JAMA Oncology




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Efficacy of Concurrent Chemoradiotherapy With S-1 vs Radiotherapy Alone for Older Patients With Esophageal CancerA Multicenter Randomized Phase 3 Clinical Trial

Yongling Ji, MD1; Xianghui Du, MD1; Weiguo Zhu, MD2; et al Yanguang Yang, MD3; Jun Ma, MD4; Li Zhang, MD5; Jiancheng Li, MD6; Hua Tao, MD7; Jianhong Xia, MD8; Haihua Yang, MD9; Jin Huang, MD10; Yong Bao, MD11; Dexi Du, MD12; Degan Liu, MD13; Xiusheng Wang, MD14; Chaoming Li, MD15; Xinmei Yang, MD16; Ming Zeng, MD, PhD17; Zhigang Liu, MD18; Wen Zheng, MD19; Juan Pu, MD20; Jun Chen, MD21; Wangyuan Hu, MD22; Peijing Li, MD1; Jin Wang, MD1; Yujin Xu, MD1; Xiao Zheng, MD1; Jianxiang Chen, MS1; Wanwei Wang, MD2; Guangzhou Tao, MD2; Jing Cai, MD3; Jizhong Zhao, MD3; Jun Zhu, MD7; Ming Jiang, MD7; Yan Yan, MD8; Guoping Xu, MD10; Shanshan Bu, MD14; Binbin Song, MD16; Ke Xie, MD17; Shan Huang, MD17; Yuanda Zheng, BS1; Liming Sheng, MD1; Xiaojing Lai, MS1; Ying Chen, MD1; Lei Cheng, MS1; Xiao Hu, MD1; Wenhao Ji, MS1; Min Fang, MD1; Yue Kong, MS1; Xiaofu Yu, MS1; Huizhang Li, MS1; Runhua Li, MS1; Lei Shi, MD23; Wei Shen, MS23; Chaonan Zhu, MS23; Junwei Lv, MD23; Rong Huang, MD24; Han He, MD24; Ming Chen, MD1,25

doi : 10.1001/jamaoncol.2021.2705

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Assessment of Prostate Cancer Treatment Among Black and White Patients During the COVID-19 Pandemic

Adrien N. Bernstein, MD1; Ruchika Talwar, MD2; Elizabeth Handorf, PhD3; et al Kaynaat Syed, MHA4; John Danella, MD5; Serge Ginzburg, MD6; Laurence Belkoff, DO7; Adam C. Reese, MD8; Jeffery Tomaszewski, MD9; Edouard Trabulsi, MD10; Eric A. Singer, MD, MA, MS11; Bruce Jacobs, MD12; Alexander Kutikov, MD1; Robert Uzzo, MD, MBA1; Jay D. Raman, MD13; Thomas Guzzo, MD, MPH2; Marc C. Smaldone, MD, MSHP1; Andres Correa, MD1

doi : 10.1001/jamaoncol.2021.2755

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Single-Fraction vs Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases (SAFRON II)The Trans Tasman Radiation Oncology Group 13.01 Phase 2 Randomized Clinical Trial

Shankar Siva, PhD1,2; Mathias Bressel, MSc3; Tao Mai, PhD4; et al Hien Le, MBBS5; Shalini Vinod, MD6; Harini de Silva, PhD7; Sean Macdonald, BSc (Hons)7; Marketa Skala, MBBS8; Nicholas Hardcastle, PhD9; Angela Rezo, MBBS10; David Pryor, MBBS4; Suki Gill, MBBS11; Braden Higgs, MBBS5; Kassandra Wagenfuehr, BSc12; Rebecca Montgomery, BBiomedSc12; Raef Awad, MD8; Brent Chesson, BAppSci (Hons)13; Thomas Eade, MBChB14; Wenchang Wong, MBBS15; Giuseppe Sasso, MBChB16; Richard De Abreu Lourenco, PhD17; Tomas Kron, PhD2,4; David Ball, MD1,2; Paul Neeson, PhD2,7; for the Stereotactic Ablative Fractionated Radiotherapy Versus Radiosurgery for Oligometastatic Neoplasia to the Lung (SAFRON) II Study Investigators

doi : 10.1001/jamaoncol.2021.2939

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Effects of Exercise on Cardiorespiratory Fitness and Biochemical Progression in Men With Localized Prostate Cancer Under Active SurveillanceThe ERASE Randomized Clinical Trial

Dong-Woo Kang, PhD1,2; Adrian S. Fairey, MD3; Normand G. Boulé, PhD1; et al Catherine J. Field, PhD4; Stephanie A. Wharton, BSc1; Kerry S. Courneya, PhD1

doi : 10.1001/jamaoncol.2021.3067

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Accelerated Hypofractionated Image-Guided vs Conventional Radiotherapy for Patients With Stage II/III Non–Small Cell Lung Cancer and Poor Performance StatusA Randomized Clinical Trial

Puneeth Iyengar, MD, PhD1,2,3; Elizabeth Zhang-Velten, MD, PhD1,2,3; Laurence Court, PhD4; et al Kenneth Westover, MD, PhD1,2,3; Yulong Yan, PhD1,2,3; Mu-Han Lin, PhD1,2,3; Zhenyu Xiong, PhD1,2,3; Mehul Patel, MD5; Douglas Rivera, MD6; Joe Chang, MD, PhD4; Mark Saunders, MD7; Anand Shivnani, MD8; Andrew Lee, MD9; Randall Hughes, MD1,2,3; David Gerber, MD1,2,3; Jonathan Dowell, MD1,2,3; Ang Gao, MS1,2,3; John Heinzerling, MD10; Ying Li, MD11; Chul Ahn, PhD1,2,3; Hak Choy, MD1,2,3; Robert Timmerman, MD1,2,3

doi : 10.1001/jamaoncol.2021.3186

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Serologic Status and Toxic Effects of the SARS-CoV-2 BNT162b2 Vaccine in Patients Undergoing Treatment for Cancer

Tal Goshen-Lago, PhD1; Ithai Waldhorn, MD1; Roy Holland, MD1; et al Moran Szwarcwort-Cohen, PhD2; Anat Reiner-Benaim, PhD3; Yael Shachor-Meyouhas, MD4,5; Khetam Hussein, MD4,5; Liana Fahoum, MSc1; Mali Baruch, BSc1; Avivit Peer, MD1; Yoram Reiter, PhD6; Ronit Almog, MD3; Michael Halberthal, MD4,5; Irit Ben-Aharon, MD, PhD1,5,6

doi : 10.1001/jamaoncol.2021.2675

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Human Papillomavirus Persistence and Association With Recurrent Cervical Intraepithelial Neoplasia After Cryotherapy vs Loop Electrosurgical Excision Procedure Among HIV-Positive WomenA Secondary Analysis of a Randomized Clinical Trial

Michael H. Chung, MD, MPH1,2,3; Hugo De Vuyst, MD, PhD4; Sharon A. Greene, PhD, MPH2; et al Nelly R. Mugo, MBChB, MMed2,5; Troy D. Querec, PhD6; Evans Nyongesa-Malava, MBChB7; Anthony Cagle, PhD2; Samah R. Sakr, MBChB7; Stanley Luchters, MD, MPH, PhD3,8; Marleen Temmerman, MD, MPH, PhD3,9; Elizabeth R. Unger, MD, PhD6; Christine J. McGrath, PhD, MPH2

doi : 10.1001/jamaoncol.2021.2683

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Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia

David Spencer Mangum, MD1; Julia A. Meyer, PhD2,3; Clinton C. Mason, PhD2; et al Soheil Shams, PhD4; Luke D. Maese, DO2; Jamie D. Gardiner, PhD5; Jonathan M. Downie, MD, PhD6; Deqing Pei, MS7; Cheng Cheng, PhD7; Adam Gleason, MS8; Minjie Luo, PhD8; Ching-Hon Pui, MD9; Richard Aplenc, MD, PhD10; Stephen P. Hunger, MD10; Mignon Loh, MD3; Mel Greaves, PhD11; Nikolaus Trede, MD, PhD12; Elizabeth Raetz, MD13; J. Kimble Frazer, MD, PhD14; Charles G. Mullighan, MD15; Michael E. Engel, MD, PhD16; Rodney R. Miles, MD, PhD17; Karen R. Rabin, MD, PhD18; Joshua D. Schiffman, MD2,5,19

doi : 10.1001/jamaoncol.2021.2723

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Cetuximab Rechallenge Plus Avelumab in Pretreated Patients With RAS Wild-type Metastatic Colorectal CancerThe Phase 2 Single-Arm Clinical CAVE Trial

Erika Martinelli, MD, PhD1; Giulia Martini, MD, PhD1; Vincenzo Famiglietti, PhD1; et al Teresa Troiani, MD, PhD1; Stefania Napolitano, MD, PhD1; Filippo Pietrantonio, MD, PhD2; Davide Ciardiello, MD1; Marinella Terminiello, MD1; Carola Borrelli, MD1; Pietro Paolo Vitiello, MD1; Filippo De Braud, MD, PhD2; Federica Morano, MD2; Antonio Avallone, MD3; Nicola Normanno, MD, PhD4; Anna Nappi, MD3; Evaristo Maiello, MD5; Tiziana Latiano, MD5; Alfredo Falcone, MD6; Chiara Cremolini, MD6; Daniele Rossini, MD6; Giuseppe Santabarbara, MD7; Carmine Pinto, MD8; Daniele Santini, MD, PhD9; Claudia Cardone, MD1,3; Nicoletta Zanaletti, MD1,3; Alessandra Di Liello1; Daniela Renato1; Lucia Esposito1; Francesca Marrone, BS1; Fortunato Ciardiello, MD, PhD1,5

doi : 10.1001/jamaoncol.2021.2915

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Effect of Cisplatin and Gemcitabine With or Without Berzosertib in Patients With Advanced Urothelial CarcinomaA Phase 2 Randomized Clinical Trial

Sumanta K. Pal, MD1; Paul H. Frankel, PhD1; Amir Mortazavi, MD2; et al Matthew Milowsky, MD3; Ulka Vaishampayan, MD4; Mamta Parikh, MD5; Yung Lyou, MD1; Peng Weng, MD6; Rahul Parikh, MD7; Benjamin Teply, MD8; Robert Dreicer, MD9; Hamid Emamekhoo, MD10; Dror Michaelson, MD11; Christopher Hoimes, MD12; Tian Zhang, MD12; Sandy Srinivas, MD13; William Y. Kim, MD3; Yujie Cui, MS1; Edward Newman, MD1; Primo N. Lara Jr, MD5

doi : 10.1001/jamaoncol.2021.3441

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Projected Association of Human Papillomavirus Vaccination With Oropharynx Cancer Incidence in the US, 2020-2045

Yuehan Zhang, ScM1; Carole Fakhry, MD1,2; Gypsyamber D’Souza, PhD1

doi : 10.1001/jamaoncol.2021.2907

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Effectiveness of Adding Everolimus to the First-line Treatment of Advanced Breast Cancer in Premenopausal Women Who Experienced Disease Progression While Receiving Selective Estrogen Receptor ModulatorsA Phase 2 Randomized Clinical Trial

Ying Fan, MD1; Tao Sun, MD2; Zhimin Shao, MD3; et al Qingyuan Zhang, MD4; Quchang Ouyang, MD5; Zhongsheng Tong, MD6; Shusen Wang, MD7; Yang Luo, MD1; Yuee Teng, MD8; Xiaojia Wang, MD9; Shu Wang, MD10; Qiang Liu, MD11; Jifeng Feng, MD12; Kunwei Shen, MD13; Yanqiu Song, MD14; Jiayu Wang, MD1; Fei Ma, MD1; Qing Li, MD1; Pin Zhang, MD1; Binghe Xu, MD, PhD1

doi : 10.1001/jamaoncol.2021.3428

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Cardioprotective Strategy for Patients With Nonmetastatic Breast Cancer Who Are Receiving an Anthracycline-Based ChemotherapyA Randomized Clinical Trial

Lorenzo Livi, MD1,2; Giuseppe Barletta, MD3; Francesca Martella, MD4; et al Calogero Saieva, MD5; Isacco Desideri, MD1,2; Carlotta Bacci, MD4; Maria Riccarda Del Bene, MD3; Mario Airoldi, MD6; Domenico Amoroso, MD7; Luigi Coltelli, MD8; Vieri Scotti, MD1,2; Carlotta Becherini, MD1,2; Luca Visani, MD1,2; Viola Salvestrini, MD1,2; Matteo Mariotti1,2; Fulvia Pedani, MD6; Marco Bernini, MD, PhD9; Luis Sanchez, MD9; Lorenzo Orzalesi, MD9; Jacopo Nori, MD10; Simonetta Bianchi, MD11; Iacopo Olivotto, MD, PhD12; Icro Meattini, MD1,2

doi : 10.1001/jamaoncol.2021.3395

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The Inclusion of Women in Global Oncology Drug Trials Over the Past 20 Years

Kristina Jenei, BSN, MSc1; Daniel E. Meyers, MD, MSc2; Vinay Prasad, MD, MPH3

doi : 10.1001/jamaoncol.2021.3686

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Use of an Analytics and Electronic Health Record–Based Approach for Targeted COVID-19 Vaccine Outreach to Marginalized Populations

Jacob Stein, MD, MPH1,2; Megan Fasold, BSN, MBA1,3; Karyn Jean Daguerre, BSN, MPH, OCN1,3; et al Jaime Richardson, BSN, OCN, CCRP1,3; Summer Cheek, BSN, OCN1,3; Marjory Charlot, MD, MPH, MSc1,2; Ethan Basch, MD, MSc1,2,4

doi : 10.1001/jamaoncol.2021.3833

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Recommendations for Age-Appropriate Testing, Timing, and Frequency of Audiologic Monitoring During Childhood Cancer TreatmentAn International Society of Paediatric Oncology Supportive Care Consensus Report

Annelot J. M. Meijer, MSc1; Marry M. van den Heuvel-Eibrink, MD, PhD1,2; Beth Brooks, MSc3,4; et al Antoinette G. am Zehnhoff-Dinnesen, MD, PhD5; Kristin R. Knight, MSc6; David R. Freyer, DO, MSc7,8,9,10; Kay W. Chang, MD11; Barbara Hero, MD, PhD12; Vassilios Papadakis, MD, PhD13; A. Lindsay Frazier, MD, PhD14; Claudia Blattmann, MD, PhD15; Rachael Windsor, MD, PhD16; Bruce Morland, MD, PhD17; Eric Bouffet, MD, PhD18; Stefan Rutkowski, MD, PhD19; Godelieve A. M. Tytgat, MD, PhD1; James I. Geller, MD20; Lisa L. Hunter, PhD21; Lillian Sung, MD, PhD18,22; Gabriele Calaminus, MD, PhD23; Bruce C. Carleton, PharmD24,25,26; Hiske W. Helleman, PhD27; Jennifer H. Foster, MD, PhD28; Mariana Kruger, MD, PhD29; Richard J. Cohn, MD, PhD30,31; Wendy Landier, MD, PhD32; Martine van Grotel, MD, PhD1; Penelope R. Brock, MD, PhD33; Alexander E. Hoetink, PhD27; Kaukab M. Rajput, PhD34; for the Society of Paediatric Oncology Supportive Care Committee

doi : 10.1001/jamaoncol.2021.2697

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Application of Information Technology to Clinical Trial Evaluation and EnrollmentA Review

Mitchell S. von Itzstein, MD1,2; Melanie Hullings, BSE2; Helen Mayo, MLS3; et al M. Shaalan Beg, MD1,2; Erin L. Williams, MBA2; David E. Gerber, MD1,2,4

doi : 10.1001/jamaoncol.2021.1165

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Anuric Kidney Failure in a Patient With Metastatic Melanoma

Avani M. Kolla, BPhil1; George Jour, MD1; Janice M. Mehnert, MD2

doi : 10.1001/jamaoncol.2021.3515

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Promoting Inclusion of Members of Racial and Ethnic Minority Groups in Cancer Drug Development

Lola Fashoyin-Aje, MD, MPH1; Julia A. Beaver, MD1; Richard Pazdur, MD1

doi : 10.1001/jamaoncol.2021.2137

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Clinical Trial Enrollment of Racial, Ethnic, and Underrepresented Groups—Leveraging a Digital Infrastructure

Matthew Culbert, MD1; Oluwadamilola T. Oladeru, MD, MA1

doi : 10.1001/jamaoncol.2021.2680

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Treatment Options for Relapsed and Refractory Multiple MyelomaA Luxury or a Challenge?

Samer Al Hadidi, MD, MS1,2; Sarvari Yellapragada, MD3

doi : 10.1001/jamaoncol.2021.2761

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Primary Chemoradiotherapy for Older Patients With Esophageal Cancer

Jennifer R. Eads, MD1; Daniel G. Haller, MD1

doi : 10.1001/jamaoncol.2021.2668

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The Intersection of Societal Inequalities and Health CareLessons Learned From the COVID-19 Pandemic

Randy Vince Jr, MD, MS1

doi : 10.1001/jamaoncol.2021.2750

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Managing Pulmonary Oligometastatic Disease With Stereotactic Body Radiation Therapy—Moving the Field Forward 1 Organ at a Time

Arya Amini, MD1

doi : 10.1001/jamaoncol.2021.2926

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The Power of Exercise to Influence Cardiovascular and Oncologic Outcomes—Survival of the Fittest

Neha Vapiwala, MD1

doi : 10.1001/jamaoncol.2021.3065

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Radiation Dose and Fractionation in Locally Advanced Lung CancerA Simple Question With a Complicated Answer

Melin J. Khandekar, MD, PhD1; Florence K. Keane, MD1

doi : 10.1001/jamaoncol.2021.3180

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Single-Dose Radiotherapy for Prostate Cancer—Lessons Learned From Single-Fraction High-Dose-Rate Brachytherapy

Bryan S. Squires, MD1; Daniel J. Krauss, MD1

doi : 10.1001/jamaoncol.2021.2691

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Single-Dose Radiotherapy for Prostate Cancer—Lessons Learned From Single-Fraction High-Dose-Rate Brachytherapy—Reply

Carlo Greco, MD1; Zvi Fuks, MD1,2

doi : 10.1001/jamaoncol.2021.2694

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Association of Adjuvant Immunotherapy Duration With Chronic Immune-Related Adverse Events

Elie Rassy, MD, MSc, MPH1; Barbara Pistilli, MD1; Caroline Robert, MD, PhD1

doi : 10.1001/jamaoncol.2021.2954

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Association of Adjuvant Immunotherapy Duration With Chronic Immune-Related Adverse Events—Reply

Douglas B. Johnson, MD, MSCI1; J. Randall Patrinely Jr, MD, MBA2; Fei Ye, PhD3

doi : 10.1001/jamaoncol.2021.2957

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Population-Based Prostate Cancer Screening With Magnetic Resonance Imaging or Ultrasonography—The IP1-PROSTAGRAM Study

Zhu Oong, MBChB, MRCP1; Omi Parikh, BSc (Hons), MBChB (Hons), MRCP1

doi : 10.1001/jamaoncol.2021.2964

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Population-Based Prostate Cancer Screening With Magnetic Resonance Imaging or Ultrasonography—The IP1-PROSTAGRAM Study—Reply

David Eldred-Evans, MBBS, MRCS1; Hashim U. Ahmed, PhD, BM, BCh, MA1

doi : 10.1001/jamaoncol.2021.2967

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Errors in Reported Primary and Secondary Outcomes and Table Numbers in a Trial of Radiotherapy for Pain Relief in Patients With Bone Metastases

Quynh-Nhu Nguyen, MD1

doi : 10.1001/jamaoncol.2021.3054

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Randomized Clinical Trials in the Era of Precision Oncology—The Role of End Points, Industry Funding, and Medical Writing Integrity

Alessandro Rizzo, MD1; Veronica Mollica1; Francesco Massari, MD1

doi : 10.1001/jamaoncol.2021.3335

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Randomized Clinical Trials in the Era of Precision Oncology—The Role of End Points, Industry Funding, and Medical Writing Integrity

David J. Stewart, MD1; Paul Wheatley-Price, MD1

doi : 10.1001/jamaoncol.2021.3338

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Randomized Clinical Trials in the Era of Precision Oncology—The Role of End Points, Industry Funding, and Medical Writing Integrity

Thomas M. Schindler, PhD1,2; Jacqueline M. Marchington, PhD, CMPP3,4; Gail V. Flores, PhD5,6

doi : 10.1001/jamaoncol.2021.3341

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Randomized Clinical Trials in the Era of Precision Oncology—The Role of End Points, Industry Funding, and Medical Writing Integrity—Reply

Joseph C. Del Paggio, MD1; Elizabeth A. Eisenhauer, MD2; Christopher M. Booth, MD2,3

doi : 10.1001/jamaoncol.2021.3344

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Immunochemotherapy as First-line Treatment for Locally Advanced or Metastatic Squamous Non–Small Cell Lung Cancers

Shujie Huang, MD1,2; Zhen Gao, MD1,3; Guibin Qiao, MD, PhD1,2,3

doi : 10.1001/jamaoncol.2021.3372

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Immunochemotherapy as First-line Treatment for Locally Advanced or Metastatic Squamous Non–Small Cell Lung Cancers—Reply

Jie Wang, MD, PhD1; Shiang Jiin Leaw, MD2; Shun Lu, MD, PhD3

doi : 10.1001/jamaoncol.2021.3375

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