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Circulating Bile Acid Profiles: A Need for Further Examination
Li Qi, Yu Tian, Yongsheng Chen
doi : 10.1210/clinem/dgab531
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3093–3112
Bile acids (BAs) are increasingly recognized as metabolic and chronobiologic integrators that synchronize the systemic metabolic response to nutrient availability. Alterations in the concentration and/or composition of circulating BAs are associated with a number of metabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), insulin resistance (IR), and metabolic associated fatty liver disease (MAFLD). This review summarizes recent evidence that links abnormal circulating BA profiles to multiple metabolic disorders, and discusses the possible mechanisms underlying the connections to determine the role of BA profiling as a novel biomarker for these abnormalities.
Rare Causes of Hypercalcemia: 2021 Update
Yasaman Motlaghzadeh, John P Bilezikian, Deborah E Sellmeyer
doi : 10.1210/clinem/dgab504
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3113–3128
Primary hyperparathyroidism and malignancy are the etiologies in 90% of cases of hypercalcemia. When these entities are not the etiology of hypercalcemia, uncommon conditions need to be considered. In 2005, Jacobs and Bilezikian published a clinical review of rare causes of hypercalcemia, focusing on mechanisms and pathophysiology. This review is an updated synopsis of rare causes of hypercalcemia, extending the observations of the original article.
Branched-chain Amino Acids and Relationship With Inflammation in Youth With Obesity: A Randomized Controlled Intervention Study
Ralph G Cosentino, James R Churilla, Samantha Josephson, Zarela Molle-Rios, Md Jobayer Hossain, Wagner L Prado, P Babu Balagopal
doi : 10.1210/clinem/dgab538
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3129–3139
Elevated concentrations of branched-chain amino acids (BCAA) are strong predictors of type 2 diabetes mellitus (T2DM). Their association with cardiovascular disease (CVD) remains uncertain, particularly in youth.
Hepatic Fat in Early Childhood Is Independently Associated With Estimated Insulin Resistance: The Healthy Start Study
Catherine C Cohen, Wei Perng, Shikha S Sundaram, Ann Scherzinger, Kartik Shankar, Dana Dabelea
doi : 10.1210/clinem/dgab541
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3140–3150
Fatty liver disease is a common metabolic abnormality in adolescents with obesity but remains understudied in early childhood.
Obesity Is Strongly Associated With Low Testosterone and Reduced Penis Growth During Development
Mario Mancini, Francesca Pecori Giraldi, Alice Andreassi, Gianna Mantellassi, Michela Salvioni, Cesare C Berra, Roberto Manfrini, Giuseppe Banderali, Franco Folli
doi : 10.1210/clinem/dgab535
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3151–3159
Growth of male genitalia represents an important marker of sexual development. Testicle size is the primary measure and little is known regards penile length changes during puberty.
Association of HbA1c With All-cause Mortality Across Varying Degrees of Glycemic Variability in Type 2 Diabetes
Jingyi Lu, Chunfang Wang, Jinghao Cai, Yun Shen, Lei Chen, Lei Zhang, Wei Lu, Wei Zhu, Gang Hu, Tian Xia, Jian Zhou
doi : 10.1210/clinem/dgab532
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3160–3167
The interaction of glycated hemoglobin A1c (HbA1c) and glycemic variability in relation to diabetes-related outcomes remains unknown.
Ex Vivo Intact Tissue Analysis Reveals Alternative Calcium-sensing Behaviors in Parathyroid Adenomas
James Koh, Run Zhang, Sanziana Roman, Quan-Yang Duh, Jessica Gosnell, Wen Shen, Insoo Suh, Julie A Sosa
doi : 10.1210/clinem/dgab524
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3168–3183
The biochemical basis for clinical variability in primary hyperparathyroidism (PHPT) is poorly understood.
Weekly Lonapegsomatropin in Treatment–Naïve Children With Growth Hormone Deficiency: The Phase 3 heiGHt Trial
Paul S Thornton, Aristides K Maniatis, Elena Aghajanova, Elena Chertok, Elpis Vlachopapadopoulou, Zhengning Lin, Wenjie Song, Eva Dam Christoffersen, Vibeke Miller Breinholt, Tatiana Kovalenko, Elene Giorgadze, Maria Korpal-Szczyrska, Paul L Hofman, David B Karpf, Aimee D Shu, Michael Beckert
doi : 10.1210/clinem/dgab529
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3184–3195
For children with growth hormone deficiency (GHD), treatment burden with daily somatropin injections [human growth hormone (hGH)] is high, which may lead to poor adherence and suboptimal overall treatment outcomes. Lonapegsomatropin (TransCon hGH) is an investigational long-acting, once-weekly prodrug for the treatment of GHD.
White Matter Microstructural Differences in Youth With Classical Congenital Adrenal Hyperplasia
Devyn L Cotter, Anisa Azad, Ryan P Cabeen, Mimi S Kim, Mitchell E Geffner, Farshid Sepehrband, Megan M Herting
doi : 10.1210/clinem/dgab520
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3196–3212
Gray matter morphology in the prefrontal cortex and subcortical regions, including the hippocampus and amygdala, are affected in youth with classical congenital adrenal hyperplasia (CAH). It remains unclear if white matter connecting these aforementioned brain regions is compromised in youth with CAH.
Analysis of Expression of Different Histone Deacetylases in Autoimmune Thyroid Disease
Pablo Sacristán-Gómez, Ana Serrano-Somavilla, Roberto González-Amaro, Rebeca Martínez-Hernández, Mónica Marazuela
doi : 10.1210/clinem/dgab526
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3213–3227
Histone deacetylases (HDACs) and histone acetyltransferases (HAT) have an important role in the regulation of gene transcription as well as in the development and function of CD4+Foxp3+ T regulatory (Treg) cells. Our group and others have reported that patients with autoimmune thyroid disease (AITD) show abnormalities in the levels and function of different Treg cell subsets.
BRAF V600E Status Sharply Differentiates Lymph Node Metastasis-associated Mortality Risk in Papillary Thyroid Cancer
Yubing Tao, Fei Wang, Xiaopei Shen, Guangwu Zhu, Rengyun Liu, David Viola, Rossella Elisei, Efisio Puxeddu, Laura Fugazzola, Carla Colombo, Barbara Jarzab, Agnieszka Czarniecka, Alfred K Lam, Caterina Mian, Federica Vianello, Linwah Yip, Garcilaso Riesco-Eizaguirre, Pilar Santisteban, Christine J O’Neill, Mark S Sywak, Roderick Clifton-Bligh, Bela Bendlova, Vlasta Sýkorová, Shihua Zhao, Yangang Wang, Mingzhao Xing
doi : 10.1210/clinem/dgab286
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3228–3238
How lymph node metastasis (LNM)-associated mortality risk is affected by BRAF V600E in papillary thyroid cancer (PTC) remains undefined.
Clinically Serious Hypoglycemia Is Rare and Not Associated With Time-in-range in Youth With New-onset Type 1 Diabetes
Ananta Addala, Dessi P Zaharieva, Angela J Gu, Priya Prahalad, David Scheinker, Bruce Buckingham, Korey K Hood, David M Maahs
doi : 10.1210/clinem/dgab522
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3239–3247
Early initiation of continuous glucose monitoring (CGM) is advocated for youth with type 1 diabetes (T1D). Data to guide CGM use on time-in-range (TIR), hypoglycemia, and the role of partial clinical remission (PCR) are limited.
Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults
Desiree M Sigala, Bettina Hieronimus, Valentina Medici, Vivien Lee, Marinelle V Nunez, Andrew A Bremer, Chad L Cox, Candice A Price, Yanet Benyam, Abhijit J Chaudhari, Yasser Abdelhafez, John P McGahan, Michael I Goran, Claude B Sirlin, Giovanni Pacini, Andrea Tura, Nancy L Keim, Peter J Havel, Kimber L Stanhope
doi : 10.1210/clinem/dgab508
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3248–3264
Studies in rodents and humans suggest that high-fructose corn syrup (HFCS)–sweetened diets promote greater metabolic dysfunction than sucrose-sweetened diets.
Whole-genome Sequencing of Follicular Thyroid Carcinomas Reveal Recurrent Mutations in MicroRNA Processing Subunit DGCR8
Johan O Paulsson, Nima Rafati, Sebastian DiLorenzo, Yi Chen, Felix Haglund, Jan Zedenius, C Christofer Juhlin
doi : 10.1210/clinem/dgab471
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3265–3282
The genomic and transcriptomic landscape of widely invasive follicular thyroid carcinomas (wiFTCs) and Hürthle cell carcinoma (HCC) are poorly characterized, and subsets of these tumors lack information on genetic driver events.
Maternal Metabolites Associated With Gestational Diabetes Mellitus and a Postpartum Disorder of Glucose Metabolism
Yu Liu, Alan Kuang, James R Bain, Michael J Muehlbauer, Olga R Ilkayeva, Lynn P Lowe, Boyd E Metzger, Christopher B Newgard, Denise M Scholtens, William L Lowe, Jr
doi : 10.1210/clinem/dgab513
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3283–3294
Gestational diabetes is associated with a long-term risk of developing a disorder of glucose metabolism. However, neither the metabolic changes characteristic of gestational diabetes in a large, multi-ancestry cohort nor the ability of metabolic changes during pregnancy, beyond glucose levels, to identify women at high risk for progression to a disorder of glucose metabolism has been examined.
Fetal Cardiac Lipid Sensing Triggers an Early and Sex-related Metabolic Energy Switch in Intrauterine Growth Restriction
Loïze Maréchal, Benoit Sicotte, Véronique Caron, Michèle Brochu, André Tremblay
doi : 10.1210/clinem/dgab496
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3295–3311
Intrauterine growth restriction (IUGR) is an immediate outcome of an adverse womb environment, exposing newborns to developing cardiometabolic disorders later in life.
Women With Chronic Hypoparathyroidism Have Low Risk of Adverse Pregnancy Outcomes
Sigridur Björnsdottir, Bart Clarke, Outi Mäkitie, Anna Sandström, Eleonor Tiblad, Tim Spelman, Olle Kämpe
doi : 10.1210/clinem/dgab503
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3312–3319
There are scarce data on the management of chronic hypoparathyroidism (hypoPT) in pregnant women.
Cardiometabolic Outcomes and Mortality in Patients with Adrenal Adenomas in a Population-based Setting
Catherine D Zhang, Dingfeng Li, Ravinder Jeet Kaur, Andreas Ebbehoj, Sumitabh Singh, Elizabeth J Atkinson, Sara J Achenbach, William F Young, Jr., Wiebke Arlt, Walter A Rocca, Irina Bancos
doi : 10.1210/clinem/dgab468
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3320–3330
While adrenal adenomas have been linked with cardiovascular morbidity in convenience samples of patients from specialized referral centers, large-scale population-based data are lacking.
Approach to the Patient With Adrenal Incidentaloma
Irina Bancos, Alessandro Prete
doi : 10.1210/clinem/dgab512
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3331–3353
Adrenal tumors are commonly discovered incidentally on cross-sectional abdominal imaging performed for reasons other than adrenal mass. Incidence of adrenal tumors increased 10-fold in the past 2 decades, with most diagnosed in older adults. In any patient with a newly discovered adrenal mass, determining whether the adrenal mass is malignant and whether it is hormonally active is equally important to guide the best management. Malignancy is diagnosed in 5% to 8% of patients with adrenal tumors, with a higher risk in young patients, if history of extra-adrenal malignancy, in those with large adrenal tumors with indeterminate imaging characteristics, and in bilateral adrenal tumors. Although overt hormone excess is uncommon in adrenal incidentalomas, mild autonomous cortisol secretion can be diagnosed in up to 30% to 50% of patients. Because autonomous cortisol secretion is associated with increased cardiovascular morbidity and metabolic abnormalities, all patients with adrenal incidentalomas require work up with dexamethasone suppression test. Management of adrenal tumors varies based on etiology, associated comorbidities, and patient’s preference. This article reviews the current evidence on the diagnosis and evaluation of patients with adrenal mass and focuses on management of the most common etiologies of adrenal incidentalomas.
Effects of Proton Pump Inhibitors on Glycemic Control and Incident Diabetes: A Systematic Review and Meta-analysis
Carol Chiung-Hui Peng, Yu-Kang Tu, Gin Yi Lee, Rachel Huai-En Chang, Yuting Huang, Khulood Bukhari, Yao-Chou Tsai, Yunting Fu, Huei-Kai Huang, Kashif M Munir
doi : 10.1210/clinem/dgab353
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3354–3366
Whether proton pump inhibitors (PPI) can improve glycemic control among individuals with diabetes or decrease the risk of incident diabetes in the general population is unclear.
Associations Between Diabetes and Idiopathic Pulmonary Fibrosis: a Study-level Pooled Analysis of 26 Million People
Chenyu Li, Yang Xiao, Jingyi Hu, Zhuowei Hu, Jianru Yan, Zhiguang Zhou, Zubing Mei
doi : 10.1210/clinem/dgab553
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages 3367–3380
Diabetes mellitus (DM) is a systemic disease characterized by chronic hyperglycemia associated with inflammation and oxidative stress, and the lung may be a target organ of diabetic microvascular damage. Several studies have indicated a positive association between idiopathic pulmonary fibrosis (IPF) and diabetes with controversial findings.
Achieving the HbA1c Target Requires Longer Time in Range in Pregnant Women With Type 1 Diabetes
Ping Ling, Daizhi Yang, Nan Gu, Xinhua Xiao, Jing Lu, Fang Liu, Zhiguang Zhou, Qin Huang, Jiajun Zhao, Mei Zhang, Ji Hu, Sihui Luo, Jianping Weng, Jinhua Yan, Xueying Zheng
doi : 10.1210/clinem/dgab502
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4309–e4317
Continuous glucose monitoring (CGM) overcomes the limitations of glycated hemoglobin (HbA1c).
Proinsulin to C-Peptide Ratio in the First Year After Diagnosis of Type 1 Diabetes
Jurhee Freese, Rawan Al-Rawi, Heather Choat, Alexandra Martin, Alison Lunsford, Hubert Tse, Gail Mick, Kenneth McCormick
doi : 10.1210/clinem/dgab463
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4318–e4326
The proinsulin to C-peptide (PI:C) ratio is reputedly a biomarker of ?-cell endoplasmic reticulum (ER) stress.
Leptin Attenuates Cardiac Hypertrophy in Patients With Generalized Lipodystrophy
My-Le Nguyen, Vandana Sachdev, Thomas R Burklow, Wen Li, Megan Startzell, Sungyoung Auh, Rebecca J Brown
doi : 10.1210/clinem/dgab499
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4327–e4339
Lipodystrophy syndromes are rare disorders of deficient adipose tissue, low leptin, and severe metabolic disease, affecting all adipose depots (generalized lipodystrophy, GLD) or only some (partial lipodystrophy, PLD). Left ventricular (LV) hypertrophy is common (especially in GLD); mechanisms may include hyperglycemia, dyslipidemia, or hyperinsulinemia.
Identification of Surgically Curable Primary Aldosteronism by Imaging in a Large, Multiethnic International Study
Gian Paolo Rossi, Filippo Crimì, Giacomo Rossitto, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Leo Schultze Kool, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S Willenberg, Peter J Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B Magill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Vin Cent Wu, Zuzana Kratka, Giulio Barbiero, Teresa Maria Seccia, Michele Battistel
doi : 10.1210/clinem/dgab482
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4340–e4349
Adrenal gland imaging is recommended by the current guidelines for the workup of primary aldosteronism (PA). However, its diagnostic performance has not been established in large, multiethnic cohorts of patients who undergo adrenal vein sampling (AVS) and adrenalectomy.
A Serum Resistin and Multicytokine Inflammatory Pathway Is Linked With and Helps Predict All-cause Death in Diabetes
Maria Giovanna Scarale, Alessandra Antonucci, Marina Cardellini, Massimiliano Copetti, Lucia Salvemini, Rossella Menghini, Tommaso Mazza, Viviana Casagrande, Gianluigi Ferrazza, Olga Lamacchia, Salvatore De Cosmo, Rosa Di Paola, Massimo Federici, Vincenzo Trischitta, Claudia Menzaghi
doi : 10.1210/clinem/dgab472
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4350–e4359
Type 2 diabetes (T2D) shows a high mortality rate, partly mediated by atherosclerotic plaque instability. Discovering novel biomarkers may help identify high-risk patients who would benefit from more aggressive and specific managements. We recently described a serum resistin and multicytokine inflammatory pathway (REMAP), including resistin, interleukin (IL)-1?, IL-6, IL-8, and TNF-?, that is associated with cardiovascular disease.
Intact Fasting Insulin Identifies Nonalcoholic Fatty Liver Disease in Patients Without Diabetes
Fernando Bril, Michael J McPhaul, Srilaxmi Kalavalapalli, Romina Lomonaco, Diana Barb, Meagan E Gray, Dov Shiffman, Charles M Rowland, Kenneth Cusi
doi : 10.1210/clinem/dgab417
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4360–e4371
Patients with nonalcoholic fatty liver disease (NAFLD) are characterized by insulin resistance and hyperinsulinism. However, insulin resistance measurements have not been shown to be good diagnostic tools to predict NAFLD in prior studies.
Longitudinal Metabolic Profiling of Maternal Obesity, Gestational Diabetes, and Hypertensive Pregnancy Disorders
Jemina Kivelä, Heidi Sormunen-Harju, Polina V Girchenko, Emilia Huvinen, Beata Stach-Lempinen, Eero Kajantie, Pia M Villa, Rebecca M Reynolds, Esa K Hämäläinen, Marius Lahti-Pulkkinen, Katja K Murtoniemi, Hannele Laivuori, Johan G Eriksson, Katri Räikkönen, Saila B Koivusalo
doi : 10.1210/clinem/dgab475
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4372–e4388
Comprehensive assessment of metabolism in maternal obesity and pregnancy disorders can provide information about the shared maternal-fetal milieu and give insight into both maternal long-term health and intergenerational transmission of disease burden.
Maximal Fat Oxidation Rate Is Higher in Fit Women and Unfit Women With Obesity, Compared to Normal-weight Unfit Women
Jacob Frandsen, Ida Marie Dahlgaard Hansen, Julie Fensmark Wismann, Maria Høyer Olsen, Morten Runge Brage-Andersen, Ronni Eg Sahl, Maria Hansen, Arthur Ingersen, Johanne Louise Modvig, Malte Schmücker, Camilla Honoré Grauslund, Flemming Dela, Steen Larsen, Jørn Wulff Helge
doi : 10.1210/clinem/dgab473
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4389–e4399
The maximal fat oxidation rate (MFO) is higher in aerobically fit vs unfit young men, but this training-related increase in MFO is attenuated in middle-aged men. Further, it has also been found that unfit men with obesity may have an elevated MFO compared to unfit normal-weight men.
Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism
Mohamed K M Shakir, Daniel I Brooks, Elizabeth A McAninch, Tatiana L Fonseca, Vinh Q Mai, Antonio C Bianco, Thanh D Hoang
doi : 10.1210/clinem/dgab478
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4400–e4413
Studies comparing levothyroxine (LT4) therapy with LT4?+?liothyronine (LT3) or desiccated thyroid extract (DTE) did not detect consistent superiority of either treatment. Here, we investigated these therapies, focusing on the whole group of LT4-treated hypothyroid patients, while also exploring the most symptomatic patients.
Sleep Habits of Women With Infertility
Esther Eisenberg, Richard S Legro, Michael P Diamond, Hao Huang, Louise M O’Brien, Yolanda R Smith, Christos Coutifaris, Karl R Hansen, Nanette Santoro, Heping Zhang
doi : 10.1210/clinem/dgab474
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4414–e4426
Sleep plays important roles in metabolic and reproductive function, and polycystic ovary syndrome (PCOS) is associated with sleep disturbances, including increased prevalence of obstructive sleep apnea.
Per- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition
Siobán D Harlow, Michelle M Hood, Ning Ding, Bhramar Mukherjee, Antonia M Calafat, John F Randolph, Jr, Ellen B Gold, Sung Kyun Park
doi : 10.1210/clinem/dgab476
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4427–e4437
Per- and polyfluoroalkyl substances (PFAS) are widespread chemicals that may affect sex hormones and accelerate reproductive aging in midlife women.
The Relation Between Adult Weight Gain, Adipocyte Volume, and the Metabolic Profile at Middle Age
Inge Verkouter, Raymond Noordam, Nellie Y Loh, Ko Willems van Dijk, Peter L Zock, Dennis O Mook-Kanamori, Saskia le Cessie, Frits R Rosendaal, Fredrik Karpe, Costantinos Christodoulides, Renée de Mutsert
doi : 10.1210/clinem/dgab477
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4438–e4447
Weight gain during adulthood increases cardiometabolic disease risk, possibly through adipocyte hypertrophy.
Fasting Plasma Glucose and Incident Colorectal Cancer: Analysis of a Nationwide Epidemiological Database
Hidetaka Itoh, Hidehiro Kaneko, Akira Okada, Yuichiro Yano, Kojiro Morita, Hikari Seki, Hiroyuki Kiriyama, Tatsuya Kamon, Katsuhito Fujiu, Satoshi Matsuoka, Sunao Nakamura, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Akira Nishiyama, Koichi Node, Hideo Yasunaga, Issei Komuro
doi : 10.1210/clinem/dgab466
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4448–e4458
Although diabetes mellitus (DM) was reported to be associated with incident colorectal cancer (CRC), the detailed association between fasting plasma glucose (FPG) and incident CRC has not been fully understood.
Neurodevelopmental Disorders, Glycemic Control, and Diabetic Complications in Type 1 Diabetes: a Nationwide Cohort Study
Shengxin Liu, Ralf Kuja-Halkola, Henrik Larsson, Paul Lichtenstein, Jonas F Ludvigsson, Ann-Marie Svensson, Soffia Gudbjörnsdottir, Magnus Tideman, Eva Serlachius, Agnieszka Butwicka
doi : 10.1210/clinem/dgab467
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4459–e4470
Neurodevelopmental disorders are more prevalent in childhood-onset type 1 diabetes than in the general population, and the symptoms may limit the individual’s ability for diabetes management.
Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density
Daniel Schmitz, Weronica E Ek, Elin Berggren, Julia Höglund, Torgny Karlsson, Åsa Johansson
doi : 10.1210/clinem/dgab507
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4471–e4486
Estradiol is the primary female sex hormone and plays an important role for skeletal health in both sexes. Several enzymes are involved in estradiol metabolism, but few genome-wide association studies (GWAS) have been performed to characterize the genetic contribution to variation in estrogen levels.
Second-tier Testing for 21-Hydroxylase Deficiency in the Netherlands: A Newborn Screening Pilot Study
Kevin Stroek, An Ruiter, Annelieke van der Linde, Mariette Ackermans, Marelle J Bouva, Henk Engel, Bernadette Jakobs, Evelien A Kemper, Erica L T van den Akker, Mirjam E van Albada, Gianni Bocca, Martijn J J Finken, Sabine E Hannema, E C A Mieke Houdijk, Hetty J van der Kamp, Vera van Tellingen, A S Paul van Trotsenburg, Nitash Zwaveling-Soonawala, Annet M Bosch, Robert de Jonge, Annemieke C Heijboer, Hedi L Claahsen-van der Grinten, Anita Boelen
doi : 10.1210/clinem/dgab464
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4487–e4496
Newborn screening (NBS) for classic congenital adrenal hyperplasia (CAH) consists of 17-hydroxyprogesterone (17-OHP) measurement with gestational age–adjusted cutoffs. A second heel puncture (HP) is performed in newborns with inconclusive results to reduce false positives.
Type 2 Diabetes Mellitus and Amyotrophic Lateral Sclerosis: Genetic Overlap, Causality, and Mediation
Haimiao Chen, Jinhui Zhang, Ting Wang, Shuo Zhang, Qingwei Lai, Shuiping Huang, Ping Zeng
doi : 10.1210/clinem/dgab465
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4497–e4508
Understanding phenotypic connection between type II diabetes (T2D) mellitus and amyotrophic lateral sclerosis (ALS) can offer valuable sight into shared disease etiology and have important implication in drug repositioning and therapeutic intervention.
Salivary Profiles of 11-oxygenated Androgens Follow a Diurnal Rhythm in Patients With Congenital Adrenal Hyperplasia
Hanna Franziska Nowotny, Matthias K Auer, Christian Lottspeich, Heinrich Schmidt, Ilja Dubinski, Martin Bidlingmaier, Jo Adaway, James Hawley, Brian Keevil, Nicole Reisch
doi : 10.1210/clinem/dgab446
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4509–e4519
Several studies have highlighted the importance of the 11-oxygenated 19-carbon (11oxC19) adrenal-derived steroids as potential biomarkers for monitoring patients with 21-hydroxylase deficiency (21OHD).
The Use of Morning Urinary Gonadotropins and Sex Hormones in the Management of Early Puberty in Chinese Girls
Shumin Zhan, Ke Huang, Wei Wu, Danni Zhang, Ana Liu, Robert M Dorazio, Jianrong Shi, Rahim Ullah, Li Zhang, Jinling Wang, Guanping Dong, Yan Ni, Junfen Fu
doi : 10.1210/clinem/dgab448
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4520–e4530
Although gonadotropin-releasing hormone stimulation test (GnRHST) is the gold standard in diagnosing central precocious puberty (CPP), it is invasive, expensive, and time-consuming, requiring multiple blood samples to measure gonadotropin levels.
Association Between Smoking Behavior and Insulin Resistance Using Triglyceride–Glucose Index Among South Korean Adults
Sung Hoon Jeong, Hye Jin Joo, Junhyun Kwon, Eun-Cheol Park
doi : 10.1210/clinem/dgab399
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4531–e4541
Insulin resistance is a determinant of diabetes. With the increasing popularity of electronic smoking, the number of dual smokers (smoking both cigarettes and electronic cigarettes [e-cigarettes]) is increasing. However, few studies have assessed the association between insulin resistance and smoking behavior, including dual smoking.
Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women
Tess V Clendenen, Wenzhen Ge, Karen L Koenig, Yelena Afanasyeva, Claudia Agnoli, Elizabeth Bertone-Johnson, Louise A Brinton, Farbod Darvishian, Joanne F Dorgan, A Heather Eliassen, Roni T Falk, Göran Hallmans, Susan E Hankinson, Judith Hoffman-Bolton, Timothy J Key, Vittorio Krogh, Hazel B Nichols, Dale P Sandler, Minouk J Schoemaker, Patrick M Sluss, Malin Sund, Anthony J Swerdlow, Kala Visvanathan, Mengling Liu, Anne Zeleniuch-Jacquotte
doi : 10.1210/clinem/dgab461
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4542–e4553
We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies.
Academic Performance in Adolescents Born to Mothers With Gestational Diabetes—A National Danish Cohort Study
Gerda Ferja Heldarskard, Anne Lærke Spangmose, Anna-Karina Aaris Henningsen, Rikke Wiingreen, Erik Lykke Mortensen, Tina Wullum Gundersen, Rikke Beck Jensen, Sine Knorr, Peter Damm, Julie Lyng Forman, Anja Pinborg, Tine Dalsgaard Clausen
doi : 10.1210/clinem/dgab451
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4554–e4564
The prevalence of gestational diabetes mellitus (GDM) is increasing, and intrauterine hyperglycemia is suspected to affect offspring cognitive function.
Do Patients With Atypical Parathyroid Adenoma Need Close Follow-up?
Federica Saponaro, Elena Pardi, Laura Mazoni, Simona Borsari, Liborio Torregrossa, Matteo Apicella, Gianluca Frustaci, Gabriele Materazzi, Paolo Miccoli, Fulvio Basolo, Claudio Marcocci, Filomena Cetani
doi : 10.1210/clinem/dgab452
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4565–e4579
Atypical parathyroid adenomas (APAs) are neoplasms with uncertain malignant potential but lack unequivocal histological signs of malignancy.
Protective Role of DHEAS in Age-related Changes in Bone Mass and Fracture Risk
Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Norifusa Iwahashi, Yayoi Matsuda, Hiroki Kaneko, Masatoshi Ogata, Tazuru Fukumoto, Eriko Terada, Yui Nakano, Ryuichi Sakamoto, Yoshihiro Ogawa
doi : 10.1210/clinem/dgab459
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4580–e4592
Dehydroepiandrosterone sulfate (DHEAS) from the adrenal cortex substantially decreases with age, which may accelerate osteoporosis. However, the association of DHEAS with bone mineral density (BMD) and fracture is inconclusive. We conducted a Mendelian randomization (MR) analysis to investigate the role of DHEAS in age-related changes in BMD and fracture risk.
Efficacy and Safety of Intravenous Pamidronate for Parathyroid Hormone-dependent Hypercalcemia in Hospitalized Patients
Rachel Chava Rosenblum, Orit Twito, Liat Barzilay-Yoseph, Erez Ramaty, Noa Klein, Pnina Rotman-Pikielny
doi : 10.1210/clinem/dgab457
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4593–e4602
Bisphosphonates are effective for hypercalcemia of malignancy (HOM). Efficacy and safety data for bisphosphonates in parathyroid hormone–related hypercalcemia (PTHRH) are rare, including pamidronate (Pam), which is not indicated for this condition.
High-throughput Molecular Analysis of Pseudohypoparathyroidism 1b Patients Reveals Novel Genetic and Epigenetic Defects
Jennifer Danzig, Dong Li, Suzanne Jan de Beur, Michael A Levine
doi : 10.1210/clinem/dgab460
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4603–e4620
Patients with pseudohypoparathyroidism type 1b (PHP1b) show disordered imprinting of the maternal GNAS allele or paternal uniparental disomy (UPD). Genetic deletions in STX16 or in upstream exons of GNAS are present in many familial but not sporadic cases.
Hyperandrogenemia in Early Adulthood Is an Independent Risk Factor for Abnormal Glucose Metabolism in Middle Age
Katri Tuorila, Meri-Maija Ollila, Marjo-Riitta Järvelin, Juha S Tapanainen, Stephen Franks, Katri Puukka, Terhi T Piltonen, Laure Morin-Papunen
doi : 10.1210/clinem/dgab456
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4621–e4633
The role of androgen excess as a contributing factor to abnormal glucose metabolism (AGM) and insulin resistance in women remains controversial.
Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein
Xiao Gao, Shengxu Li, Shiqiu Dong, Jiaqi Li, Yinkun Yan, Tao Zhang, Wei Chen
doi : 10.1210/clinem/dgab455
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4634–e4640
Both obesity and inflammation are related to accelerated aging. It is not yet known whether inflammation mediates the effects of obesity on aging.
Genetic Support of A Causal Relationship Between Iron Status and Type 2 Diabetes: A Mendelian Randomization Study
Xinhui Wang, Xuexian Fang, Wanru Zheng, Jiahui Zhou, Zijun Song, Mingqing Xu, Junxia Min, Fudi Wang
doi : 10.1210/clinem/dgab454
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4641–e4651
Iron overload is a known risk factor for type 2 diabetes (T2D); however, iron overload and iron deficiency have both been associated with metabolic disorders in observational studies.
Novel Anaplastic Thyroid Cancer PDXs and Cell Lines: Expanding Preclinical Models of Genetic Diversity
Anastasios Maniakas, Ying C Henderson, Hu Hei, Shaohua Peng, Yunyun Chen, Yujie Jiang, Shuangxi Ji, Maria Cardenas, Yulun Chiu, Diana Bell, Michelle D Williams, Marie-Claude Hofmann, Steve E Scherer, David A Wheeler, Naifa L Busaidy, Ramona Dadu, Jennifer R Wang, Maria E Cabanillas, Mark Zafereo, Faye M Johnson, Stephen Y Lai
doi : 10.1210/clinem/dgab453
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4652–e4665
Anaplastic thyroid cancer (ATC) is a rare, aggressive, and deadly disease. Robust preclinical thyroid cancer models are needed to adequately develop and study novel therapeutic agents. Patient-derived xenograft (PDX) models may resemble patient tumors by recapitulating key genetic alterations and gene expression patterns, making them excellent preclinical models for drug response evaluation.
Tildacerfont in Adults With Classic Congenital Adrenal Hyperplasia: Results from Two Phase 2 Studies
Kyriakie Sarafoglou, Chris N Barnes, Michael Huang, Erik A Imel, Ivy-Joan Madu, Deborah P Merke, David Moriarty, Samer Nakhle, Ron S Newfield, Maria G Vogiatzi, Richard J Auchus
doi : 10.1210/clinem/dgab438
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4666–e4679
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD) is typically treated with lifelong supraphysiologic doses of glucocorticoids (GCs). Tildacerfont, a corticotropin-releasing factor type-1 receptor antagonist, may reduce excess androgen production, allowing for GC dose reduction.
Identification of New Rare Variants Associated With Familial Autoimmune Thyroid Diseases by Deep Sequencing of Linked Loci
Cheuk Wun Li, Ravi Sachidanandam, Anitha Jayaprakash, Zhengzi Yi, Weijia Zhang, Mihaela Stefan-Lifshitz, Erlinda Concepcion, Yaron Tomer
doi : 10.1210/clinem/dgab440
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4680–e4687
Genetic risk factors play a major role in the pathoetiology of autoimmune thyroid diseases (AITD). So far, only common risk variants have been identified in AITD susceptibility genes. Recently, rare genetic variants have emerged as important contributors to complex diseases, and we hypothesized that rare variants play a key role in the genetic susceptibility to AITD.
Prognostic Implications of Preablation Stimulated Tg: A Retrospective Analysis of 2500 Thyroid Cancer Patients
Tian Tian, Yangmengyuan Xu, Xinyue Zhang, Bin Liu
doi : 10.1210/clinem/dgab445
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4688–e4697
The risk of persistent and recurrent disease in patients with differentiated thyroid cancer (DTC) is a continuum that ranges from very low to very high, even within the 3 primary risk categories. It is important to identify independent clinicopathological parameters to accurately predict clinical outcomes.
Combination of Mitotane and Locoregional Treatments in Low-volume Metastatic Adrenocortical Carcinoma
Alice Boilève, Elise Mathy, Charles Roux, Matthieu Faron, Julien Hadoux, Lambros Tselikas, Abir Al Ghuzlan, Ségolène Hescot, Sophie Leboulleux, Thierry de Baere, Livia Lamartina, Frédéric Deschamps, Eric Baudin
doi : 10.1210/clinem/dgab449
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4698–e4707
European and French guidelines for ENSAT stage IV low tumor burden or indolent adrenocortical carcinoma (ACC) recommend a combination of mitotane and locoregional treatments (LRT) as first-line treatment. Nevertheless, the benefit of LRT in combination with mitotane has never been evaluated in this selected group of patients.
Vitamin D Deficiency Is Associated With Higher Hospitalization Risk From COVID-19: A Retrospective Case-control Study
Edward B Jude, Stephanie F Ling, Rebecca Allcock, Beverly X Y Yeap, Joseph M Pappachan
doi : 10.1210/clinem/dgab439
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4708–e4715
One risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is postulated to be vitamin D deficiency. To better understand the role of vitamin D deficiency in the disease course of COVID-19, we undertook a retrospective case-control study in North West England.
Genetic Characterization of Short Stature Patients With Overlapping Features of Growth Hormone Insensitivity Syndromes
Afiya Andrews, Avinaash Maharaj, Emily Cottrell, Sumana Chatterjee, Pratik Shah, Louise Denvir, Katja Dumic, Artur Bossowski, Talat Mushtaq, Rade Vukovic, Mohamed Didi, Nick Shaw, Louise A Metherell, Martin O Savage, Helen L Storr
doi : 10.1210/clinem/dgab437
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4716–e4733
Growth hormone insensitivity (GHI) in children is characterized by short stature, functional insulin-like growth factor (IGF)-I deficiency, and normal or elevated serum growth hormone (GH) concentrations. The clinical and genetic etiology of GHI is expanding.
Bariatric Surgery for Hypothalamic Obesity in Craniopharyngioma Patients: A Retrospective, Matched Case–Control Study
Selveta S van Santen, Peter Wolf, Natalia Kremenevski, Cesar L Boguszewski, Hannes Beiglböck, Marta Fiocco, Mark Wijnen, Ville R Wallenius, Marry M van den Heuvel-Eibrink, Aart J van der Lely, Gudmundur Johannsson, Anton Luger, Michael Krebs, Michael Buchfelder, Patric J D Delhanty, Sebastian J C M M Neggers, Daniel S Olsson
doi : 10.1210/clinem/dgab518
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4734–e4745
Craniopharyngioma is a sellar tumor associated with high rates of pituitary deficiencies (~?98%) and hypothalamic obesity (~?50%).
Hepatic Fat in Participants With and Without Incident Diabetes in the Diabetes Prevention Program Outcome Study
Ronald B Goldberg, Mark T Tripputi, Edward J Boyko, Matthew Budoff, Zsu-Zsu Chen, Jeanne M Clark, Dana M Dabelea, Sharon L Edelstein, Robert E Gerszten, Edward Horton, Kieren J Mather, Leigh Perreault, Marinella Temprosa, Amisha Wallia, Karol Watson, Zeb Irfan
doi : 10.1210/clinem/dgab160
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4746–e4765
There is little information about fatty liver in prediabetes as it transitions to early diabetes.
Clinical Experience of the Efficacy and Safety of Low-dose Tolvaptan Therapy in a UK Tertiary Oncology Setting
Victoria Chatzimavridou-Grigoriadou, Sami Al-Othman, Georg Brabant, Angelos Kyriacou, Jennifer King, Fiona Blackhall, Peter J Trainer, Claire E Higham
doi : 10.1210/clinem/dgab131
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4766–e4775
In patients with cancer, hyponatremia is associated with increased morbidity and mortality and can delay systemic therapy.
What Is the Mechanism of Poor Endometrial Proliferation in Patients With Unexplained Infertility After Clomiphene Citrate Treatment?
Esra Cetin, Hiba Siblini, Ayman Al-Hendy
doi : 10.1210/clinem/dgab483
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4776–e4777
The HIF1?-PFKFB3 Pathway: A Key Player in Diabetic Retinopathy
Teresa Vezza, Víctor M Víctor
doi : 10.1210/clinem/dgab469
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4778–e4780
Indeterminate Thyroid Nodules: The Hazy Genomic Landscape Coming into Focus
Abberly Lott Limbach, Jennifer A Sipos
doi : 10.1210/clinem/dgab441
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4781–e4783
Of the Futility of Repeating BMD Measurement in Treated Osteoporotic Women
Roland Chapurlat
doi : 10.1210/clinem/dgab395
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4784–e4785
Potential Role for the Use of Gliptins in Cystic Fibrosis-related Diabetes
Heba M Ismail
doi : 10.1210/clinem/dgab442
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4786–e4788
Letter to the Editor from Caufriez and Copinschi: “Efficacy of Micronized Progesterone for Sleep: A Systematic Review and Meta-analysis of Randomized Controlled Trial Data”
Anne Caufriez, Georges Copinschi
doi : 10.1210/clinem/dgab493
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4789–e4790
Response to Letter to the Editor From Laidlaw: “Erythrocytosis in a Large Cohort of Trans Men Using Testosterone: A Long-term Follow-up Study on Prevalence, Determinants, and Exposure Years”
Milou C Madsen, Dennis van Dijk, Chantal M Wiepjes, Elfi B Conemans, Abel Thijs, Martin den Heijer
doi : 10.1210/clinem/dgab515
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4791–e4792
Corrigendum to: “Long-Acting Growth Hormone Preparations – Current Status and Future Considerations”
doi : 10.1210/clinem/dgab479
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Page e4793
Corrigendum to: “Genotype–Phenotype Correlations in Central Precocious Puberty Caused by MKRN3 Mutations”
doi : 10.1210/clinem/dgab394
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Page e4794
