jamainternmed.2021.2621

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Levothyroxine Use in the United States, 2008-2018

Juan P. Brito, MD; Joseph S. Ross, MD, MHS; Omar M. El Kawkgi, MD; et al.

doi : 10.1001/jamainternmed.2021.2686

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Changes Associated With the Entry of a Biosimilar in the Insulin Glargine Market

Joseph Levy, PhD; Zahra M. Chowdhury, MHS; Mariana P. Socal, MD, PhD; et al.

doi : 10.1001/jamainternmed.2021.2769

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Assessment of SARS-CoV-2 Reinfection 1 Year After Primary Infection in a Population in Lombardy, Italy

Josè Vitale, MD; Nicola Mumoli, MD; Pierangelo Clerici, MD; et al.

doi : 10.1001/jamainternmed.2021.2959

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Assessment of FDA Approval for New High-risk Therapeutic Devices Not Meeting Pivotal Study Primary End Points, 2016-2020

James L. Johnston, BS; Sanket S. Dhruva, MD, MHS; Joseph S. Ross, MD, MHS; et al.

doi : 10.1001/jamainternmed.2021.3042

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Diabetes Care and Glycemic Control During the COVID-19 Pandemic in the United States

Sadiq Y. Patel, PhD, MS, MSW; Rozalina G. McCoy, MD, MS; Michael L. Barnett, MD, MS; et al.

doi : 10.1001/jamainternmed.2021.3047

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Comparison of Spending on Common Generic Drugs by Medicare vs Costco Members

Erin Trish, PhD; Laura Gascue, MS; Rocio Ribero, PhD; et al.

doi : 10.1001/jamainternmed.2021.3366

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Sustained Wide Complex Tachycardia in a Healthy Man

Toshikazu D. Tanaka, MD, PhD; Takeki Suzuki, MD, PhD; Frank I. Marcus, MD

doi : 10.1001/jamainternmed.2021.3512

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A Common Electrocardiogram Demonstrating an Uncommon Cause

Ting-Ting Li, MD; Chuan-Hai Zhang, MD

doi : 10.1001/jamainternmed.2021.3516

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A Rare Sequence of Events in Acute Coronary Syndrome

Venkatakrishnan Ramakumar, DM; Asharam Panda, MD; Satyavir Yadav, DM

doi : 10.1001/jamainternmed.2021.4016

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Massive Discordant T-Wave Alternans and Imminent Torsades de PointesThe “Elephant in the Room�

Olatunde Ola, MD, MPH; S. Michael Gharacholou, MD, MSc; Freddy Del-Carpio Munoz, MD, MSc

doi : 10.1001/jamainternmed.2021.4021

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Uncertainty in Medicine

Alexander Chaitoff, MD, MPH

doi : 10.1001/jamainternmed.2021.3705

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Uncertainty in Medicine

Jayshil J. Patel, MD; Rachel Goodman, MD

doi : 10.1001/jamainternmed.2021.3708

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Uncertainty in Medicine—Reply

Daniel J. Morgan, MD, MS; Lisa Pineles, MA; Deborah Korenstein, MD

doi : 10.1001/jamainternmed.2021.3711

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Timely Family Meetings or Time-Limited Trials?

Sonal Admane, MD, MPH; David Hui, MD, MSc

doi : 10.1001/jamainternmed.2021.3714

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Timely Family Meetings or Time-Limited Trials?—Reply

Dong W. Chang, MD, MS; Jennifer Parrish, DO; Hal F. Yee Jr, MD, PhD

doi : 10.1001/jamainternmed.2021.3717

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Caution in Interpreting Facial Paralysis Data to Understand COVID-19 Vaccination Risks

Jing Han Ng, MD; Eng King Tan, MD

doi : 10.1001/jamainternmed.2021.4333

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Caution in Interpreting Facial Paralysis Data to Understand COVID-19 Vaccination Risks—Reply

Charles Khouri, PharmD, PhD; Matthieu Roustit, PharmD, PhD; Jean-Luc Cracowski, MD, PhD

doi : 10.1001/jamainternmed.2021.4336

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Discrepancy in the Number of Patients in the Analyses in Study of Development and Validation of the Good Outcome Following Attempted Resuscitation Score

Mark Ebell, MD, MS

doi : 10.1001/jamainternmed.2020.6664

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Error Due to Inclusion of Patients With Incomplete Data in an Analysis

doi : 10.1001/jamainternmed.2021.4695

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