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First Impressions — Should We Include Race or Ethnicity at the Beginning of Clinical Case Presentations?
Allan S. Brett, M.D., and Christopher W. Goodman, M.D.
doi : 10.1056/NEJMp2112312
N Engl J Med 2021; 385:2497-2499
Calling Out Aversive Racism in Academic Medicine
Catherine L. Chen, M.D., M.P.H., Gregg J. Gold, Ph.D., Maxime Cannesson, M.D., Ph.D., and Jennifer M. Lucero, M.D.
doi : 10.1056/NEJMp2112913
N Engl J Med 2021; 385:2499-2501
Closing the Gender Pay Gap in Medicine
Amy S. Gottlieb, M.D., and Reshma Jagsi, M.D., D.Phil.
doi : 10.1056/NEJMp2114955
N Engl J Med 2021; 385:2501-2504
Trust, Faith, and Covid
Eve Rittenberg, M.D.
doi : 10.1056/NEJMp2114695
N Engl J Med 2021; 385:2504-2505
Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
Rajiv Agarwal, M.D., Arjun D. Sinha, M.D., Andrew E. Cramer, B.S., Mary Balmes-Fenwick, M.S., Jazmyn H. Dickinson, B.S., Fangqian Ouyang, M.S., and Wanzhu Tu, Ph.D.
doi : 10.1056/NEJMoa2110730
N Engl J Med 2021; 385:2507-2519
Little evidence has been available to support the use of thiazide diuretics to treat hypertension in patients with advanced chronic kidney disease.
Ticagrelor versus Clopidogrel in CYP2C19 Loss-of-Function Carriers with Stroke or TIA
Yongjun Wang, M.D., Xia Meng, M.D., Ph.D., Anxin Wang, Ph.D., Xuewei Xie, M.D., Ph.D., Yuesong Pan, Ph.D., S. Claiborne Johnston, M.D., Ph.D., Hao Li, Ph.D., Philip M. Bath, D.Sc., F.Med.Sci., Qiang Dong, M.D., Ph.D., Anding Xu, M.D., Ph.D., Jing Jing, M.D., Ph.D., Jinxi Lin, M.D., Ph.D., Siying Niu, M.D., Yilong Wang, M.D., Ph.D., Xingquan Zhao, M.D., Ph.D., Zixiao Li, M.D., Ph.D., Yong Jiang, Ph.D., Wei Li, M.D., Ph.D., Liping Liu, M.D., Ph.D., Jie Xu, M.D., Ph.D., Liguo Chang, M.D., Lihua Wang, M.D., Ph.D., Xianbo Zhuang, M.D., Ph.D., Jinguo Zhao, M.D., Yefang Feng, M.D., Honghao Man, M.D., Guozhong Li, M.D., Ph.D., and Baojun Wang, M.D., Ph.D. for the CHANCE-2 Investigators*
doi : 10.1056/NEJMoa2111749
N Engl J Med 2021; 385:2520-2530
Comparisons between ticagrelor and clopidogrel for the secondary prevention of stroke in CYP2C19 loss-of-function carriers have not been extensively performed.
Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children
Anna Turkova, M.R.C.P.C.H., Ellen White, Ph.D., Hilda A. Mujuru, M.Med., Adeodata R. Kekitiinwa, M.Med., Cissy M. Kityo, Ph.D., Avy Violari, F.C.Paed., Abbas Lugemwa, M.D., Tim R. Cressey, Ph.D., Philippa Musoke, Ph.D., Ebrahim Variava, F.C.P.(S.A.), Mark F. Cotton, Ph.D., Moherndran Archary, Ph.D., Thanyawee Puthanakit, M.D., Osee Behuhuma, M.B., Ch.B., Robin Kobbe, M.D., Steven B. Welch, F.R.C.P.C.H., Mutsa Bwakura-Dangarembizi, M.Med., Pauline Amuge, M.Med., Elizabeth Kaudha, M.Med., Linda Barlow-Mosha, Ph.D., Shafic Makumbi, B.Sc., Nastassja Ramsagar, B.Med.Sc., Chaiwat Ngampiyaskul, M.D., Godfrey Musoro, M.Sc., Lorna Atwine, B.Sc., Afaaf Liberty, M.B., Ch.B., Victor Musiime, Ph.D., Dickson Bbuye, M.B., Ch.B., Grace M. Ahimbisibwe, M.Sc., Suwalai Chalermpantmetagul, M.Sc., Shabinah Ali, M.Sc., Tatiana Sarfati, M.Sc., Ben Wynne, M.Sc., Clare Shakeshaft, M.Sc., Angela Colbers, Ph.D., Nigel Klein, Ph.D., Sarah Bernays, Ph.D., Yacine Saïdi, Ph.D., Alexandra Coelho, Ph.D., Tiziana Grossele, B.Sc., Alexandra Compagnucci, M.D., Carlo Giaquinto, M.D., Pablo Rojo, Ph.D., Deborah Ford, Ph.D., and Diana M. Gibb, M.D. for the ODYSSEY Trial Team*
doi : 10.1056/NEJMoa2108793
N Engl J Med 2021; 385:2531-2543
Children with human immunodeficiency virus type 1 (HIV-1) infection have limited options for effective antiretroviral treatment (ART).
Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation
Steffen Desch, M.D., Anne Freund, M.D., Ibrahim Akin, M.D., Michael Behnes, M.D., Michael R. Preusch, M.D., Thomas A. Zelniker, M.D., Carsten Skurk, M.D., Ulf Landmesser, M.D., Tobias Graf, M.D., Ingo Eitel, M.D., Georg Fuernau, M.D., Hendrik Haake, M.D., Peter Nordbeck, M.D., Fabian Hammer, M.D., Ph.D., Stephan B. Felix, M.D., Christian Hassager, M.D., Thomas Engstrøm, M.D., Stephan Fichtlscherer, M.D., Jakob Ledwoch, M.D., Karsten Lenk, M.D., Michael Joner, M.D., Stephan Steiner, M.D., Christoph Liebetrau, M.D., Ingo Voigt, M.D., Uwe Zeymer, M.D., Michael Brand, M.D., Roland Schmitz, M.D., Jan Horstkotte, M.D., Claudius Jacobshagen, M.D., Janine Pöss, M.D., Mohamed Abdel-Wahab, M.D., Philipp Lurz, M.D., Ph.D., Alexander Jobs, M.D., Suzanne de Waha-Thiele, M.D., Denise Olbrich, Ph.D., Frank Sandig, Inke R. König, Ph.D., Sabine Brett, Maren Vens, Ph.D., Kathrin Klinge, Ph.D., and Holger Thiele, M.D. for the TOMAHAWK Investigators*
doi : 10.1056/NEJMoa2101909
N Engl J Med 2021; 385:2544-2553
Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest. However, the benefits of early coronary angiography and revascularization in resuscitated patients without electrocardiographic evidence of ST-segment elevation are unclear.
Determination of Brain Death
David M. Greer, M.D.
doi : 10.1056/NEJMcp2025326
N Engl J Med 2021; 385:2554-2561
Carcinoma en Cuirasse
Vinod Sharma, M.D., D.M., and Akash Kumar, M.D., D.M.
doi : 10.1056/NEJMicm2111669
N Engl J Med 2021; 385:2562
Untreated Chronic Gout
Tian Chen, M.D., and Dong-Lai Ma, M.D., Ph.D.
doi : 10.1056/NEJMicm2112548
N Engl J Med 2021; 385:e97
Case 40-2021: A 9-Year-Old Boy with Transient Weakness, Facial Droop, and Slurred Speech
Miya E. Bernson-Leung, M.D., Ed.M., Otto Rapalino, M.D., Melissa A. Walker, M.D., Ph.D., and William E. Butler, M.D.
doi : 10.1056/NEJMcpc2107358
N Engl J Med 2021; 385:2563-2572
Chlorthalidone in Advanced Chronic Kidney Disease — Have We Missed a Trick?
David C. Wheeler, M.D.
doi : 10.1056/NEJMe2118149
N Engl J Med 2021; 385:2574-2575
Genetic Profile–Guided Therapy for Stroke?
Steven K. Feske, M.D.
doi : 10.1056/NEJMe2116888
N Engl J Med 2021; 385:2576-2577
Employees of the Massachusetts Medical Society in 2021
Eric J. Rubin, M.D., Ph.D.
doi : 10.1056/NEJMe2118529
N Engl J Med 2021; 385:2578
Audio Interview: Covid-19 Vaccination and the Omicron Variant
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2120098
N Engl J Med 2021; 385:e102
A Noble Quest for Simplicity in the Chiral World
Svetlana B. Tsogoeva, Ph.D.
doi : 10.1056/NEJMcibr2116228
N Engl J Med 2021; 385:2579-2581
Tracking the Emergence of SARS-CoV-2 Alpha Variant in the United Kingdom
doi : 10.1056/NEJMc2103227
N Engl J Med 2021; 385:2582-2585
Efficacy of Natural Immunity against SARS-CoV-2 Reinfection with the Beta Variant
doi : 10.1056/NEJMc2110300
N Engl J Med 2021; 385:2585-2586
Maintenance or Discontinuation of Antidepressants in Primary Care
doi : 10.1056/NEJMc2117168
N Engl J Med 2021; 385:2586-2588
Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension
doi : 10.1056/NEJMc2117463
N Engl J Med 2021; 385:2588-2591
Placement of a Double-Lumen Endotracheal Tube
doi : 10.1056/NEJMc2117870
N Engl J Med 2021; 385:2591-2592
Race and Health — A Persistent American Dilemma
Damon S. Tweedy, M.D.
doi : 10.1056/NEJMpv2117898
N Engl J Med 2021; 385:e98
Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction
doi : 10.1056/NEJMx210024
N Engl J Med 2021; 385:2592
