PavelOsmancikMD, PhDaDaliborHermanMD, PhDaPetrNeuzilMD, CScbPavelHalaMDbMilosTaborskyMD, CSccPetrKalaMD, PhDdMartinPoloczekMDdJosefStasekMD, PhDeLudekHamanMD, PhDeMarianBrannyMD, PhDfJanChovancikMDfPavelCervinkaMD, PhDgJiriHolyMDgTomasKovarnikMD, PhDhDavidZemanekMD, PhDhStepanHavranekMD, PhDhVlastimilVancuraMD, PhDiPetrPeichlMD, PhDj…Vivek Y.ReddyMDbl∗
doi : 10.1016/j.jacc.2021.10.023
Volume 79, Issue 1, 4–11 January 2022, Pages 1-14
The PRAGUE-17 (Left Atrial Appendage Closure vs Novel Anticoagulation Agents in Atrial Fibrillation) trial demonstrated that left atrial appendage closure (LAAC) was noninferior to nonwarfarin direct oral anticoagulants (DOACs) for preventing major neurological, cardiovascular, or bleeding events in patients with atrial fibrillation (AF) who were at high risk.
Faisal M.MerchantMD
doi : 10.1016/j.jacc.2021.10.022
Volume 79, Issue 1, 4–11 January 2022, Pages 15-17
Doff B.McElhinneyMDaYulinZhangPhDaDaniel S.LeviMDbStanimirGeorgievMDcElżbieta KatarzynaBiernackaMD, PhDdBryan H.GoldsteinMDeShabanaShahanavazMDfAthar M.QureshiMDgAllison K.CabalkaMDhHollyBauser-HeatonMD, PhDiAlejandro J.TorresMDjBrian H.MorrayMDkAimee K.ArmstrongMDlOscarMillan-IturbeMDm∗Lynn F.PengMDaJamil A.AboulhosnMDnWitoldRużyłłoMD, PhDdFelixBergerMDo…StephanSchubertMDo†‡
doi : 10.1016/j.jacc.2021.10.031
Volume 79, Issue 1, 4–11 January 2022, Pages 18-32
Transcatheter pulmonary valve (TPV) replacement (TPVR) has become the standard therapy for postoperative pulmonary outflow tract dysfunction in patients with a prosthetic conduit/valve, but there is limited information about risk factors for death or reintervention after this procedure.
AlainFraisseMD, PhDabAlexanderKempnyMD, PhDacCarlesBautista-RodriguezMD, PhDab
doi : 10.1016/j.jacc.2021.10.032
Volume 79, Issue 1, 4–11 January 2022, Pages 33-34
TingLiuMD, PhDab∗Andrew G.HowarthMD, PhDac∗YinyinChenMD, PhDadAnand R.NairPhDaHsin-JungYangPhDaDaoyuanRenMDdRichardTangMDaJaneSykesBSeMichael S.KovacsPhDeDaminiDeyPhDaPiotrSlomkaPhDaJohn C.WoodMD, PhDfRobertFinneyPhDgMengsuZengMD, PhDdFrank S.PratoPhDeJosephFrancisPhDhDaniel S.BermanMDaPrediman K.ShahMDa…RohanDharmakumarPhDaj
doi : 10.1016/j.jacc.2021.10.034
Volume 79, Issue 1, 4–11 January 2022, Pages 35-48
Reperfusion therapy for acute myocardial infarction (MI) is lifesaving. However, the benefit of reperfusion therapy can be paradoxically diminished by reperfusion injury, which can increase MI size.
ColinBerryMBChB, PhDabBorjaIbáñezMD, PhDc
doi : 10.1016/j.jacc.2021.11.002
Volume 79, Issue 1, 4–11 January 2022, Pages 49-51
ElenaGibboneMDaIuliaHulutaMDaAlanWrightPhDbKypros H.NicolaidesMDaMariettaCharakidaMD, PhDac
doi : 10.1016/j.jacc.2021.10.033
Volume 79, Issue 1, 4–11 January 2022, Pages 52-62
Preeclampsia (PE) is an independent risk factor for adverse maternal cardiovascular outcomes. The role of maternal cardiac function in the pathophysiology of PE remains unclear.
Karen L.FlorioDO, MPHabAnnaGrodzinskyMD, MScbc
doi : 10.1016/j.jacc.2021.11.003
Volume 79, Issue 1, 4–11 January 2022, Pages 63-65
Luke P.DawsonMBBS, MPHabcdMarkLumMBBSbNiteshNerlekerMBBS, PhDbefStephen J.NichollsMBBS, PhDbeJamieLaylandMBChB, PhDab
doi : 10.1016/j.jacc.2021.10.035
Volume 79, Issue 1, 4–11 January 2022, Pages 66-82
Over the last 3 decades there have been substantial improvements in treatments aimed at reducing cardiovascular (CV) events. As these treatments have been developed, there have been parallel improvements in coronary imaging modalities that can assess plaque volumes and composition, using both invasive and noninvasive techniques. Plaque progression can be seen to precede CV events, and therefore, many studies have longitudinally assessed changes in plaque characteristics in response to various treatments, aiming to demonstrate plaque regression and improvements in high-risk features, with the rationale being that this will reduce CV events. In the past, decisions surrounding treatments for atherosclerosis have been informed by population-based risk scores for initiation in primary prevention and low-density lipoprotein cholesterol levels for titration in secondary prevention. If outcome data linking plaque regression to reduced CV events emerge, it may become possible to directly image plaque treatment response to guide management decisions.
MichaelLiuMPhilabJose F.FigueroaMD, MPHcYangSongMScaRishi K.WadheraMD, MPP, MPhila
doi : 10.1016/j.jacc.2021.10.006
Volume 79, Issue 1, 4–11 January 2022, Pages 83-87
JuliaGrapsaMD, PhDaChristopherBlauthBSc, MB BSaY.S.ChandrashekharMDbBernardPrendergastMD, PhDaBlairErbJr.MDcMichaelMackMDdValentinFusterMD, PhDef
doi : 10.1016/j.jacc.2021.10.015
Volume 79, Issue 1, 4–11 January 2022, Pages 88-99
A 19-year-old female patient presented with Staphylococcus aureus infective endocarditis, with suspected subdural brain hemorrhage, disseminated intravascular coagulopathy, and septic renal as well as spleen infarcts. The patient had extensive vegetations on the mitral and tricuspid valves and underwent urgent mitral and tricuspid repair. This paper discusses the clinical case and current evidence regarding the management and treatment of Staphylococcus aureus endocarditis.
XinpingChenPhDShengmiaoFuMMWeihuaXuMM
doi : 10.1016/j.jacc.2021.09.1383
Volume 79, Issue 1, 4–11 January 2022, Page e7
Cheng-YiWangMDChing-YiChenMDChih-ChengLaiMD
doi : 10.1016/j.jacc.2021.09.1385
Volume 79, Issue 1, 4–11 January 2022, Page e9
Charlesde RoquetailladeMD, PhDJérémieGuilleminMD, MSVictorBeaucotéMD, MSRomainBarthelemyMD, MSBenjamin GlennChoustermanMD, PhD
doi : 10.1016/j.jacc.2021.09.1384
Volume 79, Issue 1, 4–11 January 2022, Page e11
ArnoldoSantosMD PhDJuanMartÃnez-MillaMD, PhDCésarPérez-CalvoMD, PhDBorjaIbáñezMD, PhD
doi : 10.1016/j.jacc.2021.10.030
Volume 79, Issue 1, 4–11 January 2022, Pages e13-e14
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