Brain




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The complex enigma of tau

Masud Husain

doi : 10.1093/brain/awab433

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Wittgenstein, neurology, and neuroscience

Andrew J Larner

doi : 10.1093/brain/awab418

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MAnGLed astrocytes in traumatic brain injury: astrocytic 2-AG metabolism as a new therapeutic target

David J. Loane

doi : 10.1093/brain/awac014

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Towards therapeutic non-invasive electrical modulation of brain circuits in Parkinson’s disease

Ashwini Oswal

doi : 10.1093/brain/awab458

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Can rapamycin slow down memory decline in Alzheimer’s disease with seizures?

Ashok K. Shetty

doi : 10.1093/brain/awab474

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The role of astrocytes in prion-like mechanisms of neurodegeneration

Phillip Smethurst, Hannah Franklin, Benjamin E Clarke, Katie Sidle, Rickie Patani

doi : 10.1093/brain/awab366

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Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases

Michael Benatar, Joanne Wuu, Caroline McHutchison, Ronald B Postuma, Bradley F Boeve, Ronald Petersen, Christopher A Ross, Howard Rosen, Jalayne J Arias, Stephanie Fradette, Michael P McDermott, Jeremy Shefner, Christine Stanislaw, Sharon Abrahams, Stephanie Cosentino, Peter M Andersen, Richard S Finkel, Volkan Granit, Anne-Laure Grignon, Jonathan D Rohrer, Corey T McMillan, Murray Grossman, Ammar Al-Chalabi, Martin R Turner, First International Pre-Symptomatic ALS Workshop

doi : 10.1093/brain/awab404

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Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention

Melissa A E van de Wal, Merel J W Adjobo-Hermans, Jaap Keijer, Tom J J Schirris, Judith R Homberg, Mariusz R Wieckowski, Sander Grefte, Evert M van Schothorst, Clara van Karnebeek, Albert Quintana,Werner J H Koopman

doi : 10.1093/brain/awab426

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Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis

Mootaz M Salman, Philip Kitchen, Andrea Halsey, Marie Xun Wang, Susanna Törnroth-Horsefield, Alex C Conner, Jerome Badaut, Jeffrey J Iliff, Roslyn M Bill

doi : 10.1093/brain/awab311

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Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice

Michael J Hurley, Robert M J Deacon, A W Edith Chan, David Baker, David L Selwood, Patricia Cogram

doi : 10.1093/brain/awab246

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Transcranial alternating current stimulation for treating depression: a randomized controlled trial

Hongxing Wang, Kun Wang, Qing Xue, Mao Peng, Lu Yin, Xuecun Gu, Haixia Leng, Juan Lu, Hongzhi Liu, Di Wang, Jin Xiao, Zhichao Sun, Ning Li, Kai Dong, Qian Zhang, Shuqin Zhan, Chunqiu Fan, Baoquan Min, Aihong Zhou, Yunyan Xie, Haiqing Song, Jing Ye, Aihua Liu, Ran Gao, Liyuan Huang, Lidong Jiao, Yang Song, Huiqing Dong, Zichen Tian, Tianmei Si, Xiangyang Zhang, Xinmin Li, Atsushi Kamiya, Fiammetta Cosci, Keming Gao, Yuping Wang

doi : 10.1093/brain/awab252

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CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis

Anastasia Rumyantseva, Milica Popovic, Aleksandra Trifunovic

doi : 10.1093/brain/awab303

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Neurofilament light chain and glial fibrillary acidic protein levels in metachromatic leukodystrophy

Shanice Beerepoot, Hans Heijst, Birthe Roos, Mirjam M C Wamelink, Jaap Jan Boelens, Caroline A Lindemans, Peter M van Hasselt, Edwin H Jacobs, Marjo S van der Knaap, Charlotte E Teunissen, Nicole I Wolf

doi : 10.1093/brain/awab304

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In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy

Na Li, Pei Zhou, Hongmei Tang, Lu He, Xiang Fang, Jinxiang Zhao, Xin Wang, Yifei Qi, Chuanbo Sun, Yunting Lin, Fengying Qin, Miaomiao Yang, Zhan Zhang, Caihua Liao, Shuxin Zheng, Xiaofang Peng, Ting Xue, Qianying Zhu, Hong Li, Yan Li, Liru Liu, Jingyu Huang, Li Liu, Changgeng Peng, Angela M Kaindl, Jozef Gecz, Dingding Han, Dong Liu, Kaishou Xu, Hao Hu

doi : 10.1093/brain/awab209

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Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools

Shahram Bahrami, Guy Hindley, Bendik Slagsvold Winsvold, Kevin S O’Connell, Oleksandr Frei, Alexey Shadrin, Weiqiu Cheng, Francesco Bettella, Linn Rødevand, Ketil J Odegaard, Chun C Fan, Matti J Pirinen, Heidi M Hautakangas, HUNT All-In Headache , Anders M Dale, Srdjan Djurovic, Olav B Smeland, Ole A Andreassen

doi : 10.1093/brain/awab267

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Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons

Meritxell Llorca-Torralba, Carmen Camarena-Delgado, Irene Suárez-Pereira, Lidia Bravo, Patricia Mariscal, Jose Antonio Garcia-Partida, Carolina López�Martín, Hong Wei, Antti Pertovaara, Juan Antonio Mico, Esther Berrocoso

doi : 10.1093/brain/awab239

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Raising cGMP restores proteasome function and myelination in mice with a proteotoxic neuropathy

Jordan J S VerPlank, Joseph Gawron, Nicholas J Silvestri, M Laura Feltri, Lawrence Wrabetz, Alfred L Goldberg

doi : 10.1093/brain/awab249

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Enhancing endocannabinoid signalling in astrocytes promotes recovery from traumatic brain injury

Mei Hu, Dexiao Zhu, Jian Zhang, Fei Gao, Jack Hashem, Philip Kingsley, Lawrence J Marnett, Ken Mackie, Chu Chen

doi : 10.1093/brain/awab310

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Intracranial pressure spikes trigger spreading depolarizations

Fumiaki Oka, Homa Sadeghian, Mohammad A Yaseen, Buyin Fu, Sreekanth Kura, Tao Qin, Sava Sakadžić, Kazutaka Sugimoto, Takao Inoue, Hideyuki Ishihara, Sadahiro Nomura, Michiyasu Suzuki, Cenk Ayata

doi : 10.1093/brain/awab256

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De novo DHDDS variants cause a neurodevelopmental and neurodegenerative disorder with myoclonus

Serena Galosi, Ban H Edani, Simone Martinelli, Hana Hansikova, Erik A Eklund, Caterina Caputi, Laura Masuelli, Nicole Corsten-Janssen, Myriam Srour, Renske Oegema, Daniëlle G M Bosch, Colin A Ellis, Louise Amlie-Wolf, Andrea Accogli, Isis Atallah, Luisa Averdunk, Kristin W Barañano, Roberto Bei, Irene Bagnasco, Alfredo Brusco, Scott Demarest, Anne-Sophie Alaix, Carlo Di Bonaventura, Felix Distelmaier, Frances Elmslie, Ziv Gan-Or, Jean-Marc Good, Karen Gripp, Erik-Jan Kamsteeg, Ellen Macnamara, Carlo Marcelis, Noëlle Mercier, Joseph Peeden, Simone Pizzi, Luca Pannone, Marwan Shinawi, Camilo Toro, Nienke E Verbeek, Sunita Venkateswaran, Patricia G Wheeler, Lucie Zdrazilova, Rong Zhang, Giovanna Zorzi, Renzo Guerrini, William C Sessa, Dirk J Lefeber, Marco Tartaglia, Fadi F Hamdan, Kariona A Grabińska, Vincenzo Leuzzi

doi : 10.1093/brain/awab299

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Driving motor cortex oscillations modulates bradykinesia in Parkinson’s disease

Andrea Guerra, Donato Colella, Margherita Giangrosso, Antonio Cannavacciuolo, Giulia Paparella, Giovanni Fabbrini, Antonio Suppa, Alfredo Berardelli, Matteo Bologna

doi : 10.1093/brain/awab257

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Balance between competing spectral states in subthalamic nucleus is linked to motor impairment in Parkinson’s disease

Saed Khawaldeh, Gerd Tinkhauser, Flavie Torrecillos, Shenghong He, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Ashwini Oswal, Andrew J Quinn, Diego Vidaurre, Huiling Tan, Vladimir Litvak, Andrea Kühn, Mark Woolrich, Peter Brown

doi : 10.1093/brain/awab264

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Subthalamic and pallidal deep brain stimulation: are we modulating the same network?

Leon Sobesky, Lukas Goede, Vincent J J Odekerken, Qiang Wang, Ningfei Li, Clemens Neudorfer, Nanditha Rajamani, Bassam Al-Fatly, Martin Reich, Jens Volkmann, Rob M A de Bie, Andrea A Kühn, Andreas Horn

doi : 10.1093/brain/awab258

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Neuroimaging correlates of brain injury in Wilson’s disease: a multimodal, whole-brain MRI study

Samuel Shribman, Martina Bocchetta, Carole H Sudre, Julio Acosta-Cabronero, Maggie Burrows, Paul Cook, David L Thomas, Godfrey T Gillett, Emmanuel A Tsochatzis, Oliver Bandmann, Jonathan D Rohrer, Thomas T Warner

doi : 10.1093/brain/awab274

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Phosphorylated TDP-43 aggregates in peripheral motor nerves of patients with amyotrophic lateral sclerosis

Nilo Riva, Francesco Gentile, Federica Cerri, Francesca Gallia, Paola Podini, Giorgia Dina, Yuri Matteo Falzone, Raffaella Fazio, Christian Lunetta, Andrea Calvo, Giancarlo Logroscino, Giuseppe Lauria, Massimo Corbo, Sandro Iannaccone, Adriano Chiò, Alberto Lazzerini, Eduardo Nobile-Orazio, Massimo Filippi, Angelo Quattrini

doi : 10.1093/brain/awab285

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Neural effective connectivity explains subjective fatigue in stroke

Sasha Ondobaka, William De Doncker, Nick Ward, Annapoorna Kuppuswamy

doi : 10.1093/brain/awab287

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The BS variant of C4 protects against age-related loss of white matter microstructural integrity

Matthew Traylor, Rainer Malik, Benno Gesierich, Martin Dichgans

doi : 10.1093/brain/awab261

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Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy

Yu Young Jeong, Sinsuk Han, Nuo Jia, Mingyang Zhang, Preethi Sheshadri, Prasad Tammineni, Jasmine Cheung, Marialaina Nissenbaum, Sindhuja S Baskar, Kelvin Kwan, David J Margolis, Peng Jiang, Alexander W. Kusnecov, Qian Cai

doi : 10.1093/brain/awab243

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The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease

Sarah Gourmaud, David A Stewart, David J Irwin, Nicholas Roberts, Aaron J Barbour, Grace Eberwine, William T O’Brien, Robert Vassar, Delia M Talos, Frances E Jensen

doi : 10.1093/brain/awab268

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Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study

Negin Holland, Maura Malpetti, Timothy Rittman, Elijah E Mak, Luca Passamonti, Sanne S Kaalund, Frank H Hezemans, P Simon Jones, George Savulich, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, John T O’Brien, James B Rowe

doi : 10.1093/brain/awab282

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Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms

Masato Hosokawa, Masami Masuda-Suzukake, Hiroshi Shitara, Aki Shimozawa, Genjiro Suzuki, Hiromi Kondo, Takashi Nonaka, William Campbell, Tetsuaki Arai, Masato Hasegawa

doi : 10.1093/brain/awab289

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Structuro-functional surrogates of response to subcallosal cingulate deep brain stimulation for depression

Gavin J B Elias, Jürgen Germann, Alexandre Boutet, Aditya Pancholi, Michelle E Beyn, Kartik Bhatia, Clemens Neudorfer, Aaron Loh, Sakina J Rizvi, Venkat Bhat, Peter Giacobbe, D Blake Woodside, Sidney H Kennedy, Andres M Lozano

doi : 10.1093/brain/awab284

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Impact of autism genetic risk on brain connectivity: a mechanism for the female protective effect

Katherine E Lawrence, Leanna M Hernandez, Emily Fuster, Namita T Padgaonkar, Genevieve Patterson, Jiwon Jung, Nana J Okada, Jennifer K Lowe, Jackson N Hoekstra, Allison Jack,Elizabeth Aylward, Nadine Gaab, John D Van Horn, Raphael A Bernier, James C McPartland, Sara J Webb, Kevin A Pelphrey, Shulamite A Green, Susan Y Bookheimer, Daniel H Geschwind, Mirella Dapretto, GENDAAR Consortium

doi : 10.1093/brain/awab204

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Astrocyte–neuron interplay is critical for Alzheimer's disease pathogenesis and is rescued by TRPA1 channel blockade

Adrien Paumier, Sylvie Boisseau, Muriel Jacquier-Sarlin, Karin Pernet-Gallay, Alain Buisson, Mireille Albrieux

doi : 10.1093/brain/awab281

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Navigating the recurrent perplexity of prefrontal function

David Badre

doi : 10.1093/brain/awab414

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