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Role of Extended Mesenteric Excision in Postoperative Recurrence of Crohn's Colitis: A Single-Center Study
Zhu, Yipeng PhD1; Qian, Wenwei PhD1; Huang, Liangyu PhD2; Xu, Yihan PhD3; Guo, Zhen MD, PhD2; Cao, Lei MD2; Gong, Jianfeng MD, PhD2; Coffey, J. Calvin MD, PhD4; Shen, Bo MD5; Li, Yi MD, PhD1,2; Zhu, Weiming MD, PhD1,2
doi : 10.14309/ctg.0000000000000407
October 2021 - Volume 12 - Issue 10 - p e00407
The mesentery is involved in Crohn's disease. The impact of the extent of mesenteric resection on postoperative disease progression in Crohn's disease remains unconfirmed. This study aimed to determine the association between resection of the mesentery and postoperative outcomes in patients with Crohn's colitis (CC) undergoing colorectal surgery.
Post-Induction High Adalimumab Drug Levels Predict Biological Remission at Week 24 in Patients With Crohn's Disease
Zittan, Eran MD1,2,3,4; Steinhart, A. Hillary MD, MSc3,4; Goldstein, Pavel PhD5; Milgrom, Raquel MD3,4; Gralnek, Ian M. MD, MSHS1,2; Silverberg, Mark S. MD, PhD3,4
doi : 10.14309/ctg.0000000000000401
October 2021 - Volume 12 - Issue 10 - p e00401
We investigated whether early adalimumab drug levels (ADL) at week 4 predicted biological remission at week 24.
Specific Plasma MicroRNA Signatures in Predicting and Confirming Crohn's Disease Recurrence: Role and Pathogenic Implications
Moret-Tatay, Inés PhD1,2; Cerrillo, Elena MD, PhD1,3; Hervás, David PhD4; Iborra, Marisa MD, PhD1,2,3; Sáez-González, Esteban MD1,3; Forment, Javier PhD5; Tortosa, Luis NP1,2; Nos, Pilar MD, PhD1,2,3; Gadea, Jose PhD5; Beltrán, Belén MD, PhD1,2,3
doi : 10.14309/ctg.0000000000000416
October 2021 - Volume 12 - Issue 10 - p e00416
MicroRNAs (miRNAs) are important epigenetic regulators in Crohn's disease (CD); however, their contribution to postoperative recurrence (POR) is still unknown. We aimed to characterize the potential role of miRNAs in predicting POR in patients with CD and to identify their pathogenic implications.
Impaired Proximal Esophageal Contractility Predicts Pharyngeal Reflux in Patients With Laryngopharyngeal Reflux Symptoms
Sikavi, Daniel R. MD1; Cai, Jennifer X. MD, MPH1,2; Leung, Ryan2; Carroll, Thomas L. MD, MPH1,3; Chan, Walter W. MD, MPH1,2
doi : 10.14309/ctg.0000000000000408
October 2021 - Volume 12 - Issue 10 - p e00408
The pathophysiology of laryngopharyngeal reflux (LPR) remains incompletely understood. Proximal esophageal motor dysfunction may impair bolus clearance, increasing the risk of pharyngeal refluxate exposure. We aimed to evaluate the association of proximal esophageal contractility with objective reflux metrics.
Eosinophilic Gastroenteritis: Using Presenting Findings to Predict Disease Course
Havlichek, Daniel III MD1; Choung, Rok Seon MD, PhD2; Murray, Joseph A. MD2
doi : 10.14309/ctg.0000000000000394
October 2021 - Volume 12 - Issue 10 - p e00394
Studies on eosinophilic gastroenteritis have identified broad spectrums of disease. We aimed to characterize subtypes of disease and ascertain outcomes of each group.
Primary Sclerosing Cholangitis–Associated Cholangiocarcinoma Demonstrates High Intertumor and Intratumor Heterogeneity
Kamp, Eline J.C.A. MD1; Peppelenbosch, Maikel P. Prof. PhD1; Doukas, Michail MD, PhD2; Verheij, Joanne MD, PhD3; Ponsioen, Cyriel Y. Prof. MD, PhD4; van Marion, Ronald BSc2; Bruno, Marco J. Prof. MD, PhD1; Groot Koerkamp, Bas MD, PhD5; Dinjens, Winand N.M. Prof. PhD2; de Vries, Annemarie C. MD, PhD1
doi : 10.14309/ctg.0000000000000410
October 2021 - Volume 12 - Issue 10 - p e00410
Intertumor and intratumor heterogeneity may explain the diagnostic challenge and limited efficacy of chemotherapy for primary sclerosing cholangitis–associated cholangiocarcinoma (PSC-CCA). In this study, tumor heterogeneity was assessed through p53 and p16 protein expression analysis and next-generation sequencing (NGS) of TP53 and CDKN2A genetic alterations in PSC-associated CCA.
Global Burden and Trends in Incidence, Mortality, and Disability of Stomach Cancer From 1990 to 2017
Qin, Yuheng BS1,2,3,*; Tong, Xin MS1,2,*; Fan, Jiahui MS4; Liu, Zhenqiu PhD4,5; Zhao, Renjia BS1,2; Zhang, Tiejun Prof.1,2; Suo, Chen AP1,2,4; Chen, Xingdong Prof.4,5,6; Zhao, Genming Prof.1,2
doi : 10.14309/ctg.0000000000000406
October 2021 - Volume 12 - Issue 10 - p e00406
Stomach cancer is a serious global public health problem. The current burden of stomach cancer and its trends across time and location need to be understood to develop effective preventive strategies.
Genetic Signatures of Glucose Homeostasis: Synergistic Interplay With Long-Term Exposure to Cigarette Smoking in Development of Primary Colorectal Cancer Among African American Women
Jung, Su Yon PhD1,2
doi : 10.14309/ctg.0000000000000412
October 2021 - Volume 12 - Issue 10 - p e00412
Insulin resistance (IR)/glucose intolerance is a critical biologic mechanism for the development of colorectal cancer (CRC) in postmenopausal women. Whereas IR and excessive adiposity are more prevalent in African American (AA) women than in White women, AA women are underrepresented in genome-wide studies for systemic regulation of IR and the association with CRC risk.
Determination of Urinary Gluten Immunogenic Peptides to Assess Adherence to the Gluten-Free Diet: A Randomized, Double-Blind, Controlled Study
Monachesi, Chiara PhD1,*; Verma, Anil K. PhD1,*; Catassi, Giulia N. MD2; Franceschini, Elisa MD2; Gatti, Simona MD, PhD2; Gesuita, Rosaria PhD3; Lionetti, Elena MD, PhD2; Catassi, Carlo MD, MPH2,4
doi : 10.14309/ctg.0000000000000411
October 2021 - Volume 12 - Issue 10 - p e00411
The adherence to a gluten-free diet (GFD) is a trending topic in the management of celiac disease. The aim of our study was to evaluate the diagnostic performance of urinary gluten immunogenic peptides (GIP) determination to detect gluten contamination of the GFD.
Clinical Impact of Pathogenic Germline Variants in Pancreatic Cancer: Results From a Multicenter, Prospective, Universal Genetic Testing Study
Uson, Pedro L. S. Jr MD1,*; Samadder, N. Jewel MD, MSc, FRCPC2,3,4,*; Riegert-Johnson, Douglas MD5,3,4; Boardman, Lisa MD6; Borad, Mitesh J. MD1; Ahn, Daniel MD1; Sonbol, Mohamad B. MD1; Faigel, Douglas O. MD2; Fukami, Norio MD2; Pannala, Rahul MD2; Kunze, Katie PhD7; Golafshar, Michael MS7; Klint, Margaret MS3; Esplin, Edward D. MD, PhD8; Nussbaum, Robert L. MD8; Stewart, A. Keith MD1,3,4; Bekaii-Saab, Tanios MD1
doi : 10.14309/ctg.0000000000000414
October 2021 - Volume 12 - Issue 10 - p e00414
To report the prevalence and outcomes of unselected pancreatic cancer (PC) patients with pathogenic/likely pathogenic germline variants (PGVs) detected using a universal testing approach.
Sleep Duration, Sleep Quality, and the Development of Nonalcoholic Fatty Liver Disease: A Cohort Study
Um, Yoo Jin MD1; Chang, Yoosoo MD, PhD2,3,4; Jung, Hyun-Suk MD1,2; Cho, In Young MD5; Shin, Jun Ho MD, PhD1,6; Shin, Hocheol MD, PhD2,5; Wild, Sarah H. MB BChir, PhD7; Byrne, Christopher D. MB BCh, PhD8,9; Ryu, Seungho MD, PhD2,3,4
doi : 10.14309/ctg.0000000000000417
October 2021 - Volume 12 - Issue 10 - p e00417
The longitudinal relationship between sleep duration, sleep quality, and the risk of nonalcoholic fatty liver disease (NAFLD) is unknown. We aimed to examine the association between sleep duration, sleep quality, and NAFLD development.
Evolution of Nonmalignant Portal Vein Thrombosis in Liver Cirrhosis: A Pictorial Review
Xu, Shixue MS1,2; Guo, Xiaozhong MD1; Yang, Benqiang MD3; Romeiro, Fernando Gomes MD4; Primignani, Massimo MD5; Méndez-Sánchez, Nahum MD6; Yoshida, Eric M. MD7; Mancuso, Andrea MD8; Tacke, Frank MD, PhD9; Noronha Ferreira, Carlos MD10; De Stefano, Valerio MD11; Qi, Xingshun MD1
doi : 10.14309/ctg.0000000000000409
October 2021 - Volume 12 - Issue 10 - p e00409
Portal vein thrombosis (PVT) is a common complication in liver cirrhosis, especially in advanced cirrhosis. It may be related to a higher risk of liver-related events and liver function deterioration. Imaging examinations can not only provide an accurate diagnosis of PVT, such as the extent of thrombus involvement and the degree of lumen occupied, but also identify the nature of thrombus (i.e., benign/malignant and acute/chronic). Evolution of PVT, mainly including development, recanalization, progression, stability, and recurrence, could also be assessed based on the imaging examinations. This article briefly reviews the pathophysiology, diagnosis, classification, and evolution of PVT with an emphasis on their computed tomography imaging features.
Gastric Cancer Risk of Intestinal Metaplasia Subtypes: A Systematic Review and Meta-Analysis of Cohort Studies
Du, Sijing MM1,*; Yang, Yang MD1,*; Fang, Shuangshuang MM1,2,*; Guo, Song MD3,*; Xu, Chuchu MM1,2; Zhang, Ping MD1; Wei, Wei MD1
doi : 10.14309/ctg.0000000000000402
October 2021 - Volume 12 - Issue 10 - p e00402
Intestinal metaplasia (IM) is an independent risk factor for gastric cancer (GC). However, the subtypes of IM as a risk factor for GC remain controversial. We performed a systematic review and meta-analysis to evaluate the relationship between IM subtypes and GC risk.
Metabobariatric Endoscopy: Deflating the Balloons of Myth
Elhence, Anshuman MD, DM1; Kulkarni, Akshay MD, DM1; Ghoshal, Uday C. MD, DM1
doi : 10.14309/ctg.0000000000000413
October 2021 - Volume 12 - Issue 10 - p e00413
Association Between Serum Levels of Neurofilament Light Chains and Minimal Hepatic Encephalopathy in Patients With Liver Cirrhosis
Labenz, Christian MD1,2,3; Nagel, Michael MD1,2; Kämper, Paula1,2; Engel, Sinah MD4; Bittner, Stefan MD, PhD3; Kaps, Leonard MD, PhD1,2; Galle, Peter R. MD1,2; Schattenberg, Jörn M. MD1,2,3; Wörns, Marcus-Alexander MD1,2,5,*; Lüssi, Felix MD4,*
doi : 10.14309/ctg.0000000000000419
October 2021 - Volume 12 - Issue 10 - p e00419
Serum biomarkers for the diagnosis of minimal hepatic encephalopathy (MHE) in patients with liver cirrhosis would be desirable. In this proof-of-concept study, we investigated the association between MHE and serum levels of neurofilament light chains (sNfL) in patients with liver cirrhosis.
