European Journal of Anaesthesiology

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Bruder, Nicolas; Chew, Michelle S.; Forget, Patrice; Hansen, Tom G.; Longrois, Dan; Lukaszewicz, Anne-Claire; Pogatzki-Zahn, Esther; Van de Velde, Marc; Samama, Charles Marc

doi : 10.1097/EJA.0000000000001396

European Journal of Anaesthesiology. 38(1):1-3, January 2021.

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Peri-operative oxygen consumption revisited: An observational study in elderly patients undergoing major abdominal surgery

Jakobsson, Julia; Norén, Carl; Hagel, Eva; Kalman, Sigridur; Bartha, Erzsébet

doi : 10.1097/EJA.0000000000001302

European Journal of Anaesthesiology. 38(1):4-12, January 2021.

Monitoring oxygen consumption (VO 2 ) is neither recommended nor included in peri-operative haemodynamic algorithms aiming at optimising oxygen delivery (DO 2 ) in major abdominal surgery. Estimates of peri-operative VO 2 changes are uncertain in earlier publications and have limited generalisability in the current high-risk surgical population. In a prospective non-interventional observational study in elderly patients undergoing major abdominal procedures, we investigated the change of VO 2 after induction of anaesthesia and secondarily, the further changes during and after surgery in relation to DO 2 and estimated oxygen extraction ratio (O 2 ER) by routine monitoring.

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Urinary neprilysin for early detection of acute kidney injury after cardiac surgery: A prospective observational study

Bernardi, Martin H.; Wagner, Ludwig; Ryz, Sylvia; Puchinger, Juergen; Nixdorf, Larissa; Edlinger-Stanger, Maximilian; Geilen, Johannes; Kainz, Matthias; Hiesmayr, Michael J.; Lassnigg, Andrea

doi : 10.1097/EJA.0000000000001321

European Journal of Anaesthesiology. 38(1):13-21, January 2021.

Acute kidney injury (AKI) predicts adverse outcomes after cardiac surgery. The accuracy of using changes in serum creatinine for diagnosis and grading of AKI is limited in the peri-operative cardiac surgical setting and AKI may be underdiagnosed due to haemodilution from cardiopulmonary bypass priming and the need for intra-operative and postoperative volume resuscitation.

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Multivariable haemodynamic approach to predict the fluid challenge response: A multicentre cohort study

Messina, Antonio; Romano, Salvatore M.; Ozdemirkan, Aycan; Persona, Paolo; Tarquini, Riccardo; Cammarota, Gianmaria; Romagnoli, Stefano; Della Corte, Francesco; Bennett, Victoria; Monge Garc?a, Manuel I.; Cecconi, Maurizio; Payen, Didier

doi : 10.1097/EJA.0000000000001289

European Journal of Anaesthesiology. 38(1):22-31, January 2021.

Beat-to-beat stroke volume (SV) results from the interplay between left ventricular function and arterial load. Fluid challenge induces time-dependent responses in cardiac performance and peripheral vascular and capillary characteristics.

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Comparative effects of neurally adjusted ventilatory assist and variable pressure support on lung and diaphragmatic function in a model of acute respiratory distress syndrome: A randomised animal study

Scharffenberg, Martin; Moraes, Lillian; Güldner, Andreas; Huhle, Robert; Braune, Anja; Zeidler-Rentzsch, Ines; Kasper, Michael; Kunert-Keil, Christiane; Koch, Thea; Pelosi, Paolo; Rocco, Patricia R.M.; Gama de Abreu, Marcelo; Kiss, Thomas

doi : 10.1097/EJA.0000000000001261

European Journal of Anaesthesiology. 38(1):32-40, January 2021.

Variable assisted mechanical ventilation has been shown to improve lung function and reduce lung injury. However, differences between extrinsic and intrinsic variability are unknown.

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Prevention of atelectasis by continuous positive airway pressure in anaesthetised children: A randomised controlled study

Acosta, Cecilia M.; Lopez Vargas, Mar?a Paz; Oropel, Facundo; Valente, Lisandro; Ricci, Lila; Natal, Marcela; Suarez Sipmann, Fernando; Tusman, Gerardo Less

doi : 10.1097/EJA.0000000000001351

European Journal of Anaesthesiology. 38(1):41-48, January 2021.

Continuous positive airway pressure (CPAP) prevents peri-operative atelectasis in adults, but its effect in children has not been quantified.

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Effects on cerebral blood flow of position changes, hyperoxia, CO2 partial pressure variations and the Valsalva manoeuvre: A study in healthy volunteers

Tercero, Javier; Gracia, Isabel; Hurtado, Paola; de Riva, Nicol?s; Carrero, Enrique; Garcia-Orellana, Marta; Belda, Isabel; Rios, José; Maldonado, Felipe; Fàbregas, Neus; Valero, Ricard

doi : 10.1097/EJA.0000000000001356

European Journal of Anaesthesiology. 38(1):49-57, January 2021.

Maintaining adequate blood pressure to ensure proper cerebral blood flow (CBF) during surgery is challenging. Induced mild hypotension, sitting position or unavoidable intra-operative circumstances such as haemorrhage, added to variations in carbon dioxide and oxygen tensions, may influence perfusion. Several of these circumstances may coincide and it is unclear how these may affect CBF.

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The effect of oral ?-9-tetrahydrocannabinol on the minimal alveolar concentration of sevoflurane: A randomised, controlled, observer-blinded experimental study

Müller, Johannes; Pl?chl, Walter; Reiter, Birgit; Stimpfl, Thomas; Graf, Alexandra; Baron-Stefaniak, Joanna; Infanger, Lukas; Hamp, Thomas

doi : 10.1097/EJA.0000000000001295

European Journal of Anaesthesiology. 38(1):58-63, January 2021.

Cannabis has increasingly been used for medical and recreational purposes. The main pharmacological compound in cannabis is tetrahydrocannabinol (THC), which has sedative, anxiolytic and analgesic effects. In some animal models, THC has also been shown to reduce the minimum alveolar concentration (MAC) of halothane and cyclopropane, but its effect on sevoflurane, currently the most commonly used inhalational anaesthetic agent, has not been investigated.

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Ultrasound-guided supraclavicular vs. retroclavicular block of the brachial plexus: comparison of ipsilateral diaphragmatic function: A randomised clinical trial

Georgiadis, Paige L.; Vlassakov, Kamen V.; Patton, Megan E.; Lirk, Philipp B.; Janfaza, David R.; Zeballos, Jose L.; Quaye, Aurora N.; Patel, Vijay; Schreiber, Kristin L.

doi : 10.1097/EJA.0000000000001305

European Journal of Anaesthesiology. 38(1):64-72, January 2021.

The ultrasound-guided retroclavicular block (RCB) is a recently described alternative approach to brachial plexus blockade at the level of the cords. Although more distal blockade of the brachial plexus is thought to be associated with a lower incidence of phrenic nerve block, the impact of RCB on ipsilateral diaphragmatic function has not been formally investigated.

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Comparison of adequacy of anaesthesia monitoring with standard clinical practice monitoring during routine general anaesthesia: An international, multicentre, single-blinded randomised controlled trial

Gruenewald, Matthias; Harju, Jarkko; Preckel, Benedikt; Moln?r, Zsolt; Yli-Hankala, Arvi; Rosskopf, Florian; Koers, Lena; Orban, Agnes; Bein, Berthold; AoA Study Group

doi : 10.1097/EJA.0000000000001357

European Journal of Anaesthesiology. 38(1):73-81, January 2021.

Previous studies have suggested that monitoring the levels of both hypnosis and antinociception could reduce periods of inadequate anaesthesia. However, the evidence regarding associated benefits of this monitoring is still limited.

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