One-year access to more than 500 world journals available in the system
-
http://medilib.ir
- Duration of Time : 365 Day
Price : 300$- Special Price : 100$
Rectal Indomethacin Does Not Mitigate the Systemic Inflammatory Response Syndrome in Acute Pancreatitis: A Randomized Trial
Machicado, Jorge D. MD, MPH1,*; Mounzer, Rawad MD2,*; Paragomi, Pedram MD3; Pothoulakis, Ioannis MD3; Hart, Phil A. MD4; Conwell, Darwin L. MD, MSc4; de-Madaria, Enrique MD, PhD5; Greer, Phil MS3; Yadav, Dhiraj MD, MPH3; Whitcomb, David C. MD, PhD3; Lee, Peter J. MD4; Hinton, Alice PhD6; Papachristou, Georgios I. MD, PhD4
doi : 10.14309/ctg.0000000000000415
November 2021 - Volume 12 - Issue 11 - p e00415
Experimental data suggest that nonsteroidal antiinflammatory drugs may prevent disease severity and mortality in acute pancreatitis (AP). The aim of this study was to compare the efficacy of rectal indomethacin vs placebo in reducing the systemic inflammatory response syndrome (SIRS) score in a high-risk AP population for clinical progression.
Pancreatic Cancer–Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis
Cowan, Robert W. PhD1,2; Pratt, Erica D. PhD1,2; Kang, Jin Muk PhD1,2; Zhao, Jun PhD1,3; Wilhelm, Joshua J. MS4,5; Abdulla, Muhamad BS5; Qiao, Edmund M. BS6; Brennan, Luke P. MS7; Ulintz, Peter J. PhD6,8; Bellin, Melena D. MD4,5; Rhim, Andrew D. MD1,2
doi : 10.14309/ctg.0000000000000431
November 2021 - Volume 12 - Issue 11 - p e00431
Chronic pancreatitis is associated with an increased risk of developing pancreatic cancer, and patients with inherited forms of pancreatitis are at greatest risk. We investigated whether clinical severity of pancreatitis could also be an indicator of cancer risk independent of etiology by performing targeted DNA sequencing to assess the mutational burden in 55 cancer-associated genes.
Changing Trends of Cirrhotic and Noncirrhotic Hepatocellular Carcinoma in the Era of Directly-Acting Antiviral Agents
Mathur, Karan MD1; Mazhar, Areej MD2; Patel, Milin MD2; Dakhoul, Lara MD3; Burney, Heather MS4; Liu, Hao PhD4; Nephew, Lauren MD1; Chalasani, Naga MD1; deLemos, Andrew MD2; Gawrieh, Samer MD1
doi : 10.14309/ctg.0000000000000420
November 2021 - Volume 12 - Issue 11 - p e00420
The impact of direct-acting antivirals (DAAs) for hepatitis C virus (HCV) on burden of cirrhotic and noncirrhotic hepatocellular carcinoma (HCC) has not been examined. We assessed recent trends in liver disease etiologies of HCC and proportion of noncirrhotic HCC since DAAs introduction.
Double-Negative ?-Fetoprotein and Carbohydrate Antigen 19-9 Predict a Good Prognosis in Intrahepatic Cholangiocarcinoma: A Propensity Score Matching Analysis
Zhang, Xiaoyun MD1,2,3; Zhou, Yongjie MD2,3; Wu, Zhenru MM3; Peng, Wei MD1,2; Li, Chuan MD1,2; Yan, Lvnan MD, PhD1,2; Yang, Jiayin MD, PhD1,2; Wen, Tianfu MD, PhD1,2
doi : 10.14309/ctg.0000000000000425
November 2021 - Volume 12 - Issue 11 - p e00425
Carbohydrate antigen 19-9 (CA19-9) and ?-fetoprotein (AFP) are routinely tested in patients with liver malignancies before surgery. However, few reports have explored the relevance of the expression pattern of these 2 tumor markers regarding the prognosis of intrahepatic cholangiocarcinoma (ICC). We herein combined these 2 tumor markers to investigate the influence on ICC malignancy and patient prognosis.
Assessment of Duodenal Intraepithelial Lymphocyte Composition (Lymphogram) for Accurate and Prompt Diagnosis of Celiac Disease in Pediatric Patients
Camarero, Cristina MD, PhD1,*; De Andrés, Ana MD2,*; García-Hoz, Carlota PhD2; Roldán, Belén MD, PhD1; Muriel, Alfonso MD, PhD3; León, Francisco MD, PhD4; Roy, Garbiñe MD, PhD2
doi : 10.14309/ctg.0000000000000426
November 2021 - Volume 12 - Issue 11 - p e00426
Quantitative and phenotypic analyses of duodenal intraepithelial lymphocytes (IELs) by flow cytometry (IEL lymphogram) confer specificity and enable the diagnosis even in unconventional presentations of celiac disease (CD). To evaluate the validity of the IEL lymphograms in the pediatric population for new insights into their use as biomarkers in the natural history of CD.
The Impact of KRAS Mutation in Patients With Sporadic Nonampullary Duodenal Epithelial Tumors
Kinugasa, Hideaki MD, PhD1; Kanzaki, Hiromitsu MD, PhD1; Tanaka, Takehiro MD, PhD2; Yamamoto, Shumpei MD1; Yamasaki, Yasushi MD, PhD1; Nouso, Kazuhiro MD, PhD1; Ichimura, Kouichi MD, PhD3; Nakagawa, Masahiro MD, PhD4; Mitsuhashi, Toshiharu MD, PhD5; Okada, Hiroyuki MD, PhD1
doi : 10.14309/ctg.0000000000000424
November 2021 - Volume 12 - Issue 11 - p e00424
The genomic characterization of primary nonampullary duodenal adenocarcinoma indicates a genetic resemblance to gastric and colorectal cancers. However, a correlation between the clinical and molecular characteristics of these cancers has not been established. This study aimed to elucidate the clinicopathological features of sporadic nonampullary duodenal epithelial tumors, including their molecular characteristics and prognostic factors.
Polygenic Risk Scores for Prediction of Gastric Cancer Based on Bioinformatics Screening and Validation of Functional lncRNA SNPs
Duan, Fujiao PhD1,2; Song, Chunhua PhD2,3; Wang, Peng PhD2,3; Ye, Hua PhD2,3; Dai, Liping PhD2,3; Zhang, Jianying PhD2,3; Wang, Kaijuan PhD2,3
doi : 10.14309/ctg.0000000000000430
November 2021 - Volume 12 - Issue 11 - p e00430
Single-nucleotide polymorphisms (SNPs) are used to stratify the risk of gastric cancer. However, no study included gastric cancer–related long noncoding RNA (lncRNA) SNPs into the risk model for evaluation. This study aimed to replicate the associations of 21 lncRNA SNPs and to construct an individual risk prediction model for gastric cancer.
Association Between Peripheral Blood Monocyte Count and Mucosal Healing in Japanese Patients With Ulcerative Colitis
Furukawa, Shinya MD, PhD1; Ikeda, Yoshio MD, PhD2; Yagi, Sen MD, PhD3; Miyake, Teruki MD, PhD4; Shiraishi, Kana MD4; Tange, Kazuhiro MD5; Hashimoto, Yu MD4; Mori, Kenichirou MD, PhD6; Ninomiya, Tomoyuki MD, PhD6; Suzuki, Seiyuu MD, PhD7; Shibata, Naozumi MD, PhD8; Murakami, Hidehiro MD, PhD3; Ohashi, Katsuhisa MD, PhD9; Hasebe, Aki MD, PhD10; Tomida, Hideomi MD, PhD2; Yamamoto, Yasunori MD, PhD2; Takeshita, Eiji MD, PhD5; Hiasa, Yoichi MD, PhD4
doi : 10.14309/ctg.0000000000000429
November 2021 - Volume 12 - Issue 11 - p e00429
Monocytes play an important role in innate immunity. Some epidemiological evidence indicates an association between peripheral blood monocytes and ulcerative colitis (UC). The association between peripheral blood monocytes and mucosal healing (MH), however, remains unclear. We evaluated this issue in patients with UC.
Automatic Identification of Papillary Projections in Indeterminate Biliary Strictures Using Digital Single-Operator Cholangioscopy
Ribeiro, Tiago MD, MSc1,2,*; Saraiva, Miguel Mascarenhas MD, MSc1,2,3,*; Afonso, João MD, MSc1,2; Ferreira, João P. S. PhD4,5; Boas, Filipe Vilas MD, MSc1,2,3; Parente, Marco P. L. PhD4,5; Jorge, Renato N. PhD4,5; Pereira, Pedro MD, MSc1,2,3; Macedo, Guilherme MD, PhD1,2,3
doi : 10.14309/ctg.0000000000000418
November 2021 - Volume 12 - Issue 11 - p e00418
Characterization of biliary strictures is challenging. Papillary projections (PP) are often reported in biliary strictures with high malignancy potential during digital single-operator cholangioscopy. In recent years, the development of artificial intelligence (AI) algorithms for application to endoscopic practice has been intensely studied. We aimed to develop an AI algorithm for automatic detection of PP in digital single-operator cholangioscopy images.
A Potential Treatment of Congenital Sodium Diarrhea in Patients With Activating GUCY2C Mutations
van Vugt, Anke H.M. BSc1,2,*; Bijvelds, Marcel J.C. PhD3,*; de Jonge, Hugo R. PhD3; Meijsen, Kelly F. BASc3; Restin, Tanja MD, PhD4,5; Bryant, Manuel B. MD4; Ballauff, Antje MD6; Koot, Bart MD, PhD7; Müller, Thomas MD8; Houwen, Roderick H.J. MD, PhD1,*; Janecke, Andreas R. MD8,9,*; Middendorp, Sabine PhD1,2,10,*
doi : 10.14309/ctg.0000000000000427
November 2021 - Volume 12 - Issue 11 - p e00427
Gain-of-function mutations in guanylyl cyclase C (GCC) result in persistent diarrhea with perinatal onset. We investigated a specific GCC inhibitor, SSP2518, for its potential to treat this disorder.
Misclassification of Obesity in Claims Data
Suissa, Karine PhD1; Kim, Seoyoung C. MD, ScD, MSCE1,2; Patorno, Elisabetta MD, DrPH1
doi : 10.14309/ctg.0000000000000423
November 2021 - Volume 12 - Issue 11 - p e00423
