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Comments on metabolomics in asthma and atopic dermatitis, and patient care during the COVID-19 pandemic
Philippe Eigenmann
doi : 10.1111/pai.13664
Volume 32, Issue 8 p. 1597-1600
Known and potential molecules associated with altered B cell development leading to predominantly antibody deficiencies
Parisa Amirifar,Reza Yazdani,Gholamreza Azizi,Mohammad Reza Ranjouri,Anne Durandy,Alessandro Plebani,Vassilios Lougaris,Lennart Hammarstrom,Asghar Aghamohammadi,Hassan Abolhassani
doi : 10.1111/pai.13589
Volume 32, Issue 8 p. 1601-1615
Predominantly antibody deficiencies (PADs) encompass a heterogeneous group of disorders characterized by low immunoglobulin serum levels in the presence or absence of peripheral B cells. Clinical presentation of affected patients may include recurrent respiratory and gastrointestinal infections, invasive infections, autoimmune manifestations, allergic reactions, lymphoproliferation, and increased susceptibility to malignant transformation. In the last decades, several genetic alterations affecting B-cell development/maturation have been identified as causative of several forms of PADs, adding important information on the genetic background of PADs, which in turn should lead to a better understanding of these disorders and precise clinical management of affected patients. This review aimed to present a comprehensive overview of the known and potentially involved molecules in the etiology of PADs to elucidate the pathogenesis of these disorders and eventually offer a better prognosis for affected patients.
A role for metabolism in determining neonatal immune function
Sean R. Holm,Ben J. Jenkins,James G. Cronin,Nicholas Jones,Catherine A. Thornton
doi : 10.1111/pai.13583
Volume 32, Issue 8 p. 1616-1628
Immune responses of neonates differ markedly to those of adults, with skewed cytokine phenotypes, reduced inflammatory properties and drastically diminished memory function. Recent research efforts have started to unravel the role of cellular metabolism in determining immune cell fate and function. For studies in humans, much of the work on metabolic mechanisms underpinning innate and adaptive immune responses by different haematopoietic cell types is in adults. Studies investigating the contribution of metabolic adaptation in the unique setting of early life are just emerging, and much more work is needed to elucidate the contribution of metabolism to neonatal immune responses. Here, we discuss our current understanding of neonatal immune responses, examine some of the latest developments in neonatal immunometabolism and consider the possible role of altered metabolism to the distinctive immune phenotype of the neonate. Understanding the role of metabolism in regulating immune function at this critical stage in life has direct benefit for the child by affording opportunities to maximize immediate and long-term health. Additionally, gaining insight into the diversity of human immune function and naturally evolved immunometabolic strategies that modulate immune function could be harnessed for a wide range of opportunities including new therapeutic approaches.
Association of different enteroviruses with atopy and allergic diseases in early childhood
Tiina Palmu,Jussi Lehtonen,Laura Korhonen,Suvi M. Virtanen,Onni Niemelä,Jorma Toppari,Jorma Ilonen,Riitta Veijola,Mikael Knip,Olli H. Laitinen,Maria Lönnrot,Heikki Hyöty
doi : 10.1111/pai.13577
Volume 32, Issue 8 p. 1629-1636
Enterovirus (EV) infections, being among the most prevalent viruses worldwide, have been associated with reduced risk of allergic diseases. We sought to determine the association between EVs and allergic sensitization and disease in early childhood.
Maternal serum 25-hydroxyvitamin D levels and infant atopic dermatitis: A prospective cohort study
Youping Tian,Ying Ye,Yi Zhang,Limin Dou,Yalan Dou,Piaoping Zhao,Yuan Jiang,Xiaohua Gao,Xiaohua Zhang,Jun Huang,Liping Xiao,Liuhui Wang,Weili Yan
doi : 10.1111/pai.13582
Volume 32, Issue 8 p. 1637-1645
Maternal vitamin D status during pregnancy has been linked with the risk of atopic dermatitis (AD) in children, while the results were inconsistent. The objective of this study was to assess the potential association.
Do allergic clinical manifestations increase the risk of behavioral problems in children? A cross-sectional study
Chikae Yamaguchi,Takeshi Ebara,Masaki Futamura,Yukihiro Ohya,Midori Asano
doi : 10.1111/pai.13542
Volume 32, Issue 8 p. 1646-1653
Children with allergic clinical manifestations tend to have behavioral or emotional problems such as hyperactivity or worse mental health. However, previous studies on this association did not adequately adjust for confounders like parenting stress, demographic characteristics, or allergy presentation. This study aimed to investigate the relationship between childhood allergic clinical manifestations and behavioral problems, adjusting for confounders such as demographic characteristics, parenting stress, and allergy-related variables.
Metabolomics reveals a correlation between hydroxyeicosatetraenoic acids and allergic asthma: Evidence from three years' immunotherapy
Peiyan Zheng,Xiqing Bian,Yingying Zhai,Cheng Li,Na Li,Chuangli Hao,Huimin Huang,Wenting Luo,Zhifeng Huang,Chenxi Liao,Mingshan Xue,Ming-Quan Guo,Baoqing Sun,Jian-Lin Wu
doi : 10.1111/pai.13569
Volume 32, Issue 8 p. 1654-1662
Subcutaneous immunotherapy (SCIT) is an effective, safe, preventative treatment for allergic asthma; however, potential biomarkers for monitoring SCIT have rarely been reported.
Potential sex differences in human milk leptin and their association with asthma and wheeze phenotypes: Results of the Ulm Birth Cohorts
Linda P. Siziba,Hermann Brenner,Efrat L. Amitay,Wolfgang Koenig,Dietrich Rothenbacher,Jon Genuneit
doi : 10.1111/pai.13586
Volume 32, Issue 8 p. 1663-1672
The hormone leptin has been suggested to play a role in the respiratory and immune systems. Evidence on sex-specific concentrations of leptin in human milk and sex-specific associations with the development of asthma and wheeze has been put forward but is still scarce.
Levels of 15-HETE and TXB2 in exhaled breath condensates as markers for diagnosis of childhood asthma and its therapeutic outcome
Li-Chen Chen,Hsu-Min Tseng,Ming-Ling Kuo,Chih-Yung Chiu,Sui-Ling Liao,Kuan-Wen Su,Ming-Han Tsai,Man-Chin Hua,Shen-Hao Lai,Tsung-Chieh Yao,Kuo-Wei Yeh,Ai-Hsuan Wu,Hsiu-Yueh Yu,Jing-Long Huang,Shau-Ku Huang
doi : 10.1111/pai.13587
Volume 32, Issue 8 p. 1673-1680
Dysregulation of eicosanoids is associated with asthma and a composite of oxylipins, including exhaled leukotriene B4 (LTB4), characterizes childhood asthma. While fractional exhaled nitric oxide (FeNO) has been used as the standard for monitoring steroid responsiveness, the potential utility of eicosanoids in monitoring the therapeutic outcomes remains unclear. We aimed to examine the levels of major eicosanoids representing different metabolic pathways in exhaled breath condensates (EBCs) of children with asthma during exacerbation and after treatment.
Association of phthalate exposure and airway dysfunction with mediation by serum periostin
Hey Sung Baek,Ha Young Won,Ju Hee Kim,Eun Kyo Ha,Hye Mi Jee,Youn Ho Shin,Mi-Ae Kim,Man Yong Han
doi : 10.1111/pai.13602
Volume 32, Issue 8 p. 1681-1690
Phthalates can cause respiratory and immunological disorders. However, little is known about the role of serum periostin and YKL-40 levels in mediating the effects of phthalates. We investigated the mediating role of these biomarkers in the relationship between phthalates and airway dysfunction.
Four subtypes of childhood allergic rhinitis identified by latent class analysis
Suleyman Tolga Yavuz,Ceyda Oksel Karakus,Adnan Custovic,Ömer Kalayci
doi : 10.1111/pai.13605
Volume 32, Issue 8 p. 1691-1699
Childhood allergic rhinitis (AR) is clinically heterogenous. We aimed to identify distinct phenotypes among children with AR using data-driven techniques and to ascertain their association with patterns of symptoms, allergic sensitization, and comorbidities.
Reproducibility of eucapnic voluntary hyperpnoea for exercise-induced bronchoconstriction diagnosis in asthmatic children and adolescents
Jose Ângelo Rizzo,Edil de Albuquerque Rodrigues Filho,Adriana Velozo Gonçalves,Laienne Carla Barbosa De Barros Albuquerque,Eduardo Martins de Albuquerque,Cláudio Gonçalves de Albuquerque,Anderson Henrique Souza de Almeida,Decio Medeiros Peixoto,Marco Aurelio de Valois Correia Junior
doi : 10.1111/pai.13610
Volume 32, Issue 8 p. 1700-1708
Respiratory symptoms after exercise are frequently reported by asthmatic patients, and exercise-induced bronchoconstriction (EIB) is a frequent cause, which requires objective testing for diagnosis. Eucapnic voluntary hyperpnea (EVH) is recommended as a surrogate stimulus for this purpose. Its short-term reproducibility is not yet established in children and young adolescents with asthma.
Metabolomics reveals microbial-derived metabolites associated with immunoglobulin E responses in filaggrin-related atopic dermatitis
Chih-Yung Chiu,Gigin Lin,Chia-Jung Wang,Shuen-Iu Hung,Wen-Hung Chung
doi : 10.1111/pai.13570
Volume 32, Issue 8 p. 1709-1717
Filaggrin (FLG) gene mutation and immunoglobulin E (IgE)–mediated sensitization are the most important predictors of atopic dermatitis (AD). However, a metabolomics-based approach to address the metabolic impact of FLG mutations on allergic IgE responses for AD is still lacking. We, though, determine the relationships of metabolic profiles in AD with FLG mutations and allergic responses.
Accidental ingestions to known allergens by food allergic children and adolescents
Allison Hicks,Claire Palmer,Maureen Bauer,Carina Venter
doi : 10.1111/pai.13573
Volume 32, Issue 8 p. 1718-1729
Accidental ingestions (AI) of food allergens in children compared with adolescents with food allergies are poorly characterized. It is suggested that AIs are higher in adolescents than children and that their reactions may be more severe, presumptively due, at least in part, to increased risk-taking behavior. We compared reported AIs in children versus adolescents.
Food-induced anaphylaxis morbidity: Emergency department and hospitalization data support preventive strategies
Luciana Kase Tanno,Evangeline Clark,Myriam Mamodaly,Victoria Cardona,Motohiro Ebisawa,Ignacio Asontegui,Mario Sanchez-Borges,Alexandra F. Santos,Alessandro Fiocchi,Margitta Worm,Davide Caimmi,Patricia Latour Staffeld,Antonella Muraro,Ruby Pawankar,Paul Allen Greenberger,Bernard Yu-Hor Thong,Bryan Martin,Pascal Demoly
doi : 10.1111/pai.13578
Volume 32, Issue 8 p. 1730-1742
Anaphylaxis is a recognized public health issue. There is no doubt that food-induced anaphylaxis (FIA) has tremendous impact on the quality of life of patients and their families and increases direct and indirect costs. FIA is associated with increasing rates of emergency department admissions and hospitalizations and implies the risk of death. Morbidity epidemiological data are a key to tailor public health actions to this non-communicable disease. The aim of this article was to review published morbidity epidemiological data relating to FIA and potential risk factors, in order to provide evidence-based recommendations to reduce the risk of severe adverse outcomes.
Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic children
Stefano Nebbia,Cristina Lamberti,Simona Cirrincione,Alberto Acquadro,Simona Abbà,Marina Ciuffo,Daniela Torello Marinoni,Marcello Manfredi,Emilio Marengo,Roberta Calzedda,Giovanna Monti,Laura Cavallarin,Maria Gabriella Giuffrida
doi : 10.1111/pai.13579
Volume 32, Issue 8 p. 1743-1755
Hazelnut allergy, which is characterized by symptoms that range from mild to severe, is one of the most common allergies in children throughout Europe, and an accurate diagnosis of this allergy is therefore essential. However, lipophilic allergens, such as oleosins, are generally underrepresented in diagnostic tests. We therefore sought to characterize the IgE reactivity of raw and roasted hazelnut oleosins, using the sera of hazelnut-allergic pediatric patients.
Mass food challenges in a vacant COVID-19 stepdown facility: Exceptional opportunity provides a model for the future
Aideen M. Byrne,Juan Trujillo,John Fitzsimons,Tariq Mohammed,Robert Ghent,Cathryn O’Carroll,David Coghlan,Jonathan O’B Hourihane,Ali Alsaleemi,Aoife Cassidy,Eva Corbet,Rita Creighton,Yvonne d’Art,Linda Farren,Rachel Flanagan,Niamh Flynn,Ruth Franklin,Claire Gray,Paul Harding,Ciara Hendrick,Fionnuala Heraghty,Sadhbh Hurley,Valerie Kavanagh,Dhanis Lad,Karen Leddy,Sarah Lewis,Triona McGlynn,Danielle O’Connor,Phil O’Neill,Orla O’Shea,Ann O’Toole,Rachel Quinn,Aisling Reid,Alison Russell,Emma Ruth,Anne Rynne,P Bhusan Sanneerappa,Mairead Sheehan,Claire Thompson,Ciara Tobin,James Trayer,Alison Wallace,Nicola Walsh,Fiona Wilson,on behalf of the Children's Health Ireland (CHI) Food Challenge Initiative Team
doi : 10.1111/pai.13580
Volume 32, Issue 8 p. 1756-1763
Internationally, the COVID-19 pandemic severely curtailed access to hospital facilities for those awaiting elective/semi-elective procedures. For allergic children in Ireland, already waiting up to 4 years for an elective oral food challenge (OFC), the restrictions signified indefinite delay. At the time of the initiative, there were approx 900 children on the Children's Health Ireland (CHI) waiting list. In July 2020, a project was facilitated by short-term (6 weeks) access to an empty COVID stepdown facility built, in a hotel conference centre, commandeered by the Health Service Executive (HSE), Ireland. The aim of this study was to achieve the rapid roll-out of an offsite OFC service, delivering high throughput of long waiting patients, while aligning with existing hospital policies and quality standards, international allergy guidelines and national social distancing standards.
Childhood food allergy and food allergen sensitisation are associated with adult airways disease: A birth cohort study
Wei Chern Gavin Fong,Adrian Chan,Hongmei Zhang,John W. Holloway,Graham Roberts,Ramesh Kurukulaaratchy,Syed Hasan Arshad
doi : 10.1111/pai.13592
Volume 32, Issue 8 p. 1764-1772
Childhood food allergy (FA) and food allergen sensitization (FAS) are associated with allergic airway disease(s) [AAD] (asthma and rhinitis) in childhood. However, the associations between childhood FA/FAS and AAD in adulthood are not well described.
Deriving health utility indices from a food allergy quality-of-life questionnaire
Gang Chen,Audrey DunnGalvin,Matthew Greenhawt,Marcus Shaker,Dianne E. Campbell
doi : 10.1111/pai.13604
Volume 32, Issue 8 p. 1773-1780
The Food Allergy Quality-of-Life Questionnaire-Parent Form (FAQLQ-PF) is widely used to assess food allergy–specific health-related quality of life (FAQL), but cannot be used directly in cost-utility analyses, which require health state utility (HSU) scores. Currently, limited evidence is available regarding the HSU of food-allergic children/adolescents. This study aimed to develop mapping algorithms from the FAQLQ-PF onto HSU scores generated by generic, preference-based, health-related quality-of-life (HRQL) instruments.
Clarithromycin hypersensitivity in children: Is there a link with ?-lactam hypersensitivity?
Ayse Suleyman,Esra Yucel,Sevgi Sipahi Cimen,Zeynep Hizli Demirkale,Cevdet Ozdemir,Zeynep Ulker Tamay,Nermin Guler
doi : 10.1111/pai.13588
Volume 32, Issue 8 p. 1781-1787
Clarithromycin hypersensitivity is reported as the most common cause of non-?-lactam antibiotic allergy in children. Clarithromycin is frequently prescribed in cases of suspected ?-lactam hypersensitivity. Oral provocation tests stand as the gold standard to confirm drug hypersensitivity as diagnostic value of skin tests is variable. We analyzed the frequency of true clarithromycin hypersensitivity ratio and its relationship with ?-lactam allergy among children with suspected clarithromycin hypersensitivity and evaluated the diagnostic value of skin tests.
Patterns of response and drugs involved in hypersensitivity reactions to beta-lactams in children
Isabel Torres-Rojas,Diana Pérez-Alzate,Maria Luisa Somoza,Elisa Haroun Diaz,Francisco Javier Ruano Pérez,Ana Prieto-Moreno Pfeifer,Teodorikez W. Jimenez-Rodriguez,Javier Fernandez Sánchez,Miguel Blanca,Gabriela Canto Diez,Natalia Blanca-López
doi : 10.1111/pai.13608
Volume 32, Issue 8 p. 1788-1795
Beta-lactams generate different allergenic determinants that induce selective or cross-reactive drug hypersensitivity reactions (DHRs). We aimed to identify the drugs involved, the selectivity of the response, the mechanism, and the value of the different diagnostic tests for establishing a diagnosis in children evaluated for DHRs to beta-lactams.
Diverse clinical features and diagnostic delay in monogenic inborn errors of immunity: A call for access to genetic testing
Anna Branch,Bhavi Modi,Bahar Bahrani,Kyla J. Hildebrand,Scott B. Cameron,Anne K. Junker,Stuart E. Turvey,Catherine M. Biggs
doi : 10.1111/pai.13571
Volume 32, Issue 8 p. 1796-1803
Inborn errors of immunity (IEIs) are a group of conditions affecting immune system development and function. Due to their clinical heterogeneity and lack of provider awareness, patients suffer from long diagnostic delays that increase morbidity and mortality. Next-generation sequencing facilitates earlier diagnosis and treatment of IEIs, but too often patients are unable to see the benefit of this technology due to gaps in providers’ knowledge regarding which patients to test and barriers to accessing sequencing.
Biallelic TRAF3IP2 variants causing chronic mucocutaneous candidiasis in a child harboring a STAT1 variant
Pilar Blanco Lobo,Wei-Te Lei,Simon J. Pelham,Paloma Guisado Hernández,Isabel Villaoslada,Beatriz de Felipe,José Manuel Lucena,Jean-Laurent Casanova,Peter Olbrich,Anne Puel,Olaf Neth
doi : 10.1111/pai.13603
Volume 32, Issue 8 p. 1804-1812
Inherited chronic mucocutaneous candidiasis (CMC) is often caused by inborn errors of immunity, impairing the response to, or the production of IL-17A and IL-17F. About half of the cases carry STAT1 gain-of-function (GOF) mutations. Only few patients have been reported with mutations of TRAF3IP2, a gene encoding the adaptor ACT1 essential for IL-17 receptor(R) signaling. We investigated a 10-year-old girl with CMC, carrying a heterozygous variant of STAT1 and compound heterozygous variants of TRAF3IP2.
Bacterial lysate treatment in allergic disease: A systematic review and meta-analysis
Chengmei Li,Hua Zhou,Wei Zhang,Datian Che
doi : 10.1111/pai.13572
Volume 32, Issue 8 p. 1813-1823
The aim of this review was to assess the efficacy of bacterial lysate treatment in patients with allergic disease.
Childhood CCL18, CXCL10 and CXCL11 levels differentially relate to and predict allergy development
Johanna Huoman,Sadia Haider,Angela Simpson,Clare S. Murray,Adnan Custovic,Maria C. Jenmalm
doi : 10.1111/pai.13574
Volume 32, Issue 8 p. 1824-1832
Chemokines are important mediators in immune cell recruitment, contributing to allergy development. However, extensive studies of chemokines in the circulation in relation to the presence and development of allergic diseases remain scarce. Our aim was to investigate associations of circulating allergy-related chemokines with the development of asthma and sensitization cross-sectionally and longitudinally in a population-based cohort.
Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology
Nicola Cotugno,Alessandra Ruggiero,Giuseppe Rubens Pascucci,Francesco Bonfante,Maria Raffaella Petrara,Chiara Pighi,Loredana Cifaldi,Paola Zangari,Stefania Bernardi,Laura Cursi,Veronica Santilli,Emma Concetta Manno,Donato Amodio,Giulia Linardos,Livia Piccioni,Maria Antonietta Barbieri,Daniela Perrotta,Andrea Campana,Daniele Donà,Carlo Giaquinto,the CACTUS Study Team,Carlo Concato,Petter Brodin,Paolo Rossi,Anita De Rossi,Paolo Palma
doi : 10.1111/pai.13585
Volume 32, Issue 8 p. 1833-1842
Although SARS-CoV-2 immunizations have started in most countries, children are not currently included in the vaccination programs; thus, it remains crucial to define their anti-SARS-CoV-2 immune response in order to minimize the risk for other epidemic waves. This study sought to provide a description of the virology ad anti-SARS-CoV-2 immunity in children with distinct symptomatology.
Differential maturation trajectories of innate antiviral immunity in health and atopy
Anastasia Georgountzou,Dimitra Kokkinou,Stella Taka,Paraskevi Maggina,John Lakoumentas,Vassiliki Papaevangelou,Maria Tsolia,Paraskevi Xepapadaki,Evangelos Andreakos,Nikolaos G. Papadopoulos
doi : 10.1111/pai.13601
Volume 32, Issue 8 p. 1843-1856
The maturation of innate immune responses in health and atopy is still incompletely understood.
Recurrent assessment of lymphocyte subsets in 32 patients with multisystem inflammatory syndrome in children (MIS-C)
Magdalena Okarska-Napiera?a,Joanna Ma?dziuk,Wojciech Feleszko,Anna Stelmaszczyk-Emmel,Mariusz Panczyk,Urszula Demkow,Ernest Kuchar
doi : 10.1111/pai.13611
Volume 32, Issue 8 p. 1857-1865
Lymphopenia is a hallmark of multisystem inflammatory syndrome in children (MIS-C). We aimed to characterize lymphocyte subsets' shifts and their correlations with other severity markers of MIS-C.
Cost-utility of tiotropium for children with severe asthma in patients aged 1–5 years
Jefferson Antonio Buendía,Carlos E. Rodriguez-Martinez,Monica P. Sossa-Briceño
doi : 10.1111/pai.13590
Volume 32, Issue 8 p. 1866-1868
Proteome signature difference between respiratory viruses is associated with severity of bronchiolitis
Tadao Ooka,Yoshihiko Raita,Debby Ngo,Jonathan M. Mansbach,Zhaozhong Zhu,Carlos A. Camargo Jr.,Kohei Hasegawa
doi : 10.1111/pai.13606
Volume 32, Issue 8 p. 1869-1872
Comparison of dietary intake between milk-allergic and non-food-allergic children
Kyle Gibson,Stephanie Stanley,Shradha Agarwal,Marion Groetch,Supinda Bunyavanich
doi : 10.1111/pai.13581
Volume 32, Issue 8 p. 1872-1876
The impact of COVID-19 lockdown on infants' coronavirus exposure and routine healthcare access in Ireland: The CORAL birth cohort study at 6 months.
Marguerite Lawler,Ruth Franklin,Naomi McCallion,Aideen M. Byrne,John Fitzsimons,Meredith Kinoshita,Martin White,Liam O'Mahony,Jonathan Hourihane
doi : 10.1111/pai.13591
Volume 32, Issue 8 p. 1876-1879
Bacterial microbiota composition of fresh unpasteurized cow's milk and home-made and commercially available fermented milk products
Pieter de Waal,Shane Murray,Katie Lennard,Jeanne Korsman,Michael Levin
doi : 10.1111/pai.13607
Volume 32, Issue 8 p. 1879-1882
