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Cerebral venous sinus thrombosis associated with COVID-19 vaccine-induced thrombocytopenia: Improvement in mortality rate over time
Barbara Casolla, Charlotte Cordonnier
doi : 10.1111/ene.15151
Pages: 1-2 First Published: 19 October 2021
Magnetic resonance imaging findings in focal-onset status epilepticus
Silvana Sarria-Estrada, Estevo Santamarina, Manuel Quintana, Deborah Pareto, Maria Sueiras, Cristina Auger, Manuel Toledo, Alex Rovira
doi : 10.1111/ene.15065
Pages: 3-11 First Published: 14 August 2021
Magnetic resonance imaging (MRI) is commonly used in the diagnostic work-up for status epilepticus (SE). The purpose of this study was to characterize MRI features in SE patients and determine their association with clinical and electroencephalography (EEG) findings. The mid-term consequences of baseline MRI features were also analysed.
Seizure prevalence in neurodegenerative diseases—a study of autopsy proven cases
Jonathan Vöglein, Irena Kostova, Thomas Arzberger, Soheyl Noachtar, Marianne Dieterich, Jochen Herms, Peer Schmitz, Viktoria Ruf, Otto Windl, Sigrun Roeber, Mikael Simons, Günter U. Höglinger, Adrian Danek, Armin Giese, Johannes Levin
doi : 10.1111/ene.15089
Pages: 12-18 First Published: 02 September 2021
Knowledge about the seizure prevalence in the whole symptomatic course, from disease onset to death, in neurodegenerative diseases (ND) is lacking. Therefore, the aim was to investigate seizure prevalence and associated clinical implications in neuropathologically diagnosed ND.
Epilepsy, electroclinical features, and long-term outcomes in Pitt–Hopkins syndrome due to pathogenic variants in the TCF4 gene
Sara Matricardi, Paolo Bonanni, Giulia Iapadre, Maurizio Elia, Elisabetta Cesaroni, Alberto Danieli, Susanna Negrin, Luca Zagaroli, Francesca Felicia Operto, Marco Carotenuto, Francesco Pisani, Emanuela Claudia Turco, Alessandro Orsini, Alice Bonuccelli, Salvatore Savasta, Daniela Concolino, Giuseppe Di Cara, Pasquale Striano, Alberto Verrotti
doi : 10.1111/ene.15104
Pages: 19-25 First Published: 14 September 2021
Pitt–Hopkins syndrome (PTHS) is a rare neurodevelopmental disorder caused by deletions/variants in the TCF4 gene. Seizures may be present in up to half of the patients, leading to a more severe disease burden. This study aims to analyse the electroclinical phenotype, treatment options, and long-term outcomes of epilepsy in PTHS.
Increased delta power as a scalp marker of epileptic activity: a simultaneous scalp and intracranial electroencephalography study
Pia De Stefano, Margherita Carboni, Renaud Marquis, Laurent Spinelli, Margitta Seeck, Serge Vulliemoz
doi : 10.1111/ene.15106
Pages: 26-35 First Published: 15 September 2021
The purpose was to evaluate whether intracranial interictal epileptiform discharges (IEDs) that are not visible on the scalp are associated with changes in the frequency spectrum on scalp electroencephalograms (EEGs).
Serum neurofilament light chain as a surrogate of cognitive decline in sporadic and familial frontotemporal dementia
Anuschka Silva-SpÃnola, Marisa Lima, Maria João Leitão, João Durães, Miguel Tábuas-Pereira, Maria Rosário Almeida, Isabel Santana, Inês Baldeiras
doi : 10.1111/ene.15058
Pages: 36-46 First Published: 10 August 2021
Neurofilament light chain (NfL) has recently been proposed as a promising biomarker in frontotemporal dementia (FTD). We investigated the correlation of both cerebrospinal fluid (CSF) and serum NfL with detailed neuropsychological data and cognitive decline in a cohort of sporadic and familial FTD.
Construction of immune/Creutzfeldt–Jakob disease-related gene coexpression network to predict biomarkers
Xiaoou Hai, Jiaming Zhou, Guangyan Liu
doi : 10.1111/ene.15063
Pages: 47-58 First Published: 13 August 2021
Creutzfeldt–Jakob disease (CJD) is a transmissible spongiform encephalopathy characterized by rapid onset and high mortality. Despite considerable progress in the treatment and diagnosis of CJD, patient prognosis remains poor. Many studies have found that the immune response is associated with the pathophysiology of CJD. However, few studies have reported coexpression correlations between genes associated with CJD and the immune response. This study was undertaken to construct a network of coexpressed immune- and CJD-related genes that may reveal new biomarkers and therapeutic targets for CJD.
Development and validation of the dialysis dementia risk score: A retrospective, population-based, nested case-control study
Tsai-Chieh Ling, Chiung-Chih Chang, Chung-Yi Li, Junne-Ming Sung, Chien-Yao Sun, Kuen-Jer Tsai, Ya-Yun Cheng, Jia-Ling Wu, Yi-Ting Kuo, Yu-Tzu Chang
doi : 10.1111/ene.15123
Pages: 59-68 First Published: 24 September 2021
Dementia is prevalent and underdiagnosed in the dialysis population. We aimed to develop and validate a simple dialysis dementia scoring system to facilitate identification of individuals who are at high risk for dementia.
Efficacy and safety of botulinum toxin for treating sialorrhea: A systematic review and meta-analysis
Ya-Chien Yu, Chen-Chih Chung, Yu-Kang Tu, Chien-Tai Hong, Kee-Hsin Chen, Ka-Wai Tam, Yi-Chun Kuan
doi : 10.1111/ene.15083
Pages: 69-80 First Published: 27 August 2021
Sialorrhea often happens in patients with neurologic disorders, and botulinum toxin (BoNT), which inhibits acetylcholine activation, may be an effective treatment for drooling. This systematic review and meta-analysis of randomized control trials aims to evaluate the efficacy and safety of BoNT in adults and children with sialorrhea due to neurological disorders.
Automated speech analysis in early untreated Parkinson's disease: Relation to gender and dopaminergic transporter imaging
Jan Rusz, Tereza Tykalová, Michal Novotný, David Zogala, Evžen Růži�ka, Petr Dušek
doi : 10.1111/ene.15099
Pages: 81-90 First Published: 09 September 2021
The mechanisms underlying speech abnormalities in Parkinson's disease (PD) remain poorly understood, with most of the available evidence based on male patients. This study aimed to estimate the occurrence and characteristics of speech disorder in early, drug-naive PD patients with relation to gender and dopamine transporter imaging.
Adult-onset idiopathic dystonia: A national data-linkage study to determine epidemiological, social deprivation, and mortality characteristics
Grace A. Bailey, Anna Rawlings, Fatemeh Torabi, Owen Pickrell, Kathryn J. Peall
doi : 10.1111/ene.15114
Pages: 91-104 First Published: 20 September 2021
Accurate epidemiological information is essential for the improved understanding of dystonia syndromes, as well as better provisioning of clinical services and providing context for diagnostic decision-making. Here, we determine epidemiological, social deprivation, and mortality characteristics of adult-onset idiopathic dystonia in the Welsh population.
A full year of the COVID-19 pandemic with two infection waves and its impact on ischemic stroke patient care in Germany
Daniel Richter, Jens Eyding, Ralph Weber, Dirk Bartig, Armin Grau, Werner Hacke, Christos Krogias
doi : 10.1111/ene.15057
Pages: 105-113 First Published: 09 August 2021
Many countries worldwide, including Germany, reported that the first wave of the coronavirus disease 2019 (COVID-19) pandemic in early 2020 influenced the care of acute ischemic stroke (AIS) patients, but data are lacking for further pandemic wave periods.
Fibroblast growth factor 23 is associated with risk of intracerebral hemorrhage
Edith H. Svensson, Martin Söderholm
doi : 10.1111/ene.15060
Pages: 114-120 First Published: 11 August 2021
Fibroblast growth factor 23 (FGF23) is an osteogenic hormone associated with chronic kidney disease and is an emerging risk factor for several cardiovascular diseases. The association of FGF23 with stroke is unclear. The aim of this study was to investigate the association of FGF23 with incident intracerebral hemorrhage (ICH).
Brain magnetic resonance imaging lesion load at diagnosis, severity at onset and outcomes in Susac syndrome: A prospective cohort study
Carole Scheifer, Marie-Cécile Henry Feugeas, Mélanie Roriz, Fleur Cohen Aubart, Serge Doan, Eric Jouvent, Isabelle Klein, Carla Machado, Diane Rouzaud, Thomas Papo, Karim Sacré, the French Susac Study Group
doi : 10.1111/ene.15062
Pages: 121-129 First Published: 12 August 2021
Susac syndrome (SuS) is a rare occlusive microvessel disease of the brain, retina and inner ear. We aimed to determine whether brain lesion load at the acute phase predicts poor outcomes in SuS.
Type of headache at onset and risk for complications in reversible cerebral vasoconstriction syndrome
Kristin Sophie Lange, Ophélie Forster, Jérôme Mawet, Gabrielle Tuloup, Cécilia Burcin, Lucas Corti, Claire Duflos, Caroline Roos, Anne Ducros
doi : 10.1111/ene.15064
Pages: 130-137 First Published: 13 August 2021
In a recent Italian study, 30% of patients with reversible cerebral vasoconstriction syndrome (RCVS) presented without thunderclap headache (TCH), and tended to present more severe forms of RCVS than patients with TCH. We aimed to analyze the risk for complications of RCVS in patients with and without TCH at onset.
Simulation-based training improves process times in acute stroke care (STREAM)
Ferdinand O. Bohmann, Katharina Gruber, Natalia Kurka, Laurent M. Willems, Eva Herrmann, Richard du Mesnil de Rochemont, Peter Scholz, Heike Rai, Philipp Zickler, Michael Ertl, Ansgar Berlis, Sven Poli, Annerose Mengel, Peter Ringleb, Simon Nagel, Johannes Pfaff, Frank A. Wollenweber, Lars Kellert, Moriz Herzberg, Luzie Koehler, Karl Georg Haeusler, Anna Alegiani, Charlotte Schubert, Caspar Brekenfeld, Christopher E. J. Doppler, Özgür A. Onur, Christoph Kabbasch, Tanja Manser, Helmuth Steinmetz, Waltraud Pfeilschifter, the STREAM Trial investigators
doi : 10.1111/ene.15093
Pages: 138-148 First Published: 03 September 2021
The objective of the STREAM Trial was to evaluate the effect of simulation training on process times in acute stroke care.
Predicting atrial fibrillation after cryptogenic stroke via a clinical risk score—a prospective observational study
Markus Kneihsl, Egbert Bisping, Daniel Scherr, Harald Mangge, Simon Fandler-Höfler, Isabella Colonna, Melanie Haidegger, Sebastian Eppinger, Edith Hofer, Franz Fazekas, Christian Enzinger, Thomas Gattringer
doi : 10.1111/ene.15102
Pages: 149-157 First Published: 14 September 2021
Atrial fibrillation (AF) often remains undiagnosed in cryptogenic stroke (CS), mostly because of limited availability of cardiac long-term rhythm monitoring. There is an unmet need for a pre-selection of CS patients benefitting from such work-up. A clinical risk score was therefore developed for the prediction of AF after CS and its performance was evaluated over 1 year of follow-up.
Synergistic associations of cognitive and motor impairments with functional outcome in covert cerebral small vessel disease
Hanna Jokinen, Hanna M. Laakso, Matti Ahlström, Anne Arola, Juha Lempiäinen, Johanna Pitkänen, Teemu Paajanen, Sietske A. M. Sikkes, Juha Koikkalainen, Jyrki Lötjönen, Antti Korvenoja, Timo Erkinjuntti, Susanna Melkas
doi : 10.1111/ene.15108
Pages: 158-167 First Published: 15 September 2021
Cognitive and motor impairments are the key clinical manifestations of cerebral small vessel disease (SVD), but their combined effects on functional outcome have not been elucidated. This study investigated the interactions and mediating effects of cognitive and motor functions on instrumental activities of daily living (IADL) and quality of life in older individuals with various degrees of white matter hyperintensities (WMH).
Trends in the incidence and mortality of intracerebral hemorrhage, and the associated risk factors, in Denmark from 2004 to 2017
Tine Glavind Bülow Pedersen, Nicklas Vinter, Morten Schmidt, Lars Frost, Pia Cordsen, Grethe Andersen, Søren Paaske Johnsen
doi : 10.1111/ene.15110
Pages: 168-177 First Published: 15 September 2021
The distribution of the major modifiable risk factors for intracerebral hemorrhage (ICH) changes rapidly. These changes call for contemporary data from large-scale population-based studies. The aim of the present study was to examine trends in incidence, risk factors, and mortality in ICH patients from 2004 to 2017.
SMASH-U aetiological classification: A predictor of long-term functional outcome after intracerebral haemorrhage
Yuchao Jia, Guo Li, Guini Song, Xiaodong Ye, Yuyan Yang, Kai Lu, Shanshan Huang, Suiqiang Zhu
doi : 10.1111/ene.15111
Pages: 178-187 First Published: 17 September 2021
SMASH-U is a systematic aetiological classification system for intracerebral haemorrhage (ICH) proven to be a predictor of post-ICH haematoma expansion and mortality. However, its role in predicting functional outcome remains elusive. Therefore, we aimed to investigate whether SMASH-U is associated with long-term functional outcome after ICH and improves the accuracy of prediction when added to max-ICH score.
Sex differences in vascular risk factors, in-hospital management, and outcomes of patients with acute ischemic stroke in China
Hong-Qiu Gu, Chun-Juan Wang, Xin Yang, Chelsea Liu, Xia Wang, Xing-Quan Zhao, Yi-Long Wang, Li-Ping Liu, Xia Meng, Yong Jiang, Hao Li, Yong-Jun Wang, Zi-Xiao Li
doi : 10.1111/ene.15124
Pages: 188-198 First Published: 26 September 2021
Previous assessments of sex differences for patients with acute ischemic stroke were limited in a specific region or population, narrow scope, or small sample size.
Pre-eclampsia, gestational diabetes and hypertensive disorders in patients with intracranial aneurysms: A case–control study
Satu Kotikoski, Arttu Kurtelius, Heidi J. Nurmonen, Juho Paavola, Virve Kärkkäinen, Terhi J. Huuskonen, Jukka Huttunen, Timo Koivisto, Mikael von und zu Fraunberg, Juha E. Jääskeläinen, Antti E. Lindgren
doi : 10.1111/ene.15125
Pages: 199-207 First Published: 27 September 2021
The aim of this study was to define the prevalence of pre-eclampsia, gestational hypertension (HT), chronic HT, and gestational diabetes during pregnancy in a defined population of patients with saccular intracranial aneurysms (sIAs).
“But it's a nice compromise� – Qualitative multi-centre study of barriers and facilitators to acute telestroke cooperation in a regional stroke network
Loraine Busetto, Melek Sert, Franziska Herzog, Johanna Hoffmann, Christina Stang, Hemasse Amiri, Fatih Seker, Jan Purrucker, Sibu Mundiyanapurath, Peter Arthur Ringleb, Simon Nagel, Martin Bendszus, Wolfgang Wick, Christoph Gumbinger
doi : 10.1111/ene.15130
Pages: 208-216 First Published: 28 September 2021
Telemedical services can be used to complement on-site services when demand for specialists exceeds supply or when specialists are not evenly distributed across health systems. Using stroke as an example, this study aimed to explore how patients and staff experience telestroke cooperation in a stroke network in Germany.
Potential of intraoperative ultrasonographic assessment of the spinal cord central echo complex in predicting postoperative neurological recovery of degenerative cervical myelopathy
Guoliang Chen, Huachuan Wu, Ningning Chen, Meng Wang, Liangyu Shi, Jiachun Li, Fuxin Wei, Zuofeng Xu, Xizhe Liu, Shaoyu Liu
doi : 10.1111/ene.15109
Pages: 217-224 First Published: 15 September 2021
The spinal cord central echo complex (SCCEC) is a special ultrasonography-based intramedullary structure, but its clinical significance in degenerative cervical myelopathy (DCM) is undefined. This study aimed to explore the potential of the SCCEC in predicting postoperative neurological recovery in DCM.
Higher-quality diet and non-consumption of meat are associated with less self-determined disability progression in people with multiple sclerosis: A longitudinal cohort study
Steve Simpson-Yap, Nupur Nag, Yasmine Probst, George Jelinek, Sandra Neate
doi : 10.1111/ene.15066
Pages: 225-236 First Published: 14 August 2021
Modifiable lifestyle factors, including diet, may affect clinical outcomes in multiple sclerosis (MS). This study assessed the relationships between diet, and disability, fatigue, and depression risk in people with MS.
Lesion features on magnetic resonance imaging discriminate multiple sclerosis patients
Sandra M. Hurtado Rúa, Ulrike W. Kaunzner, Sneha Pandya, Elizabeth Sweeney, Ceren Tozlu, Amy Kuceyeski, Thanh D. Nguyen, Susan A. Gauthier
doi : 10.1111/ene.15067
Pages: 237-246 First Published: 17 August 2021
Magnetic resonance imaging (MRI) provides insight into various pathological processes in multiple sclerosis (MS) and may provide insight into patterns of damage among patients.
Retinoids are not linked to risk of multiple sclerosis: A Danish nationwide cohort study
Filipe Cortes-Figueiredo, Nete Munk Nielsen, Egon Stenager, Friedemann Paul, Jesper Hallas, Kasper Bruun Kristensen
doi : 10.1111/ene.15116
Pages: 247-256 First Published: 18 September 2021
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system with an undetermined etiology. Retinoids may have immunomodulatory effects that favorably influence MS progression. We aimed to explore the yet unknown relationship between exposure to retinoids and the risk of acquiring MS.
A real-world study of alemtuzumab in a cohort of Italian patients
Cinzia Valeria Russo, Francesco Saccà , Jessica Frau, Pietro Annovazzi, Elisabetta Signoriello, Simona Bonavita, Roberta Grasso, Marinella Clerico, Cinzia Cordioli, Alice Laroni, Marco Capobianco, Valentina Torri Clerici, Arianna Sartori, Paola Cavalla, Giorgia Teresa Maniscalco, Sara La Gioia, Francesca Caleri, Alessia Giugno, Rosa Iodice, Antonio Carotenuto, Eleonora Cocco, Giuseppe Fenu, Mauro Zaffaroni, Damiano Baroncini, Giacomo Lus, Antonio Gallo, Stefania Federica De Mercanti, Caterina Lapucci, Valeria Di Francescantonio, Laura Brambilla, Maria Pia Sormani, Alessio Signori
doi : 10.1111/ene.15121
Pages: 257-266 First Published: 24 September 2021
Real-world data on alemtuzumab are limited and do not provide evidence of its effectiveness after various disease-modifying therapies (DMTs). Our aim was to provide real-world data on the impact of clinical variables and previous DMTs on clinical response to alemtuzumab.
Expanding the clinical spectrum of anti-IgLON5 disease: A multicenter retrospective study
You Ni, Dingding Shen, Ying Zhang, Yaying Song, Yining Gao, Qinming Zhou, Lu He, Dou Yin, Ying Wang, Fan Song, Meiyuan Chen, Yajun Lian, Yuan Chen, Xing Zhao, Xiang Zhang, Xiangjun Chen, Yuting Wang, Ling Zhang, Nanxun Mo, Dong Lv, Jun Liu, Zhifeng Mao, Lisheng Peng, Sheng Chen
doi : 10.1111/ene.15117
Pages: 267-276 First Published: 20 September 2021
We conducted this study to describe detailed the clinical characteristics, ancillary test results and treatment response of a group of Chinese patients with anti-IgLON5 disease.
Correlation analysis between regional homogeneity and executive dysfunction in anti-N-methyl-D-aspartate receptor encephalitis patients
Peirong Wu, Xiaomin Pang, Xiulin Liang, Wutong Wei, Xinrong Li, Jingyuan Zhao, Jinou Zheng
doi : 10.1111/ene.15119
Pages: 277-285 First Published: 21 September 2021
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is characterized by a range of cognitive impairments, especially in executive function. Our study aims to identify the abnormal regional homogeneity (ReHo) in anti-NMDAR encephalitis patients and its relationship with the executive function.
Corneal nerve loss is related to the severity of painful diabetic neuropathy
Alise Kalteniece, Maryam Ferdousi, Shazli Azmi, Saif Ullah Khan, Anne Worthington, Andrew Marshall, Catharina G. Faber, Giuseppe Lauria, Andrew J. M. Boulton, Handrean Soran, Rayaz A. Malik
doi : 10.1111/ene.15129
Pages: 286-294 First Published: 27 September 2021
Previously it has been shown that patients with painful diabetic neuropathy (PDN) have greater corneal nerve loss compared to patients with painless diabetic neuropathy. This study investigated if the severity of corneal nerve loss was related to the severity of PDN.
Functional connectivity changes in complex migraine aura: beyond the visual network
Marcello Silvestro, Alessandro Tessitore, Federica Di Nardo, Fabrizio Scotto di Clemente, Francesca Trojsi, Mario Cirillo, Fabrizio Esposito, Gioacchino Tedeschi, Antonio Russo
doi : 10.1111/ene.15061
Pages: 295-304 First Published: 12 August 2021
Although the majority of migraine with aura (MwA) patients experience simple visual aura, a discrete percentage also report somatosensory, dysphasic or motor symptoms (the so-called complex auras). The wide aura clinical spectrum led to an investigation of whether the heterogeneity of the aura phenomenon could be produced by different neural correlates, suggesting an increased visual cortical excitability in complex MwA. The aim was to explore whether complex MwA patients are characterized by more pronounced connectivity changes of the visual network and whether functional abnormalities may extend beyond the visual network encompassing also the sensorimotor network in complex MwA patients compared to simple visual MwA patients.
Alterations of brain structural MRI are associated with outcome of surgical treatment in trigeminal neuralgia
Luigi Albano, Federica Agosta, Silvia Basaia, Antonella Castellano, Roberta Messina, Veronica Parisi, Lina Raffaella Barzaghi, Andrea Falini, Pietro Mortini, Massimo Filippi
doi : 10.1111/ene.15105
Pages: 305-317 First Published: 14 September 2021
To assess magnetic resonance imaging (MRI) alterations occurring in patients with trigeminal neuralgia (TN) and to explore the predictive ability of MRI for initial surgical outcome and long-term pain relief/recurrence after Gamma Knife radiosurgery (GKS).
Lessons learned from people with neurological diseases at the time of COVID-19: The EFNA-EAN survey
Benedetta Bodini, Elena Moro, Joke Jaarsma, Elizabeth Cunningham, Johann Sellner, Donna Walsh, on behalf of the EANcore COVID-19 Task Force
doi : 10.1111/ene.15087
Pages: 318-323 First Published: 30 August 2021
The European Federation of Neurological Associations (EFNA), in partnership with the NeuroCOVID-19 taskforce of the European Academy of Neurology (EAN), has investigated the impact of the first wave of the COVID-19 pandemic on individuals with neurological diseases, as well as the hopes and fears of these patients about the post-pandemic phase.
Corpus callosum hypersignals and focal atrophy: Neuroimaging findings in globular glial tauopathy type I
Jiri Keller, Anna Kavkova, Radoslav Matej, Zsolt Cséfalvay, Robert Rusina
doi : 10.1111/ene.15090
Pages: 324-328 First Published: 01 September 2021
Globular glial tauopathies (GGTs) have heterogeneous presentations; little evidence regarding typical clinical and magnetic resonance imaging (MRI) presentations are available.
Evaluation of CSF1R-related adult onset leukoencephalopathy with axonal spheroids and pigmented glia diagnostic criteria
Xavier Ayrignac, Clarisse Carra-Dallière, Pekes Codjia, Kevin Mouzat, Giovanni Castelnovo, Emmanuel Ellie, Frédérique Etcharry-Bouyx, Serge Belliard, Cecilia Marelli, Florence Portet, Isabelle Le Ber, Francoise Durand-Dubief, Guillaume Mathey, Bruno Stankoff, Imen Dorboz, Severine Drunat, Odile Boespflug-Tanguy, Nicolas Menjot de Champfleur, Serge Lumbroso, Fanny Mochel, Pierre Labauge
doi : 10.1111/ene.15115
Pages: 329-334 First Published: 19 September 2021
Diagnostic criteria for adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) due to colony-stimulating factor 1 receptor (CSF1R) mutation have recently been proposed. Our objective was to assess their accuracy in an independent multicenter cohort.
Exploring the causal inference of migraine on stroke: A Mendelian randomization study
Keon-Joo Lee, Soo Ji Lee, Hee-Joon Bae, Joohon Sung
doi : 10.1111/ene.15101
Pages: 335-338 First Published: 12 September 2021
Previous observational studies have reported that patients with migraine have an increased risk of stroke. We explored whether migraine has a causal effect on stroke using a two-sample Mendelian randomization approach.
Declining mortality of cerebral venous sinus thrombosis with thrombocytopenia after SARS-CoV-2 vaccination
Anita van de Munckhof, Katarzyna Krzywicka, Diana Aguiar de Sousa, Mayte Sánchez van Kammen, Mirjam R. Heldner, Katarina Jood, Erik Lindgren, Turgut Tatlisumak, Jukka Putaala, Johanna A. Kremer Hovinga, Saskia Middeldorp, Marcel Levi, Marcel Arnold, José M. Ferro, Jonathan M. Coutinho
doi : 10.1111/ene.15113
Pages: 339-344 First Published: 18 September 2021
High mortality rates have been reported in patients with cerebral venous sinus thrombosis (CVST) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) after vaccination with adenoviral vector SARS-CoV-2 vaccines. The aim of this study was to evaluate whether the mortality of patients with CVST-VITT has decreased over time.
RNF170 mutation causes autosomal dominant sensory ataxia with variable pyramidal involvement
Sien H. Van Daele, Matthieu Moisse, Valérie Race, Amélie Van Eesbeeck, Liesbeth Keldermans, Sascha Vermeer, Hilde Van Esch, Kristl G. Claeys, Philip Van Damme
doi : 10.1111/ene.15091
Pages: 345-349 First Published: 01 September 2021
Although hereditary ataxias are a group of clinically and genetically heterogeneous disorders, specific clinical clues can sometimes incriminate certain genes. This can trigger genetic testing in sporadic patients or prompt dissecting certain genes more thoroughly when initial genetic testing is negative. Also for the assembly of gene panels and interpretation of the results, genotype−phenotype correlations remain important to establish.
Aspirin, paracetamol (acetaminophen) and caffeine for the treatment of acute migraine attacks: A systemic review and meta-analysis of randomized placebo-controlled trials
Hans Christoph Diener, Charly Gaul, Walter Lehmacher, Thomas Weiser
doi : 10.1111/ene.15103
Pages: 350-357 First Published: 14 September 2021
Many migraine patients rely on over-the-counter analgesics for the treatment of migraine attacks. Fixed-dose combinations of aspirin, paracetamol and caffeine (APC) have been used for treating migraine in many countries for a long time. We performed a meta-analysis for the comparison of APC versus placebo, which has not been done to date.
Mirror therapy for unilateral neglect after stroke: A systematic review
Yuqian Zhang, Ying Xing, Congqin Li, Yan Hua, Jian Hu, Yuyuan Wang, Ru Ya, Qiong Meng, Yulong Bai
doi : 10.1111/ene.15122
Pages: 358-371 First Published: 24 September 2021
The effect of mirror therapy for unilateral neglect after stroke currently remains uncertain.
Familial clustering of primary lateral sclerosis and amyotrophic lateral sclerosis: Supplementary evidence for a continuum
José Gazulla, Silvia Izquierdo-Alvarez, Emilio Ruiz-Fernández, José Berciano
doi : 10.1111/ene.15146
Pages: e1-e2 First Published: 25 October 2021
Reply to the letter from Gazulla et al.
Philippe Corcia, Christian Lunetta, Philippe Couratier, Patrick Vourc'h, Marta Gromicho, Claude Desnuelle, Marie-Hélène Soriani, Susana Pinto, Mamede de Carvalho
doi : 10.1111/ene.15134
Pages: e3-e4 First Published: 08 October 2021
Comment on “Predictive factors for a severe course of COVID-19 infection in myasthenia gravis patients with an overall impact on myasthenic status and survivalâ€� by JakubÃková et al.
Giuliana Galassi, Alessandro Marchioni
doi : 10.1111/ene.15131
Pages: e5-e6 First Published: 29 September 2021
Predictive factors for a severe course of COVID-19 infection in myasthenia gravis patients with an overall impact on myasthenic outcome status and survival
Michala Jakubikova, Michaela Tyblova, Adam Tesar, Horakova Magda, Vlazna Daniela, Rysankova Irena, Novakova Iveta, Doleckova Kristyna, Dusek Pavel, Pitha Jiri, Vohanka Stanislav, Bednarik Josef
doi : 10.1111/ene.15158
Pages: e7-e8 First Published: 26 October 2021
