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Environmental Pollution, Climate Change, and a Critical Role for the Endocrinologist
Paul M Stewart, Raghavendra G Mirmira, Ursula B Kaiser, Editor-in-Chief and Deputy Editors, The Journal of Clinical Endocrinology & Metabolism
doi : 10.1210/clinem/dgab721
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3381–3384
Steroid Sulfation in Adrenal Tumors
Jonathan Wolf Mueller, Nora Vogg, Thomas Alec Lightning, Isabel Weigand, Cristina L Ronchi, Paul A Foster, Matthias Kroiss
doi : 10.1210/clinem/dgab182
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3385–3397
The adrenal cortex produces specific steroid hormones including steroid sulfates such as dehydroepiandrosterone sulfate (DHEAS), the most abundant steroid hormone in the human circulation. Steroid sulfation involves a multistep enzyme machinery that may be impaired by inborn errors of steroid metabolism. Emerging data suggest a role of steroid sulfates in the pathophysiology of adrenal tumors and as potential biomarkers.
Coronary Vasculature and Myocardial Structure in HIV: Physiologic Insights From the Renin–Angiotensin–Aldosterone System
Suman Srinivasa, Teressa S Thomas, Meghan N Feldpausch, Gail K Adler, Steven K Grinspoon
doi : 10.1210/clinem/dgab112
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3398–3412
The landscape of HIV medicine dramatically changed with the advent of contemporary antiretroviral therapies, which has allowed persons with HIV (PWH) to achieve good virologic control, essentially eliminating HIV-related complications and increasing life expectancy. As PWH are living longer, noncommunicable diseases, such as cardiovascular disease (CVD), have become a leading cause of morbidity and mortality in PWH with rates that are 50% to 100% higher than in well-matched persons without HIV. In this review, we focus on disease of the coronary microvasculature and myocardium in HIV. We highlight a key hormonal system important to cardiovascular endocrinology, the renin-angiotensin-aldosterone system (RAAS), as a potential mediator of inflammatory driven-vascular and myocardial injury and consider RAAS blockade as a physiologically targeted strategy to reduce CVD in HIV.
BDV Syndrome: An Emerging Syndrome With Profound Obesity and Neurodevelopmental Delay Resembling Prader–Willi Syndrome
Elisabeth Bosch, Moritz Hebebrand, Bernt Popp, Theresa Penger, Bettina Behring, Helen Cox, Shelley Towner, Cornelia Kraus, William G Wilson, Shagufta Khan, Mandy Krumbiegel, Arif B Ekici, Steffen Uebe, Regina Trollmann, Joachim Woelfle, André Reis, Georgia Vasileiou
doi : 10.1210/clinem/dgab592
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3413–3427
CPE encodes carboxypeptidase E, an enzyme that converts proneuropeptides and propeptide hormones to bioactive forms. It is widely expressed in the endocrine and central nervous system. To date, 4 individuals from 2 families with core clinical features including morbid obesity, neurodevelopmental delay, and hypogonadotropic hypogonadism, harboring biallelic loss-of-function (LoF) CPE variants, have been reported.
Associations of Homocysteine Metabolism With the Risk of Spinal Osteoarthritis Progression in Postmenopausal Women
Masaki Nakano, Yukio Nakamura, Tomohiko Urano, Akiko Miyazaki, Takako Suzuki, Kazuki Watanabe, Jun Takahashi, Masataka Shiraki
doi : 10.1210/clinem/dgab591
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3428–3438
Although homocysteine accumulation is a reported risk factor for several age-related disorders, little is known about its relationship with osteoarthritis (OA).
Effect of Metabolite Levels on Type 2 Diabetes Mellitus and Glycemic Traits: A Mendelian Randomization Study
Yue Sun, Ya-Ke Lu, Hao-Yu Gao, Yu-Xiang Yan
doi : 10.1210/clinem/dgab581
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3439–3447
To assess the causal associations of plasma levels of metabolites with type 2 diabetes mellitus (T2DM) and glycemic traits.
The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study
Raimo Jauhiainen, Jagadish Vangipurapu, Annamaria Laakso, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso
doi : 10.1210/clinem/dgab562
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3448–3454
To investigate the significance of 9 amino acids as risk factors for incident cardiovascular disease events in 9584 Finnish men.
High-affinity ZnT8 Autoantibodies by Electrochemiluminescence Assay Improve Risk Prediction for Type 1 Diabetes
Xiaofan Jia, Ling He, Dongmei Miao, Kathleen Waugh, Cristy Geno Rasmussen, Fran Dong, Andrea K Steck, Marian Rewers, Liping Yu
doi : 10.1210/clinem/dgab575
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3455–3463
Single ZnT8 autoantibody (ZnT8A) positivity by standard radiobinding assay (RBA) is commonly seen in nondiabetes population-based screening and the risk of progression to type 1 diabetes (T1D) in subjects with single ZnT8A is unknown.
Pilot Trial of Vitamin D3 and Calcifediol in Healthy Vitamin D Deficient Adults: Does It Change the Fecal Microbiome?
Albert Shieh, S Melanie Lee, Venu Lagishetty, Carter Gottleib, Jonathan P Jacobs, John S Adams
doi : 10.1210/clinem/dgab573
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3464–3476
Experimental studies suggest that vitamin D receptor signaling may benefit the gut microbiome. In humans, whether vitamin D supplementation directly alters the gut microbiome is not well studied.
Clinical Characteristics and Incidences of Benign and Malignant Insulinoma Using a National Inpatient Database in Japan
Kayo Ikeda Kurakawa, Akira Okada, Katsunori Manaka, Takaaki Konishi, Taisuke Jo, Sachiko Ono, Kazuaki Uda, Nobuaki Michihata, Hiroki Matsui, Kiyohide Fushimi, Satoko Yamaguchi, Toshimasa Yamauchi, Masaomi Nangaku, Hideo Yasunaga, Takashi Kadowaki
doi : 10.1210/clinem/dgab559
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3477–3486
Insulinoma is the most common pancreatic functional neuroendocrine neoplasm, yet little information on recent clinical practice in patients with insulinoma, especially malignant insulinoma, is available.
Incidence of Benign and Malignant Tumors in Patients With Acromegaly Is Increased: A Nationwide Population-based Study
Daniela Esposito, Oskar Ragnarsson, Gudmundur Johannsson, Daniel S Olsson
doi : 10.1210/clinem/dgab560
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3487–3496
Whether cancer risk in acromegaly is increased remains controversial, and the risk of benign tumors has been little studied.
Insulin Secretion Predicts the Response to Antidiabetic Therapy in Patients With New-onset Diabetes
S Abdelgani, C Puckett, J Adams, C Triplitt, R A DeFronzo, M Abdul-Ghani
doi : 10.1210/clinem/dgab403
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3497–3504
The results of the present study demonstrate that beta cell function in newly diagnosed T2DM patients is the key predictor of response to glucose lowering medications and provides a practical tool (C-Pep120 /C-Pep0) to guide the choice of glucose lowering agent.
Epicardial and Pericardial Adiposity Without Myocardial Steatosis in Cushing Syndrome
Peter Wolf, Benjamin Marty, Khaoula Bouazizi, Nadjia Kachenoura, Céline Piedvache, Anne Blanchard, Sylvie Salenave, Mikaël Prigent, Christel Jublanc, Christiane Ajzenberg, Céline Droumaguet, Jacques Young, Anne-Lise Lecoq, Emmanuelle Kuhn, Helene Agostini, Severine Trabado, Pierre G Carlier, Bruno Fève, Alban Redheuil, Philippe Chanson, Peter Kamenický
doi : 10.1210/clinem/dgab556
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3505–3514
Cardiovascular disease is the leading cause of death in patients with Cushing syndrome. Cortisol excess and adverse metabolic profile could increase cardiac fat, which can subsequently impair cardiac structure and function.
Initiating Pancreatic Neuroendocrine Tumor (pNET) Screening in Young MEN1 Patients: Results From the DutchMEN Study Group
Mirthe J Klein Haneveld, Mark J C van Treijen, Carolina R C Pieterman, Olaf M Dekkers, Annenienke van de Ven, Wouter W de Herder, Wouter T Zandee, Madeleine L Drent, Peter H Bisschop, Bas Havekes, Menno R Vriens, Annemarie A Verrijn Stuart, Gerlof D Valk, Rachel S van Leeuwaarde
doi : 10.1210/clinem/dgab569
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3515–3525
Nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs) are highly prevalent and constitute an important cause of mortality in patients with multiple endocrine neoplasia type 1 (MEN1). Still, the optimal age to initiate screening for pNETs is under debate.
Placental miR-3940-3p Is Associated With Maternal Insulin Resistance in Late Pregnancy
Fernanda Alvarado-Flores, Tomoko Kaneko-Tarui, William Beyer, Jacqueline Katz, Tianjiao Chu, Patrick Catalano, Yoel Sadovsky, Marie-France Hivert, Perrie O’Tierney-Ginn
doi : 10.1210/clinem/dgab571
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3526–3535
An increase in maternal insulin resistance (IR) during pregnancy is essential for normal fetal growth. The mechanisms underlying this adaptation are poorly understood. Placental factors are believed to instigate and maintain these changes, as IR decreases shortly after delivery. Methylation of placental gene loci that are common targets for miRNAs are associated with maternal IR.
PSMA Expression in Differentiated Thyroid Cancer: Association With Radioiodine, 18FDG Uptake, and Patient Outcome
Renaud Ciappuccini, Virginie Saguet-Rysanek, Florence Giffard, Idlir Licaj, Marine Dorbeau, Bénédicte Clarisse, Laurent Poulain, Stéphane Bardet
doi : 10.1210/clinem/dgab563
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3536–3545
Little is known about prostate-specific membrane antigen (PSMA) expression in patients with cervical involvement of differentiated thyroid cancer (DTC).
Remnant Cholesterol and Cardiovascular Mortality in Patients With Type 2 Diabetes and Incident Diabetic Nephropathy
Dahai Yu, Zheng Wang, Xiaoxue Zhang, Bingjie Qu, Yamei Cai, Shuang Ma, Zhanzheng Zhao, David Simmons
doi : 10.1210/clinem/dgab533
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3546–3554
The association between remnant cholesterol (remnant-C) and cardiovascular mortality in patients with type 2 diabetes (T2D) and incident diabetic nephropathy remains unclear.
International Multicenter Validation Study of the SAGIT® Instrument in Acromegaly
Andrea Giustina, Marcello D Bronstein, Philippe Chanson, Stephan Petersenn, Felipe F Casanueva, Caroline Sert, Aude Houchard, Shlomo Melmed
doi : 10.1210/clinem/dgab536
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3555–3568
The SAGIT® instrument (SAGIT) has been developed to enable accurate characterization of acromegaly disease activity.
Lenvatinib Targets PDGFR-? Pericytes and Inhibits Synergy With Thyroid Carcinoma Cells: Novel Translational Insights
Asumi Iesato, Stephanie Li, Giovanni Roti, Michele R Hacker, Andrew H Fischer, Carmelo Nucera
doi : 10.1210/clinem/dgab552
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3569–3590
Pericyte populations abundantly express tyrosine kinases (eg, platelet-derived growth factor receptor-? [PDGFR-?]) and impact therapeutic response. Lenvatinib is a clinically available tyrosine kinase inhibitor that also targets PDGFR-?. Duration of therapeutic response was shorter in patients with greater disease burden and metastasis. Patients may develop drug resistance and tumor progression.
Cabergoline Stimulates Human Endometrial Stromal Cell Decidualization and Reverses Effects of Interleukin-1? In Vitro
Jie Yu, Sarah L Berga, Qingying Meng, Mingjing Xia, Trudy A Kohout, Marcel van Duin, Robert N Taylor
doi : 10.1210/clinem/dgab511
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3591–3604
Human embryonic implantation is regulated by neuroendocrine hormones, ovarian steroids, growth factors, and cytokines. Sympathetic innervation of the uterus also may play a role.
Case Studies in Pediatric Lipid Disorders and Their Management
Ambika P Ashraf, Bhuvana Sunil, Vaneeta Bamba, Emily Breidbart, Preneet Cheema Brar, Stephanie Chung, Anshu Gupta, Aditi Khokhar, Seema Kumar, Marissa Lightbourne, Manmohan K Kamboj, Ryan S Miller, Nivedita Patni, Vandana Raman, Amy S Shah, Don P Wilson, Brenda Kohn On behalf of the PES Drugs and Therapeutics Committee and Lipid Special Interest Group
doi : 10.1210/clinem/dgab568
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3605–3620
Identification of modifiable risk factors, including genetic and acquired disorders of lipid and lipoprotein metabolism, is increasingly recognized as an opportunity to prevent premature cardiovascular disease (CVD) in at-risk youth. Pediatric endocrinologists are at the forefront of this emerging public health concern and can be instrumental in beginning early interventions to prevent premature CVD-related events during adulthood.
Approach to Diagnosing a Pediatric Patient With Severe Insulin Resistance in Low- or Middle-income Countries
Alise A van Heerwaarde, Renz C W Klomberg, Conny M A van Ravenswaaij-Arts, Hans Kristian Ploos van Amstel, Aartie Toekoen, Fariza Jessurun, Abhimanyu Garg, Daniëlle C M van der Kaay
doi : 10.1210/clinem/dgab549
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3621–3633
Diabetes mellitus (DM) in children is most often caused by impaired insulin secretion (type 1 DM). In some children, the underlying mechanism for DM is increased insulin resistance, which can have different underlying causes. While the majority of these children require insulin dosages less than 2.0 U/kg/day to achieve normoglycemia, higher insulin requirements indicate severe insulin resistance. Considering the therapeutic challenges in patients with severe insulin resistance, early diagnosis of the underlying cause is essential in order to consider targeted therapies and to prevent diabetic complications. Although rare, several disorders can attribute to severe insulin resistance in pediatric patients. Most of these disorders are diagnosed through advanced diagnostic tests, which are not commonly available in low- or middle-income countries. Based on a case of DM with severe insulin resistance in a Surinamese adolescent who was later confirmed to have autosomal recessive congenital generalized lipodystrophy, type 1 (Berardinelli–Seip syndrome), we provide a systematic approach to the differential diagnosis and work-up. We show that a thorough review of medical history and physical examination generally provide sufficient information to diagnose a child with insulin-resistant DM correctly, and, therefore, our approach is especially applicable to low- or middle-income countries.
Procalcitonin as an Alternative Tumor Marker of Medullary Thyroid Carcinoma
Luca Giovanella, Maria Luisa Garo, Luca Ceriani, Gaetano Paone, Alfredo Campenni’, Federica D’Aurizio
doi : 10.1210/clinem/dgab564
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3634–3643
Calcitonin (CT) measurement is pivotal in the management of medullary thyroid carcinoma (MTC), but several pitfalls can affect its reliability. Procalcitonin (ProCT) has been reported as a promising alternative MTC tumor marker.
Cardiovascular Outcomes in Thyroid Cancer Patients Treated With Thyroidectomy: A Meta-analysis
Eun Kyung Lee, Hwa Young Ahn, Eu Jeong Ku, Won Sang Yoo, Young Ki Lee, Kee-Hyun Nam, Young Jun Chai, Shinje Moon, Yuh-Seog Jung
doi : 10.1210/clinem/dgab576
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3644–3654
Thyroid dysfunction is associated with an increased risk of cardiovascular disease (CVD) in the general population; however, it remains controversial whether differentiated thyroid cancer (DTC) treatment, including thyroidectomy and thyroid-stimulating hormone suppression, further increases the risk of CVD.
Effect of TSH Suppression Therapy on Bone Mineral Density in Differentiated Thyroid Cancer: A Systematic Review and Meta-analysis
Eu Jeong Ku, Won Sang Yoo, Eun Kyung Lee, Hwa Young Ahn, Seung Hoon Woo, Jun Hwa Hong, Hyun Kyung Chung, Jin-Woo Park
doi : 10.1210/clinem/dgab539
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages 3655–3667
Because subclinical hyperthyroidism increases the risk of osteoporosis and fractures, concerns are growing about the long-term skeletal safety of TSH suppression therapy after total thyroidectomy in patients with differentiated thyroid cancer (DTC).
Challenges and Opportunities for Osteoporosis Care During the COVID-19 Pandemic
Sara J Cromer, Elaine W Yu
doi : 10.1210/clinem/dgab570
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4795–e4808
The coronavirus disease 2019 (COVID-19) has both directly and indirectly affected osteoporosis diagnosis and treatment throughout the world.
Thyrotropin, Hyperthyroidism, and Bone Mass
Se-Min Kim, Vitaly Ryu, Sari Miyashita, Funda Korkmaz, Daria Lizneva, Sakshi Gera, Rauf Latif, Terry F Davies, Jameel Iqbal, Tony Yuen, Mone Zaidi
doi : 10.1210/clinem/dgab548
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4809–e4821
Thyrotropin (TSH), traditionally seen as a pituitary hormone that regulates thyroid glands, has additional roles in physiology including skeletal remodeling. Population-based observations in people with euthyroidism or subclinical hyperthyroidism indicated a negative association between bone mass and low-normal TSH. The findings of correlative studies were supported by small intervention trials using recombinant human TSH (rhTSH) injection, and genetic and case-based evidence. Genetically modified mouse models, which disrupt the reciprocal relationship between TSH and thyroid hormone, have allowed us to examine an independent role of TSH. Since the first description of osteoporotic phenotype in haploinsufficient Tshr+/– mice with normal thyroid hormone levels, the antiosteoclastic effect of TSH has been documented in both in vitro and in vivo studies. Further studies showed that increased osteoclastogenesis in Tshr-deficient mice was mediated by tumor necrosis factor ?. Low TSH not only increased osteoclastogenesis, but also decreased osteoblastogenesis in bone marrow–derived primary osteoblast cultures. However, later in vivo studies using small and intermittent doses of rhTSH showed a proanabolic effect, which suggests that its action might be dose and frequency dependent. TSHR was shown to interact with insulin-like growth factor 1 receptor, and vascular endothelial growth factor and Wnt pathway might play a role in TSH’s effect on osteoblasts. The expression and direct skeletal effect of a biologically active splice variant of the TSH? subunit (TSH?v) in bone marrow–derived macrophage and other immune cells suggest a local skeletal effect of TSHR. Further studies of how locally secreted TSH?v and systemic TSH? interact in skeletal remodeling through the endocrine, immune, and skeletal systems will help us better understand the hyperthyroidism-induced bone disease.
Toward an Improved Classification of Type 2 Diabetes: Lessons From Research into the Heterogeneity of a Complex Disease
Maria J Redondo, Ashok Balasubramanyam
doi : 10.1210/clinem/dgab545
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4822–e4833
Accumulating evidence indicates that type 2 diabetes (T2D) is phenotypically heterogeneous. Defining and classifying variant forms of T2D are priorities to better understand its pathophysiology and usher clinical practice into an era of “precision diabetes.”
Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis
Elvira V Bräuner, Youn-Hee Lim, Trine Koch, Cecilie S Uldbjerg, Laura S Gregersen, Marc K Pedersen, Hanne Frederiksen, Jørgen H Petersen, Brent A Coull, Anna-Maria Andersson, Martha Hickey, Niels E Skakkebæk, Russ Hauser, Anders Juul
doi : 10.1210/clinem/dgab523
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4834–e4860
The incidence of many hormone-dependent diseases, including testicular cancer, has sharply increased in all high-income countries during the 20th century. This is not fully explained by established risk factors. Concurrent, increasing exposure to antiandrogenic environmental endocrine disrupting chemicals (EDCs) in fetal life may partially explain this trend. This systematic review assessed available evidence regarding the association between environmental EDC exposure and risk of testicular cancer (seminomas and nonseminomas). Following PRISMA guidelines, a search of English peer-reviewed literature published prior to December 14, 2020 in the databases PubMed and Embase® was performed. Among the 279 identified records, 19 were eligible for quality assessment and 10 for further meta-analysis. The completeness of reporting was high across papers, but over 50% were considered subject to potential risk of bias. Mean age at diagnosis was 31.9 years. None considered effects of EDC multipollutant mixtures. The meta-analyses showed that maternal exposure to combined EDCs was associated with a higher risk of testicular cancer in male offspring [summary risk ratios: 2.16, (95% CI:1.78-2.62), 1.93 (95% CI:1.49-2.48), and 2.78 (95% CI:2.27-3.41) for all, seminoma, and nonseminoma, respectively]. Similarly, high maternal exposures to grouped organochlorines and organohalogens were associated with higher risk of seminoma and nonseminoma in the offspring. Summary estimates related to postnatal adult male EDC exposures were inconsistent. Maternal, but not postnatal adult male, EDC exposures were consistently associated with a higher risk of testicular cancer, particularly risk of nonseminomas. However, the quality of studies was mixed, and considering the fields complexity, more prospective studies of prenatal EDC multipollutant mixture exposures and testicular cancer are needed.
Dysregulation of the Hypothalamic–Pituitary–Testicular Axis due to Energy Deficit
Mathis Grossmann, Gary A Wittert
doi : 10.1210/clinem/dgab517
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4861–e4871
Although gonadal axis dysregulation from energy deficit is well recognized in women, the effects of energy deficit on the male gonadal axis have received much less attention.
New Horizons: Is Obesity a Disorder of Neurotransmission?
Alexandre Caron, Natalie Jane Michael
doi : 10.1210/clinem/dgab421
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4872–e4886
Obesity is a disease of the nervous system. While some will view this statement as provocative, others will take it as obvious. Whatever our side is, the pharmacology tells us that targeting the nervous system works for promoting weight loss. It works, but at what cost? Is the nervous system a safe target for sustainable treatment of obesity? What have we learned—and unlearned—about the central control of energy balance in the last few years? Herein we provide a thought-provoking exploration of obesity as a disorder of neurotransmission. We discuss the state of knowledge on the brain pathways regulating energy homeostasis that are commonly targeted in anti-obesity therapy and explore how medications affecting neurotransmission such as atypical antipsychotics, antidepressants, and antihistamines relate to body weight. Our goal is to provide the endocrine community with a conceptual framework that will help expending our understanding of the pathophysiology of obesity, a disease of the nervous system.
New Horizons—Addressing Healthcare Disparities in Endocrine Disease: Bias, Science, and Patient Care
Marshall H Chin
doi : 10.1210/clinem/dgab229
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4887–e4902
Unacceptable healthcare disparities in endocrine disease have persisted for decades, and 2021 presents a difficult evolving environment. The COVID-19 pandemic has highlighted the gross structural inequities that drive health disparities, and antiracism demonstrations remind us that the struggle for human rights continues. Increased public awareness and discussion of disparities present an urgent opportunity to advance health equity. However, it is more complicated to change the behavior of individuals and reform systems because societies are polarized into different factions that increasingly believe, accept, and live different realities.
Metastatic Medullary Thyroid Cancer: The Role of 68Gallium-DOTA-Somatostatin Analogue PET/CT and Peptide Receptor Radionuclide Therapy
Aimee R Hayes, Alexander Crawford, Khulood Al Riyami, Christine Tang, Jamshed Bomanji, Stephanie E Baldeweg, Damian Wild, Daniel Morganstein, Alice Harry, Simona Grozinsky-Glasberg, Kira Oleinikov, Bernard Khoo, Martyn E Caplin, Guillaume P Nicolas, Ashley B Grossman
doi : 10.1210/clinem/dgab588
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4903–e4916
Metastatic medullary thyroid cancer (MTC) is a rare malignancy with minimal treatment options. Many, but not all, MTCs express somatostatin receptors.
Dysregulation of Components of the Inflammasome Machinery After Bariatric Surgery: Novel Targets for a Chronic Disease
Vicente Herrero-Aguayo, Prudencio Sáez-Martínez, Juan L López-Cánovas, Juan J Prados-Carmona, María D Alcántara-Laguna, Fernando L López, María J Molina-Puerta, Alfonso Calañas-Continente, Antonio Membrives, Juan Castilla, Juan Ruiz-Ravelo, Rosario Alonso-Echague, Elena M Yubero-Serrano, Justo P Castaño, Manuel D Gahete, María A Gálvez-Moreno, Raúl M Luque, Aura D Herrera-Martínez
doi : 10.1210/clinem/dgab586
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4917–e4934
Obesity is a metabolic chronic disease with important associated morbidities and mortality. Bariatric surgery is the most effective treatment for maintaining long-term weight loss in severe obesity and, consequently, for decreasing obesity-related complications, including chronic inflammation.
Higher CNV Frequencies in Chromosome 14 of Girls With Turner Syndrome Phenotype
Naincy Purwar, Pradeep Tiwari, Nitish Mathur, Himanshu Sharma, Rahul Sahlot, Umesh Garg, Balram Sharma, Aditya Saxena, Sandeep K Mathur
doi : 10.1210/clinem/dgab572
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4935–e4955
Precise genotype-phenotype correlations in Turner syndrome (TS) have not yet been deciphered. The chromosomal basis of the clinical TS phenotype in the absence of X chromosome aberrations on conventional karyotyping remains more and less unexplored.
In1-Ghrelin Splicing Variant as a Key Element in the Pathophysiological Association Between Obesity and Prostate Cancer
Juan M Jiménez-Vacas, Antonio J Montero-Hidalgo, Enrique Gómez-Gómez, Antonio C Fuentes-Fayos, Francisco Ruiz-Pino, Ipek Guler, Antonio Camargo, Francisco J Anglada, Julia Carrasco-Valiente, Manuel Tena-Sempere, André Sarmento-Cabral, Justo P Castaño, Manuel D Gahete, Raúl M Luque
doi : 10.1210/clinem/dgab516
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4956–e4968
Recent studies emphasize the importance of considering the metabolic status to develop personalized medicine approaches. This is especially relevant in prostate cancer (PCa), wherein the diagnostic capability of prostate-specific antigen (PSA) dramatically drops when considering patients with PSA levels ranging from 3 to 10 ng/mL, the so-called grey zone. Hence, additional noninvasive diagnostic and/or prognostic PCa biomarkers are urgently needed, especially in the metabolic-status context.
A Blood-based Polyamine Signature Associated With MEN1 Duodenopancreatic Neuroendocrine Tumor Progression
Johannes F Fahrmann, Amanda R Wasylishen, Carolina R C Pieterman, Ehsan Irajizad, Jody Vykoukal, Eunice Murage, Ranran Wu, Jennifer B Dennison, Hansini Krishna, Christine B Peterson, Guillermina Lozano, Hua Zhao, Kim-Anh Do, Daniel M Halperin, Sunita K Agarwal, Jenny E Blau, Jaydira Del Rivero, Naris Nilubol, Mary F Walter, James M Welch, Lee S Weinstein, Menno R Vriens, Rachel S van Leeuwaarde, Mark J C van Treijen, Gerlof D Valk, Nancy D Perrier, Samir M Hanash
doi : 10.1210/clinem/dgab554
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4969–e4980
Duodenopancreatic neuroendocrine tumors (dpNETs) frequently occur in patients with multiple endocrine neoplasia type 1 (MEN1), and metastatic dpNET is the primary cause of disease-related mortality. There is a need for biomarkers that can identify patients with MEN1-related dpNETs that are at high risk of developing distant metastasis. Polyamines have tumor-promoting roles in several cancer types.
Geographic, Gender, and Seasonal Variation of Diabetes: A Nationwide Study With 1.4 Million Participants
Yuanfeng Zhang, Mingkun Tong, Bo Wang, Zumin Shi, Ping Wang, Liming Li, Yi Ning, Tao Lu
doi : 10.1210/clinem/dgab543
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4981–e4992
China has experienced a rapid increase in the prevalence of diabetes.
Systems-Level Opportunities in the Management of Primary Hyperparathyroidism: An Informatics-based Assessment
Nardeen B Dawood, Chi-Hong Tseng, Dalena T Nguyen, Kimberly L Yan, Masha J Livhits, Angela M Leung, Michael W Yeh
doi : 10.1210/clinem/dgab540
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e4993–e5000
Primary hyperparathyroidism (PHPT), a leading cause of hypercalcemia and secondary osteoporosis, is underdiagnosed.
Weight Loss Prior to Pregnancy and Early Gestational Glycemia: Prepare, a Randomized Clinical Trial
Erin S LeBlanc, Ning X Smith, Kimberly K Vesco, Teresa A Hillier, Victor J Stevens
doi : 10.1210/clinem/dgab547
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5001–e5010
Women with elevated body mass index are encouraged to lose weight before pregnancy, but no trials have tested the effects of prepregnancy weight loss on risk of developing gestational diabetes.
Associations of Body Mass Index and Waist Circumference in Young Adulthood with Later Life Incident Diabetes
Nandini Nair, Eric Vittinghoff, Mark J Pletcher, Elizabeth C Oelsner, Norrina B Allen, Chiadi E Ndumele, Nancy A West, Elsa S Strotmeyer, Kenneth J Mukamal, David S Siscovick, Mary L Biggs, Blandine Laferrère, Andrew E Moran, Yiyi Zhang
doi : 10.1210/clinem/dgab551
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5011–e5020
The independent contribution of young adult exposure to overweight and obesity to later-life incident diabetes is not well studied.
Serum Glycine Levels Are Associated With Cortical Bone Properties and Fracture Risk in Men
Anna L Eriksson, Nele Friedrich, Magnus K Karlsson, Östen Ljunggren, Mattias Lorentzon, Maria Nethander, Henri Wallaschofski, Dan Mellström, Claes Ohlsson
doi : 10.1210/clinem/dgab544
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5021–e5029
In a recent study a pattern of 27 metabolites, including serum glycine, associated with bone mineral density (BMD).
Body Mass Index and Risk of COVID-19 Diagnosis, Hospitalization, and Death: A Cohort Study of 2 524 926 Catalans
Martina Recalde, Andrea Pistillo, Sergio Fernandez-Bertolin, Elena Roel, Maria Aragon, Heinz Freisling, Daniel Prieto-Alhambra, Edward Burn, Talita Duarte-Salles
doi : 10.1210/clinem/dgab546
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5030–e5042
A comprehensive understanding of the association between body mass index (BMI) and coronavirus disease 2019 (COVID-19) is still lacking.
Asthma in Youth and Early-onset Type 2 Diabetes: A Nationwide Study of 1.72 Million Israeli Adolescents
Michael Shapiro, Chen Arbel, Inbar Zucker, Gingy Ronen Balmor, Miri Lutski, Estela Derazne, Zivan Beer, Orit Pinhas-Hamiel, Ofri Mosenzon, Dorit Tzur, Arnon Afek, Amir Tirosh, Tali Cukierman-Yaffe, Hertzel C Gerstein, Vered Rosenberg, Gabriel Chodick, Itamar Raz, Gilad Twig
doi : 10.1210/clinem/dgab542
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5043–e5053
The prevalence of both asthma and early-onset diabetes is on the rise; however, the association between them remains unclear. We examined a possible association of asthma at adolescence with type 2 diabetes in young adulthood.
Changes in Serum Calcium and Treatment of Hypoparathyroidism During Pregnancy and Lactation: A Single-center Case Series
Jia-Jia Wang, Ou Wang, Ya-Bing Wang, Jing Yang, An Song, Yan Jiang, Mei Li, Wei-Bo Xia, Xiao-Ping Xing
doi : 10.1210/clinem/dgab530
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5054–e5063
Hypoparathyroidism (hypo-PT) is rare, and studies on hypo-PT, especially during pregnancy and lactation, are limited.
Genetically Determined TSH Level Within Reference Range Is Inversely Associated With Alzheimer Disease
Gloria Hoi-Yee Li, Ching-Lung Cheung, Elaine Yun-Ning Cheung, Wai-Chi Chan, Kathryn Choon-Beng Tan
doi : 10.1210/clinem/dgab527
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5064–e5074
Contradictory findings were reported in observational studies on the association of thyroid function (thyrotropin [TSH] and free thyroxine [FT4] levels) with Alzheimer disease (AD).
Migration, Gestational Diabetes, and Adverse Pregnancy Outcomes: A Nationwide Study of Singleton Deliveries in Denmark
Karoline Kragelund Nielsen, Gregers Stig Andersen, Peter Damm, Anne-Marie Nybo Andersen
doi : 10.1210/clinem/dgab528
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5075–e5087
It remains unclear if migrants have different odds for adverse outcomes associated with gestational diabetes mellitus (GDM).
Vertebral Fractures Occur Despite Control of Acromegaly and Are Predicted by Cortical Volumetric Bone Mineral Density
Martin Kužma, Peter Va?uga, Ivana Ságová, Dušan Pávai, Peter Jackuliak, Zdenko Killinger, Neil Binkley, Renaud Winzenrieth, Juraj Payer
doi : 10.1210/clinem/dgab259
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5088–e5096
Recent studies suggest that cortical bone could also play a role in vertebral fracture (VF) development in acromegaly.
The Association Between Long-term Exposure to Ambient Air Pollution and Bone Strength in China
Jialong Wu, Bing Guo, Han Guan, Fei Mi, Jingru Xu, Basang, Yajie Li, Haojiang Zuo, Lei Wang, Shiyu Feng, Jing Wei, Gongbo Chen, Shanshan Li, Yonglan Wei, Yuming Guo, Xing Zhao on behalf of the China Muti-Ethnic Cohort (CMEC) collaborative group
doi : 10.1210/clinem/dgab462
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5097–e5108
Evidence regarding the association of long-term exposure to air pollution on bone strength or osteoporosis is rare, especially in highly polluted low- and middle-income countries. Little is known about whether the association between air pollution and bone strength changes at different bone strength distributions.
The Effect of Melatonin on Incretin Hormones: Results From Experimental and Randomized Clinical Studies
Esben Stistrup Lauritzen, Julie Støy, Cecilie Bæch-Laursen, Niels Grarup, Niels Jessen, Torben Hansen, Niels Møller, Bolette Hartmann, Jens Juul Holst, Ulla Kampmann
doi : 10.1210/clinem/dgab521
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5109–e5123
Glucose homeostasis is under circadian control through both endocrine and intracellular mechanisms, with several lines of evidence suggesting that melatonin affects glucose homeostasis.
Cross-species Association Between Telomere Length and Glucocorticoid Exposure
Richard S Lee, Peter P Zandi, Alicia Santos, Anna Aulinas, Jenny L Carey, Susan M Webb, Mary E McCaul, Eugenia Resmini, Gary S Wand
doi : 10.1210/clinem/dgab519
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5124–e5135
Chronic exposure to glucocorticoids (GCs) or stress increases the risk of medical disorders, including cardiovascular and neuropsychiatric disorders. GCs contribute to accelerated aging; however, while the link between chronic GC exposure and disease onset is well established, the underpinning mechanisms are not clear.
Associations Between Antidepressant Use and Advanced Diabetes Outcomes in Patients with Depression and Diabetes Mellitus
Chi-Shin Wu, Le-Yin Hsu, Yi-Jiun Pan, Shi-Heng Wang
doi : 10.1210/clinem/dgab443
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5136–e5146
Comorbid depression in patients with diabetes deteriorates the prognosis. Antidepressants might attenuate the adverse effects of depression; however, they are associated with cardiometabolic adverse effects.
Hypothalamic-Pituitary Autoimmunity and Related Impairment of Hormone Secretions in Chronic Fatigue Syndrome
Annamaria De Bellis, Giuseppe Bellastella, Vlenia Pernice, Paolo Cirillo, Miriam Longo, Antonietta Maio, Lorenzo Scappaticcio, Maria Ida Maiorino, Antonio Bellastella, Katherine Esposito, José G Montoya
doi : 10.1210/clinem/dgab429
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5147–e5155
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic illness that reduces the quality of life. A potential role of neuroendocrine autoimmune dysfunction has been hypothesized.
Pregnancy-specific Adaptations in Leptin and Melanocortin Neuropeptides in Early Human Gestation
Maria Andrikopoulou, Sunil K Panigrahi, Giselle D Jaconia, Cynthia Gyamfi-Bannerman, Richard M Smiley, Gabrielle Page-Wilson
doi : 10.1210/clinem/dgab510
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5156–e5164
Pregnancy is characterized by increased appetitive drive beginning early in gestation, yet the central mechanisms underlying this adaptation are poorly understood in humans. To elucidate central mechanisms underlying appetite regulation in early pregnancy, we examine plasma and cerebrospinal fluid (CSF) leptin and Agouti-related peptide (AgRP) as well as CSF proopiomelanocortin (POMC) as surrogates for brain melanocortin activity.
Influence of Free Fatty Acid Concentrations and Weight Loss on Adipose Tissue Direct Free Fatty Acid Storage Rates
Qingyi Jia, B Gisella Carranza Leon, Michael D Jensen
doi : 10.1210/clinem/dgab501
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5165–e5179
The factors that determine the recycling of free fatty acids (FFA) back into different adipose tissue depots via the direct storage pathway are not completely understood.
Bone Microarchitecture Decline and Risk of Fall and Fracture in Men With Poor Physical Performance—The STRAMBO Study
Philippe Paul Wagner, Danielle E Whittier, Dominique Foesser, Steven K Boyd, Roland Chapurlat, Pawel Szulc
doi : 10.1210/clinem/dgab506
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5180–e5194
High fracture risk in individuals with low muscle strength is attributed to high risk of falls.
Osteoporotic Fractures and Vertebral Body Reshaping in Children With Glucocorticoid-treated Rheumatic Disorders
Leanne M Ward, Jinhui Ma, Marie-Eve Robinson, Maya Scharke, Josephine Ho, Kristin Houghton, Adam Huber, Rosie Scuccimarri, Julie Barsalou, Johannes Roth, Nazih Shenouda, Mary Ann Matzinger, Brian Lentle, Jacob L Jaremko, Khaldoun Koujok, Karen Watanabe Duffy, Robert Stein, Anne Marie Sbrocchi, Celia Rodd, Paivi M Miettunen, Claire M A LeBlanc, Maggie Larche, Roman Jurencak, Elizabeth A Cummings, Robert Couch, David A Cabral, Stephanie Atkinson, Nathalie Alos, Elizabeth Sykes, Victor N Konji, Frank Rauch, Kerry Siminoski, Bianca Lang
doi : 10.1210/clinem/dgab494
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5195–e5207
Osteoporotic fractures are an important cause of morbidity in children with glucocorticoid-treated rheumatic disorders.
Novel Laboratory Index, Based on Fasting Blood Parameters, Accurately Reflects Insulin Sensitivity
Monika Karczewska-Kupczewska, Agnieszka Niko?ajuk, Magdalena Stefanowicz, Natalia Matulewicz, Maria Arnoriaga-Rodriguez, Jose Manuel Fernandez-Real, Marek Str?czkowski
doi : 10.1210/clinem/dgab489
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5208–e5221
Simple and reliable measurement of insulin sensitivity may be important for the prevention of insulin-resistance-related diseases. Surrogate indices of insulin sensitivity are of limited utility in population without signs of metabolic syndrome.
Zoledronic Acid vs Placebo in Pediatric Glucocorticoid-induced Osteoporosis: A Randomized, Double-blind, Phase 3 Trial
Leanne M Ward, Anup Choudhury, Nathalie Alos, David A Cabral, Celia Rodd, Anne Marie Sbrocchi, Shayne Taback, Raja Padidela, Nick J Shaw, Eva Hosszu, Mikhail Kostik, Ekaterina Alexeeva, Kebashni Thandrayen, Nazih Shenouda, Jacob L Jaremko, Gangadhar Sunkara, Sarfaraz Sayyed, R Paul Aftring, Craig F Munns
doi : 10.1210/clinem/dgab458
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5222–e5235
Glucocorticoids (GCs) prescribed for chronic pediatric illnesses are associated with osteoporotic fractures.
Predicting Malignancy in Pediatric Thyroid Nodules: Early Experience With Machine Learning for Clinical Decision Support
Lebohang Radebe, Daniëlle C M van der Kaay, Jonathan D Wasserman, Anna Goldenberg
doi : 10.1210/clinem/dgab435
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5236–e5246
To develop a machine learning tool to integrate clinical data for the prediction of non-benign thyroid cytology and histology.
Cardiovascular Disease Risk Factors and Metabolic Morbidity in a Longitudinal Study of Congenital Adrenal Hyperplasia
Ahmed Torky, Ninet Sinaii, Smita Jha, Jay Desai, Diala El-Maouche, Ashwini Mallappa, Deborah P Merke
doi : 10.1210/clinem/dgab133
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5247–e5257
Patients with congenital adrenal hyperplasia (CAH) are exposed to hyperandrogenism and supraphysiologic glucocorticoids, both of which can increase risk of metabolic morbidity.
Cardiovascular Events in Polycystic Ovary Syndrome: Is the Debate Settled for Good?
Damian G Romero, Licy L Yanes Cardozo
doi : 10.1210/clinem/dgab509
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5258–e5259
Role of Vitamin D in COVID-19: Active or Passive?
Bess Dawson-Hughes
doi : 10.1210/clinem/dgab505
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5260–e5261
The Forks in the Road of Thyroid Eye Disease
Christine C Krieger
doi : 10.1210/clinem/dgab500
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5262–e5263
Distinguishing Self-limited Delayed Puberty From Permanent Hypogonadotropic Hypogonadism: How and Why?
Jennifer Harrington, Mark R Palmert
doi : 10.1210/clinem/dgab498
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5264–e5266
Rescue of Neurological Development in Congenital Hypothyroidism: We Should Leave No Stone Unturned
Luca Persani
doi : 10.1210/clinem/dgab487
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5267–e5269
Letter to the Editor From Karakilic and Saygili: “Radiological Thoracic Vertebral Fractures Are Highly Prevalent in COVID-19 and Predict Disease Outcomes”
Ersen Karakilic, Emre Sedar Saygili
doi : 10.1210/clinem/dgab604
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Page e5270
Letter to the Editor From Viola et al: “Calcifediol Treatment and COVID-19-related Outcomes”
Viola Viola, Giulia Leanza, Flavia Tramontana
doi : 10.1210/clinem/dgab565
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5271–e5272
Letter to the Editor From Woolcott and Castilla-Bancayán: “Diabetes Increases Severe COVID-19 Outcomes Primarily in Younger Adults: Age and Diabetes in COVID-19 Severity”
Orison O Woolcott, Juan P Castilla-Bancayán
doi : 10.1210/clinem/dgab582
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5273–e5274
Letter to the Editor From Laidlaw et al: “Erythrocytosis in a Large Cohort of Transgender Men Using Testosterone: A Long-term Follow-up Study on Prevalence, Determinants, and Exposure Years”
Michael K Laidlaw, Andre Van Mol, Quentin Van Meter, Jeffrey E Hansen
doi : 10.1210/clinem/dgab514
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5275–e5276
Response to Letter to the Editor From Woolcott and Castilla-Bancayán: “Diabetes Increases Severe COVID-19 Outcomes Primarily in Younger Adults”
Marc Diedisheim, Etienne Dancoisne, Jean-François Gautier, Etienne Larger, Emmanuel Cosson, Bruno Fève, Philippe Chanson, Sébastien Czernichow, Sopio Tatulashvili, Marie-Laure Raffin-Sanson, Kankoé Sallah, Muriel Bourgeon, Christiane Ajzenberg, Agnès Hartemann, Christel Daniel, Thomas Moreau, Ronan Roussel, Louis Potier
doi : 10.1210/clinem/dgab583
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5277–e5278
Response Letter to the Editor From Viola et al: “Diminishing Value From Multiple Serial Bone Densitometry in Women Receiving Antiresorptive Medication for Osteoporosis”
Gregory A Kline, Suzanne N Morin, Sidney Feldman, Lisa M Lix, William D Leslie
doi : 10.1210/clinem/dgab587
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5279–e5280
Response to Letter to the Editor From Viola et al: “Calcifediol Treatment and COVID-19-related Outcomes”
Xavier Nogues, José Manuel Quesada-Gomez, Natalia Garcia-Giralt
doi : 10.1210/clinem/dgab566
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Pages e5281–e5282
Erratum to: Correlation Between Telomere Attrition of Zona Fasciculata and Adrenal Weight Reduction in Older Men
doi : 10.1210/clinem/dgab534
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Page e5283
Erratum to: Letter to the Editor from Lao and Merke: “Ehlers–Danlos Syndrome: Molecular and Clinical Characterization of TNXA/TNXB Chimeras in Congenital Adrenal Hyperplasia”
doi : 10.1210/clinem/dgab537
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 12, December 2021, Page e5284
