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Double-Blind Reviews: A Step Toward Eliminating Unconscious Bias
Shmidt, Eugenia MD1; Jacobson, Brian C. MD, MPH, FACG2
doi : 10.14309/ctg.0000000000000443
January 2022 - Volume 13 - Issue 1 - p e00443
Limited Access to Integral Care: Digital Therapeutics Show Promise of Scalable Solutions to Behavioral Interventions
Riehl, Megan E. PsyD, MA1
doi : 10.14309/ctg.0000000000000444
January 2022 - Volume 13 - Issue 1 - p e00444
Functional gastrointestinal disorders, or disorders of gut-brain interaction, present significant biological, psychological, and social burdens to the individual and society at large. Emerging research shows that because of the multifactorial nature of these conditions, multidisciplinary treatment is typically needed. Traditional medical approaches now benefit from the addition of nutrition therapy and psychogastroenterology, or the use of evidence-based psychological treatments tailored to gastrointestinal conditions. Currently, there are significant barriers to receiving psychogastroenterology services and it is likely that digital therapeutics have an important place in improving treatment access and outcomes for a select group of patients.
The 5Ms of Geriatrics in Gastroenterology: The Path to Creating Age-Friendly Care for Older Adults With Inflammatory Bowel Diseases and Cirrhosis
Kochar, Bharati MD, MS1,2,3,*; Ufere, Nneka N. MD, MSCE1,2,*; Ritchie, Christine S. MD, MSPH2,3,4; Lai, Jennifer C. MD, MBA5
doi : 10.14309/ctg.0000000000000445
January 2022 - Volume 13 - Issue 1 - p e00445
The number of Americans 65 years or older in 2060 will be more than double what it was in 2014. Approximately 40% of patients seen in gastroenterology (GI) and hepatology practices in the United States are 60 years or older. Adapting care delivery models, curating data on shifting risk-benefit decisions with geriatric syndromes, understanding appropriate assessments, and focusing on tailored implementation strategies are challenges that are actively confronting us as we provide care for a burgeoning population of older adults. Limited availability of geriatric specialists results in an onus of specialists caring for older adults, such as gastroenterologists, to innovate and develop tailored, comprehensive, and evidence-based care for adults in later life stages. In this article, we present the 5M framework from geriatrics to achieve age-friendly healthcare. The 5Ms are medications, mind, mobility, multicomplexity, and what matters most. We apply the 5M framework to 2 chronic conditions commonly encountered in clinical GI practice: inflammatory bowel diseases and cirrhosis. We highlight knowledge gaps and outline future directions to expand evidence-based care and advance the creation of age-friendly GI care.
Artificial Intelligence for Detecting and Delineating Margins of Early ESCC Under WLI Endoscopy
Liu, Wei MD1,*; Yuan, Xianglei MD1,*; Guo, Linjie MD1; Pan, Feng MD2; Wu, Chuncheng MM1; Sun, Zhongshang MM2; Tian, Feng MM3; Yuan, Cong MM4; Zhang, Wanhong MM5; Bai, Shuai BN1; Feng, Jing MM6; Hu, Yanxing PhD6; Hu, Bing MD1
doi : 10.14309/ctg.0000000000000433
January 2022 - Volume 13 - Issue 1 - p e00433
Conventional white light imaging (WLI) endoscopy is the most common screening technique used for detecting early esophageal squamous cell carcinoma (ESCC). Nevertheless, it is difficult to detect and delineate margins of early ESCC using WLI endoscopy. This study aimed to develop an artificial intelligence (AI) model to detect and delineate margins of early ESCC under WLI endoscopy.
Animal Naming Test Is Associated With Poor Patient-Reported Outcomes and Frailty in People With and Without Cirrhosis: A Prospective Cohort Study
Tapper, Elliot B. MD1; Kenney, Brooke MPH2; Nikirk, Samantha MPH1; Levine, Deborah A. MD, MPH3; Waljee, Akbar K. MD, MSc1,2
doi : 10.14309/ctg.0000000000000447
January 2022 - Volume 13 - Issue 1 - p e00447
Cognitive dysfunction is a major driver of care complexity, poor patient-reported outcomes, and frailty for people with cirrhosis. The performance and clinical associations of the animal naming test (ANT) in the general population are unknown. We evaluated ANT performance in a representative sample of older Americans with and without chronic liver disease (CLD).
Metabolic Dysfunction–Associated Fatty Liver Disease Increases Colon Cancer Risk: A Nationwide Cohort Study
Lee, Hokyou MD1,*; Lee, Hye Won MD, PhD2,3,4,*; Kim, Seung Up MD, PhD2,3,4; Chang Kim, Hyeon MD, PhD1
doi : 10.14309/ctg.0000000000000435
January 2022 - Volume 13 - Issue 1 - p e00435
The association between nonalcoholic fatty liver disease (NAFLD) and colorectal cancer (CRC) has been controversial. Using the new consensus-driven definition, we evaluated the association of metabolic dysfunction–associated fatty liver disease (MAFLD) with the risk of developing CRC.
Antibiotic Therapy and Risk of Early-Onset Colorectal Cancer: A National Case-Control Study
Nguyen, Long H. MD, MS1,2,*; Cao, Yin ScD, MPH3,4,*; Batyrbekova, Nurgul PhD5,6; Roelstraete, Bjorn PhD6; Ma, Wenjie ScD1,2; Khalili, Hamed MD, MPH1,2; Song, Mingyang MBBS, ScD1,2,7; Chan, Andrew T. MD, MPH1,2,8,9; Ludvigsson, Jonas F. MD, PhD10,11,12,13,14
doi : 10.14309/ctg.0000000000000437
January 2022 - Volume 13 - Issue 1 - p e00437
Antibiotic use has emerged as a risk factor for colorectal neoplasia and is hypothesized as a contributor to the rising incidence of colorectal cancer under age 50 years or early-onset colorectal cancer (EOCRC). However, the impact of antibiotic use and risk of EOCRC is unknown.
Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression
Stallhofer, Johannes MD1,2; Veith, Lisa MD1; Diegelmann, Julia PhD1,3; Probst, Philipp PhD4; Brand, Stephan MD1,5; Schnitzler, Fabian MD1; Olszak, Torsten MD1; Török, Helga MD1; Mayerle, Julia MD1; Stallmach, Andreas MD2; Beigel, Florian MD1
doi : 10.14309/ctg.0000000000000450
January 2022 - Volume 13 - Issue 1 - p e00450
Iron deficiency and vitamin D deficiency are common comorbidities in inflammatory bowel disease (IBD). Accumulating evidence indicates that active 1,25-dihydroxyvitamin D (1,25(OH)D) may enhance iron absorption by suppressing hepcidin. We investigated the influence of vitamin D on iron metabolism in patients with IBD and on the expression of genes facilitating intestinal epithelial iron absorption.
Combined Endoscopic and Radiologic Healing Is Associated With a Better Prognosis Than Endoscopic Healing Only in Patients With Crohn's Disease Receiving Anti-TNF Therapy
Oh, Kyunghwan MD, MSc1,*; Oh, Eun Hye MD, MSc2,*; Noh, Soo Min MD, MSc1; Park, Seong Ho MD, PhD3; Kim, Nayoung MSc4; Hwang, Sung Wook MD, PhD1,5,6; Park, Sang Hyoung MD, PhD1,5,6; Yang, Dong-Hoon MD, PhD1,6; Byeon, Jeong-Sik MD, PhD1,6; Myung, Seung-Jae MD, PhD1,6; Yang, Suk-Kyun MD, PhD1,5,6; Ye, Byong Duk MD, PhD1,5,6
doi : 10.14309/ctg.0000000000000442
January 2022 - Volume 13 - Issue 1 - p e00442
Although endoscopic healing (EH) is recommended as the therapeutic goal in patients with Crohn's disease (CD), combined EH and radiologic healing (RH) could be a more ideal therapeutic goal considering the transmural nature of CD. We compared the prognosis of patients with CD who achieved EH, RH, both EH and RH (deep healing; DH), or no healing under treatment with anti-tumor necrosis factor (TNF) agents.
Equivalent Cellular and Humoral Immunity to Varicella Zoster Virus in Patients With Inflammatory Bowel Disease and Healthy Older Adults for Whom Immunization Is Recommended
Caldera, Freddy DO, MS1; Wald, Arnold MD1; Saha, Sumona MD, MPH1; Smith, Ryan MD2; McCrone, Sue BS3; Farraye, Francis A. MD, MSc4; Hayney, Mary S. PharmD, MPH3
doi : 10.14309/ctg.0000000000000446
January 2022 - Volume 13 - Issue 1 - p e00446
Patients with inflammatory bowel disease (IBD) are at an increased risk of herpes zoster (HZ). HZ is caused by reactivation of the varicella zoster virus (VZV) and is prevented by strong VZV-specific cell-mediated immunity. The aim of our study was to evaluate whether patients with IBD had lower or equivalent protection compared with healthy controls (HCs) at age 50 years and older.
Circulating Dipeptidyl Peptidase Activity Is a Potential Biomarker for Inflammatory Bowel Disease
Jaenisch, Simone E. PhD1,2; Abbott, Catherine A. PhD2,3; Gorrell, Mark D. PhD4; Bampton, Peter MBBS, MD1; Butler, Ross N. PhD5; Yazbeck, Roger PhD1,2
doi : 10.14309/ctg.0000000000000452
January 2022 - Volume 13 - Issue 1 - p e00452
Dipeptidyl peptidase (DPP)-4 is part of a larger family of proteases referred to as DPPs. DPP4 has been suggested as a possible biomarker for inflammatory bowel disease (IBD). Circulating DPP4 (cDPP4) enzyme activity was investigated as a potential biomarker for IBD. In addition, DPP enzyme activity and gene expression were quantified in colonic tissue of patients with IBD and non-IBD.
Safety and Efficacy of Nonoperative Treatment in Esophageal Perforation Caused by Foreign Bodies
Liao, Foqiang MD1; Zhu, Zhenhua MD1; Pan, Xiaolin MD1; Li, Bimin MD1; Zhu, Yin MD1; Chen, Youxiang MD1; Shu, Xu MD, PhD1,2
doi : 10.14309/ctg.0000000000000451
January 2022 - Volume 13 - Issue 1 - p e00451
Esophageal foreign bodies are often treated by endoscopy, but the treatment of esophageal perforation caused by foreign bodies remains controversial. The purpose of this study was to investigate the safety and efficacy of nonoperative treatment of esophageal perforation caused by foreign bodies.
Acute and Chronic Pancreatitis Disease Prevalence, Classification, and Comorbidities: A Cohort Study of the UK BioBank
Spagnolo, Daniel M. PhD1,2; Greer, Phil J. MS1; Ohlsen, Celeste Shelton PhD, CGC1; Mance, Shannon MPH, RN3; Ellison, Mitchell PhD1; Breze, Cameron MS1; Busby, Ben PhD4; Whitcomb, David C. MD, PhD1-3; Haupt, Mark MD1
doi : 10.14309/ctg.0000000000000455
January 2022 - Volume 13 - Issue 1 - p e00455
Pancreatitis is a complex syndrome that results from many etiologies. Large well-characterized cohorts are needed to further understand disease risk and prognosis.
Gut Dysbiosis Could Be a Major Factor for the Effects of Low-Grade Endotoxemia in COVID-19 Comment on: Low-Grade Endotoxemia and Thrombosis in COVID-19
Chen, Jiezhong PhD1; Vitetta, Luis MD, PhD1,2
doi : 10.14309/ctg.0000000000000440
January 2022 - Volume 13 - Issue 1 - p e00440
Reply to Chen and Vitetta
Violi, Francesco MD1; Pignatelli, Pasquale MD1,2; Oliva, Alessandra MD3; Cammisotto, Vittoria MSc4
doi : 10.14309/ctg.0000000000000448
January 2022 - Volume 13 - Issue 1 - p e00448
Comment on “Internet Cognitive-Behavioral Therapy for Painful Chronic Pancreatitis: A Pilot Feasibility Randomized Controlled Trial”
Han, Chao MD1,*; Lin, Xi MD1,*; Lv, Yan-Wei MD1,*; Hu, Liang-Hao MD1
doi : 10.14309/ctg.0000000000000439
January 2022 - Volume 13 - Issue 1 - p e00439
Response to Han et al.
Palermo, Tonya M. PhD
doi : 10.14309/ctg.0000000000000449
January 2022 - Volume 13 - Issue 1 - p e00449
Controls and Result Interpretations in Studies of Urine Gluten Peptide Determinations
Sousa, Carolina PhD1; Comino, Isabel PhD1; Cebolla, Ángel PhD2; Coto, Laura PhD Student2; Segura, Verónica PhD Student1; Ruiz-Carnicer, Ángela PhD1; de Lourdes Moreno, María PhD1
doi : 10.14309/ctg.0000000000000456
January 2022 - Volume 13 - Issue 1 - p e00456
Correction to: Gastric Cancer Risk of Intestinal Metaplasia Subtypes: A Systematic Review and Meta-Analysis of Cohort Studies
Du, Sijing MM1,*; Yang, Yang MD1,*; Fang, Shuangshuang MM1,2,*; Guo, Song MD3,*; Xu, Chuchu MM1,2; Zhang, Ping MD1; Wei, Wei MD1
doi : 10.14309/ctg.0000000000000432
January 2022 - Volume 13 - Issue 1 - p e00432
