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The Protection Conferred by HSD17B13 rs72613567 Polymorphism on Risk of Steatohepatitis and Fibrosis May Be Limited to Selected Subgroups of Patients With NAFLD
Vilar-Gomez, Eduardo MD, PhD1; Pirola, Carlos J. PhD2; Sookoian, Silvia MD, PhD3; Wilson, Laura A. ScM4; Liang, Tiebing PhD1; Chalasani, Naga MD1
doi : 10.14309/ctg.0000000000000400
September 2021 - Volume 12 - Issue 9 - p e00400
Our study aimed to explore how PNPLA3 rs738409 or phenotypic risk factors may moderate the relationship between HSD17B13 rs72613567 and risk of steatohepatitis and fibrosis.
Strongly Divergent Impact of Adherence Patterns on Efficacy of Colorectal Cancer Screening: The Need to Refine Adherence Statistics
Heisser, Thomas MSc1,2; Cardoso, Rafael MSc2,3; Guo, Feng MD, PhD1,2; Moellers, Tobias PhD1; Hoffmeister, Michael PhD1; Brenner, Hermann MD, MPH1,3,4
doi : 10.14309/ctg.0000000000000399
September 2021 - Volume 12 - Issue 9 - p e00399
The performance of colorectal cancer (CRC) screening programs depends on the adherence to screening offers. However, identical adherence levels may result from varying patterns of the population's screening behavior. We quantified the effects of different adherence patterns on the long-term performance of CRC screening for annual fecal immunochemical testing and screening colonoscopy at 10-year intervals.
Genetic Analysis of Archived Tumor Specimens for Hereditary Colorectal Cancer Syndromes in the Cajuns of Louisiana, a US Founder Population
Karlitz, Jordan J. MD1,2; Phillips, Amanda MD, MPH3; Sorrells, Kelly S. MD4; Rao, Shanti MD5
doi : 10.14309/ctg.0000000000000392
September 2021 - Volume 12 - Issue 9 - p e00392
The Louisiana Acadian region (population 1.2 million), home of the Cajuns, has among the highest US colorectal cancer (CRC) rates. Although Cajuns are a known genetic founder population, studies assessing for hereditary CRC have not been performed.
Trajectories of Lymphocyte Counts in the Early Phase of Acute Pancreatitis Are Associated With Infected Pancreatic Necrosis
Zhou, Jing MSc1; Chen, Wensong MSc2; Liu, Yang MSc3; Qu, Cheng MD3; Jiang, Wendi MSc3; Yin, Jiangtao MD2; Lin, Jiajia PhD3; Mao, Wenjian MD2,4; Ye, Bo PhD3; Zhou, Jing MSc3; Ke, Lu PhD3,5; Tong, Zhihui MD3; Liu, Yuxiu MSc2,4; Li, Weiqin MD1,3,5
doi : 10.14309/ctg.0000000000000405
September 2021 - Volume 12 - Issue 9 - p e00405
Infected pancreatic necrosis (IPN) is an important complication of acute pancreatitis (AP). Absolute lymphocyte count (ALC) was reported to be associated with immunosuppression and the development of IPN. The aim of this study was to describe the trajectory of ALC during the early phase of AP and assess its association with IPN.
Liquid Biopsy in Gastric Cancer: Analysis of Somatic Cancer Tissue Mutations in Plasma Cell-Free DNA for Predicting Disease State and Patient Survival
Varkalaite, Greta MSc1; Forster, Michael PhD2; Franke, Andre PhD2; Kupcinskas, Juozas MD, PhD1,3; Skieceviciene, Jurgita PhD1
doi : 10.14309/ctg.0000000000000403
September 2021 - Volume 12 - Issue 9 - p e00403
Gastric cancer (GC) diagnosis in late stages and high mortality rates are the main issues that require new noninvasive molecular tools. We aimed to assess somatic mutational profiles in GC tissue and plasma cell-free DNA (cfDNA), evaluate their concordance rate, and analyze the role of multilayer molecular profiling to predict disease state and prognosis.
Risk Factors for Bleeding After Endoscopic Submucosal Dissection for Gastric Cancer in Elderly Patients Older Than 80 Years in Japan
Sugimoto, Mitsushige MD, PhD1,2; Hatta, Waku MD, PhD3; Tsuji, Yosuke MD, PhD4; Yoshio, Toshiyuki MD, PhD5; Yabuuchi, Yohei MD, PhD6; Hoteya, Shu MD, PhD7; Doyama, Hisashi MD, PhD8; Nagami, Yasuaki MD, PhD9; Hikichi, Takuto MD, PhD10; Kobayashi, Masakuni MD, PhD11; Morita, Yoshinori MD, PhD12,13; Sumiyoshi, Tetsuya MD14; Iguchi, Mikitaka MD, PhD15; Tomida, Hideomi MD16,17; Inoue, Takuya MD, PhD18; Mikami, Tatsuya MD, PhD19; Hasatani, Kenkei MD, PhD20; Nishikawa, Jun MD, PhD21; Matsumura, Tomoaki MD, PhD22; Nebiki, Hiroko MD, PhD23; Nakamatsu, Dai MD24; Ohnita, Ken MD, PhD25; Suzuki, Haruhisa MD, PhD26; Ueyama, Hiroya MD, PhD27; Hayashi, Yoshito MD, PhD28; Murata, Masaki MD2,29; Yamaguchi, Shinjiro MD, PhD30; Michida, Tomoki MD, PhD31,32; Yada, Tomoyuki MD33; Asahina, Yoshiro MD, PhD34; Narasaka, Toshiaki MD, PhD35; Kuribayashi, Shiko MD, PhD36; Kiyotoki, Shu MD, PhD37; Mabe, Katsuhiro MD, PhD38; Fujishiro, Mitsuhiro MD, PhD39; Masamune, Atsushi MD, PhD3; Kawai, Takashi MD, PhD1
doi : 10.14309/ctg.0000000000000404
September 2021 - Volume 12 - Issue 9 - p e00404
As the aging of people in a society advances, the number of elderly patients older than 80 years in Japan with gastric cancer continues to increase. Although delayed ulcer bleeding is a major adverse event after endoscopic submucosal dissection (ESD), little is known about characteristic risk factors for bleeding in elderly patients undergoing ESD. This study aimed to evaluate risk factors for delayed bleeding after ESD for gastric cancer in elderly patients older than 80 years.
Insights Into the Oral Microbiome and Barrett's Esophagus Early Detection: A Narrative Review
Zhang, Zhenzhen PhD1; Curran, Grace BS2; Altinok Dindar, Duygu MD, PhD2; Wu, Ying PhD3; Wu, Hui PhD3; Sharpton, Thomas PhD4,5; Zhao, Lianmei PhD6; Lieberman, David MD7; Otaki, Fouad MD7
doi : 10.14309/ctg.0000000000000390
September 2021 - Volume 12 - Issue 9 - p e00390
Barrett's esophagus (BE) prevalence has increased steadily over the past several decades and continues to be the only known precursor of esophageal adenocarcinoma. The exact cause of BE is still unknown. Most evidence has linked BE to gastroesophageal reflux disease, which injures squamous esophageal mucosa and can result in the development of columnar epithelium with intestinal metaplasia. However, this relationship is inconsistent—not all patients with severe gastroesophageal reflux disease develop BE. There is increasing evidence that the host microbiome spanning the oral and esophageal environments differs in patients with and without BE. Several studies have documented the oral and esophageal microbiome's composition for BE with inconsistent findings. The scarcity and inconsistency of the literature and the dynamic phenomena of microbiota all warrant further studies to validate the findings and dissect the effects of oral microbiota, which are considered a viable proxy to represent esophageal microbiota by many researchers. This review aims to summarize the variability of the oral and esophageal microbiome in BE by using the example of Streptococcus to discuss the limitations of the current studies and suggest future directions. Further characterization of the sensitivity and specificity of the oral microbiome as a potential risk prediction or prevention marker of BE is critical, which will help develop noninvasive early detection methods for BE, esophageal adenocarcinoma, and other esophageal diseases.
