Greenberg, Sydney B. MD; Shaheen, Nicholas J. MD, MPH
doi : 10.14309/ajg.0000000000001586
February 2022 - Volume 117 - Issue 2 - p 201-204
Dawod, Enad MD1; Nieto, Jose DO2; Saab, Sammy MD, MPH3
doi : 10.14309/ajg.0000000000001551
February 2022 - Volume 117 - Issue 2 - p 205-208
Brunt, Hartman MD, MSHCM1,2; Chapman, J. Casey MD1,2,3
doi : 10.14309/ajg.0000000000001569
February 2022 - Volume 117 - Issue 2 - p 209-212
Ertem, Furkan U. MD1; Hartman, Doug MD1; Dubner, Howard M. MD1
doi : 10.14309/ajg.0000000000001536
February 2022 - Volume 117 - Issue 2 - p 214
Yang, Daopeng MD1; Zhuang, Bowen MD, PhD1; Xie, Xiaohua MD, PhD1
doi : 10.14309/ajg.0000000000001542
February 2022 - Volume 117 - Issue 2 - p 215
Jinushi, Ryuhei MD1; Ishii, Naoki MD, PhD, MPH1; Fukuyama, Kozo MD, PhD2
doi : 10.14309/ajg.0000000000001544
February 2022 - Volume 117 - Issue 2 - p 216
Yu, Shunjie MD1,*; Pan, Ling MD1,*; Ma, Jiahui MD1; Cao, Hailong MD1
doi : 10.14309/ajg.0000000000001568
February 2022 - Volume 117 - Issue 2 - p 217
Matsuura, Noriko MD1; Kato, Motohiko MD1,2; Shimoda, Masayuki MD3,4; Yahagi, Naohisa MD1
doi : 10.14309/ajg.0000000000001546
February 2022 - Volume 117 - Issue 2 - p 218
Chua, Wen Jie1,2; Wan, Wei Keat MBChB, FRCPath(UK)3; Yew Tan, Damien Meng MBBS, MRCP, MCI2,4
doi : 10.14309/ajg.0000000000001524
February 2022 - Volume 117 - Issue 2 - p 213
Kimura, Hidenori MD1,2; Imai, Kenichiro MD1; Hotta, Kinichi MD1; Ito, Sayo MD1; Kishida, Yoshihiro MD, PhD1; Ono, Hiroyuki MD, PhD1
doi : 10.14309/ajg.0000000000001601
February 2022 - Volume 117 - Issue 2 - p 219
Qiao, Qiu-Jian BA1; Zhang, Hong MD2; Wang, Yan-Hong BA1; Yang, Shi-Ming PhD1; Liu, Lu BA1; Bai, Jian-Ying PhD1; Fan, Chao-Qiang MD1
doi : 10.14309/ajg.0000000000001412
February 2022 - Volume 117 - Issue 2 - p 220
doi : 10.14309/ajg.0000000000001123
February 2022 - Volume 117 - Issue 2 - p 221-222
Parsa, Nasim MD
doi : 10.14309/ajg.0000000000001612
February 2022 - Volume 117 - Issue 2 - p 223
Cancer Risk in Patients with and Relatives of Serrated Polyposis Syndrome and Sporadic Sessile Serrated Lesions
Shoreibah, Mohamed MD
doi : 10.14309/ajg.0000000000001613
February 2022 - Volume 117 - Issue 2 - p 224
Acute On Chronic Liver Failure Clinical Guidelines
Bajaj, Jasmohan S. MD, MS, FACG1; O'Leary, Jacqueline G. MD, MPH, FACG2; Lai, Jennifer C. MD, MBA3; Wong, Florence MD, FACG4; Long, Millie D. MD, MPH, FACG (Methodologist)5; Wong, Robert J. MD, MS, FACG (Methodologist)6; Kamath, Patrick S. MD7
doi : 10.14309/ajg.0000000000001595
February 2022 - Volume 117 - Issue 2 - p 225-252
In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging as a major cause of mortality. These guidelines indicate the preferred approach to the management of patients with acute-on-chronic liver failure and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation process. In instances where the evidence was not appropriate for Grading of Recommendations, Assessment, Development, and Evaluation, but there was consensus of significant clinical merit, key concept statements were developed using expert consensus. These guidelines are meant to be broadly applicable and should be viewed as the preferred, but not only, approach to clinical scenarios.
Cacoub, Patrice MD, PhD1,2,3,4; Asselah, Tarik MD, PhD5,6
doi : 10.14309/ajg.0000000000001575
February 2022 - Volume 117 - Issue 2 - p 253-263
People living with hepatitis B virus (HBV) chronic infection are exposed to high rates of liver complications including end-stage liver disease and hepatocellular carcinoma. Extrahepatic manifestations of HBV infection have long been underestimated. Several of these extrahepatic syndromes have been well described, including systemic vasculitides, glomerulonephritis, and cutaneous manifestations. Other manifestations have been more recently described such as hematological malignancies and neurological diseases. These extrahepatic manifestations are associated with significant morbidity and mortality. Although not completely understood, underlying mechanisms include HBV-induced local and systemic inflammation. Suppression of HBV replication usually improves extrahepatic manifestations. This review will discuss how HBV induces inflammation and the extrahepatic manifestations of HBV infection to guide clinical management.
Ma, Christopher MD, MPH1,2,3; Jairath, Vipul MD, PhD3,4,5; Feagan, Brian G. MD3,4,5; Guizzetti, Leonardo PhD3; Zou, Guangyong PhD3,5,6; McFarlane, Stefanie C. BMath3; Shackelton, Lisa M. PhD3; Collins, Margaret H. MD7; Hirano, Ikuo MD8; de Rooij, Willemijn E. MD9; Schaeffer, David F. MD10; Pai, Rish K. MD, PhD11; Bredenoord, Albert J. MD, PhD9; Dellon, Evan S. MD, MPH12
doi : 10.14309/ajg.0000000000001571
February 2022 - Volume 117 - Issue 2 - p 264-271
The optimal instrument for assessing histologic disease activity in patients with eosinophilic esophagitis (EoE) is unclear. We assessed the responsiveness of the EoE Histologic Scoring System (EoE-HSS) when compared with that of the peak eosinophil count (PEC).
Hiremath, Girish MD, MPH1; Sun, Lili PhD2; Correa, Hernan MD3; Acra, Sari MD, MPH1; Collins, Margaret H. MD4; Bonis, Peter MD5; Arva, Nicoleta C. MD, PhD6; Capocelli, Kelley E. MD7; Falk, Gary W. MD, MS8; King, Eileen PhD9; Gonsalves, Nirmala MD10; Gupta, Sandeep K. MD11; Hirano, Ikuo MD10; Mukkada, Vincent A. MD12; Martin, Lisa J. PhD12; Putnam, Philip E. MD12; Spergel, Jonathan M. MD, PhD13; Wechsler, Joshua B. MD, MS1; Yang, Guang-Yu MD, PhD14; Aceves, Seema S. MD, PhD15; Furuta, Glenn T. MD1; Rothenberg, Marc. E. MD, PhD16; Koyama, Tatsuki PhD2; Dellon, Evan S. MD, MPH17
doi : 10.14309/ajg.0000000000001587
February 2022 - Volume 117 - Issue 2 - p 272-279
Approximately half of esophageal biopsies from patients with eosinophilic esophagitis (EoE) contain inadequate lamina propria, making it impossible to determine the lamina propria fibrosis (LPF). This study aimed to develop and validate a web-based tool to predict LPF in esophageal biopsies with inadequate lamina propria.
Tan, Mimi C. MD, MPH1; Jamali, Taher MD2; Nguyen, Theresa H. MD, MPH1,3; Galvan, Amy MPH1; Sealock, Robert J. MD1; Khan, Anam MD4; Zarrin-Khameh, Neda MD, MPH5; Holloman, Ashley MD5; Kampagianni, Ourania MD5; Ticas, David Henriquez MD5; Liu, Yan MS1,3; El-Serag, Hashem B. MD, MPH2,3; Thrift, Aaron P. PhD6,7
doi : 10.14309/ajg.0000000000001576
February 2022 - Volume 117 - Issue 2 - p 280-287
Several US subgroups have increased risk of gastric cancer and gastric intestinal metaplasia (GIM) and may benefit from targeted screening. We evaluated demographic and clinical risk factors for GIM and examined the interaction between race/ethnicity and birthplace on GIM risk.
Lee, Hye Won MD, PhD1,2,3,*; Park, Soo Young MD, PhD4,*; Lee, Yu Rim MD, PhD4; Lee, Hyein BS3; Lee, Jae Seung MD1,2,3; Kim, Seung Up MD, PhD1,2,3; Park, Jun Yong MD, PhD1,2,3; Kim, Do Young MD, PhD1,2,3; Ahn, Sang Hoon MD, PhD1,2,3; Kim, Beom Kyung MD, PhD1,2,3
doi : 10.14309/ajg.0000000000001497
February 2022 - Volume 117 - Issue 2 - p 288-294
The necessity of antiviral therapy (AVT) for hepatitis B virus (HBV)-infected compensated cirrhosis with low-level viremia (LLV) is controversial. Herein, we evaluated its natural history.
Duong, Nikki K. MD1; Shrestha, Shreesh MD1; Park, Dan MD1; Shahab, Omer MD1; Fagan, Andrew BS1; Malpaya, Zenaida NP1; Gallagher, Mary L. NP1; Morris, April NP1; Davis, Brian C. MD1; Bajaj, Jasmohan S. MD, MS, FACG1
doi : 10.14309/ajg.0000000000001550
February 2022 - Volume 117 - Issue 2 - p 295-300
Bowel movement (BM) frequency is used to titrate lactulose for hepatic encephalopathy (HE). However, stool consistency using the Bristol stool scale (BSS, 0–7) is often ignored.
Morales-Arráez, D. MD, PhD1,2; Ventura-Cots, M. MD, PhD1; Altamirano, J. MD, PhD3; Abraldes, J.G. MD, PhD4; Cruz-Lemini, M. MD5; Thursz, M.R. MD, PhD6; Atkinson, S.R. MD, PhD1,6; Sarin, S.K. MD, PhD7; Kim, W. MD, PhD8; Chavez-Araujo, R. MD9; Higuera-de la Tijera, M.F. MD, PhD10; Singal, A.K. MD11; Shah, V.H. MD12; Kamath, P.S. MD12; Duarte-Rojo, A. MD, PhD13; Charles, E.A. RN1; Vargas, V. MD, PhD14; Jager, M. MD15; Rautou, P.E. MD, PhD15,16; Rincon, D. MD17; Zamarripa, F. MD18; Restrepo-Gutiérrez, J.C. MD, PhD19; Torre, A. MD20; Lucey, M.R. MD21; Arab, J.P. MD22; Mathurin, P. MD, PhD23,24; Louvet, A. MD, PhD23; García-Tsao, G. MD25; González, J.A. MD26; Verna, E.C. MD27; Brown, R.S. Jr MD28; Argemi, J. MD, PhD1,29; Fernández-Carillo, C. MD, PhD1; Clemente, A. MD1,30,31; Alvarado-Tapias, E. MD, PhD1; Forrest, E. MD32; Allison, M. MD, PhD33; Bataller, R. MD, PhD1
doi : 10.14309/ajg.0000000000001596
February 2022 - Volume 117 - Issue 2 - p 301-310
Several scoring systems predict mortality in alcohol-associated hepatitis (AH), including the Maddrey discriminant function (mDF) and model for end-stage liver disease (MELD) score developed in the United States, Glasgow alcoholic hepatitis score in the United Kingdom, and age, bilirubin, international normalized ratio, and creatinine score in Spain. To date, no global studies have examined the utility of these scores, nor has the MELD-sodium been evaluated for outcome prediction in AH. In this study, we assessed the accuracy of different scores to predict short-term mortality in AH and investigated additional factors to improve mortality prediction.
van Kleef, Laurens A. MD1; Hofman, Amy MSc2; Voortman, Trudy PhD2; de Knegt, Robert J. MD, PhD1
doi : 10.14309/ajg.0000000000001584
February 2022 - Volume 117 - Issue 2 - p 311-318
The disease burden of nonalcoholic fatty liver disease (NAFLD) increases rapidly, in line with the obesity pandemic. Physical activity has been linked to a lower risk of NAFLD. However, the impact of different intensities of activity and sedentary behavior and whether their effects on NAFLD are explained by metabolic health remain unclear.
Cartee, Amanda K. MD1,2; Choung, Rok Seon MD1; King, Katherine S. MS3; Wang, Suyue PhD4; Dzuris, John L. PhD4; Anderson, Robert P. MD4; Van Dyke, Carol T. CCRP1; Hinson, Chadrick A. BA1; Marietta, Eric PhD1; Katzka, David A. MD1; Nehra, Vandana MD1; Grover, Madhusudan MBBS1; Murray, Joseph A. MD1
doi : 10.14309/ajg.0000000000001565
February 2022 - Volume 117 - Issue 2 - p 319-326
Treated patients with celiac disease (CeD) and nonceliac gluten sensitivity (NCGS) report acute, transient, incompletely understood symptoms after suspected gluten exposure. To determine whether (i) blinded gluten exposure induces symptoms, (ii) subjects accurately identify gluten exposure, and (iii) serum interleukin-2 (IL-2) levels distinguish CeD from NCGS subjects after gluten exposure.
Rahmi, Gabriel MD, PhD1; Cholet, Franck MD2; Gaudric, Marianne MD3; Filippi, Jérôme MD4; Duburque, Clotilde MD5; Bramli, Slim MD6; Quentin, Vincent MD7; Alavi, Zarrin MSc, MEng8; Nowak, Emmanuel PhD8; Saurin, Jean Christophe MD, PhD9; Cellier, Christophe MD, PhD1; Quénéhervé, Lucille MD, PhD2; PREPINTEST working group
doi : 10.14309/ajg.0000000000001597
February 2022 - Volume 117 - Issue 2 - p 327-335
The aim of our study was to compare clear liquid diet with 2 different polyethylene glycol (PEG)-based bowel preparation methods regarding diagnostic yield of small bowel capsule endoscopy (SBCE) in patients with suspected small bowel bleeding (SBB).
Kanth, Priyanka MD, MS1,2; Yu, Zhe MS2; Keener, Megan B. MS2; Koptiuch, Cathryn MS, CGC2; Kohlmann, Wendy K. MS, CGC2; Neklason, Deborah W. PhD2,3; Westover, Michelle MS4; Curtin, Karen PhD, MStat2,3
doi : 10.14309/ajg.0000000000001572
February 2022 - Volume 117 - Issue 2 - p 336-342
Patients with serrated polyposis syndrome (SPS) and their first-degree relatives (FDRs) have increased colorectal cancer (CRC) risk. Patients with sporadic sessile serrated lesion (SSL) have risk for progression to CRC. Yet familial risks of common extracolonic cancers and even CRC in these cohorts are poorly understood. Our aim was to examine cancer risk for patients with SPS and sporadic SSL and their close and more distant relatives using a large population database.
Karstensen, John Gásdal MD, PhD1,2; Bülow, Steffen MD, DMSci1; Burisch, Johan MD, PhD3; Ellebæk, Mark Bremholm MD, PhD4; Ostapiuk, Marcin MD, PhD5; Pommergaard, Hans Christian MD, PhD6; Schmidt, Palle Nordblad MD, PhD3
doi : 10.14309/ajg.0000000000001582
February 2022 - Volume 117 - Issue 2 - p 343-345
In patients with familial adenomatous polyposis, the Spigelman classification is recommended for staging and risk stratification of duodenal adenomatosis. Although the classification has been used for decades, it has never been formally validated.
Schuitenmaker, Jeroen M. MD; van Dijk, Mitch MD; Oude Nijhuis, Renske A.B. MD; Smout, André J.P.M. MD, PhD; Bredenoord, Albert J. MD, PhD
doi : 10.14309/ajg.0000000000001588
February 2022 - Volume 117 - Issue 2 - p 346-351
The aim of this study was to investigate the effect of spontaneous sleep positions on the occurrence of nocturnal gastroesophageal reflux.
Tan, Chin Kimg MD1,2; Wang, Lai Mun MB, BCh, BAO3,4; Goh, Lynne MBBS3,4; Li, James Weiquan MBBS1,2,5; Lin, Jinlin MBBS6; Ang, Tiing Leong MBBS1,2,5
doi : 10.14309/ajg.0000000000001583
February 2022 - Volume 117 - Issue 2 - p 352-354
Rajarajen, Arun Prabhahar MD1; Sethi, Jasmine MD, DM1; Shaji, Alan MBBS2; Singh, Anupam Kumar MD, DM3; Mitra, Saikat MD4; Vaiphei, Kim MD4
doi : 10.14309/ajg.0000000000001592
February 2022 - Volume 117 - Issue 2 - p 355
Sanagapalli, Santosh MBBS, PhD, FRACP1,2; Sweis, Rami MD, PhD3
doi : 10.14309/ajg.0000000000001600
February 2022 - Volume 117 - Issue 2 - p 356
Carlson, Dustin A. MD, MS1; Pandolfino, John E. MD, MS1
doi : 10.14309/ajg.0000000000001599
February 2022 - Volume 117 - Issue 2 - p 356-357
Kelly, Colleen R. MD, AGAF, FACG1; Fischer, Monika MD, MSc, AGAF, FACG2; Allegretti, Jessica R. MD, MPH, FACG3; LaPlante, Kerry PharmD, FCCP, FIDSA4; Stewart, David B. MD, FACS, FASCRS5; Limketkai, Berkeley N. MD, PhD, FACG6; Stollman, Neil H. MD, FACG7
doi : 10.14309/ajg.0000000000001529
February 2022 - Volume 117 - Issue 2 - p 358
Dunbar, Ellyn K. MS1,2; Greer, Phil J. MS1,3; Amann, Stephen T. MD4; Alkaade, Samer MD5,6; Banks, Peter MD7; Brand, Randall MD1; Conwell, Darwin L. MD, MSc7,8; Forsmark, Christopher E. MD9; Gardner, Timothy B. MD10; Guda, Nalini M. MD11,12; Lewis, Michele D. MD13; Machicado, Jorge D. MD1,14; Muniraj, Thiruvengadam MD, PhD1,15; Papachristou, Georgios I. MD, PhD1,8; Romagnuolo, Joseph MD16,17; Sandhu, Bimaljit S. MD18,19; Sherman, Stuart MD20; Slivka, Adam MD, PhD1; Wilcox, C. Mel MD21; Yadav, Dhiraj MD, MPH1; Whitcomb, David C. MD, PhD1,2,22; for the NAPS2 Consortium
doi : 10.14309/ajg.0000000000001549
February 2022 - Volume 117 - Issue 2 - p 359
doi : 10.14309/ajg.0000000000001620
February 2022 - Volume 117 - Issue 2 - p 360
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